NO20070324L - Forbindelser og fremgangsmater for inhibering av BCL proteiner med bindingspartnere - Google Patents

Forbindelser og fremgangsmater for inhibering av BCL proteiner med bindingspartnere

Info

Publication number
NO20070324L
NO20070324L NO20070324A NO20070324A NO20070324L NO 20070324 L NO20070324 L NO 20070324L NO 20070324 A NO20070324 A NO 20070324A NO 20070324 A NO20070324 A NO 20070324A NO 20070324 L NO20070324 L NO 20070324L
Authority
NO
Norway
Prior art keywords
compounds
methods
binding partners
bcl proteins
inhibiting bcl
Prior art date
Application number
NO20070324A
Other languages
English (en)
Inventor
Wei Deng
Asimina T Georges Evangelinos
Alfredo C Castro
Kristopher M Depew
Michael A Foley
Christian C Fritz
Michael J Grogan
Nafeeza Hafeez
Edward B Holson
Brian T Hopkins
Nii O Koney
Tao Liu
David A Mann
Lisa A Marcaurelle
Daniel A Snyder
Dennis J Underwood
Andrew A Wylie
Lin-Chen Yu
Linping Zhang
Original Assignee
Infinity Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infinity Pharmaceuticals Inc filed Critical Infinity Pharmaceuticals Inc
Publication of NO20070324L publication Critical patent/NO20070324L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det beskrives isoksazolinderivater som binder til Bcl-proteiner og inhiberer Bcl-funksjon. Et annet aspekt angår preparater omfattende et isoksazolinderivat som beskrevet. Videre tilveiebringes metoder for behandling og modulering av forstyrrelser assosiert med hyperproliferering, for eksempel cancer.
NO20070324A 2004-06-17 2007-01-17 Forbindelser og fremgangsmater for inhibering av BCL proteiner med bindingspartnere NO20070324L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58061604P 2004-06-17 2004-06-17
US65930105P 2005-03-07 2005-03-07
PCT/US2005/021524 WO2006009869A1 (en) 2004-06-17 2005-06-17 Coumpounds and methods for inhibiting the interaction of bcl proteins with binding partners

Publications (1)

Publication Number Publication Date
NO20070324L true NO20070324L (no) 2007-03-19

Family

ID=35335774

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070324A NO20070324L (no) 2004-06-17 2007-01-17 Forbindelser og fremgangsmater for inhibering av BCL proteiner med bindingspartnere

Country Status (22)

Country Link
US (1) US7851637B2 (no)
EP (1) EP1768966B1 (no)
JP (1) JP5064213B2 (no)
KR (1) KR101195351B1 (no)
CN (1) CN101006065B (no)
AT (1) ATE548359T1 (no)
AU (1) AU2005265131B2 (no)
BR (1) BRPI0511070A (no)
CA (1) CA2570780C (no)
EC (1) ECSP067099A (no)
ES (1) ES2382383T3 (no)
HK (1) HK1105963A1 (no)
IL (1) IL179904A (no)
MA (1) MA28702B1 (no)
MX (1) MXPA06014754A (no)
NO (1) NO20070324L (no)
NZ (1) NZ552183A (no)
PL (1) PL1768966T3 (no)
PT (1) PT1768966E (no)
RU (1) RU2416606C2 (no)
WO (1) WO2006009869A1 (no)
ZA (1) ZA200610405B (no)

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BRPI0511070A (pt) 2004-06-17 2007-11-27 Infinity Pharmaceuticals Inc compostos e processos para inibição da interação de proteìnas bcl com parceiros de ligação
US8624027B2 (en) * 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
TWI403320B (zh) 2005-12-16 2013-08-01 Infinity Discovery Inc 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法
TWI389895B (zh) * 2006-08-21 2013-03-21 Infinity Discovery Inc 抑制ｂｃｌ蛋白質與結合夥伴間之交互作用的化合物及方法
EP1897956A1 (en) 2006-09-06 2008-03-12 Lonza AG Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase
BRPI0907754A2 (pt) * 2008-02-08 2015-07-21 Aileron Therapeutics Inc Macrociclos peptidomiméticos terapêuticos
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WO2010021752A1 (en) * 2008-08-21 2010-02-25 Alvine Pharmaceuticals, Inc. Formulation for oral administration of proteins
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
UA108193C2 (uk) * 2008-12-04 2015-04-10 Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
MX2011005922A (es) * 2008-12-05 2011-06-16 Abbott Lab Derivados de sulfonamida como agentes inductores de apoptosis selectiva de bcl-2 para el tratamiento del cancer y enfermedades inmunes.
TWI537269B (zh) * 2009-05-26 2016-06-11 艾伯維巴哈馬有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘發劑
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CA2939121C (en) 2014-01-28 2020-11-24 Mayo Foundation For Medical Education And Research Effective treatment of osteoarthritis, pulmonary disease, ophthalmic disease, and atherosclerosis by removing senescent cells at the site of the disease
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
US10709692B2 (en) * 2015-12-04 2020-07-14 Denali Therapeutics Inc. Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (RIPK1)
CA3103604C (en) 2016-03-28 2023-09-26 Presage Biosciences, Inc. Pharmaceutical combinations for the treatment of cancer
WO2021233948A1 (en) 2020-05-19 2021-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to treat a pathogen lung infection
US20230270816A1 (en) 2020-07-06 2023-08-31 INSERM (Institute National de la Santé et de la Recherche Médicale) Combination of antineoplastic antibiotics and bcl-2 inhibitors for the treatment of npm-1-driven acute myeloid leukemia (aml)

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Also Published As

Publication number Publication date
RU2416606C2 (ru) 2011-04-20
AU2005265131A1 (en) 2006-01-26
MXPA06014754A (es) 2007-06-22
CN101006065A (zh) 2007-07-25
ES2382383T3 (es) 2012-06-07
MA28702B1 (fr) 2007-06-01
PT1768966E (pt) 2012-05-23
JP2008503489A (ja) 2008-02-07
CN101006065B (zh) 2012-07-11
CA2570780A1 (en) 2006-01-26
BRPI0511070A (pt) 2007-11-27
WO2006009869A1 (en) 2006-01-26
ATE548359T1 (de) 2012-03-15
JP5064213B2 (ja) 2012-10-31
HK1105963A1 (en) 2008-02-29
ECSP067099A (es) 2007-04-26
NZ552183A (en) 2009-10-30
EP1768966B1 (en) 2012-03-07
US7851637B2 (en) 2010-12-14
IL179904A0 (en) 2007-05-15
KR101195351B1 (ko) 2012-10-29
IL179904A (en) 2011-11-30
PL1768966T3 (pl) 2012-08-31
CA2570780C (en) 2013-12-03
KR20070046068A (ko) 2007-05-02
RU2007101276A (ru) 2008-08-10
US20060025460A1 (en) 2006-02-02
EP1768966A1 (en) 2007-04-04
AU2005265131B2 (en) 2012-02-23
ZA200610405B (en) 2008-03-26

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