ATE486937T1 - Chimärische heteromultimerische adhesine - Google Patents
Chimärische heteromultimerische adhesineInfo
- Publication number
- ATE486937T1 ATE486937T1 AT97932526T AT97932526T ATE486937T1 AT E486937 T1 ATE486937 T1 AT E486937T1 AT 97932526 T AT97932526 T AT 97932526T AT 97932526 T AT97932526 T AT 97932526T AT E486937 T1 ATE486937 T1 AT E486937T1
- Authority
- AT
- Austria
- Prior art keywords
- adhesins
- chimeric
- heteromultimeric
- erbb2
- heteromultimer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000014413 Neuregulin Human genes 0.000 abstract 1
- 108050003475 Neuregulin Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000002860 competitive effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Adhesives Or Adhesive Processes (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2164096P | 1996-07-12 | 1996-07-12 | |
US79832697A | 1997-02-10 | 1997-02-10 | |
PCT/US1997/011825 WO1998002540A1 (en) | 1996-07-12 | 1997-07-08 | Chimeric heteromultimer adhesins |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE486937T1 true ATE486937T1 (de) | 2010-11-15 |
Family
ID=26694954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97932526T ATE486937T1 (de) | 1996-07-12 | 1997-07-08 | Chimärische heteromultimerische adhesine |
Country Status (13)
Country | Link |
---|---|
US (3) | US6696290B2 (de) |
EP (2) | EP0938556B1 (de) |
JP (2) | JP4274581B2 (de) |
CN (1) | CN1202247C (de) |
AT (1) | ATE486937T1 (de) |
AU (1) | AU722178B2 (de) |
BR (1) | BR9710357A (de) |
CA (1) | CA2258721C (de) |
DE (1) | DE69740038D1 (de) |
DK (1) | DK0912734T3 (de) |
IL (1) | IL127891A0 (de) |
NZ (1) | NZ333325A (de) |
WO (1) | WO1998002540A1 (de) |
Families Citing this family (63)
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EP1053256B9 (de) * | 1998-01-26 | 2012-01-18 | Genentech, Inc. | Antikörper gegen "death receptor 4" (dr4) und deren verwendungen |
US6417168B1 (en) | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
EP1745799B1 (de) | 1998-03-04 | 2015-09-02 | The Trustees of The University of Pennsylvania | Zusammensetzungen und Verfahren zur Behandlung von Tumoren |
DE69939374D1 (de) * | 1998-03-17 | 2008-10-02 | Genentech Inc | Zu vegf und bmp1 homologe polypeptide |
US6635249B1 (en) | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
US20030022233A1 (en) * | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
AUPQ105799A0 (en) | 1999-06-18 | 1999-07-08 | Victor Chang Cardiac Research Institute, The | Cell growth inhibition |
AUPQ841800A0 (en) * | 2000-06-28 | 2000-07-20 | Biomolecular Research Institute Limited | Truncated egf receptor |
EP2177616B1 (de) * | 2000-08-08 | 2012-02-29 | ZymoGenetics, Inc. | Lösliche Zcyctor 11 Cytokinrezeptoren |
US20020119148A1 (en) * | 2000-09-01 | 2002-08-29 | Gerritsen Mary E. | ErbB4 antagonists |
US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
US20030133939A1 (en) * | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
WO2003012045A2 (en) * | 2001-07-31 | 2003-02-13 | Wayne State University | Hybrid proteins with neuregulin heparin-binding domain for targeting to heparan sulfate proteoglycans |
EP1283053A1 (de) | 2001-08-09 | 2003-02-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibitore der HER3 Aktivität |
US7919098B2 (en) * | 2002-03-26 | 2011-04-05 | Zensun ( Shanghai ) Sci & Tech Co., Ltd. | ErbB-3 based methods and compositions for treating neoplasms |
WO2003099320A1 (en) | 2002-05-24 | 2003-12-04 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
JP2006516117A (ja) * | 2002-11-21 | 2006-06-22 | ジェネンテック・インコーポレーテッド | 抗ErbB2抗体を用いた非悪性疾病または疾患の治療 |
EA010055B1 (ru) * | 2003-03-19 | 2008-06-30 | Байоджен Айдек Ма Инк. | ВЫДЕЛЕННАЯ НУКЛЕИНОВАЯ КИСЛОТА, КОДИРУЮЩАЯ ПОЛИПЕПТИД Sp35, ПОЛИПЕПТИД Sp35 И СПОСОБЫ ПРИМЕНЕНИЯ НУКЛЕИНОВОЙ КИСЛОТЫ И ПОЛИПЕПТИДА |
CA2558811A1 (en) * | 2004-03-08 | 2005-09-22 | Zymogenetics, Inc. | Dimeric fusion proteins and materials and methods for producing them |
KR101239542B1 (ko) * | 2004-06-24 | 2013-03-07 | 바이오겐 아이덱 엠에이 인코포레이티드 | 탈수초화를 수반하는 병의 치료 |
DE602005022475D1 (de) | 2004-10-22 | 2010-09-02 | Zymogenetics Inc | Anti-il-22ra-antikörper und bindungspartner und verfahren zur anwendung bei entzündungen |
ATE557038T1 (de) | 2005-06-03 | 2012-05-15 | Ares Trading Sa | Herstellung von rekombinantem il-18 bindendem protein |
WO2007008547A2 (en) | 2005-07-08 | 2007-01-18 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
ES2460517T3 (es) | 2005-07-25 | 2014-05-13 | Emergent Product Development Seattle, Llc | Reducción de células b mediante el uso de moléculas de unión específica a cd37 y de unión específica a cd20 |
NZ598421A (en) * | 2005-12-02 | 2013-11-29 | Biogen Idec Inc | Treatment of Conditions Involving Demyelination |
KR20090057936A (ko) * | 2006-02-08 | 2009-06-08 | 타게티드 몰레큘라 다이아그노스틱스, 엘엘씨 | 2가 erbb 리간드 결합 분자 및 그의 제조 방법 및 사용방법 |
CN101611150A (zh) * | 2006-02-08 | 2009-12-23 | 利佳赛普特有限责任公司 | 二价ErbB配体结合分子及其制备和使用方法 |
CA2643478C (en) | 2006-02-23 | 2019-06-18 | Novocell, Inc. | Compositions and methods useful for culturing differentiable cells |
AU2007257683A1 (en) * | 2006-06-12 | 2007-12-21 | Symphogen A/S | Pan-cell surface receptor- specific therapeutics |
KR101571027B1 (ko) * | 2006-06-12 | 2015-11-23 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | 효과기 기능을 갖는 단일쇄 다가 결합 단백질 |
US7932055B2 (en) * | 2006-06-22 | 2011-04-26 | Novo Nordisk A/S | Soluble heterodimeric CD94/NKG2 receptors fusion proteins |
WO2007147901A1 (en) * | 2006-06-22 | 2007-12-27 | Novo Nordisk A/S | Production of bispecific antibodies |
US8128926B2 (en) | 2007-01-09 | 2012-03-06 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
EP2647388A1 (de) | 2007-02-16 | 2013-10-09 | Merrimack Pharmaceuticals, Inc. | Antikörper gegen ERBB3 und Verwendungen davon |
US20090258005A1 (en) * | 2007-05-29 | 2009-10-15 | Trubion Pharmaceuticals Inc. | Therapeutic compositions and methods |
US20090304590A1 (en) * | 2007-05-29 | 2009-12-10 | Wyeth | Therapeutic compositions and methods |
US20100297121A1 (en) * | 2007-10-11 | 2010-11-25 | Biogen Idec Ma Inc. | Methods for Treating Pressure Induced Optic Neuropathy, Preventing Neuronal Degeneration and Promoting Neuronal Cell Survival Via Administration of LINGO-1 Antagonists and TrkB Agonists |
WO2009052184A2 (en) * | 2007-10-16 | 2009-04-23 | Receptor Biologix, Inc. | Compositions comprising optimized her1 and her3 multimers and methods of use thereof |
US20110123553A1 (en) * | 2007-11-08 | 2011-05-26 | Biogen Idec Ma Inc. | Use of LINGO-4 Antagonists in the Treatment of Conditions Involving Demyelination |
CN102099377A (zh) * | 2008-04-11 | 2011-06-15 | 新兴产品开发西雅图有限公司 | Cd37免疫治疗剂及其与双功能化学治疗剂的联合 |
NZ590605A (en) | 2008-07-09 | 2012-11-30 | Biogen Idec Inc | Compositions comprising antibodies to lingo or fragments thereof |
PE20120015A1 (es) | 2008-08-15 | 2012-01-26 | Merrimack Pharmaceuticals Inc | Metodos y sistemas para predecir la respuesta de las celulas tumorales a un agente terapeutico |
EP2346526A2 (de) | 2008-09-22 | 2011-07-27 | Massachusetts Institute of Technology | Zusammensetzungen und verfahren zur verwendung von liganden-dimeren |
AU2009324939B2 (en) | 2008-11-25 | 2015-07-09 | Genentech, Inc. | Isoform specific anti-HER4 antibodies |
JP5926680B2 (ja) * | 2009-07-28 | 2016-05-25 | リガセプト・エルエルシー | 広範囲のErbBリガンド結合分子ならびにそれを調製および使用するための方法 |
MX2012008958A (es) | 2010-02-18 | 2012-08-23 | Genentech Inc | Antagonista de neurogulina y usos de los mismos para el tratamiento contra el cancer. |
DK2544680T3 (en) | 2010-03-11 | 2015-04-27 | Merrimack Pharmaceuticals Inc | USE OF ErbB3 INHIBITORS IN TREATMENT OF TRIPLE-NEGATIVE BREAST CANCER |
US9029328B2 (en) | 2010-03-24 | 2015-05-12 | The Brigham And Women's Hospital, Inc. | Methods for cardioprotection and cardioregeneration with dimers of EGF family ligands |
TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
WO2012103114A2 (en) * | 2011-01-24 | 2012-08-02 | Jason Hill | Therapeutic chimeric ligand binding proteins and methods for their use |
MX2014013950A (es) | 2012-05-14 | 2015-02-17 | Biogen Idec Inc | Antagonistas de proteina que interactua con el receptor nogo 2 que contiene repeticion rica en leucina y dominio de inmunoglobulina (lingo-2) para el tratamiento de afecciones que involucran neuronas motoras. |
WO2014051567A1 (en) * | 2012-09-26 | 2014-04-03 | Morehouse School Of Medicine | Chimeric neuregulins and method of making and use thereof |
EP3693381A1 (de) | 2013-02-18 | 2020-08-12 | Vegenics Pty Limited | Ligandbindende moleküle und verwendungen davon |
AU2014285079A1 (en) | 2013-07-05 | 2016-01-21 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Soluble CD33 for treating myelodysplastic syndromes (MDS) |
WO2015100459A2 (en) | 2013-12-27 | 2015-07-02 | Merrimack Pharmaceuticals, Inc. | Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies |
EP3242893A1 (de) | 2015-01-08 | 2017-11-15 | Biogen MA Inc. | Lingo-1-antagonisten und verwendungen zur behandlung von demyelinisierungserkrankungen |
US10184006B2 (en) | 2015-06-04 | 2019-01-22 | Merrimack Pharmaceuticals, Inc. | Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors |
CA2999138C (en) | 2015-09-21 | 2024-05-21 | Aptevo Research And Development Llc | Cd3 binding polypeptides |
KR20180117529A (ko) | 2017-04-19 | 2018-10-29 | 주식회사 프로티나 | 단백질-단백질 상호작용 분석에 의한 약물 반응성 예측 방법 |
WO2019132517A1 (ko) * | 2017-12-26 | 2019-07-04 | 주식회사 프로티나 | 세포 내 또는 세포 간 단백질-단백질 상호작용 분석 방법 및 장치 |
CN110669139A (zh) * | 2019-09-18 | 2020-01-10 | 沣潮医药科技(上海)有限公司 | 二聚体免疫粘附素、药物组合物和用途 |
CN111018999B (zh) * | 2019-12-05 | 2022-07-12 | 沣潮医药科技(上海)有限公司 | 二聚体免疫融合蛋白、药物组合物和用途 |
Family Cites Families (22)
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US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US4968603A (en) | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
NZ226414A (en) | 1987-10-02 | 1992-07-28 | Genentech Inc | Cd4 peptide adhesion variants and their preparation and use |
US5336603A (en) | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
WO1990006953A2 (en) | 1988-12-22 | 1990-06-28 | Genentech, Inc. | Method for preparing water soluble polypeptides |
US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
DK0479909T3 (da) | 1989-06-29 | 1997-04-07 | Medarex Inc | Bispecifikke reagenser til AIDS-behandling |
US5183884A (en) | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
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-
1997
- 1997-07-08 DE DE69740038T patent/DE69740038D1/de not_active Expired - Lifetime
- 1997-07-08 DK DK97932526.3T patent/DK0912734T3/da active
- 1997-07-08 CA CA2258721A patent/CA2258721C/en not_active Expired - Lifetime
- 1997-07-08 BR BR9710357A patent/BR9710357A/pt not_active Application Discontinuation
- 1997-07-08 EP EP97934059A patent/EP0938556B1/de not_active Expired - Lifetime
- 1997-07-08 AU AU35962/97A patent/AU722178B2/en not_active Expired
- 1997-07-08 CN CNB971962499A patent/CN1202247C/zh not_active Expired - Lifetime
- 1997-07-08 NZ NZ333325A patent/NZ333325A/en not_active IP Right Cessation
- 1997-07-08 EP EP97932526A patent/EP0912734B1/de not_active Expired - Lifetime
- 1997-07-08 WO PCT/US1997/011825 patent/WO1998002540A1/en active Application Filing
- 1997-07-08 IL IL12789197A patent/IL127891A0/xx not_active IP Right Cessation
- 1997-07-08 AT AT97932526T patent/ATE486937T1/de not_active IP Right Cessation
- 1997-07-08 JP JP50608998A patent/JP4274581B2/ja not_active Expired - Lifetime
-
1999
- 1999-03-12 US US09/267,985 patent/US6696290B2/en not_active Expired - Lifetime
-
2003
- 2003-12-22 US US10/746,176 patent/US7659368B2/en not_active Expired - Fee Related
-
2006
- 2006-09-28 US US11/536,354 patent/US20070081994A1/en not_active Abandoned
-
2007
- 2007-12-12 JP JP2007321420A patent/JP2008115187A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU722178B2 (en) | 2000-07-27 |
EP0938556A1 (de) | 1999-09-01 |
DE69740038D1 (de) | 2010-12-16 |
DK0912734T3 (da) | 2011-02-07 |
AU3596297A (en) | 1998-02-09 |
CN1225129A (zh) | 1999-08-04 |
WO1998002540A1 (en) | 1998-01-22 |
US7659368B2 (en) | 2010-02-09 |
BR9710357A (pt) | 1999-08-17 |
US20040138417A1 (en) | 2004-07-15 |
IL127891A0 (en) | 1999-10-28 |
US6696290B2 (en) | 2004-02-24 |
CA2258721C (en) | 2014-09-09 |
EP0912734B1 (de) | 2010-11-03 |
EP0938556B1 (de) | 2005-03-09 |
CN1202247C (zh) | 2005-05-18 |
US20030199020A1 (en) | 2003-10-23 |
JP4274581B2 (ja) | 2009-06-10 |
US20070081994A1 (en) | 2007-04-12 |
JP2008115187A (ja) | 2008-05-22 |
JP2000515372A (ja) | 2000-11-21 |
EP0912734A1 (de) | 1999-05-06 |
CA2258721A1 (en) | 1998-01-22 |
NZ333325A (en) | 2000-06-23 |
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