DK1427711T3 - Oxazolidinon og/eller isoxazolinderivater som antibakterielle midler - Google Patents
Oxazolidinon og/eller isoxazolinderivater som antibakterielle midlerInfo
- Publication number
- DK1427711T3 DK1427711T3 DK02765019T DK02765019T DK1427711T3 DK 1427711 T3 DK1427711 T3 DK 1427711T3 DK 02765019 T DK02765019 T DK 02765019T DK 02765019 T DK02765019 T DK 02765019T DK 1427711 T3 DK1427711 T3 DK 1427711T3
- Authority
- DK
- Denmark
- Prior art keywords
- oxazolidinone
- antibacterial agents
- isoxazoline derivatives
- isoxazoline
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0121942A GB0121942D0 (en) | 2001-09-11 | 2001-09-11 | Chemical compounds |
GB0215420A GB0215420D0 (en) | 2002-07-04 | 2002-07-04 | Chemical compounds |
PCT/GB2002/004120 WO2003022824A1 (en) | 2001-09-11 | 2002-09-09 | Oxazolidinone and/or isoxazoline as antibacterial agents |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1427711T3 true DK1427711T3 (da) | 2005-10-17 |
Family
ID=26246531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02765019T DK1427711T3 (da) | 2001-09-11 | 2002-09-09 | Oxazolidinon og/eller isoxazolinderivater som antibakterielle midler |
Country Status (26)
Country | Link |
---|---|
US (2) | US7396847B2 (da) |
EP (1) | EP1427711B1 (da) |
JP (1) | JP2005507386A (da) |
KR (1) | KR20040044886A (da) |
CN (1) | CN1639136A (da) |
AR (1) | AR036778A1 (da) |
AT (1) | ATE299502T1 (da) |
AU (1) | AU2002329393B2 (da) |
BR (1) | BR0212458A (da) |
CA (1) | CA2459766A1 (da) |
CO (1) | CO5560609A2 (da) |
DE (1) | DE60205030T2 (da) |
DK (1) | DK1427711T3 (da) |
ES (1) | ES2244802T3 (da) |
HK (1) | HK1065789A1 (da) |
HU (1) | HUP0401005A3 (da) |
IL (1) | IL160739A0 (da) |
IS (1) | IS7175A (da) |
MX (1) | MXPA04002303A (da) |
NO (1) | NO327010B1 (da) |
NZ (1) | NZ531621A (da) |
PL (1) | PL369183A1 (da) |
PT (1) | PT1427711E (da) |
RU (1) | RU2004111285A (da) |
SI (1) | SI1427711T1 (da) |
WO (1) | WO2003022824A1 (da) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6667299B1 (en) * | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
US7022705B2 (en) | 2001-10-25 | 2006-04-04 | Astrazeneca Ab | Isoxazoline derivatives useful as antimicrobials |
NZ535591A (en) | 2002-02-28 | 2006-07-28 | Astrazeneca Ab | Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them |
BR0308056A (pt) * | 2002-02-28 | 2004-12-07 | Astrazeneca Ab | Composto, pró-droga, método para a produção de um efeito antibacteriano em um animal de sangue quente, uso de um composto, composição farmacêutica, e, processo para a preparação de um composto |
MXPA04010099A (es) * | 2002-04-25 | 2004-12-13 | Basf Ag | Isoxazolinas sustituidas por 3 - heteroarilo. |
TW200420573A (en) * | 2002-09-26 | 2004-10-16 | Rib X Pharmaceuticals Inc | Bifunctional heterocyclic compounds and methods of making and using same |
AU2003302404B2 (en) * | 2002-11-28 | 2008-06-19 | Astrazeneca Ab | Oxazolidinone and / or isoxazoline derivatives as antibacterial agents |
GB0227701D0 (en) * | 2002-11-28 | 2003-01-08 | Astrazeneca Ab | Chemical compounds |
CA2507628A1 (en) * | 2002-11-28 | 2004-06-10 | Astrazeneca Ab | Oxazolidinones as antibacterial agents |
GB0229522D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
GB0229521D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
GB0229526D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
GB0304723D0 (en) * | 2003-03-01 | 2003-04-02 | Astrazeneca Ab | Chemical compounds |
TW200500360A (en) | 2003-03-01 | 2005-01-01 | Astrazeneca Ab | Hydroxymethyl compounds |
US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
WO2005012271A2 (en) * | 2003-07-29 | 2005-02-10 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
PT1656370E (pt) | 2003-06-03 | 2012-11-29 | Rib X Pharmaceuticals Inc | Compostos biaril-heterocíclicos e métodos de os produzir e de os utilizar |
ES2536001T3 (es) * | 2003-07-29 | 2015-05-19 | Melinta Therapeutics, Inc. | Procedimiento para la síntesis de biariloxazolidinonas |
TW200526649A (en) | 2003-12-17 | 2005-08-16 | Rib X Pharmaceuticals Inc | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
KR100854211B1 (ko) * | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
US8202843B2 (en) | 2004-02-27 | 2012-06-19 | Rib-X Pharmaceuticals, Inc. | Macrocyclic compounds and methods of making and using the same |
GB0411596D0 (en) * | 2004-05-25 | 2004-06-30 | Astrazeneca Ab | Chemical process |
US20080064689A1 (en) * | 2004-05-25 | 2008-03-13 | Astrazeneca Ab | 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents |
CA2567457A1 (en) * | 2004-05-25 | 2005-12-08 | Astrazeneca Ab | 3- (4- (2-dihydroisoxazol-3-ylpyridin-5-yl) phenyl) -5-triazol-1-ylmethyloxazolidin-2-one derivaives as mao inhibitors for the treatment of bacterial infections |
DOP2005000123A (es) | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
EP1799677A1 (en) * | 2004-10-08 | 2007-06-27 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
US7592335B2 (en) | 2005-04-15 | 2009-09-22 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
ATE496914T1 (de) | 2005-06-08 | 2011-02-15 | Rib X Pharmaceuticals Inc | Verfahren zur synthese von triazolen |
DK1934238T3 (da) | 2005-08-24 | 2017-09-18 | Melinta Therapeutics Inc | Triazolforbindelser og fremgangsmåder til fremstilling og anvendelse af disse |
US8470985B2 (en) | 2005-08-24 | 2013-06-25 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
WO2010042887A2 (en) | 2008-10-10 | 2010-04-15 | Trius Therapeutics | Methods for preparing oxazolidinones and compositions containing them |
AU2010210627B2 (en) | 2009-02-03 | 2016-03-03 | Merck Sharp & Dohme Llc | Crystalline form of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate |
US8580767B2 (en) | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
KR101561964B1 (ko) | 2013-11-15 | 2015-10-20 | 한국과학기술연구원 | 옥사졸리디논 화합물 및 이를 포함하는 c형 간염 예방 또는 치료용 약학 조성물 |
WO2016136963A1 (ja) * | 2015-02-27 | 2016-09-01 | 彰彦 石川 | カケロマイシンおよびその誘導体の製造方法 |
CN106083994B (zh) * | 2016-04-18 | 2019-12-06 | 南京曼杰生物科技有限公司 | 取代的噁唑烷酮水溶性衍生物及其应用 |
US20170333305A1 (en) * | 2016-05-23 | 2017-11-23 | Microban Products Company | Topical skin product having retention property |
US11452719B2 (en) | 2017-12-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Pharmaceutical compositions of tedizolid phosphate |
CN113149924B (zh) * | 2021-03-29 | 2023-11-03 | 苏州大学 | 一种异噁唑啉的简单制备方法 |
CN113831517A (zh) * | 2021-09-09 | 2021-12-24 | 万凯新材料股份有限公司 | 抗菌及抗紫外聚酯的制备方法 |
Family Cites Families (46)
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US4948801A (en) | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
US5043443A (en) * | 1988-07-29 | 1991-08-27 | Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives |
SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
GB9521508D0 (en) | 1995-10-20 | 1995-12-20 | Zeneca Ltd | Chemical compounds |
GB9601666D0 (en) | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
GB9604301D0 (en) | 1996-02-29 | 1996-05-01 | Zeneca Ltd | Chemical compounds |
GB9609919D0 (en) | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
GB9614236D0 (en) | 1996-07-06 | 1996-09-04 | Zeneca Ltd | Chemical compounds |
GB9614238D0 (en) | 1996-07-06 | 1996-09-04 | Zeneca Ltd | Chemical compounds |
GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
JP2001514259A (ja) | 1997-08-29 | 2001-09-11 | ゼネカ・リミテッド | アミノメチルオキソオキサゾリジニルベンゼン誘導体 |
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WO1999033839A1 (en) | 1997-12-26 | 1999-07-08 | Cheil Jedang Corporation | Cephem derivatives and a method for producing the compounds and an antibacterial composition containing the compounds |
GB9812019D0 (en) | 1998-06-05 | 1998-07-29 | Zeneca Ltd | Chemical compounds |
TR200003595T2 (tr) | 1998-06-05 | 2001-07-23 | Astrazeneca Ab | Kimyasal bileşikler |
CA2319495A1 (en) | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
GB9821938D0 (en) | 1998-10-09 | 1998-12-02 | Zeneca Ltd | Chemical compounds |
GB9928499D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical processes and intermediates |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
EP1289984A4 (en) | 2000-06-05 | 2004-11-24 | Dong A Pharm Co Ltd | NEW OXAZOLIDE DERIVATIVES AND A METHOD FOR THEIR PRODUCTION |
DE10034625A1 (de) | 2000-07-17 | 2002-01-31 | Bayer Ag | Heterocyclisch substituierte Thienyl-Phenyl-Oxazolidinone |
DE10034624A1 (de) | 2000-07-17 | 2002-01-31 | Bayer Ag | Aryl-substituierte Thienyl-1,3-oxazolidin-2-one als Cytokin-Inhibitoren |
US20020115669A1 (en) * | 2000-08-31 | 2002-08-22 | Wiedeman Paul E. | Oxazolidinone chemotherapeutic agents |
YU52403A (sh) | 2000-12-26 | 2006-03-03 | Dr.Reddy's Research Foundation | Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže |
GB0108794D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compound |
ES2268011T3 (es) | 2001-04-07 | 2007-03-16 | Astrazeneca Ab | Oxazolidinonas que contienen un grupo sulfonimida como antibioticos. |
GB0108793D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
GB0108764D0 (en) | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
GB0113299D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical process & intermediates |
GB0113297D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical Process |
GB0113298D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Purification process and intermediates |
GB0113300D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Purification process |
US7049443B2 (en) | 2001-07-12 | 2006-05-23 | Pharmacia & Upjohn Company | Amide-containing compound having improved solubility and method of improving the solubility of an amide-containing compound |
GB0118407D0 (en) | 2001-07-27 | 2001-09-19 | Cipla Ltd | Oxazolidinone derivatives as antibacterial agents |
WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
WO2003031441A1 (en) | 2001-10-04 | 2003-04-17 | Morphochen Aktiengesellschaft Für Kombinatorische Chemie | Multiple action compounds |
US20050043374A1 (en) | 2001-10-25 | 2005-02-24 | Gravestock Michael Barry | Aryl substituted oxazolidinones with antibacterial activity |
US7022705B2 (en) | 2001-10-25 | 2006-04-04 | Astrazeneca Ab | Isoxazoline derivatives useful as antimicrobials |
NZ535591A (en) | 2002-02-28 | 2006-07-28 | Astrazeneca Ab | Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them |
BR0308056A (pt) | 2002-02-28 | 2004-12-07 | Astrazeneca Ab | Composto, pró-droga, método para a produção de um efeito antibacteriano em um animal de sangue quente, uso de um composto, composição farmacêutica, e, processo para a preparação de um composto |
JP2003335762A (ja) | 2002-05-20 | 2003-11-28 | Meiji Seika Kaisha Ltd | 新規ビフェニル誘導体 |
TW200420573A (en) | 2002-09-26 | 2004-10-16 | Rib X Pharmaceuticals Inc | Bifunctional heterocyclic compounds and methods of making and using same |
AU2003302404B2 (en) * | 2002-11-28 | 2008-06-19 | Astrazeneca Ab | Oxazolidinone and / or isoxazoline derivatives as antibacterial agents |
-
2002
- 2002-09-09 PT PT02765019T patent/PT1427711E/pt unknown
- 2002-09-09 WO PCT/GB2002/004120 patent/WO2003022824A1/en active IP Right Grant
- 2002-09-09 KR KR10-2004-7003558A patent/KR20040044886A/ko not_active Application Discontinuation
- 2002-09-09 CN CNA028223276A patent/CN1639136A/zh active Pending
- 2002-09-09 BR BR0212458-0A patent/BR0212458A/pt not_active IP Right Cessation
- 2002-09-09 EP EP02765019A patent/EP1427711B1/en not_active Expired - Lifetime
- 2002-09-09 HU HU0401005A patent/HUP0401005A3/hu unknown
- 2002-09-09 DK DK02765019T patent/DK1427711T3/da active
- 2002-09-09 RU RU2004111285/04A patent/RU2004111285A/ru not_active Application Discontinuation
- 2002-09-09 CA CA002459766A patent/CA2459766A1/en not_active Abandoned
- 2002-09-09 PL PL02369183A patent/PL369183A1/xx not_active Application Discontinuation
- 2002-09-09 IL IL16073902A patent/IL160739A0/xx unknown
- 2002-09-09 US US10/489,266 patent/US7396847B2/en not_active Expired - Fee Related
- 2002-09-09 NZ NZ531621A patent/NZ531621A/en unknown
- 2002-09-09 ES ES02765019T patent/ES2244802T3/es not_active Expired - Lifetime
- 2002-09-09 AT AT02765019T patent/ATE299502T1/de not_active IP Right Cessation
- 2002-09-09 SI SI200230188T patent/SI1427711T1/sl unknown
- 2002-09-09 MX MXPA04002303A patent/MXPA04002303A/es active IP Right Grant
- 2002-09-09 JP JP2003526899A patent/JP2005507386A/ja active Pending
- 2002-09-09 DE DE60205030T patent/DE60205030T2/de not_active Expired - Fee Related
- 2002-09-09 AU AU2002329393A patent/AU2002329393B2/en not_active Ceased
- 2002-09-11 AR ARP020103440A patent/AR036778A1/es unknown
-
2004
- 2004-03-09 CO CO04021466A patent/CO5560609A2/es not_active Application Discontinuation
- 2004-03-10 IS IS7175A patent/IS7175A/is unknown
- 2004-04-05 NO NO20041428A patent/NO327010B1/no not_active IP Right Cessation
- 2004-10-29 HK HK04108506A patent/HK1065789A1/xx not_active IP Right Cessation
-
2008
- 2008-05-28 US US12/128,135 patent/US20100137243A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2003022824A1 (en) | 2003-03-20 |
ES2244802T3 (es) | 2005-12-16 |
PL369183A1 (en) | 2005-04-18 |
IL160739A0 (en) | 2004-08-31 |
HK1065789A1 (en) | 2005-03-04 |
AU2002329393B2 (en) | 2008-06-12 |
EP1427711B1 (en) | 2005-07-13 |
US7396847B2 (en) | 2008-07-08 |
SI1427711T1 (sl) | 2005-12-31 |
CN1639136A (zh) | 2005-07-13 |
NO327010B1 (no) | 2009-04-06 |
NZ531621A (en) | 2005-06-24 |
BR0212458A (pt) | 2004-10-19 |
KR20040044886A (ko) | 2004-05-31 |
US20050107435A1 (en) | 2005-05-19 |
DE60205030D1 (de) | 2005-08-18 |
CO5560609A2 (es) | 2005-09-30 |
US20100137243A1 (en) | 2010-06-03 |
JP2005507386A (ja) | 2005-03-17 |
EP1427711A1 (en) | 2004-06-16 |
HUP0401005A3 (en) | 2007-11-28 |
ATE299502T1 (de) | 2005-07-15 |
NO20041428L (no) | 2004-06-08 |
RU2004111285A (ru) | 2005-10-10 |
IS7175A (is) | 2004-03-10 |
DE60205030T2 (de) | 2006-04-20 |
CA2459766A1 (en) | 2003-03-20 |
HUP0401005A2 (hu) | 2004-08-30 |
MXPA04002303A (es) | 2004-06-29 |
AR036778A1 (es) | 2004-10-06 |
PT1427711E (pt) | 2005-11-30 |
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