NO952253L - Tropon-substituerte, fenyloksazolidinon-antibakterielle midler - Google Patents
Tropon-substituerte, fenyloksazolidinon-antibakterielle midlerInfo
- Publication number
- NO952253L NO952253L NO952253A NO952253A NO952253L NO 952253 L NO952253 L NO 952253L NO 952253 A NO952253 A NO 952253A NO 952253 A NO952253 A NO 952253A NO 952253 L NO952253 L NO 952253L
- Authority
- NO
- Norway
- Prior art keywords
- antibacterial agents
- tropon
- substituted
- substituted phenyloxazolidinone
- phenyloxazolidinone antibacterial
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
Abstract
En ny klasse av fenyloxazolidi- non-antibakterielle midler som har, som deres iøynefallende strukturelle trekk, en vedhengende substituert tropongruppe, er beskrevet. Mellom- produkter og fremgangsmåter for fremstilling av disse antibiotikaer er også beskrevet. Disse forbindel- ser er anvendbare aritibakterielle midler for å utrydde eller regulere ømfintlige organismer. I formel (I) (I) har R , R og R de samme betydnin- 4 ger som i krav l, og R er valgt fra gruppen bestående av (a), (b), (c) og (d) hvori R og Ra er like eller for- skjellige og er valgtfra gruppen bestående av (C,-C0)-alkyl eventu- 1 o elt substituert med klor, fluor, hydroxy, (C1,-CR8)-alkoxy, amino, (C,-Ca)-alkylamino, (C1-C8)- dialkylamino.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98858992A | 1992-12-08 | 1992-12-08 | |
US377893A | 1993-01-13 | 1993-01-13 | |
US6635693A | 1993-05-21 | 1993-05-21 | |
PCT/US1993/009589 WO1994013649A1 (en) | 1992-12-08 | 1993-10-14 | Tropone-substituted phenyloxazolidinone antibacterial agents |
Publications (2)
Publication Number | Publication Date |
---|---|
NO952253D0 NO952253D0 (no) | 1995-06-07 |
NO952253L true NO952253L (no) | 1995-08-08 |
Family
ID=27357482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO952253A NO952253L (no) | 1992-12-08 | 1995-06-07 | Tropon-substituerte, fenyloksazolidinon-antibakterielle midler |
Country Status (20)
Country | Link |
---|---|
US (1) | US5523403A (no) |
EP (1) | EP0673370B1 (no) |
JP (1) | JP3558088B2 (no) |
KR (1) | KR100276382B1 (no) |
AT (1) | ATE161833T1 (no) |
AU (1) | AU670842B2 (no) |
CA (1) | CA2147753C (no) |
CZ (1) | CZ288788B6 (no) |
DE (1) | DE69316240T2 (no) |
DK (1) | DK0673370T3 (no) |
ES (1) | ES2111188T3 (no) |
FI (1) | FI952798A0 (no) |
GR (1) | GR3026228T3 (no) |
HU (1) | HUT74099A (no) |
NO (1) | NO952253L (no) |
NZ (1) | NZ257031A (no) |
PL (1) | PL175782B1 (no) |
RU (1) | RU2119484C1 (no) |
SK (1) | SK282453B6 (no) |
WO (1) | WO1994013649A1 (no) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5668286A (en) * | 1994-03-15 | 1997-09-16 | Pharmacia & Upjohn Company | Oxazolidinone derivatives and pharmaceutical compositions containing them |
JPH11511467A (ja) * | 1995-09-15 | 1999-10-05 | ファルマシア・アンド・アップジョン・カンパニー | 5−アミドメチルα,β−飽和および不飽和3−アリールブチロラクトン抗菌剤 |
GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
GB9609919D0 (en) * | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
EP0920421B1 (en) * | 1996-08-21 | 2002-11-06 | PHARMACIA & UPJOHN COMPANY | Isoxazoline derivatives useful as antimicrobials |
US5998414A (en) * | 1996-08-22 | 1999-12-07 | Hoechst Marion Roussel, Inc. | Troponyl piperazines as dopamine D4 receptor ligands |
GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
GB9717807D0 (en) * | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
ES2284216T3 (es) * | 1997-11-07 | 2007-11-01 | PHARMACIA & UPJOHN COMPANY LLC | Procedeimiento para producir oxazolidinonas. |
GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
US6083967A (en) * | 1997-12-05 | 2000-07-04 | Pharmacia & Upjohn Company | S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones |
AU764184B2 (en) | 1998-01-23 | 2003-08-14 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
HUP0103082A3 (en) * | 1998-06-05 | 2002-12-28 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
TW572757B (en) * | 1998-08-24 | 2004-01-21 | Bristol Myers Squibb Co | Novel isoxazolinone antibacterial agents |
US6420349B1 (en) | 1998-08-24 | 2002-07-16 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
AU4224699A (en) | 1999-01-27 | 2000-08-18 | Pharmacia & Upjohn Company | Assays for modulators of elongation factor p activity |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
US6465456B2 (en) | 2000-06-29 | 2002-10-15 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
JP2004518677A (ja) | 2000-12-21 | 2004-06-24 | ファルマシア・アンド・アップジョン・カンパニー | 抗菌性キノロン誘導体および細菌感染を治療するためのその使用 |
AU2002360238B2 (en) * | 2001-04-17 | 2007-11-15 | Kyorin Pharmaceutical Co., Ltd. | Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof |
TW200302095A (en) * | 2002-01-25 | 2003-08-01 | Upjohn Co | Oxazolidinone cotherapy |
MXPA04007468A (es) * | 2002-02-05 | 2004-11-10 | Upjohn Co | Derivados de tiadiazinona antimicrobianos y su aplicacion para el tratamiento de infecciones bacterianas. |
US7141588B2 (en) * | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
AR038536A1 (es) * | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
WO2003084534A1 (en) * | 2002-03-29 | 2003-10-16 | Pharmacia & Upjohn Company Llc | Parenteral, intravenous, and oral administration of oxazolidinones for treating diabetic foot infections |
EP1539745B1 (en) * | 2002-08-12 | 2006-03-29 | Pharmacia & Upjohn Company LLC | N-aryl-2-oxazolidinones and their derivatives |
ATE344036T1 (de) * | 2002-11-21 | 2006-11-15 | Pharmacia & Upjohn Co Llc | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5- carbonsäureamid-derivate und verwandte verbindungen als antibakterielle mittel |
US8050281B2 (en) * | 2003-01-31 | 2011-11-01 | Qwest Communications International Inc. | Alert gateway, systems and methods |
US8813142B2 (en) * | 2003-01-31 | 2014-08-19 | Qwest Communications International Inc. | Methods, systems and apparatus for providing video transmissions over multiple media |
US7474742B2 (en) * | 2003-01-31 | 2009-01-06 | Qwest Communications International Inc. | Environmentally-controlled network interface device and methods |
CA2515311A1 (en) * | 2003-02-07 | 2004-08-19 | Warner-Lambert Company Llc | Antibacterial agents |
US20040204463A1 (en) * | 2003-04-01 | 2004-10-14 | Harris Christina Renee | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
AR045690A1 (es) | 2003-06-03 | 2005-11-09 | Rib X Pharmaceuticals Inc | Compuestos biaril heterociclicos y metodos para preparar y utilizar los mismos |
DE602004027811D1 (de) | 2003-07-02 | 2010-08-05 | Kyorin Seiyaku Kk | Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon |
EP1646630A1 (en) * | 2003-07-02 | 2006-04-19 | Merck & Co., Inc. | Oxazolidinone antibiotics and derivatives thereof |
CA2529293A1 (en) * | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof |
JP2007521282A (ja) * | 2003-07-02 | 2007-08-02 | メルク アンド カンパニー インコーポレーテッド | オキサゾリジノン抗生物質およびその誘導体 |
MXPA06002188A (es) * | 2003-08-25 | 2006-04-27 | Warner Lambert Co | Nuevos compuestos antimicrobianos de ariloxazolidinona. |
US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
US7129259B2 (en) | 2003-12-17 | 2006-10-31 | Rib-X Pharmaceuticals, Inc. | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
DE602006019870D1 (de) | 2005-06-08 | 2011-03-10 | Rib X Pharmaceuticals Inc | Verfahren zur synthese von triazolen |
CA2647605A1 (en) | 2006-03-31 | 2007-10-11 | Research Foundation Itsuu Laboratory | Novel compound having heterocyclic ring |
WO2007116960A1 (ja) * | 2006-04-06 | 2007-10-18 | Research Foundation Itsuu Laboratory | 炭素環を有するオキサゾリジノン誘導体 |
CN101883768A (zh) | 2007-10-02 | 2010-11-10 | 财团法人乙卯研究所 | 具有7元杂环的噁唑烷酮衍生物 |
WO2010042887A2 (en) * | 2008-10-10 | 2010-04-15 | Trius Therapeutics | Methods for preparing oxazolidinones and compositions containing them |
UA114068C2 (xx) | 2009-02-03 | 2017-04-25 | Кристалічні частинки (r)-3-(4-(2-(2-метилтетразол-5-іл)піридин-5-іл)-3-фторфеніл)-5-гідроксиметилоксазолідин-2-ондиводеньфосфату | |
US8580767B2 (en) * | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE29607E (en) * | 1969-03-18 | 1978-04-11 | Delalande S. A. | Derivatives of 5-hydroxymethyl-3-substituted-2-oxazolidinones, process of preparation thereof and therapeutic application |
LU80081A1 (fr) * | 1977-08-26 | 1979-05-15 | Delalande Sa | Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique |
US4128654A (en) * | 1978-02-10 | 1978-12-05 | E. I. Du Pont De Nemours And Company | 5-Halomethyl-3-phenyl-2-oxazolidinones |
US4340606A (en) * | 1980-10-23 | 1982-07-20 | E. I. Du Pont De Nemours And Company | 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents |
FR2500450A1 (fr) * | 1981-02-25 | 1982-08-27 | Delalande Sa | Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique |
DE3149608A1 (de) * | 1981-12-15 | 1983-08-04 | Dr. Madaus & Co, 5000 Köln | Substituierte tropolone, verfahren zur herstellung derselben und diese enthaltende pharmazeutische zubereitungen |
US4461773A (en) * | 1982-09-15 | 1984-07-24 | E. I. Dupont De Nemours And Company | P-Oxooxazolidinylbenzene compounds as antibacterial agents |
ES533097A0 (es) * | 1983-06-07 | 1985-08-01 | Du Pont | Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno. |
US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
CA1260948A (en) * | 1984-12-05 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents |
US4921869A (en) * | 1987-10-09 | 1990-05-01 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
CA1320730C (en) * | 1987-10-16 | 1993-07-27 | The Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl aroylbenzene derivatives useful as antibacterial agents |
US4977173A (en) * | 1987-10-21 | 1990-12-11 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl ethenylbenzene derivatives useful as antibacterial agents |
DE3884563T2 (de) * | 1987-10-21 | 1994-02-17 | Du Pont Merck Pharma | Aminomethyl-oxo-oxazolidinyl-ethenylbenzen-Derivate, nützlich als antibakterielles Mittel. |
US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
-
1993
- 1993-10-14 AT AT93923304T patent/ATE161833T1/de not_active IP Right Cessation
- 1993-10-14 RU RU95114378A patent/RU2119484C1/ru not_active IP Right Cessation
- 1993-10-14 ES ES93923304T patent/ES2111188T3/es not_active Expired - Lifetime
- 1993-10-14 CZ CZ19951366A patent/CZ288788B6/cs not_active IP Right Cessation
- 1993-10-14 HU HU9501670A patent/HUT74099A/hu unknown
- 1993-10-14 DE DE69316240T patent/DE69316240T2/de not_active Expired - Fee Related
- 1993-10-14 SK SK746-95A patent/SK282453B6/sk unknown
- 1993-10-14 NZ NZ257031A patent/NZ257031A/en unknown
- 1993-10-14 JP JP51413894A patent/JP3558088B2/ja not_active Expired - Fee Related
- 1993-10-14 AU AU53239/94A patent/AU670842B2/en not_active Ceased
- 1993-10-14 PL PL93309283A patent/PL175782B1/pl not_active IP Right Cessation
- 1993-10-14 WO PCT/US1993/009589 patent/WO1994013649A1/en active IP Right Grant
- 1993-10-14 DK DK93923304T patent/DK0673370T3/da active
- 1993-10-14 KR KR1019950702303A patent/KR100276382B1/ko not_active IP Right Cessation
- 1993-10-14 EP EP93923304A patent/EP0673370B1/en not_active Expired - Lifetime
- 1993-10-14 CA CA002147753A patent/CA2147753C/en not_active Expired - Fee Related
-
1995
- 1995-05-22 US US08/445,594 patent/US5523403A/en not_active Expired - Fee Related
- 1995-06-07 NO NO952253A patent/NO952253L/no unknown
- 1995-06-07 FI FI952798A patent/FI952798A0/fi not_active IP Right Cessation
-
1998
- 1998-02-25 GR GR980400408T patent/GR3026228T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3026228T3 (en) | 1998-05-29 |
PL309283A1 (en) | 1995-10-02 |
WO1994013649A1 (en) | 1994-06-23 |
CZ288788B6 (cs) | 2001-09-12 |
CA2147753A1 (en) | 1994-06-23 |
US5523403A (en) | 1996-06-04 |
SK282453B6 (sk) | 2002-02-05 |
RU2119484C1 (ru) | 1998-09-27 |
HUT74099A (en) | 1996-11-28 |
ATE161833T1 (de) | 1998-01-15 |
JPH08504205A (ja) | 1996-05-07 |
RU95114378A (ru) | 1997-06-10 |
NZ257031A (en) | 1996-07-26 |
DE69316240T2 (de) | 1998-05-20 |
FI952798A (fi) | 1995-06-07 |
NO952253D0 (no) | 1995-06-07 |
ES2111188T3 (es) | 1998-03-01 |
AU5323994A (en) | 1994-07-04 |
AU670842B2 (en) | 1996-08-01 |
KR100276382B1 (ko) | 2000-12-15 |
PL175782B1 (pl) | 1999-02-26 |
CZ136695A3 (en) | 1995-10-18 |
FI952798A0 (fi) | 1995-06-07 |
DK0673370T3 (da) | 1998-09-07 |
DE69316240D1 (de) | 1998-02-12 |
EP0673370A1 (en) | 1995-09-27 |
EP0673370B1 (en) | 1998-01-07 |
HU9501670D0 (en) | 1995-08-28 |
SK74695A3 (en) | 1995-10-11 |
CA2147753C (en) | 2004-08-03 |
JP3558088B2 (ja) | 2004-08-25 |
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