PT1427711E - Derivados de oxazolidinona e/ou isoxazolina como agentes antibacterianos - Google Patents

Derivados de oxazolidinona e/ou isoxazolina como agentes antibacterianos

Info

Publication number
PT1427711E
PT1427711E PT02765019T PT02765019T PT1427711E PT 1427711 E PT1427711 E PT 1427711E PT 02765019 T PT02765019 T PT 02765019T PT 02765019 T PT02765019 T PT 02765019T PT 1427711 E PT1427711 E PT 1427711E
Authority
PT
Portugal
Prior art keywords
oxazolidinone
antibacterial agents
isoxazoline derivatives
isoxazoline
derivatives
Prior art date
Application number
PT02765019T
Other languages
English (en)
Inventor
Gravestock Michael Barry
Hales Neil James
Swain Michael Lingard
Hauck Sheila Irene
Mills Stuart Dennett
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0121942A external-priority patent/GB0121942D0/en
Priority claimed from GB0215420A external-priority patent/GB0215420D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PT1427711E publication Critical patent/PT1427711E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18Oxygen atoms
    • C07D263/20Oxygen atoms attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PT02765019T 2001-09-11 2002-09-09 Derivados de oxazolidinona e/ou isoxazolina como agentes antibacterianos PT1427711E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0121942A GB0121942D0 (en) 2001-09-11 2001-09-11 Chemical compounds
GB0215420A GB0215420D0 (en) 2002-07-04 2002-07-04 Chemical compounds

Publications (1)

Publication Number Publication Date
PT1427711E true PT1427711E (pt) 2005-11-30

Family

ID=26246531

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02765019T PT1427711E (pt) 2001-09-11 2002-09-09 Derivados de oxazolidinona e/ou isoxazolina como agentes antibacterianos

Country Status (26)

Country Link
US (2) US7396847B2 (pt)
EP (1) EP1427711B1 (pt)
JP (1) JP2005507386A (pt)
KR (1) KR20040044886A (pt)
CN (1) CN1639136A (pt)
AR (1) AR036778A1 (pt)
AT (1) ATE299502T1 (pt)
AU (1) AU2002329393B2 (pt)
BR (1) BR0212458A (pt)
CA (1) CA2459766A1 (pt)
CO (1) CO5560609A2 (pt)
DE (1) DE60205030T2 (pt)
DK (1) DK1427711T3 (pt)
ES (1) ES2244802T3 (pt)
HK (1) HK1065789A1 (pt)
HU (1) HUP0401005A3 (pt)
IL (1) IL160739A0 (pt)
IS (1) IS7175A (pt)
MX (1) MXPA04002303A (pt)
NO (1) NO327010B1 (pt)
NZ (1) NZ531621A (pt)
PL (1) PL369183A1 (pt)
PT (1) PT1427711E (pt)
RU (1) RU2004111285A (pt)
SI (1) SI1427711T1 (pt)
WO (1) WO2003022824A1 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667299B1 (en) * 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
JP2005512975A (ja) 2001-10-25 2005-05-12 アストラゼネカ アクチボラグ 抗菌薬として有用なイソキサゾリン誘導体
CA2477344A1 (en) 2002-02-28 2003-09-04 Astrazeneca Ab 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents
CN1653064A (zh) 2002-02-28 2005-08-10 阿斯特拉曾尼卡有限公司 噁唑烷酮衍生物、其制备方法以及包含它们的药用组合物
EA008445B1 (ru) * 2002-04-25 2007-06-29 Басф Акциенгезельшафт 3-гетероарилзамещенные изоксазолины
US7091196B2 (en) * 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
CA2507628A1 (en) 2002-11-28 2004-06-10 Astrazeneca Ab Oxazolidinones as antibacterial agents
GB0227701D0 (en) * 2002-11-28 2003-01-08 Astrazeneca Ab Chemical compounds
CA2507468A1 (en) * 2002-11-28 2004-06-10 Astrazeneca Ab Oxazolidinone and / or isoxazoline derivatives as antibacterial agents
GB0229521D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229526D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229522D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
GB0304723D0 (en) * 2003-03-01 2003-04-02 Astrazeneca Ab Chemical compounds
AR045690A1 (es) 2003-06-03 2005-11-09 Rib X Pharmaceuticals Inc Compuestos biaril heterociclicos y metodos para preparar y utilizar los mismos
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
JP4777246B2 (ja) * 2003-07-29 2011-09-21 リブ−エックス ファーマシューティカルズ,インコーポレイテッド ビアリールオキサゾリジノンの合成方法
EP1660465B1 (en) * 2003-07-29 2014-12-17 Melinta Therapeutics, Inc. Process for the synthesis of biaryl oxazolidinones
JP2007514782A (ja) 2003-12-17 2007-06-07 リブ−エックス ファーマシューティカルズ,インコーポレイテッド ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
CA2567457A1 (en) * 2004-05-25 2005-12-08 Astrazeneca Ab 3- (4- (2-dihydroisoxazol-3-ylpyridin-5-yl) phenyl) -5-triazol-1-ylmethyloxazolidin-2-one derivaives as mao inhibitors for the treatment of bacterial infections
GB0411596D0 (en) * 2004-05-25 2004-06-30 Astrazeneca Ab Chemical process
US20080064689A1 (en) * 2004-05-25 2008-03-13 Astrazeneca Ab 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents
DOP2005000123A (es) 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
WO2006038100A1 (en) * 2004-10-08 2006-04-13 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
EP1874782A1 (en) 2005-04-15 2008-01-09 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2006133397A2 (en) 2005-06-08 2006-12-14 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
US8470985B2 (en) 2005-08-24 2013-06-25 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
US8278281B2 (en) 2005-08-24 2012-10-02 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
KR101674146B1 (ko) * 2008-10-10 2016-11-08 머크 샤프 앤드 돔 코포레이션 옥사졸리디논 및 이를 포함하는 조성물을 제조하는 방법
KR101739923B1 (ko) 2009-02-03 2017-05-25 머크 샤프 앤드 돔 코포레이션 R)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형
US8580767B2 (en) 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
KR101561964B1 (ko) 2013-11-15 2015-10-20 한국과학기술연구원 옥사졸리디논 화합물 및 이를 포함하는 c형 간염 예방 또는 치료용 약학 조성물
EP3263572B1 (en) * 2015-02-27 2021-12-15 Seed Research Institute Co., Ltd. Method for producing kakeromycin and derivatives thereof
CN106083994B (zh) * 2016-04-18 2019-12-06 南京曼杰生物科技有限公司 取代的噁唑烷酮水溶性衍生物及其应用
US20170333305A1 (en) * 2016-05-23 2017-11-23 Microban Products Company Topical skin product having retention property
EP3723758A4 (en) 2017-12-13 2021-06-23 Merck Sharp & Dohme Corp. PHARMACEUTICAL COMPOSITIONS OF TEDIZOLID PHOSPHATE
CN113149924B (zh) * 2021-03-29 2023-11-03 苏州大学 一种异噁唑啉的简单制备方法
CN113831517A (zh) * 2021-09-09 2021-12-24 万凯新材料股份有限公司 抗菌及抗紫外聚酯的制备方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5043443A (en) * 1988-07-29 1991-08-27 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives
SK283420B6 (sk) 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
GB9521508D0 (en) 1995-10-20 1995-12-20 Zeneca Ltd Chemical compounds
GB9601666D0 (en) 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9604301D0 (en) 1996-02-29 1996-05-01 Zeneca Ltd Chemical compounds
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9614236D0 (en) 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9614238D0 (en) 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
EP1007525A1 (en) 1997-08-29 2000-06-14 Zeneca Limited Aminometyl oxooxazolidinyl benzene derivatives
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
WO1999033839A1 (en) 1997-12-26 1999-07-08 Cheil Jedang Corporation Cephem derivatives and a method for producing the compounds and an antibacterial composition containing the compounds
GB9812019D0 (en) 1998-06-05 1998-07-29 Zeneca Ltd Chemical compounds
US6617339B1 (en) 1998-06-05 2003-09-09 Syngenta Limited Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
CA2319495A1 (en) 1998-06-08 1999-12-16 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
GB9821938D0 (en) 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB9928499D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical processes and intermediates
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
NZ522990A (en) * 2000-06-05 2003-08-29 Dong A Pharm Novel oxazolidinone derivatives and a process for the preparation thereof
DE10034625A1 (de) 2000-07-17 2002-01-31 Bayer Ag Heterocyclisch substituierte Thienyl-Phenyl-Oxazolidinone
DE10034624A1 (de) 2000-07-17 2002-01-31 Bayer Ag Aryl-substituierte Thienyl-1,3-oxazolidin-2-one als Cytokin-Inhibitoren
US20020115669A1 (en) * 2000-08-31 2002-08-22 Wiedeman Paul E. Oxazolidinone chemotherapeutic agents
YU52403A (sh) 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
GB0108793D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
ES2268011T3 (es) 2001-04-07 2007-03-16 Astrazeneca Ab Oxazolidinonas que contienen un grupo sulfonimida como antibioticos.
GB0108764D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0108794D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compound
GB0113300D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Purification process
GB0113297D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Chemical Process
GB0113299D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Chemical process & intermediates
GB0113298D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Purification process and intermediates
CA2452513A1 (en) 2001-07-12 2003-01-23 Pharmacia & Upjohn Company Amide-containing compound having improved solubility and method of improving the solubility of an amide-containing compound
GB0118407D0 (en) 2001-07-27 2001-09-19 Cipla Ltd Oxazolidinone derivatives as antibacterial agents
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
WO2003031441A1 (en) 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
JP2005512975A (ja) 2001-10-25 2005-05-12 アストラゼネカ アクチボラグ 抗菌薬として有用なイソキサゾリン誘導体
GB2396350A (en) 2001-10-25 2004-06-23 Astrazeneca Ab Aryl substituted oxazolidinones with antibacterial activity
CN1653064A (zh) 2002-02-28 2005-08-10 阿斯特拉曾尼卡有限公司 噁唑烷酮衍生物、其制备方法以及包含它们的药用组合物
CA2477344A1 (en) 2002-02-28 2003-09-04 Astrazeneca Ab 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents
JP2003335762A (ja) 2002-05-20 2003-11-28 Meiji Seika Kaisha Ltd 新規ビフェニル誘導体
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
CA2507468A1 (en) * 2002-11-28 2004-06-10 Astrazeneca Ab Oxazolidinone and / or isoxazoline derivatives as antibacterial agents

Also Published As

Publication number Publication date
HUP0401005A2 (hu) 2004-08-30
AR036778A1 (es) 2004-10-06
RU2004111285A (ru) 2005-10-10
US20050107435A1 (en) 2005-05-19
NO327010B1 (no) 2009-04-06
BR0212458A (pt) 2004-10-19
HUP0401005A3 (en) 2007-11-28
MXPA04002303A (es) 2004-06-29
EP1427711B1 (en) 2005-07-13
AU2002329393B2 (en) 2008-06-12
ES2244802T3 (es) 2005-12-16
PL369183A1 (en) 2005-04-18
US7396847B2 (en) 2008-07-08
DE60205030D1 (de) 2005-08-18
SI1427711T1 (sl) 2005-12-31
US20100137243A1 (en) 2010-06-03
NO20041428L (no) 2004-06-08
CO5560609A2 (es) 2005-09-30
EP1427711A1 (en) 2004-06-16
DK1427711T3 (da) 2005-10-17
CA2459766A1 (en) 2003-03-20
HK1065789A1 (en) 2005-03-04
CN1639136A (zh) 2005-07-13
IL160739A0 (en) 2004-08-31
WO2003022824A1 (en) 2003-03-20
IS7175A (is) 2004-03-10
NZ531621A (en) 2005-06-24
KR20040044886A (ko) 2004-05-31
JP2005507386A (ja) 2005-03-17
DE60205030T2 (de) 2006-04-20
ATE299502T1 (de) 2005-07-15

Similar Documents

Publication Publication Date Title
PT1427711E (pt) Derivados de oxazolidinona e/ou isoxazolina como agentes antibacterianos
IL168747A0 (en) Oxazolidinone and/or isoxazoline derivatives as antibacterial agents
MA26866A1 (fr) Agents antibacteriens consistant en 3-aminoquinazoline-2,4-diones
DE60238194D1 (de) Isoxazolinderivate und herbizide
DE60142180D1 (de) Lichtstabilisierte antimikrobielle mittel
DE60131138D1 (de) Antibakterielle mittel
BR0207025B1 (pt) derivado de isoxazolina e herbicida contendo o mesmo como o ingrediente ativo.
DK1555267T3 (da) 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLER
ATE457641T1 (de) Synergistische herbizide mittel
GB0303836D0 (en) Oxazolidinones and their use as antibacterial agents
DE60317711D1 (de) Kationische porphyrin-derivate als antibakterielle mittel
DE50115239D1 (de) Herbizide Mittel
ATE317222T1 (de) Herbizide mittel
EE200400004A (et) Oksasolidinoonide derivaadid kui antibakteriaalsed ained
ATE329487T1 (de) Herbizide mittel
DE60239613D1 (de) Antibakterielle zusammensetzung für medizinische werkzeuge
PT1181288E (pt) Oxazolidinonas biciclicas como agentes antibacterianos
ATE316335T1 (de) Herbizide mittel
DE60102936D1 (de) Antibakterielle mutiline
DE60214138D1 (de) Isoxazolin-derivate als antidepressiva
GB0118407D0 (en) Oxazolidinone derivatives as antibacterial agents
DE60135877D1 (de) Antibakterielle zusammensetzung
PT1268469E (pt) N-(heterociclil)benzeno ou piridino-sulfonamidas como agentes anti-tromboticos eanti-coagulantes
DE50209187D1 (de) Antibakterielle makrozyklen
PT1289514E (pt) Utilizacao de compostos 1-amino-5-fenilpentano-3-ol e/ou 1-amino-6-fenil-hexano-3-ol substituidos como medicamentos