MA28702B1 - Composes et procedes pour l'inhibition de l'interaction de proteines bcl avec des partenaires de liaison - Google Patents
Composes et procedes pour l'inhibition de l'interaction de proteines bcl avec des partenaires de liaisonInfo
- Publication number
- MA28702B1 MA28702B1 MA29588A MA29588A MA28702B1 MA 28702 B1 MA28702 B1 MA 28702B1 MA 29588 A MA29588 A MA 29588A MA 29588 A MA29588 A MA 29588A MA 28702 B1 MA28702 B1 MA 28702B1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- methods
- protein interaction
- bcl protein
- inhibiting bcl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58061604P | 2004-06-17 | 2004-06-17 | |
US65930105P | 2005-03-07 | 2005-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA28702B1 true MA28702B1 (fr) | 2007-06-01 |
Family
ID=35335774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA29588A MA28702B1 (fr) | 2004-06-17 | 2006-12-29 | Composes et procedes pour l'inhibition de l'interaction de proteines bcl avec des partenaires de liaison |
Country Status (22)
Country | Link |
---|---|
US (1) | US7851637B2 (fr) |
EP (1) | EP1768966B1 (fr) |
JP (1) | JP5064213B2 (fr) |
KR (1) | KR101195351B1 (fr) |
CN (1) | CN101006065B (fr) |
AT (1) | ATE548359T1 (fr) |
AU (1) | AU2005265131B2 (fr) |
BR (1) | BRPI0511070A (fr) |
CA (1) | CA2570780C (fr) |
EC (1) | ECSP067099A (fr) |
ES (1) | ES2382383T3 (fr) |
HK (1) | HK1105963A1 (fr) |
IL (1) | IL179904A (fr) |
MA (1) | MA28702B1 (fr) |
MX (1) | MXPA06014754A (fr) |
NO (1) | NO20070324L (fr) |
NZ (1) | NZ552183A (fr) |
PL (1) | PL1768966T3 (fr) |
PT (1) | PT1768966E (fr) |
RU (1) | RU2416606C2 (fr) |
WO (1) | WO2006009869A1 (fr) |
ZA (1) | ZA200610405B (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1768966T3 (pl) | 2004-06-17 | 2012-08-31 | Infinity Discovery Inc | Związki i sposoby hamowania oddziaływania białek BCL z partnerami wiążącymi |
US7842815B2 (en) | 2004-06-17 | 2010-11-30 | Infinity Pharmaceuticals, Inc. | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners |
US8624027B2 (en) * | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
TWI403320B (zh) | 2005-12-16 | 2013-08-01 | Infinity Discovery Inc | 用於抑制bcl蛋白和結合夥伴間之交互作用的化合物及方法 |
TWI389895B (zh) | 2006-08-21 | 2013-03-21 | Infinity Discovery Inc | 抑制bcl蛋白質與結合夥伴間之交互作用的化合物及方法 |
EP1897956A1 (fr) | 2006-09-06 | 2008-03-12 | Lonza AG | Procédé de préparation d'amines optiquement actives par résolution optique en utilisant d'une oméga-transaminase bactérienne |
CN104474529A (zh) * | 2008-02-08 | 2015-04-01 | 爱勒让治疗公司 | 治疗性的拟肽大环化合物 |
US20110086834A1 (en) * | 2008-06-26 | 2011-04-14 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
US8980254B2 (en) | 2008-08-21 | 2015-03-17 | Alvine Pharmaceuticals, Inc. | Formulation for oral administration of proteins |
US20100160322A1 (en) | 2008-12-04 | 2010-06-24 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
UA108193C2 (uk) * | 2008-12-04 | 2015-04-10 | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань | |
US8557983B2 (en) | 2008-12-04 | 2013-10-15 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
HUE029289T2 (en) * | 2008-12-05 | 2017-02-28 | Abbvie Inc | Sulfonamide derivatives as Bcl-2 selective apoptosis inducers for the treatment of cancer and immune diseases |
US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
US8546399B2 (en) * | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
PE20120345A1 (es) * | 2009-05-26 | 2012-05-17 | Abbvie Bahamas Ltd | Derivados de 2-(1h-pirrolo[2,3-b]piridin-5-iloxi)-n-fenilsulfonilbenzamida como inhibidores de proteinas anti-apoptoticas |
US8314250B2 (en) * | 2009-11-24 | 2012-11-20 | Hoffmann-La Roche Inc. | Sultam derivatives |
MX2016009753A (es) | 2014-01-28 | 2017-07-07 | Buck Inst For Res On Aging | Metodos y composiciones para exterminar celulas senescentes y para tratar enfermedades y trastornos asociados con la senectud. |
WO2015160975A2 (fr) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Polythérapies |
US10709692B2 (en) * | 2015-12-04 | 2020-07-14 | Denali Therapeutics Inc. | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (RIPK1) |
CA3018932C (fr) | 2016-03-28 | 2021-10-26 | Presage Biosciences, Inc. | Combinaisons pharmaceutiques pour le traitement du cancer |
WO2021233948A1 (fr) | 2020-05-19 | 2021-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédé de traitement d'une infection pulmonaire par un pathogène |
WO2022008464A1 (fr) | 2020-07-06 | 2022-01-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinaison d'antibiotiques anti néoplasiques et d'inhibiteurs de bcl-2 pour le traitement de la leucémie myéloïde aiguë (lma) entraînée par npm-1 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH445129A (fr) | 1964-04-29 | 1967-10-15 | Nestle Sa | Procédé pour la préparation de composés d'inclusion à poids moléculaire élevé |
US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
US3426011A (en) | 1967-02-13 | 1969-02-04 | Corn Products Co | Cyclodextrins with anionic properties |
US3453257A (en) | 1967-02-13 | 1969-07-01 | Corn Products Co | Cyclodextrin with cationic properties |
US3453259A (en) | 1967-03-22 | 1969-07-01 | Corn Products Co | Cyclodextrin polyol ethers and their oxidation products |
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
JPS55133364A (en) * | 1979-04-03 | 1980-10-17 | Mitsubishi Petrochem Co Ltd | Preparation of isoxazolidine derivative |
US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
DE3643012A1 (de) | 1986-12-17 | 1988-06-30 | Hoechst Ag | 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
DE3829594A1 (de) * | 1988-09-01 | 1990-03-15 | Bayer Ag | Neue renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln |
DE3926822A1 (de) * | 1989-08-14 | 1991-02-21 | Hoechst Ag | Peptide mit bradykinin-antagonistischer wirkung |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
KR100188801B1 (ko) | 1990-05-18 | 1999-06-01 | 엥겔하르트 라피체 | 이속사졸-4카복스아미드 및 하이드록시알킬리덴 시아노아세트아미드 및 이들 화합물을 함유하는 약제학적 조성물 |
US5294617A (en) | 1993-04-23 | 1994-03-15 | American Cyanamid Company | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones |
BR9408137A (pt) | 1993-11-24 | 1997-08-12 | Du Pont Merck Pharma | Composto éster de prodroga método de tratamento composição farmacêutica e método de inibição |
EP0730587B1 (fr) * | 1993-11-26 | 1999-12-08 | Pfizer Inc. | 3-phenyl-2-isoxazolines utiles comme agents anti-inflammatoires |
ES2118557T3 (es) | 1994-03-09 | 1998-09-16 | Pfizer | Compuestos de isoxazolina como inhibidores de la liberacion de tnf. |
IL115849A0 (en) | 1994-11-03 | 1996-01-31 | Merz & Co Gmbh & Co | Tangential filtration preparation of liposomal drugs and liposome product thereof |
US5514505A (en) | 1995-05-15 | 1996-05-07 | Xerox Corporation | Method for obtaining improved image contrast in migration imaging members |
DE19539638A1 (de) | 1995-10-25 | 1997-04-30 | Hoechst Ag | Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen |
US6221865B1 (en) * | 1995-11-06 | 2001-04-24 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
IT1283836B1 (it) | 1996-08-28 | 1998-04-30 | Viv Int Spa | Procedimento per decorare profilati metallici,in materiale plastico e simili e relativa apparecchiatura |
WO1998016830A2 (fr) | 1996-10-16 | 1998-04-23 | The President And Fellows Of Harvard College | Systeme de criblage par gouttelettes |
WO1998050031A1 (fr) * | 1997-05-07 | 1998-11-12 | University Of Pittsburgh | Inhibiteurs de proteines isoprenyle transferases |
WO2001016115A1 (fr) | 1999-09-01 | 2001-03-08 | Chemrx Advanced Technologies, Inc. | Procede relatif a la synthese d'isoxazolidines |
KR100399361B1 (ko) * | 1999-11-04 | 2003-09-26 | 주식회사 엘지생명과학 | 캐스파제 억제제 함유 치료제 조성물 |
DE60237115D1 (de) | 2001-05-30 | 2010-09-02 | Univ Georgetown | Synergistische Kombination von (-) -Gossypol mit Docetaxel oder Paclitaxel zur Behandlung von Krebs. |
US20030119894A1 (en) | 2001-07-20 | 2003-06-26 | Gemin X Biotechnologies Inc. | Methods for treatment of cancer or neoplastic disease and for inhibiting growth of cancer cells and neoplastic cells |
FR2840807B1 (fr) | 2002-06-12 | 2005-03-11 | Composition cosmetique de soin et/ou de maquillage, structuree par des polymeres silicones et des organogelateurs, sous forme rigide | |
PL1768966T3 (pl) | 2004-06-17 | 2012-08-31 | Infinity Discovery Inc | Związki i sposoby hamowania oddziaływania białek BCL z partnerami wiążącymi |
-
2005
- 2005-06-17 PL PL05762701T patent/PL1768966T3/pl unknown
- 2005-06-17 NZ NZ552183A patent/NZ552183A/en not_active IP Right Cessation
- 2005-06-17 AU AU2005265131A patent/AU2005265131B2/en not_active Ceased
- 2005-06-17 AT AT05762701T patent/ATE548359T1/de active
- 2005-06-17 CA CA2570780A patent/CA2570780C/fr not_active Expired - Fee Related
- 2005-06-17 KR KR1020077001087A patent/KR101195351B1/ko not_active IP Right Cessation
- 2005-06-17 WO PCT/US2005/021524 patent/WO2006009869A1/fr active Application Filing
- 2005-06-17 US US11/156,364 patent/US7851637B2/en not_active Expired - Fee Related
- 2005-06-17 JP JP2007516793A patent/JP5064213B2/ja not_active Expired - Fee Related
- 2005-06-17 CN CN2005800281288A patent/CN101006065B/zh not_active Expired - Fee Related
- 2005-06-17 MX MXPA06014754A patent/MXPA06014754A/es active IP Right Grant
- 2005-06-17 RU RU2007101276/04A patent/RU2416606C2/ru not_active IP Right Cessation
- 2005-06-17 BR BRPI0511070-0A patent/BRPI0511070A/pt active Search and Examination
- 2005-06-17 PT PT05762701T patent/PT1768966E/pt unknown
- 2005-06-17 EP EP05762701A patent/EP1768966B1/fr active Active
- 2005-06-17 ES ES05762701T patent/ES2382383T3/es active Active
-
2006
- 2006-12-07 IL IL179904A patent/IL179904A/en not_active IP Right Cessation
- 2006-12-12 ZA ZA200610405A patent/ZA200610405B/en unknown
- 2006-12-20 EC EC2006007099A patent/ECSP067099A/es unknown
- 2006-12-29 MA MA29588A patent/MA28702B1/fr unknown
-
2007
- 2007-01-17 NO NO20070324A patent/NO20070324L/no not_active Application Discontinuation
- 2007-10-17 HK HK07111188.2A patent/HK1105963A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN101006065A (zh) | 2007-07-25 |
JP5064213B2 (ja) | 2012-10-31 |
ATE548359T1 (de) | 2012-03-15 |
RU2007101276A (ru) | 2008-08-10 |
EP1768966B1 (fr) | 2012-03-07 |
NZ552183A (en) | 2009-10-30 |
KR20070046068A (ko) | 2007-05-02 |
CA2570780C (fr) | 2013-12-03 |
CN101006065B (zh) | 2012-07-11 |
RU2416606C2 (ru) | 2011-04-20 |
PL1768966T3 (pl) | 2012-08-31 |
IL179904A (en) | 2011-11-30 |
KR101195351B1 (ko) | 2012-10-29 |
CA2570780A1 (fr) | 2006-01-26 |
PT1768966E (pt) | 2012-05-23 |
JP2008503489A (ja) | 2008-02-07 |
BRPI0511070A (pt) | 2007-11-27 |
EP1768966A1 (fr) | 2007-04-04 |
AU2005265131B2 (en) | 2012-02-23 |
WO2006009869A1 (fr) | 2006-01-26 |
AU2005265131A1 (en) | 2006-01-26 |
IL179904A0 (en) | 2007-05-15 |
NO20070324L (no) | 2007-03-19 |
MXPA06014754A (es) | 2007-06-22 |
US7851637B2 (en) | 2010-12-14 |
US20060025460A1 (en) | 2006-02-02 |
HK1105963A1 (en) | 2008-02-29 |
ECSP067099A (es) | 2007-04-26 |
ES2382383T3 (es) | 2012-06-07 |
ZA200610405B (en) | 2008-03-26 |
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