PT1427711E - Derivados de oxazolidinona e/ou isoxazolina como agentes antibacterianos - Google Patents
Derivados de oxazolidinona e/ou isoxazolina como agentes antibacterianosInfo
- Publication number
- PT1427711E PT1427711E PT02765019T PT02765019T PT1427711E PT 1427711 E PT1427711 E PT 1427711E PT 02765019 T PT02765019 T PT 02765019T PT 02765019 T PT02765019 T PT 02765019T PT 1427711 E PT1427711 E PT 1427711E
- Authority
- PT
- Portugal
- Prior art keywords
- oxazolidinone
- antibacterial agents
- isoxazoline derivatives
- isoxazoline
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0121942A GB0121942D0 (en) | 2001-09-11 | 2001-09-11 | Chemical compounds |
GB0215420A GB0215420D0 (en) | 2002-07-04 | 2002-07-04 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1427711E true PT1427711E (pt) | 2005-11-30 |
Family
ID=26246531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT02765019T PT1427711E (pt) | 2001-09-11 | 2002-09-09 | Derivados de oxazolidinona e/ou isoxazolina como agentes antibacterianos |
Country Status (26)
Country | Link |
---|---|
US (2) | US7396847B2 (pt) |
EP (1) | EP1427711B1 (pt) |
JP (1) | JP2005507386A (pt) |
KR (1) | KR20040044886A (pt) |
CN (1) | CN1639136A (pt) |
AR (1) | AR036778A1 (pt) |
AT (1) | ATE299502T1 (pt) |
AU (1) | AU2002329393B2 (pt) |
BR (1) | BR0212458A (pt) |
CA (1) | CA2459766A1 (pt) |
CO (1) | CO5560609A2 (pt) |
DE (1) | DE60205030T2 (pt) |
DK (1) | DK1427711T3 (pt) |
ES (1) | ES2244802T3 (pt) |
HK (1) | HK1065789A1 (pt) |
HU (1) | HUP0401005A3 (pt) |
IL (1) | IL160739A0 (pt) |
IS (1) | IS7175A (pt) |
MX (1) | MXPA04002303A (pt) |
NO (1) | NO327010B1 (pt) |
NZ (1) | NZ531621A (pt) |
PL (1) | PL369183A1 (pt) |
PT (1) | PT1427711E (pt) |
RU (1) | RU2004111285A (pt) |
SI (1) | SI1427711T1 (pt) |
WO (1) | WO2003022824A1 (pt) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6667299B1 (en) * | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
JP2005512975A (ja) | 2001-10-25 | 2005-05-12 | アストラゼネカ アクチボラグ | 抗菌薬として有用なイソキサゾリン誘導体 |
CA2477344A1 (en) | 2002-02-28 | 2003-09-04 | Astrazeneca Ab | 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents |
CN1653064A (zh) | 2002-02-28 | 2005-08-10 | 阿斯特拉曾尼卡有限公司 | 噁唑烷酮衍生物、其制备方法以及包含它们的药用组合物 |
EA008445B1 (ru) * | 2002-04-25 | 2007-06-29 | Басф Акциенгезельшафт | 3-гетероарилзамещенные изоксазолины |
US7091196B2 (en) * | 2002-09-26 | 2006-08-15 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using same |
CA2507628A1 (en) | 2002-11-28 | 2004-06-10 | Astrazeneca Ab | Oxazolidinones as antibacterial agents |
GB0227701D0 (en) * | 2002-11-28 | 2003-01-08 | Astrazeneca Ab | Chemical compounds |
CA2507468A1 (en) * | 2002-11-28 | 2004-06-10 | Astrazeneca Ab | Oxazolidinone and / or isoxazoline derivatives as antibacterial agents |
GB0229521D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
GB0229526D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
GB0229522D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
TW200500360A (en) * | 2003-03-01 | 2005-01-01 | Astrazeneca Ab | Hydroxymethyl compounds |
GB0304723D0 (en) * | 2003-03-01 | 2003-04-02 | Astrazeneca Ab | Chemical compounds |
AR045690A1 (es) | 2003-06-03 | 2005-11-09 | Rib X Pharmaceuticals Inc | Compuestos biaril heterociclicos y metodos para preparar y utilizar los mismos |
US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
JP4777246B2 (ja) * | 2003-07-29 | 2011-09-21 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | ビアリールオキサゾリジノンの合成方法 |
EP1660465B1 (en) * | 2003-07-29 | 2014-12-17 | Melinta Therapeutics, Inc. | Process for the synthesis of biaryl oxazolidinones |
JP2007514782A (ja) | 2003-12-17 | 2007-06-07 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法 |
KR100854211B1 (ko) * | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
EP2716647A3 (en) | 2004-02-27 | 2014-08-20 | Rib-X Pharmaceuticals, Inc. | Macrocyclic compounds and methods of making and using the same |
CA2567457A1 (en) * | 2004-05-25 | 2005-12-08 | Astrazeneca Ab | 3- (4- (2-dihydroisoxazol-3-ylpyridin-5-yl) phenyl) -5-triazol-1-ylmethyloxazolidin-2-one derivaives as mao inhibitors for the treatment of bacterial infections |
GB0411596D0 (en) * | 2004-05-25 | 2004-06-30 | Astrazeneca Ab | Chemical process |
US20080064689A1 (en) * | 2004-05-25 | 2008-03-13 | Astrazeneca Ab | 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents |
DOP2005000123A (es) | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
WO2006038100A1 (en) * | 2004-10-08 | 2006-04-13 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
EP1874782A1 (en) | 2005-04-15 | 2008-01-09 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
WO2006133397A2 (en) | 2005-06-08 | 2006-12-14 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of triazoles |
US8470985B2 (en) | 2005-08-24 | 2013-06-25 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
US8278281B2 (en) | 2005-08-24 | 2012-10-02 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
KR101674146B1 (ko) * | 2008-10-10 | 2016-11-08 | 머크 샤프 앤드 돔 코포레이션 | 옥사졸리디논 및 이를 포함하는 조성물을 제조하는 방법 |
KR101739923B1 (ko) | 2009-02-03 | 2017-05-25 | 머크 샤프 앤드 돔 코포레이션 | R)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형 |
US8580767B2 (en) | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
KR101561964B1 (ko) | 2013-11-15 | 2015-10-20 | 한국과학기술연구원 | 옥사졸리디논 화합물 및 이를 포함하는 c형 간염 예방 또는 치료용 약학 조성물 |
EP3263572B1 (en) * | 2015-02-27 | 2021-12-15 | Seed Research Institute Co., Ltd. | Method for producing kakeromycin and derivatives thereof |
CN106083994B (zh) * | 2016-04-18 | 2019-12-06 | 南京曼杰生物科技有限公司 | 取代的噁唑烷酮水溶性衍生物及其应用 |
US20170333305A1 (en) * | 2016-05-23 | 2017-11-23 | Microban Products Company | Topical skin product having retention property |
EP3723758A4 (en) | 2017-12-13 | 2021-06-23 | Merck Sharp & Dohme Corp. | PHARMACEUTICAL COMPOSITIONS OF TEDIZOLID PHOSPHATE |
CN113149924B (zh) * | 2021-03-29 | 2023-11-03 | 苏州大学 | 一种异噁唑啉的简单制备方法 |
CN113831517A (zh) * | 2021-09-09 | 2021-12-24 | 万凯新材料股份有限公司 | 抗菌及抗紫外聚酯的制备方法 |
Family Cites Families (46)
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US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
US5043443A (en) * | 1988-07-29 | 1991-08-27 | Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives |
SK283420B6 (sk) | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
GB9521508D0 (en) | 1995-10-20 | 1995-12-20 | Zeneca Ltd | Chemical compounds |
GB9601666D0 (en) | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
GB9604301D0 (en) | 1996-02-29 | 1996-05-01 | Zeneca Ltd | Chemical compounds |
GB9609919D0 (en) | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
GB9614236D0 (en) | 1996-07-06 | 1996-09-04 | Zeneca Ltd | Chemical compounds |
GB9614238D0 (en) | 1996-07-06 | 1996-09-04 | Zeneca Ltd | Chemical compounds |
GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
EP1007525A1 (en) | 1997-08-29 | 2000-06-14 | Zeneca Limited | Aminometyl oxooxazolidinyl benzene derivatives |
GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
WO1999033839A1 (en) | 1997-12-26 | 1999-07-08 | Cheil Jedang Corporation | Cephem derivatives and a method for producing the compounds and an antibacterial composition containing the compounds |
GB9812019D0 (en) | 1998-06-05 | 1998-07-29 | Zeneca Ltd | Chemical compounds |
US6617339B1 (en) | 1998-06-05 | 2003-09-09 | Syngenta Limited | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
CA2319495A1 (en) | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
GB9821938D0 (en) | 1998-10-09 | 1998-12-02 | Zeneca Ltd | Chemical compounds |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
GB9928499D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical processes and intermediates |
GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
NZ522990A (en) * | 2000-06-05 | 2003-08-29 | Dong A Pharm | Novel oxazolidinone derivatives and a process for the preparation thereof |
DE10034625A1 (de) | 2000-07-17 | 2002-01-31 | Bayer Ag | Heterocyclisch substituierte Thienyl-Phenyl-Oxazolidinone |
DE10034624A1 (de) | 2000-07-17 | 2002-01-31 | Bayer Ag | Aryl-substituierte Thienyl-1,3-oxazolidin-2-one als Cytokin-Inhibitoren |
US20020115669A1 (en) * | 2000-08-31 | 2002-08-22 | Wiedeman Paul E. | Oxazolidinone chemotherapeutic agents |
YU52403A (sh) | 2000-12-26 | 2006-03-03 | Dr.Reddy's Research Foundation | Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže |
GB0108793D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
ES2268011T3 (es) | 2001-04-07 | 2007-03-16 | Astrazeneca Ab | Oxazolidinonas que contienen un grupo sulfonimida como antibioticos. |
GB0108764D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
GB0108794D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compound |
GB0113300D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Purification process |
GB0113297D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical Process |
GB0113299D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical process & intermediates |
GB0113298D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Purification process and intermediates |
CA2452513A1 (en) | 2001-07-12 | 2003-01-23 | Pharmacia & Upjohn Company | Amide-containing compound having improved solubility and method of improving the solubility of an amide-containing compound |
GB0118407D0 (en) | 2001-07-27 | 2001-09-19 | Cipla Ltd | Oxazolidinone derivatives as antibacterial agents |
WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
WO2003031441A1 (en) | 2001-10-04 | 2003-04-17 | Morphochen Aktiengesellschaft Für Kombinatorische Chemie | Multiple action compounds |
JP2005512975A (ja) | 2001-10-25 | 2005-05-12 | アストラゼネカ アクチボラグ | 抗菌薬として有用なイソキサゾリン誘導体 |
GB2396350A (en) | 2001-10-25 | 2004-06-23 | Astrazeneca Ab | Aryl substituted oxazolidinones with antibacterial activity |
CN1653064A (zh) | 2002-02-28 | 2005-08-10 | 阿斯特拉曾尼卡有限公司 | 噁唑烷酮衍生物、其制备方法以及包含它们的药用组合物 |
CA2477344A1 (en) | 2002-02-28 | 2003-09-04 | Astrazeneca Ab | 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents |
JP2003335762A (ja) | 2002-05-20 | 2003-11-28 | Meiji Seika Kaisha Ltd | 新規ビフェニル誘導体 |
US7091196B2 (en) | 2002-09-26 | 2006-08-15 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using same |
CA2507468A1 (en) * | 2002-11-28 | 2004-06-10 | Astrazeneca Ab | Oxazolidinone and / or isoxazoline derivatives as antibacterial agents |
-
2002
- 2002-09-09 MX MXPA04002303A patent/MXPA04002303A/es active IP Right Grant
- 2002-09-09 KR KR10-2004-7003558A patent/KR20040044886A/ko not_active Application Discontinuation
- 2002-09-09 JP JP2003526899A patent/JP2005507386A/ja active Pending
- 2002-09-09 IL IL16073902A patent/IL160739A0/xx unknown
- 2002-09-09 CA CA002459766A patent/CA2459766A1/en not_active Abandoned
- 2002-09-09 ES ES02765019T patent/ES2244802T3/es not_active Expired - Lifetime
- 2002-09-09 BR BR0212458-0A patent/BR0212458A/pt not_active IP Right Cessation
- 2002-09-09 EP EP02765019A patent/EP1427711B1/en not_active Expired - Lifetime
- 2002-09-09 HU HU0401005A patent/HUP0401005A3/hu unknown
- 2002-09-09 DE DE60205030T patent/DE60205030T2/de not_active Expired - Fee Related
- 2002-09-09 US US10/489,266 patent/US7396847B2/en not_active Expired - Fee Related
- 2002-09-09 WO PCT/GB2002/004120 patent/WO2003022824A1/en active IP Right Grant
- 2002-09-09 AT AT02765019T patent/ATE299502T1/de not_active IP Right Cessation
- 2002-09-09 NZ NZ531621A patent/NZ531621A/en unknown
- 2002-09-09 RU RU2004111285/04A patent/RU2004111285A/ru not_active Application Discontinuation
- 2002-09-09 PL PL02369183A patent/PL369183A1/xx not_active Application Discontinuation
- 2002-09-09 PT PT02765019T patent/PT1427711E/pt unknown
- 2002-09-09 DK DK02765019T patent/DK1427711T3/da active
- 2002-09-09 SI SI200230188T patent/SI1427711T1/sl unknown
- 2002-09-09 CN CNA028223276A patent/CN1639136A/zh active Pending
- 2002-09-09 AU AU2002329393A patent/AU2002329393B2/en not_active Ceased
- 2002-09-11 AR ARP020103440A patent/AR036778A1/es unknown
-
2004
- 2004-03-09 CO CO04021466A patent/CO5560609A2/es not_active Application Discontinuation
- 2004-03-10 IS IS7175A patent/IS7175A/is unknown
- 2004-04-05 NO NO20041428A patent/NO327010B1/no not_active IP Right Cessation
- 2004-10-29 HK HK04108506A patent/HK1065789A1/xx not_active IP Right Cessation
-
2008
- 2008-05-28 US US12/128,135 patent/US20100137243A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
HUP0401005A2 (hu) | 2004-08-30 |
AR036778A1 (es) | 2004-10-06 |
RU2004111285A (ru) | 2005-10-10 |
US20050107435A1 (en) | 2005-05-19 |
NO327010B1 (no) | 2009-04-06 |
BR0212458A (pt) | 2004-10-19 |
HUP0401005A3 (en) | 2007-11-28 |
MXPA04002303A (es) | 2004-06-29 |
EP1427711B1 (en) | 2005-07-13 |
AU2002329393B2 (en) | 2008-06-12 |
ES2244802T3 (es) | 2005-12-16 |
PL369183A1 (en) | 2005-04-18 |
US7396847B2 (en) | 2008-07-08 |
DE60205030D1 (de) | 2005-08-18 |
SI1427711T1 (sl) | 2005-12-31 |
US20100137243A1 (en) | 2010-06-03 |
NO20041428L (no) | 2004-06-08 |
CO5560609A2 (es) | 2005-09-30 |
EP1427711A1 (en) | 2004-06-16 |
DK1427711T3 (da) | 2005-10-17 |
CA2459766A1 (en) | 2003-03-20 |
HK1065789A1 (en) | 2005-03-04 |
CN1639136A (zh) | 2005-07-13 |
IL160739A0 (en) | 2004-08-31 |
WO2003022824A1 (en) | 2003-03-20 |
IS7175A (is) | 2004-03-10 |
NZ531621A (en) | 2005-06-24 |
KR20040044886A (ko) | 2004-05-31 |
JP2005507386A (ja) | 2005-03-17 |
DE60205030T2 (de) | 2006-04-20 |
ATE299502T1 (de) | 2005-07-15 |
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