CA2405349C - Derives d'oxazolidinone ayant une activite antibiotique - Google Patents
Derives d'oxazolidinone ayant une activite antibiotique Download PDFInfo
- Publication number
- CA2405349C CA2405349C CA2405349A CA2405349A CA2405349C CA 2405349 C CA2405349 C CA 2405349C CA 2405349 A CA2405349 A CA 2405349A CA 2405349 A CA2405349 A CA 2405349A CA 2405349 C CA2405349 C CA 2405349C
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- ring
- optionally substituted
- alkoxy
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Abstract
L'invention porte sur des composés de la formule (I), ou sur un sel de ceux-ci acceptable d'un point de vue pharmaceutique, ou un ester de ceux-ci hydrolysable in vivo. HET représente un noyau hétéroaryle à 5 éléments lié à N, éventuellement substitué, sur un atome C, par un groupe oxo ou thioxo; et/ou par 1 ou 2 groupes (1-4C) alkyle; et/ou est substitué, sur un atome d'azote disponible, par (1-4C)alkyle; ou bien HET représente un noyau hétéroaryle à 6 éléments lié à N contenant jusqu'à trois hétéroatomes d'azote au total, éventuellement substitué sur un atome C tel que précité; Q est sélectionné, par exemple, à partir de Q1. R?2¿ et R?3¿ représentent indépendamment hydrogène ou fluoro; T est sélectionné dans une plage de groupes, par exemple, de la formule (TC5): dans laquelle Rc représente, par exemple, R?13¿CO-, R?13¿SO¿2?-ou R?13¿CS-; où R?13¿ représente, par exemple, (1-10C)alkyle ou R?14¿C(O)O(1-6C)alkyle, R?14¿ représentant (1-10C)alkyle éventuellement substitué. Ces composés sont utiles comme agents antibactériens. L'invention porte également sur leurs procédés de fabrication et sur des compositions pharmaceutiques les contenant.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0009803.8A GB0009803D0 (en) | 2000-04-25 | 2000-04-25 | Chemical compounds |
GB0009803.8 | 2000-04-25 | ||
PCT/GB2001/001815 WO2001081350A1 (fr) | 2000-04-25 | 2001-04-23 | Derives d'oxazolidinone ayant une activite antibiotique |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2405349A1 CA2405349A1 (fr) | 2001-11-01 |
CA2405349C true CA2405349C (fr) | 2011-08-02 |
Family
ID=9890314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2405349A Expired - Lifetime CA2405349C (fr) | 2000-04-25 | 2001-04-23 | Derives d'oxazolidinone ayant une activite antibiotique |
Country Status (29)
Country | Link |
---|---|
US (1) | US7141583B2 (fr) |
EP (1) | EP1286998B2 (fr) |
JP (1) | JP2003531211A (fr) |
KR (1) | KR100858771B1 (fr) |
CN (1) | CN1277829C (fr) |
AT (1) | ATE268778T1 (fr) |
AU (1) | AU781784B2 (fr) |
BR (1) | BR0110240A (fr) |
CA (1) | CA2405349C (fr) |
CZ (1) | CZ20023527A3 (fr) |
DE (1) | DE60103754T3 (fr) |
DK (1) | DK1286998T4 (fr) |
EE (1) | EE200200598A (fr) |
ES (1) | ES2220759T5 (fr) |
GB (1) | GB0009803D0 (fr) |
HK (1) | HK1053114A1 (fr) |
HU (1) | HUP0300416A2 (fr) |
IL (2) | IL152284A0 (fr) |
IS (1) | IS6583A (fr) |
MX (1) | MXPA02010453A (fr) |
NO (1) | NO328549B1 (fr) |
NZ (1) | NZ521765A (fr) |
PL (1) | PL358326A1 (fr) |
PT (1) | PT1286998E (fr) |
RU (1) | RU2002131455A (fr) |
SI (1) | SI1286998T2 (fr) |
TR (1) | TR200402261T4 (fr) |
WO (1) | WO2001081350A1 (fr) |
ZA (1) | ZA200208187B (fr) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0113299D0 (en) * | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical process & intermediates |
PT1427711E (pt) | 2001-09-11 | 2005-11-30 | Astrazeneca Ab | Derivados de oxazolidinona e/ou isoxazolina como agentes antibacterianos |
EP1443930A1 (fr) | 2001-10-25 | 2004-08-11 | AstraZeneca AB | Derives d'isoxazoline utilises en tant qu'agents antimicrobiens |
KR100445437B1 (ko) * | 2002-02-08 | 2004-08-21 | 한국과학기술연구원 | 네오마이신-옥사졸리디논 헤테로 이합체, 그의 제조방법및 그의 용도 |
AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
CA2477379A1 (fr) * | 2002-02-28 | 2003-09-04 | Astrazeneca Ab | Composes chimiques |
IL163688A0 (en) | 2002-02-28 | 2005-12-18 | Astrazeneca Ab | 3-Cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and theiruse as antibacterial agents |
CA2491287A1 (fr) | 2002-08-12 | 2004-02-19 | Pharmacia & Upjohn Company | N-aryl-2-oxazolidinones et leurs derives |
US7091196B2 (en) | 2002-09-26 | 2006-08-15 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using same |
US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
ES2271660T3 (es) | 2002-11-21 | 2007-04-16 | PHARMACIA & UPJOHN COMPANY LLC | Derivados de n-(4-piperazin-1-il)-fenil-2-oxazolidinona-5-carboxamida y compuestos relacionados como agentes antibacterianos. |
EP1581524A2 (fr) * | 2002-11-28 | 2005-10-05 | AstraZeneca AB | Derives d`oxazolidinones comme agents bactericides |
GB0227701D0 (en) * | 2002-11-28 | 2003-01-08 | Astrazeneca Ab | Chemical compounds |
GB0229522D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
US7012088B2 (en) | 2003-02-24 | 2006-03-14 | Pharmacia & Upjohn Company | Indolone oxazolidinones and derivatives thereof |
GB0304723D0 (en) * | 2003-03-01 | 2003-04-02 | Astrazeneca Ab | Chemical compounds |
GB0306357D0 (en) | 2003-03-20 | 2003-04-23 | Astrazeneca Ab | Chemical compounds |
GB0306358D0 (en) | 2003-03-20 | 2003-04-23 | Astrazeneca Ab | Chemical compounds |
BRPI0409217A (pt) | 2003-04-09 | 2006-03-28 | Pharmacia & Upjohn Co Llc | derivados e análogos antimicrobianos da [3.1.0]bicicloexilfeniloxazolidinona |
US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
CN100457742C (zh) * | 2003-06-03 | 2009-02-04 | 瑞伯-X医药品有限公司 | 联芳基杂环化合物的制备和用途 |
EP2492264A3 (fr) | 2003-06-03 | 2012-12-19 | Rib-X Pharmaceuticals, Inc. | Composes Heterocycliques Biaryle Et Procedes De Production Et d'utilisation Associes |
CA2530140C (fr) | 2003-07-02 | 2010-11-09 | Merck & Co., Inc. | Antibiotiques a base d'oxazolidinone substituee par un groupe cyclipropyl et derives |
EP1646630A1 (fr) * | 2003-07-02 | 2006-04-19 | Merck & Co., Inc. | Antibiotiques de type oxazolidinones et derives de ceux-ci |
WO2005012270A2 (fr) * | 2003-07-29 | 2005-02-10 | Rib-X Pharmaceuticals, Inc. | Composes contenant des biarylamines heterocycliques, des amides et du soufre, et procedes de production et d'utilisation de ces composes |
MXPA06002188A (es) * | 2003-08-25 | 2006-04-27 | Warner Lambert Co | Nuevos compuestos antimicrobianos de ariloxazolidinona. |
US7687627B2 (en) * | 2003-09-08 | 2010-03-30 | Wockhardt Limited | Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy |
US7304050B2 (en) | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
WO2005042523A1 (fr) * | 2003-11-03 | 2005-05-12 | Il-Dong Pharm. Co., Ltd. | Nouveau derive d'oxazolidinone et son procede de production |
EP1713785A1 (fr) | 2003-12-17 | 2006-10-25 | Rib-X Pharmaceuticals, Inc. | Composes heterocycliques de biaryle halogenes et methodes de fabrication et d'utilisation |
KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
EP1723159B1 (fr) | 2004-02-27 | 2019-06-12 | Melinta Therapeutics, Inc. | Composes macrocycliques et leurs procedes de fabrication et d'utilisation |
JP2008500317A (ja) * | 2004-05-25 | 2008-01-10 | アストラゼネカ アクチボラグ | 抗菌剤としての3−’4−{6−置換アルカノイル)ピリジン−3−イル}−3−フェニル−5−(1h−1,2,3−トリアゾール−1−イルメチル)−1,3−オキサゾリジン−2−オン |
US20080021071A1 (en) * | 2004-05-25 | 2008-01-24 | Astrazeneca Ab | 3-{4-(Pyridin-3-Yl) Phenyl}-5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents |
CN100360525C (zh) * | 2004-09-16 | 2008-01-09 | 中国科学院上海药物研究所 | 一类新的噁唑烷酮衍生物、其制备方法和用途 |
KR100629327B1 (ko) | 2004-10-20 | 2006-09-29 | 한국과학기술연구원 | 신규 트리아졸릴메틸옥사졸리디논 유도체 |
WO2006133397A2 (fr) | 2005-06-08 | 2006-12-14 | Rib-X Pharmaceuticals, Inc. | Procede permettant de realiser la synthese de triazoles |
JP2009506066A (ja) | 2005-08-24 | 2009-02-12 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | トリアゾール化合物ならびにこれを作製する方法および使用する方法 |
JP2009506063A (ja) | 2005-08-24 | 2009-02-12 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | トリアゾール化合物ならびにこれを作製する方法および使用する方法 |
JP2009526036A (ja) * | 2006-02-08 | 2009-07-16 | ファイザー・プロダクツ・インク | 抗菌剤としてのオキシインドールを含有するオキサゾリジノン |
CN100406455C (zh) * | 2006-02-20 | 2008-07-30 | 中国科学院上海药物研究所 | 含三氮唑基的噁唑烷酮类化合物及其制备方法和用途 |
WO2008021338A2 (fr) * | 2006-08-15 | 2008-02-21 | Wyeth | Dérivés d'oxazolidone tricycliques utiles en tant que modulateurs du récepteur de la progestérone |
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WO2009157423A1 (fr) | 2008-06-24 | 2009-12-30 | 財団法人乙卯研究所 | Dérivé d’oxazolidinone contenant un cycle condensé |
CN106220621B (zh) * | 2008-10-10 | 2019-06-11 | 默沙东公司 | 制备噁唑烷酮类的方法及含有噁唑烷酮类的组合物 |
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US8580767B2 (en) * | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
CN101792437B (zh) * | 2010-03-10 | 2012-01-25 | 天津药物研究院 | 一类三氮唑的衍生物、其制备方法和用途 |
US9464062B2 (en) | 2012-11-28 | 2016-10-11 | Temple University—Of the Commonwealth System of Higher Education | Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2B activity modulators |
JP7304043B2 (ja) * | 2015-07-22 | 2023-07-06 | アナベックス ライフ サイエンシズ コーポレイション | テトラヒドロ-n,n-ジメチル-2,2-ジフェニル-3-フランメタンアミンヒドロクロリドの結晶形態、かかる形態の作製方法およびその薬学的組成物 |
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CN111560014A (zh) * | 2020-05-13 | 2020-08-21 | 河南科技大学第一附属医院 | 一种杀菌消毒所用噁唑链接三唑类药物分子及其制备方法和应用 |
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-
2000
- 2000-04-25 GB GBGB0009803.8A patent/GB0009803D0/en not_active Ceased
-
2001
- 2001-04-23 AU AU48636/01A patent/AU781784B2/en not_active Ceased
- 2001-04-23 SI SI200130129T patent/SI1286998T2/sl unknown
- 2001-04-23 CN CNB01811640XA patent/CN1277829C/zh not_active Expired - Fee Related
- 2001-04-23 PL PL01358326A patent/PL358326A1/xx not_active Application Discontinuation
- 2001-04-23 DE DE60103754T patent/DE60103754T3/de not_active Expired - Lifetime
- 2001-04-23 ES ES01921669T patent/ES2220759T5/es not_active Expired - Lifetime
- 2001-04-23 JP JP2001578439A patent/JP2003531211A/ja active Pending
- 2001-04-23 BR BR0110240-0A patent/BR0110240A/pt not_active Application Discontinuation
- 2001-04-23 AT AT01921669T patent/ATE268778T1/de active
- 2001-04-23 NZ NZ521765A patent/NZ521765A/en not_active IP Right Cessation
- 2001-04-23 CZ CZ20023527A patent/CZ20023527A3/cs unknown
- 2001-04-23 TR TR2004/02261T patent/TR200402261T4/xx unknown
- 2001-04-23 HU HU0300416A patent/HUP0300416A2/hu unknown
- 2001-04-23 IL IL15228401A patent/IL152284A0/xx unknown
- 2001-04-23 MX MXPA02010453A patent/MXPA02010453A/es active IP Right Grant
- 2001-04-23 KR KR1020027014321A patent/KR100858771B1/ko not_active IP Right Cessation
- 2001-04-23 DK DK01921669T patent/DK1286998T4/da active
- 2001-04-23 EE EEP200200598A patent/EE200200598A/xx unknown
- 2001-04-23 WO PCT/GB2001/001815 patent/WO2001081350A1/fr active IP Right Grant
- 2001-04-23 US US10/258,355 patent/US7141583B2/en not_active Expired - Fee Related
- 2001-04-23 EP EP01921669A patent/EP1286998B2/fr not_active Expired - Lifetime
- 2001-04-23 RU RU2002131455/04A patent/RU2002131455A/ru not_active Application Discontinuation
- 2001-04-23 PT PT01921669T patent/PT1286998E/pt unknown
- 2001-04-23 CA CA2405349A patent/CA2405349C/fr not_active Expired - Lifetime
-
2002
- 2002-10-10 ZA ZA200208187A patent/ZA200208187B/en unknown
- 2002-10-14 IL IL152284A patent/IL152284A/en not_active IP Right Cessation
- 2002-10-16 IS IS6583A patent/IS6583A/is unknown
- 2002-10-23 NO NO20025091A patent/NO328549B1/no not_active IP Right Cessation
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2003
- 2003-07-25 HK HK03105394A patent/HK1053114A1/xx not_active IP Right Cessation
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