DK0912734T3 - Kimæriske heteromultimer-adhæsiner - Google Patents
Kimæriske heteromultimer-adhæsinerInfo
- Publication number
- DK0912734T3 DK0912734T3 DK97932526.3T DK97932526T DK0912734T3 DK 0912734 T3 DK0912734 T3 DK 0912734T3 DK 97932526 T DK97932526 T DK 97932526T DK 0912734 T3 DK0912734 T3 DK 0912734T3
- Authority
- DK
- Denmark
- Prior art keywords
- chimeric
- adhesins
- heteromultimeric
- heteromultimer
- erbb2
- Prior art date
Links
- 239000000853 adhesive Substances 0.000 title 1
- 230000001070 adhesive effect Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000014413 Neuregulin Human genes 0.000 abstract 1
- 108050003475 Neuregulin Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000002860 competitive effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Adhesives Or Adhesive Processes (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2164096P | 1996-07-12 | 1996-07-12 | |
US79832697A | 1997-02-10 | 1997-02-10 | |
PCT/US1997/011825 WO1998002540A1 (en) | 1996-07-12 | 1997-07-08 | Chimeric heteromultimer adhesins |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0912734T3 true DK0912734T3 (da) | 2011-02-07 |
Family
ID=26694954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97932526.3T DK0912734T3 (da) | 1996-07-12 | 1997-07-08 | Kimæriske heteromultimer-adhæsiner |
Country Status (13)
Country | Link |
---|---|
US (3) | US6696290B2 (da) |
EP (2) | EP0912734B1 (da) |
JP (2) | JP4274581B2 (da) |
CN (1) | CN1202247C (da) |
AT (1) | ATE486937T1 (da) |
AU (1) | AU722178B2 (da) |
BR (1) | BR9710357A (da) |
CA (1) | CA2258721C (da) |
DE (1) | DE69740038D1 (da) |
DK (1) | DK0912734T3 (da) |
IL (1) | IL127891A0 (da) |
NZ (1) | NZ333325A (da) |
WO (1) | WO1998002540A1 (da) |
Families Citing this family (63)
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ATE517125T1 (de) * | 1998-01-26 | 2011-08-15 | Genentech Inc | ANTIKÖRPER GEGEN ßDEATH RECEPTOR 4ß (DR4) UND DEREN VERWENDUNGEN |
EP1745799B1 (en) | 1998-03-04 | 2015-09-02 | The Trustees of The University of Pennsylvania | Compositions and methods of treating tumors |
US6417168B1 (en) | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
CA2322792C (en) * | 1998-03-17 | 2010-09-14 | Genentech, Inc. | Polypeptides homologous to vegf and bmp1 |
US6635249B1 (en) * | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
US20030022233A1 (en) * | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
AUPQ105799A0 (en) | 1999-06-18 | 1999-07-08 | Victor Chang Cardiac Research Institute, The | Cell growth inhibition |
AUPQ841800A0 (en) * | 2000-06-28 | 2000-07-20 | Biomolecular Research Institute Limited | Truncated egf receptor |
WO2002012345A2 (en) | 2000-08-08 | 2002-02-14 | Zymogenetics, Inc. | Soluble zcytor 11 cytokine receptors |
US20020119148A1 (en) * | 2000-09-01 | 2002-08-29 | Gerritsen Mary E. | ErbB4 antagonists |
US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20030133939A1 (en) * | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
JP4314113B2 (ja) * | 2001-07-31 | 2009-08-12 | ウェイン・ステイト・ユニバーシティ | ヘパラン硫酸プロテオグリカンに対する標的化のための、ニューレグリンヘパリン結合ドメインとのハイブリッドタンパク質 |
EP1283053A1 (en) | 2001-08-09 | 2003-02-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibitors of HER3 activity |
JP4660094B2 (ja) * | 2002-03-26 | 2011-03-30 | ゼンサン (シャンハイ) サイ−テク. リミテッド | 新生物を治療するためのErbB3に基づく方法および組成物 |
AU2002304965A1 (en) | 2002-05-24 | 2003-12-12 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
AU2003295798B2 (en) * | 2002-11-21 | 2009-09-10 | Genentech, Inc. | Therapy of non-malignant diseases or disorders with anti-ErbB2 antibodies |
DK2248899T3 (da) * | 2003-03-19 | 2015-06-29 | Biogen Ma Inc | NOGO-receptorbindende protein |
WO2005087810A2 (en) * | 2004-03-08 | 2005-09-22 | Zymogenetics, Inc. | Dimeric fusion proteins and materials and methods for producing them |
EP1776136B1 (en) * | 2004-06-24 | 2012-10-03 | Biogen Idec MA Inc. | Treatment of conditions involving demyelination |
KR101238684B1 (ko) | 2004-10-22 | 2013-03-04 | 지모제넥틱스, 인코포레이티드 | 항-il-22ra 항체 및 결합 파트너 및 염증에서의사용방법 |
DK2267024T3 (da) | 2005-06-03 | 2012-06-25 | Ares Trading Sa | Fremstilling af rekombinant II-18 bindingsprotein |
SG163591A1 (en) | 2005-07-08 | 2010-08-30 | Biogen Idec Inc | Sp35 antibodies and uses thereof |
UA97469C2 (uk) * | 2005-07-25 | 2012-02-27 | Емерджент Продакт Дівелопмент Сіетл, Елелсі | Гуманізована специфічна до cd37 зв'язувальна молекула імуноглобуліну |
JP5312039B2 (ja) * | 2005-12-02 | 2013-10-09 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 脱髄の関与する状態の処置 |
EP2010665A4 (en) * | 2006-02-08 | 2010-10-27 | Targeted Molecular Diagnostics | BURIENT ERBB LIGAND BINDING MOLECULES AND METHODS FOR THEIR PREPARATION AND USE |
CN101611150A (zh) * | 2006-02-08 | 2009-12-23 | 利佳赛普特有限责任公司 | 二价ErbB配体结合分子及其制备和使用方法 |
DK2420565T3 (da) | 2006-02-23 | 2017-12-04 | Viacyte Inc | Anvendelige sammensætninger og fremgangsmåder til dyrkning af differentierbare celler |
CA2655205A1 (en) * | 2006-06-12 | 2007-12-21 | Receptor Biologix Inc. | Pan-cell surface receptor- specific therapeutics |
SG172698A1 (en) * | 2006-06-12 | 2011-07-28 | Trubion Pharmaceuticals Inc | Single-chain multivalent binding proteins with effector function |
ATE555383T1 (de) * | 2006-06-22 | 2012-05-15 | Novo Nordisk As | Lösliche heterodimere rezeptoren und ihre verwendung |
WO2007147901A1 (en) * | 2006-06-22 | 2007-12-27 | Novo Nordisk A/S | Production of bispecific antibodies |
US8128926B2 (en) | 2007-01-09 | 2012-03-06 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
KR101598229B1 (ko) | 2007-02-16 | 2016-02-26 | 메리맥 파마슈티컬즈, 인크. | Erbb3에 대한 항체 및 이의 용도 |
WO2008150485A2 (en) * | 2007-05-29 | 2008-12-11 | Wyeth | Erbb2 binding proteins and use thereof |
US20090304590A1 (en) * | 2007-05-29 | 2009-12-10 | Wyeth | Therapeutic compositions and methods |
WO2009048605A1 (en) * | 2007-10-11 | 2009-04-16 | Biogen Idec Ma Inc. | Methods for treating pressure induced optic neuropathy, preventing neuronal degeneration and promoting neuronal cell, survival via administration of lingo-1 antagonists and trkb agonists |
RU2010119556A (ru) * | 2007-10-16 | 2011-11-27 | Симфоген А/С (Dk) | Композиции, содержащие оптимизированные мультимеры her1 и her3, и способы их применения |
EP2217697B1 (en) * | 2007-11-08 | 2015-06-10 | Biogen MA Inc. | Use of lingo-4 antagonists in the treatment of conditions involving demyelination |
RS51975B (en) * | 2008-04-11 | 2012-02-29 | Emergent Product Development Seattle Llc. | CD37 IMMUNOTHERAPEUTIC PRODUCT AND ITS COMBINATION WITH BIFUNCTIONAL CHEMOTHERAPEUTIC AGENTS |
EP2315779A2 (en) * | 2008-07-09 | 2011-05-04 | Biogen Idec MA Inc. | Compositions comprising antibodies to lingo or fragments thereof |
NZ591137A (en) | 2008-08-15 | 2012-10-26 | Merrimack Pharmaceuticals Inc | Methods and systems for predicting response of cells to a therapeutic agent |
EP2346526A2 (en) | 2008-09-22 | 2011-07-27 | Massachusetts Institute of Technology | Compositions of and methods of using ligand dimers |
ES2528929T3 (es) | 2008-11-25 | 2015-02-13 | Genentech, Inc. | Anticuerpos anti-HER4 específicos de isoforma |
RU2012105766A (ru) * | 2009-07-28 | 2013-09-10 | Лигацепт, Лимитед Лиабилити Компани | МОЛЕКУЛЫ, СВЯЗЫВАЮЩИЕ ШИРОКИЙ СПЕКТР ЛИГАНДОВ ErbB И СПОСОБЫ ИХ ПРИГОТОВЛЕНИЯ И ИСПОЛЬЗОВАНИЯ |
PL2536748T3 (pl) | 2010-02-18 | 2015-01-30 | Genentech Inc | Antagoniści neureguliny i ich zastosowanie w leczeniu nowotworu |
JP2013522237A (ja) | 2010-03-11 | 2013-06-13 | メリマック ファーマシューティカルズ インコーポレーティッド | トリプルネガティブおよび基底様乳癌の治療におけるerbb3阻害剤の使用 |
EP2555788B1 (en) | 2010-03-24 | 2017-10-11 | Massachusetts Institute of Technology | NEUREGULIN DIMER FOR AN ErbB/HER RECEPTOR FOR USE IN REDUCING CARDIOTOXICITY. |
TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
WO2012103114A2 (en) * | 2011-01-24 | 2012-08-02 | Jason Hill | Therapeutic chimeric ligand binding proteins and methods for their use |
JP2015518829A (ja) | 2012-05-14 | 2015-07-06 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | 運動ニューロンに関する状態の処置のためのlingo−2アンタゴニスト |
WO2014051567A1 (en) * | 2012-09-26 | 2014-04-03 | Morehouse School Of Medicine | Chimeric neuregulins and method of making and use thereof |
CA2901226C (en) | 2013-02-18 | 2020-11-17 | Vegenics Pty Limited | Vascular endothelial growth factor binding proteins |
JP6673200B2 (ja) | 2013-07-05 | 2020-03-25 | エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド | 骨髄異形成症候群(mds)を治療するための可溶性cd33 |
WO2015100459A2 (en) | 2013-12-27 | 2015-07-02 | Merrimack Pharmaceuticals, Inc. | Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies |
WO2016112270A1 (en) | 2015-01-08 | 2016-07-14 | Biogen Ma Inc. | Lingo-1 antagonists and uses for treatment of demyelinating disorders |
US10184006B2 (en) | 2015-06-04 | 2019-01-22 | Merrimack Pharmaceuticals, Inc. | Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors |
UA126278C2 (uk) | 2015-09-21 | 2022-09-14 | Аптево Рісьорч Енд Девелопмент Ллс | Поліпептиди, які зв'язують cd3 |
KR20180117529A (ko) | 2017-04-19 | 2018-10-29 | 주식회사 프로티나 | 단백질-단백질 상호작용 분석에 의한 약물 반응성 예측 방법 |
WO2019132517A1 (ko) * | 2017-12-26 | 2019-07-04 | 주식회사 프로티나 | 세포 내 또는 세포 간 단백질-단백질 상호작용 분석 방법 및 장치 |
CN110669139A (zh) * | 2019-09-18 | 2020-01-10 | 沣潮医药科技(上海)有限公司 | 二聚体免疫粘附素、药物组合物和用途 |
CN111018999B (zh) * | 2019-12-05 | 2022-07-12 | 沣潮医药科技(上海)有限公司 | 二聚体免疫融合蛋白、药物组合物和用途 |
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US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US4968603A (en) | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
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US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
ATE217887T1 (de) | 1988-12-22 | 2002-06-15 | Genentech Inc | Verfahren zur herstellung von wasserlöslichen polypeptiden |
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-
1997
- 1997-07-08 EP EP97932526A patent/EP0912734B1/en not_active Expired - Lifetime
- 1997-07-08 EP EP97934059A patent/EP0938556B1/en not_active Expired - Lifetime
- 1997-07-08 JP JP50608998A patent/JP4274581B2/ja not_active Expired - Lifetime
- 1997-07-08 CA CA2258721A patent/CA2258721C/en not_active Expired - Lifetime
- 1997-07-08 DE DE69740038T patent/DE69740038D1/de not_active Expired - Lifetime
- 1997-07-08 NZ NZ333325A patent/NZ333325A/en not_active IP Right Cessation
- 1997-07-08 DK DK97932526.3T patent/DK0912734T3/da active
- 1997-07-08 IL IL12789197A patent/IL127891A0/xx not_active IP Right Cessation
- 1997-07-08 BR BR9710357A patent/BR9710357A/pt not_active Application Discontinuation
- 1997-07-08 AT AT97932526T patent/ATE486937T1/de not_active IP Right Cessation
- 1997-07-08 CN CNB971962499A patent/CN1202247C/zh not_active Expired - Lifetime
- 1997-07-08 WO PCT/US1997/011825 patent/WO1998002540A1/en active Application Filing
- 1997-07-08 AU AU35962/97A patent/AU722178B2/en not_active Expired
-
1999
- 1999-03-12 US US09/267,985 patent/US6696290B2/en not_active Expired - Lifetime
-
2003
- 2003-12-22 US US10/746,176 patent/US7659368B2/en not_active Expired - Fee Related
-
2006
- 2006-09-28 US US11/536,354 patent/US20070081994A1/en not_active Abandoned
-
2007
- 2007-12-12 JP JP2007321420A patent/JP2008115187A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU722178B2 (en) | 2000-07-27 |
US7659368B2 (en) | 2010-02-09 |
EP0912734A1 (en) | 1999-05-06 |
JP2008115187A (ja) | 2008-05-22 |
CN1202247C (zh) | 2005-05-18 |
US6696290B2 (en) | 2004-02-24 |
AU3596297A (en) | 1998-02-09 |
ATE486937T1 (de) | 2010-11-15 |
US20040138417A1 (en) | 2004-07-15 |
CN1225129A (zh) | 1999-08-04 |
CA2258721A1 (en) | 1998-01-22 |
JP2000515372A (ja) | 2000-11-21 |
EP0938556B1 (en) | 2005-03-09 |
NZ333325A (en) | 2000-06-23 |
DE69740038D1 (da) | 2010-12-16 |
IL127891A0 (en) | 1999-10-28 |
EP0938556A1 (en) | 1999-09-01 |
EP0912734B1 (en) | 2010-11-03 |
US20030199020A1 (en) | 2003-10-23 |
JP4274581B2 (ja) | 2009-06-10 |
BR9710357A (pt) | 1999-08-17 |
WO1998002540A1 (en) | 1998-01-22 |
CA2258721C (en) | 2014-09-09 |
US20070081994A1 (en) | 2007-04-12 |
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