ATE247162T1 - Selbstinduzierer - Google Patents

Selbstinduzierer

Info

Publication number
ATE247162T1
ATE247162T1 AT92908821T AT92908821T ATE247162T1 AT E247162 T1 ATE247162 T1 AT E247162T1 AT 92908821 T AT92908821 T AT 92908821T AT 92908821 T AT92908821 T AT 92908821T AT E247162 T1 ATE247162 T1 AT E247162T1
Authority
AT
Austria
Prior art keywords
pct
date oct
sec
compound
gene expression
Prior art date
Application number
AT92908821T
Other languages
English (en)
Inventor
Barrie Walsham Bycroft
Paul Williams
Gordon Sidney Anderson Stewart
Siri Ram Chhabra
Paul Stead
Michael Kenneth Winson
Philip John Hill
Catherine Elizabeth Dunn Rees
Nigel John Bainton
Original Assignee
Univ Nottingham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nottingham filed Critical Univ Nottingham
Application granted granted Critical
Publication of ATE247162T1 publication Critical patent/ATE247162T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Control Of Eletrric Generators (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT92908821T 1991-04-18 1992-04-16 Selbstinduzierer ATE247162T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919108307A GB9108307D0 (en) 1991-04-18 1991-04-18 Autoinducer
PCT/GB1992/000713 WO1992018614A1 (en) 1991-04-18 1992-04-16 Autoinducer

Publications (1)

Publication Number Publication Date
ATE247162T1 true ATE247162T1 (de) 2003-08-15

Family

ID=10693505

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92908821T ATE247162T1 (de) 1991-04-18 1992-04-16 Selbstinduzierer

Country Status (10)

Country Link
US (1) US5593827A (de)
EP (1) EP0580692B1 (de)
JP (1) JPH06506588A (de)
AT (1) ATE247162T1 (de)
CA (1) CA2105395A1 (de)
DE (1) DE69233160T2 (de)
DK (1) DK0580692T3 (de)
ES (1) ES2203610T3 (de)
GB (1) GB9108307D0 (de)
WO (1) WO1992018614A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7077894A (en) * 1993-07-02 1995-01-24 University Of Nottingham, The Immunosuppressant and antiallergic compounds, e.g. n-(3-oxohexanoyl) homoserine lactone
US6936447B1 (en) 2000-04-03 2005-08-30 University Of Iowa Research Foundation Autoinducer molecule
US5591872A (en) * 1993-08-09 1997-01-07 The University Of Iowa Research Foundation Autoinducer molecule
US5759798A (en) * 1995-12-08 1998-06-02 Woods Hole Oceanographic Institution Assays, test kits and bacteria for detection of autoinducers
DE69836218T2 (de) * 1997-06-18 2007-09-06 Montana State University - Bozeman Homoserinlactone zum regulieren von biofilmen und methoden zur anwendung
US6455031B1 (en) 1997-06-18 2002-09-24 David G Davies Methods and compositions for controlling biofilm development
GB9725599D0 (en) * 1997-12-04 1998-02-04 Univ Nottingham Control of biofilm formation
US6395282B1 (en) 1998-04-16 2002-05-28 University Of Rochester Immunogenic conjugates of Gram-negative bacterial autoinducer molecules
US6756404B2 (en) * 1998-06-18 2004-06-29 The Research & Development Institute, Inc. Autoinducer compounds
US6337347B1 (en) * 1998-06-18 2002-01-08 The Research & Development Institute, Inc. Autoinducer compounds
JP2003526327A (ja) * 1998-12-02 2003-09-09 プリンストン ユニバーシティー 細菌性疾患発症を調節する組成物および方法
US6720415B2 (en) 1998-12-02 2004-04-13 Princeton University Compositions and methods for regulating bacterial pathogenesis
US7326542B2 (en) * 1998-12-02 2008-02-05 Princeton University Compositions and methods for regulating bacterial pathogenesis
EP1507010B1 (de) * 1999-07-01 2009-08-12 Calgene LLC Kontrolle der Genexpression in eukaryotischen Zellen
DK1190079T3 (da) 1999-07-01 2006-10-09 Calgene Llc Regulering af genekspression i eukaryote celler
AU7343800A (en) 1999-09-03 2001-04-10 Quorum Sciences, Inc. Quorum sensing signaling in bacteria
GB9924195D0 (en) * 1999-10-13 1999-12-15 Univ Nottingham N-Acyl homoserine lactones for the treatment of cardiac tachyarrhythmias Ischaemic heart disease or congestive heart failure
GB0007588D0 (en) * 2000-03-30 2000-05-17 Univ Nottingham N-Acyl homoserine lactones
WO2001085773A2 (en) * 2000-05-10 2001-11-15 Princeton University Luxo-sigma54 interactions and methods of use
JP2003532698A (ja) * 2000-05-10 2003-11-05 プリンストン ユニバーシティ 細菌の増殖および病理発生を調節するための化合物ならびに方法
US6703513B1 (en) 2000-06-02 2004-03-09 K-Quay Enterprises Llc Production and use of derivatized homoserine lactones
AU2001286976A1 (en) * 2000-08-31 2002-03-13 East Carolina University Novel autoinducer molecules and uses therefor
US7651699B2 (en) 2001-01-08 2010-01-26 Pathway Intermediates Limited Autoinducer compounds and their uses
JP2005506953A (ja) * 2001-05-21 2005-03-10 クオレックス・ファーマシューティカルズ・インコーポレーテッド 細菌の調節方法
GB0122026D0 (en) * 2001-09-12 2001-10-31 Univ Nottingham Insulitis
DE10219031A1 (de) * 2002-04-29 2003-11-20 Bayer Ag Verfahren und Vorrichtung zum Nachweis biologisch aktiver Substanzen
EP1359226B1 (de) 2002-04-29 2006-11-22 Bayer Innovation GmbH Verfahren und Vorrichtung zum Nachweis biologisch aktiver Substanzen
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
JP5133067B2 (ja) 2005-02-04 2013-01-30 ウイスコンシン アラムナイ リサーチ ファウンデーシヨン クオラムセンシング細菌におけるコミュニケーション及び毒性を変更するための化合物及び方法
GB0512238D0 (en) * 2005-06-15 2005-07-27 Univ Cambridge Tech Anti-inflammatory agents
GB0610042D0 (en) 2006-05-22 2006-06-28 Univ Nottingham Substituted n-acyl homoserine lactones
US7910622B2 (en) 2007-03-19 2011-03-22 Wisconsin Alumni Research Foundation Modulation of bacterial quorum sensing with synthetic ligands
US7662967B2 (en) * 2007-08-02 2010-02-16 Cambridge Enterprise Limited Anti-inflammatory compounds and compositions
GB2452696B (en) * 2007-08-02 2009-09-23 Cambridge Entpr Ltd 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
WO2009036081A1 (en) * 2007-09-10 2009-03-19 University Of Kentucky Research Foundation Systems and methods for diagnosis and monitoring of bacteria-related conditions
EP2447221A4 (de) * 2009-06-22 2013-01-02 Sumitomo Heavy Industries Verfahren zur behandlung von ammoniakstickstoffhaltigen abwässern
US8624063B2 (en) 2009-06-30 2014-01-07 Wisconsin Alumni Research Foundation Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing
US9073884B2 (en) 2010-06-04 2015-07-07 The Regents Of The University Of California Anti-inflammatory and quorum sensing inhibition compounds and methods of making and using them
JP5579523B2 (ja) * 2010-07-23 2014-08-27 国立大学法人 東京大学 創傷治療のための医薬
CN106146378B (zh) * 2015-03-23 2018-09-18 兰州大学 一种酰化高丝氨酸内酯类化合物及其环保应用
US10526278B2 (en) 2017-10-19 2020-01-07 Wisconsin Alumni Research Foundation Inhibitors of quorum sensing receptor LasR

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861709A (en) * 1985-05-31 1989-08-29 Technicon Research A.G. Detection and/or identification of microorganisms in a test sample using bioluminescence or other exogenous genetically-introduced marker
US5196318A (en) * 1990-06-26 1993-03-23 The Texas A&M University System Precisely regulated expression of deleterious genes

Also Published As

Publication number Publication date
EP0580692B1 (de) 2003-08-13
ES2203610T3 (es) 2004-04-16
GB9108307D0 (en) 1991-06-05
CA2105395A1 (en) 1992-10-19
DE69233160D1 (de) 2003-09-18
WO1992018614A1 (en) 1992-10-29
DK0580692T3 (da) 2003-12-08
DE69233160T2 (de) 2004-06-09
EP0580692A1 (de) 1994-02-02
US5593827A (en) 1997-01-14
JPH06506588A (ja) 1994-07-28

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