DE69316240T2 - Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel - Google Patents
Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittelInfo
- Publication number
- DE69316240T2 DE69316240T2 DE69316240T DE69316240T DE69316240T2 DE 69316240 T2 DE69316240 T2 DE 69316240T2 DE 69316240 T DE69316240 T DE 69316240T DE 69316240 T DE69316240 T DE 69316240T DE 69316240 T2 DE69316240 T2 DE 69316240T2
- Authority
- DE
- Germany
- Prior art keywords
- tropon
- group
- antibacterial agent
- derivatives substituted
- phenyloxazolidinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98858992A | 1992-12-08 | 1992-12-08 | |
US377893A | 1993-01-13 | 1993-01-13 | |
US6635693A | 1993-05-21 | 1993-05-21 | |
PCT/US1993/009589 WO1994013649A1 (en) | 1992-12-08 | 1993-10-14 | Tropone-substituted phenyloxazolidinone antibacterial agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69316240D1 DE69316240D1 (de) | 1998-02-12 |
DE69316240T2 true DE69316240T2 (de) | 1998-05-20 |
Family
ID=27357482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69316240T Expired - Fee Related DE69316240T2 (de) | 1992-12-08 | 1993-10-14 | Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel |
Country Status (20)
Country | Link |
---|---|
US (1) | US5523403A (de) |
EP (1) | EP0673370B1 (de) |
JP (1) | JP3558088B2 (de) |
KR (1) | KR100276382B1 (de) |
AT (1) | ATE161833T1 (de) |
AU (1) | AU670842B2 (de) |
CA (1) | CA2147753C (de) |
CZ (1) | CZ288788B6 (de) |
DE (1) | DE69316240T2 (de) |
DK (1) | DK0673370T3 (de) |
ES (1) | ES2111188T3 (de) |
FI (1) | FI952798A (de) |
GR (1) | GR3026228T3 (de) |
HU (1) | HUT74099A (de) |
NO (1) | NO952253L (de) |
NZ (1) | NZ257031A (de) |
PL (1) | PL175782B1 (de) |
RU (1) | RU2119484C1 (de) |
SK (1) | SK282453B6 (de) |
WO (1) | WO1994013649A1 (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5668286A (en) * | 1994-03-15 | 1997-09-16 | Pharmacia & Upjohn Company | Oxazolidinone derivatives and pharmaceutical compositions containing them |
AU6902096A (en) * | 1995-09-15 | 1997-04-01 | Pharmacia & Upjohn Company | 5-amidomethyl alpha, beta-saturated and -unsaturated 3-aryl butyrolactone antibacterial agents |
GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
GB9609919D0 (en) | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
AU3973697A (en) * | 1996-08-21 | 1998-03-06 | Pharmacia & Upjohn Company | Isoxazoline derivatives useful as antimicrobials |
US5998414A (en) * | 1996-08-22 | 1999-12-07 | Hoechst Marion Roussel, Inc. | Troponyl piperazines as dopamine D4 receptor ligands |
GB9717807D0 (en) * | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
RU2205822C2 (ru) * | 1997-11-07 | 2003-06-10 | Фармация Энд Апджон Компани | Способы получения (s)-оксазолидинонов, (s)-вторичный спирт, соединение, способ получения спирта |
GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
US6083967A (en) * | 1997-12-05 | 2000-07-04 | Pharmacia & Upjohn Company | S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones |
US6239152B1 (en) | 1998-01-23 | 2001-05-29 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
IL140084A0 (en) * | 1998-06-05 | 2002-02-10 | Astra Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
TW572757B (en) * | 1998-08-24 | 2004-01-21 | Bristol Myers Squibb Co | Novel isoxazolinone antibacterial agents |
US6420349B1 (en) | 1998-08-24 | 2002-07-16 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
WO2000045177A1 (en) | 1999-01-27 | 2000-08-03 | Pharmacia & Upjohn Company | Assays for modulators of elongation factor p activity |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
US6465456B2 (en) | 2000-06-29 | 2002-10-15 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
JP2004518677A (ja) * | 2000-12-21 | 2004-06-24 | ファルマシア・アンド・アップジョン・カンパニー | 抗菌性キノロン誘導体および細菌感染を治療するためのその使用 |
US6897230B2 (en) * | 2001-04-17 | 2005-05-24 | Kyorin Pharmaceutical Co., Ltd. | Bicyclo[3/1/0] hexane containing oxazolidinone antibiotics and derivatives thereof |
TW200302095A (en) * | 2002-01-25 | 2003-08-01 | Upjohn Co | Oxazolidinone cotherapy |
MXPA04007468A (es) * | 2002-02-05 | 2004-11-10 | Upjohn Co | Derivados de tiadiazinona antimicrobianos y su aplicacion para el tratamiento de infecciones bacterianas. |
US7141588B2 (en) * | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
AR038536A1 (es) * | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
US20030216330A1 (en) * | 2002-03-29 | 2003-11-20 | Pharmacia & Upjohn | Parenteral, intravenous, and oral administration of oxazolidinones for treating diabetic foot infections |
BR0313400A (pt) * | 2002-08-12 | 2005-07-12 | Pharmacia & Upjohn Co Llc | N-aril-2-oxazolidinonas e seus derivados |
CA2502017A1 (en) * | 2002-11-21 | 2004-06-03 | Pharmacia & Upjohn Company Llc | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents |
US8813142B2 (en) * | 2003-01-31 | 2014-08-19 | Qwest Communications International Inc. | Methods, systems and apparatus for providing video transmissions over multiple media |
US8050281B2 (en) * | 2003-01-31 | 2011-11-01 | Qwest Communications International Inc. | Alert gateway, systems and methods |
US7474742B2 (en) * | 2003-01-31 | 2009-01-06 | Qwest Communications International Inc. | Environmentally-controlled network interface device and methods |
EP1594865A2 (de) * | 2003-02-07 | 2005-11-16 | Warner-Lambert Company LLC | Antibakterielle mittel |
US20040204463A1 (en) * | 2003-04-01 | 2004-10-14 | Harris Christina Renee | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
PL1656370T3 (pl) | 2003-06-03 | 2013-03-29 | Melinta Subsidiary Corp | Biarylowe związki heterocykliczne oraz sposoby ich wytwarzania i stosowania |
US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
NZ544237A (en) | 2003-07-02 | 2008-09-26 | Merck & Co Inc | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof |
US20070185132A1 (en) * | 2003-07-02 | 2007-08-09 | Yasumichi Fukuda | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo |
JP2007521282A (ja) * | 2003-07-02 | 2007-08-02 | メルク アンド カンパニー インコーポレーテッド | オキサゾリジノン抗生物質およびその誘導体 |
AU2004256086B2 (en) * | 2003-07-02 | 2007-12-06 | Kyorin Pharmaceutical Co., Ltd. | Oxazolidinone antibiotics and derivatives thereof |
CA2536480A1 (en) * | 2003-08-25 | 2005-03-03 | Warner-Lambert Company Llc | Novel antimicrobial aryloxazolidinone compounds |
US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
JP2007514782A (ja) * | 2003-12-17 | 2007-06-07 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法 |
KR100854211B1 (ko) * | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
EP1904489B1 (de) | 2005-06-08 | 2011-01-26 | Rib-X Pharmaceuticals, Inc. | Verfahren zur synthese von triazolen |
TW200804358A (en) * | 2006-03-31 | 2008-01-16 | Res Found Itsuu Lab | Novel compound having heterocycle |
JPWO2007116960A1 (ja) * | 2006-04-06 | 2009-08-20 | 財団法人乙卯研究所 | 炭素環を有するオキサゾリジノン誘導体 |
WO2009044777A1 (ja) | 2007-10-02 | 2009-04-09 | Research Foundation Itsuu Laboratory | 7員ヘテロ環を有するオキサゾリジノン誘導体 |
RU2659792C1 (ru) | 2008-10-10 | 2018-07-04 | Мерк Шарп Энд Домэ Корп. | Оксазолидиноны и способ их очистки |
KR101739923B1 (ko) | 2009-02-03 | 2017-05-25 | 머크 샤프 앤드 돔 코포레이션 | R)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형 |
US8580767B2 (en) * | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE29607E (en) * | 1969-03-18 | 1978-04-11 | Delalande S. A. | Derivatives of 5-hydroxymethyl-3-substituted-2-oxazolidinones, process of preparation thereof and therapeutic application |
LU80081A1 (fr) * | 1977-08-26 | 1979-05-15 | Delalande Sa | Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique |
US4128654A (en) * | 1978-02-10 | 1978-12-05 | E. I. Du Pont De Nemours And Company | 5-Halomethyl-3-phenyl-2-oxazolidinones |
US4340606A (en) * | 1980-10-23 | 1982-07-20 | E. I. Du Pont De Nemours And Company | 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents |
FR2500450A1 (fr) * | 1981-02-25 | 1982-08-27 | Delalande Sa | Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique |
DE3149608A1 (de) * | 1981-12-15 | 1983-08-04 | Dr. Madaus & Co, 5000 Köln | Substituierte tropolone, verfahren zur herstellung derselben und diese enthaltende pharmazeutische zubereitungen |
US4461773A (en) * | 1982-09-15 | 1984-07-24 | E. I. Dupont De Nemours And Company | P-Oxooxazolidinylbenzene compounds as antibacterial agents |
US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
ES8506659A1 (es) * | 1983-06-07 | 1985-08-01 | Du Pont | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
CA1260948A (en) * | 1984-12-05 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents |
US4921869A (en) * | 1987-10-09 | 1990-05-01 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
CA1320730C (en) * | 1987-10-16 | 1993-07-27 | The Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents |
CA1317594C (en) * | 1987-10-21 | 1993-05-11 | Chung-Ho Park | Aminomethyloxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents |
US4977173A (en) * | 1987-10-21 | 1990-12-11 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents |
US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
-
1993
- 1993-10-14 DE DE69316240T patent/DE69316240T2/de not_active Expired - Fee Related
- 1993-10-14 AU AU53239/94A patent/AU670842B2/en not_active Ceased
- 1993-10-14 EP EP93923304A patent/EP0673370B1/de not_active Expired - Lifetime
- 1993-10-14 CA CA002147753A patent/CA2147753C/en not_active Expired - Fee Related
- 1993-10-14 ES ES93923304T patent/ES2111188T3/es not_active Expired - Lifetime
- 1993-10-14 SK SK746-95A patent/SK282453B6/sk unknown
- 1993-10-14 DK DK93923304T patent/DK0673370T3/da active
- 1993-10-14 KR KR1019950702303A patent/KR100276382B1/ko not_active IP Right Cessation
- 1993-10-14 AT AT93923304T patent/ATE161833T1/de not_active IP Right Cessation
- 1993-10-14 WO PCT/US1993/009589 patent/WO1994013649A1/en active IP Right Grant
- 1993-10-14 HU HU9501670A patent/HUT74099A/hu unknown
- 1993-10-14 JP JP51413894A patent/JP3558088B2/ja not_active Expired - Fee Related
- 1993-10-14 NZ NZ257031A patent/NZ257031A/en unknown
- 1993-10-14 CZ CZ19951366A patent/CZ288788B6/cs not_active IP Right Cessation
- 1993-10-14 PL PL93309283A patent/PL175782B1/pl not_active IP Right Cessation
- 1993-10-14 RU RU95114378A patent/RU2119484C1/ru not_active IP Right Cessation
-
1995
- 1995-05-22 US US08/445,594 patent/US5523403A/en not_active Expired - Fee Related
- 1995-06-07 FI FI952798A patent/FI952798A/fi not_active IP Right Cessation
- 1995-06-07 NO NO952253A patent/NO952253L/no unknown
-
1998
- 1998-02-25 GR GR980400408T patent/GR3026228T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CZ136695A3 (en) | 1995-10-18 |
HUT74099A (en) | 1996-11-28 |
NO952253D0 (no) | 1995-06-07 |
JPH08504205A (ja) | 1996-05-07 |
RU2119484C1 (ru) | 1998-09-27 |
PL175782B1 (pl) | 1999-02-26 |
ATE161833T1 (de) | 1998-01-15 |
PL309283A1 (en) | 1995-10-02 |
SK282453B6 (sk) | 2002-02-05 |
CZ288788B6 (cs) | 2001-09-12 |
FI952798A0 (fi) | 1995-06-07 |
AU5323994A (en) | 1994-07-04 |
CA2147753C (en) | 2004-08-03 |
NZ257031A (en) | 1996-07-26 |
GR3026228T3 (en) | 1998-05-29 |
NO952253L (no) | 1995-08-08 |
DE69316240D1 (de) | 1998-02-12 |
US5523403A (en) | 1996-06-04 |
EP0673370A1 (de) | 1995-09-27 |
AU670842B2 (en) | 1996-08-01 |
RU95114378A (ru) | 1997-06-10 |
CA2147753A1 (en) | 1994-06-23 |
WO1994013649A1 (en) | 1994-06-23 |
DK0673370T3 (da) | 1998-09-07 |
HU9501670D0 (en) | 1995-08-28 |
EP0673370B1 (de) | 1998-01-07 |
ES2111188T3 (es) | 1998-03-01 |
FI952798A (fi) | 1995-06-07 |
KR100276382B1 (ko) | 2000-12-15 |
JP3558088B2 (ja) | 2004-08-25 |
SK74695A3 (en) | 1995-10-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |