ATE299502T1 - Oxazolidinon- und/oder isoxazolinderivate als antibakterielle mittel - Google Patents

Oxazolidinon- und/oder isoxazolinderivate als antibakterielle mittel

Info

Publication number
ATE299502T1
ATE299502T1 AT02765019T AT02765019T ATE299502T1 AT E299502 T1 ATE299502 T1 AT E299502T1 AT 02765019 T AT02765019 T AT 02765019T AT 02765019 T AT02765019 T AT 02765019T AT E299502 T1 ATE299502 T1 AT E299502T1
Authority
AT
Austria
Prior art keywords
oxazolidinone
antibacterial agents
isoxazoline derivatives
isoxazoline
derivatives
Prior art date
Application number
AT02765019T
Other languages
English (en)
Inventor
Michael Barry Gravestock
Neil James Hales
Michael Lingard Swain
Sheila Irene Hauck
Stuart Dennett Mills
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0121942A external-priority patent/GB0121942D0/en
Priority claimed from GB0215420A external-priority patent/GB0215420D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE299502T1 publication Critical patent/ATE299502T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18Oxygen atoms
    • C07D263/20Oxygen atoms attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT02765019T 2001-09-11 2002-09-09 Oxazolidinon- und/oder isoxazolinderivate als antibakterielle mittel ATE299502T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0121942A GB0121942D0 (en) 2001-09-11 2001-09-11 Chemical compounds
GB0215420A GB0215420D0 (en) 2002-07-04 2002-07-04 Chemical compounds
PCT/GB2002/004120 WO2003022824A1 (en) 2001-09-11 2002-09-09 Oxazolidinone and/or isoxazoline as antibacterial agents

Publications (1)

Publication Number Publication Date
ATE299502T1 true ATE299502T1 (de) 2005-07-15

Family

ID=26246531

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02765019T ATE299502T1 (de) 2001-09-11 2002-09-09 Oxazolidinon- und/oder isoxazolinderivate als antibakterielle mittel

Country Status (26)

Country Link
US (2) US7396847B2 (de)
EP (1) EP1427711B1 (de)
JP (1) JP2005507386A (de)
KR (1) KR20040044886A (de)
CN (1) CN1639136A (de)
AR (1) AR036778A1 (de)
AT (1) ATE299502T1 (de)
AU (1) AU2002329393B2 (de)
BR (1) BR0212458A (de)
CA (1) CA2459766A1 (de)
CO (1) CO5560609A2 (de)
DE (1) DE60205030T2 (de)
DK (1) DK1427711T3 (de)
ES (1) ES2244802T3 (de)
HK (1) HK1065789A1 (de)
HU (1) HUP0401005A3 (de)
IL (1) IL160739A0 (de)
IS (1) IS7175A (de)
MX (1) MXPA04002303A (de)
NO (1) NO327010B1 (de)
NZ (1) NZ531621A (de)
PL (1) PL369183A1 (de)
PT (1) PT1427711E (de)
RU (1) RU2004111285A (de)
SI (1) SI1427711T1 (de)
WO (1) WO2003022824A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667299B1 (en) * 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
US7022705B2 (en) 2001-10-25 2006-04-04 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
KR20040087329A (ko) * 2002-02-28 2004-10-13 아스트라제네카 아베 3-시클릴-5-(질소-함유 5-원 고리) 메틸-옥사졸리디논유도체 및 그의 항균제로서의 용도
JP2005531504A (ja) 2002-02-28 2005-10-20 アストラゼネカ アクチボラグ 化学化合物
PL373888A1 (en) * 2002-04-25 2005-09-19 Basf Aktiengesellschaft 3-heteroaryl substituted 5-methyloxymethyl isoxazolines used as herbicides
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
GB0227701D0 (en) * 2002-11-28 2003-01-08 Astrazeneca Ab Chemical compounds
KR20050084010A (ko) * 2002-11-28 2005-08-26 아스트라제네카 아베 항균제로서의 옥사졸리디논
AU2003302404B2 (en) * 2002-11-28 2008-06-19 Astrazeneca Ab Oxazolidinone and / or isoxazoline derivatives as antibacterial agents
GB0229526D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229522D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
GB0229521D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
GB0304723D0 (en) * 2003-03-01 2003-04-02 Astrazeneca Ab Chemical compounds
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
AR045690A1 (es) 2003-06-03 2005-11-09 Rib X Pharmaceuticals Inc Compuestos biaril heterociclicos y metodos para preparar y utilizar los mismos
ES2536001T3 (es) * 2003-07-29 2015-05-19 Melinta Therapeutics, Inc. Procedimiento para la síntesis de biariloxazolidinonas
EP1660465B1 (de) * 2003-07-29 2014-12-17 Melinta Therapeutics, Inc. Verfahren zur synthese von biaryloxazolidinonen
WO2005061468A1 (en) 2003-12-17 2005-07-07 Rib-X Pharmaceuticals, Inc. Halogenated biaryl heterocyclic compounds and methods of making and using the same
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
CN102816194A (zh) 2004-02-27 2012-12-12 瑞伯-X医药品有限公司 大环化合物以及其制作和使用方法
GB0411596D0 (en) * 2004-05-25 2004-06-30 Astrazeneca Ab Chemical process
JP2008500319A (ja) * 2004-05-25 2008-01-10 アストラゼネカ アクチボラグ 細菌感染症の治療のためのmao阻害剤としての3−(4−(2−ジヒドロイソオキサゾール−3−イルピリジン−5−イル)フェニル−5−トリアゾール−1−イルメチルオキサゾリジン−2−オン誘導体
US20080064689A1 (en) * 2004-05-25 2008-03-13 Astrazeneca Ab 3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents
DOP2005000123A (es) 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
EP1799677A1 (de) * 2004-10-08 2007-06-27 Ranbaxy Laboratories Limited Oxazolidinon-derivate mit antimikrobieller funktion
US7592335B2 (en) 2005-04-15 2009-09-22 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
US8399660B2 (en) 2005-06-08 2013-03-19 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
WO2007025089A2 (en) 2005-08-24 2007-03-01 Rib-X Pharmaceutical, Inc. Triazole compounds and methods of making and using the same
WO2007025098A2 (en) 2005-08-24 2007-03-01 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
WO2010042887A2 (en) 2008-10-10 2010-04-15 Trius Therapeutics Methods for preparing oxazolidinones and compositions containing them
PE20120585A1 (es) 2009-02-03 2012-06-13 Trius Therapeutics Forma cristalina del fosfato de dihidrogeno r)-3-(4-(2-(2-metiltetrazol-5-il) piridin-5-il)-3-fluorofensil)-5-hidroximetil oxazolidin-2-ona
US8580767B2 (en) 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
KR101561964B1 (ko) 2013-11-15 2015-10-20 한국과학기술연구원 옥사졸리디논 화합물 및 이를 포함하는 c형 간염 예방 또는 치료용 약학 조성물
CN115160248A (zh) * 2015-02-27 2022-10-11 海洋规划生物工厂株式会社 Kakeromycin及其衍生物的制造方法
CN106083994B (zh) * 2016-04-18 2019-12-06 南京曼杰生物科技有限公司 取代的噁唑烷酮水溶性衍生物及其应用
US20170333305A1 (en) * 2016-05-23 2017-11-23 Microban Products Company Topical skin product having retention property
US11452719B2 (en) 2017-12-13 2022-09-27 Merck Sharp & Dohme Llc Pharmaceutical compositions of tedizolid phosphate
CN113149924B (zh) * 2021-03-29 2023-11-03 苏州大学 一种异噁唑啉的简单制备方法
CN113831517A (zh) * 2021-09-09 2021-12-24 万凯新材料股份有限公司 抗菌及抗紫外聚酯的制备方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948801A (en) 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5043443A (en) * 1988-07-29 1991-08-27 Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives
SK283420B6 (sk) 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
GB9521508D0 (en) 1995-10-20 1995-12-20 Zeneca Ltd Chemical compounds
GB9601666D0 (en) 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9604301D0 (en) 1996-02-29 1996-05-01 Zeneca Ltd Chemical compounds
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9614236D0 (en) 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9614238D0 (en) 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
EP1007525A1 (de) 1997-08-29 2000-06-14 Zeneca Limited Oxooxazolidinylbenzolderivate
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
WO1999033839A1 (en) 1997-12-26 1999-07-08 Cheil Jedang Corporation Cephem derivatives and a method for producing the compounds and an antibacterial composition containing the compounds
BR9910971A (pt) 1998-06-05 2001-02-13 Astrazeneca Ab Composto, processos para a preparação de um composto e para produzir um efeito antibacteriano em um animal de sangue quente, uso de um composto, e, composição farmacêutica
GB9812019D0 (en) 1998-06-05 1998-07-29 Zeneca Ltd Chemical compounds
EP1085846A2 (de) 1998-06-08 2001-03-28 Advanced Medicine, Inc. Mehrfachbindende inhibitoren des microsomalen triglyceridtransferase-proteins
GB9821938D0 (en) 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB9928499D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical processes and intermediates
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
HUP0301562A2 (hu) * 2000-06-05 2003-12-29 Dong A Pharm. Co., Ltd. Új oxazolidinonszármazékok és eljárás ezek előállítására, ezeket tartalmazó gyógyszerkészítmények
DE10034625A1 (de) 2000-07-17 2002-01-31 Bayer Ag Heterocyclisch substituierte Thienyl-Phenyl-Oxazolidinone
DE10034624A1 (de) 2000-07-17 2002-01-31 Bayer Ag Aryl-substituierte Thienyl-1,3-oxazolidin-2-one als Cytokin-Inhibitoren
US20020115669A1 (en) * 2000-08-31 2002-08-22 Wiedeman Paul E. Oxazolidinone chemotherapeutic agents
YU52403A (sh) 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
GB0108794D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compound
GB0108793D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
ES2268011T3 (es) 2001-04-07 2007-03-16 Astrazeneca Ab Oxazolidinonas que contienen un grupo sulfonimida como antibioticos.
GB0108764D0 (en) 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0113297D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Chemical Process
GB0113298D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Purification process and intermediates
GB0113299D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Chemical process & intermediates
GB0113300D0 (en) 2001-06-01 2001-07-25 Astrazeneca Ab Purification process
CA2452513A1 (en) 2001-07-12 2003-01-23 Pharmacia & Upjohn Company Amide-containing compound having improved solubility and method of improving the solubility of an amide-containing compound
GB0118407D0 (en) 2001-07-27 2001-09-19 Cipla Ltd Oxazolidinone derivatives as antibacterial agents
WO2003031443A1 (de) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual action antibiotics
WO2003031441A1 (en) 2001-10-04 2003-04-17 Morphochen Aktiengesellschaft Für Kombinatorische Chemie Multiple action compounds
US7022705B2 (en) 2001-10-25 2006-04-04 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
ATE323087T1 (de) 2001-10-25 2006-04-15 Aryl substituierte oxazolidinone mit antibacterieller activität
KR20040087329A (ko) 2002-02-28 2004-10-13 아스트라제네카 아베 3-시클릴-5-(질소-함유 5-원 고리) 메틸-옥사졸리디논유도체 및 그의 항균제로서의 용도
JP2005531504A (ja) 2002-02-28 2005-10-20 アストラゼネカ アクチボラグ 化学化合物
JP2003335762A (ja) 2002-05-20 2003-11-28 Meiji Seika Kaisha Ltd 新規ビフェニル誘導体
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
AU2003302404B2 (en) * 2002-11-28 2008-06-19 Astrazeneca Ab Oxazolidinone and / or isoxazoline derivatives as antibacterial agents

Also Published As

Publication number Publication date
ES2244802T3 (es) 2005-12-16
NO327010B1 (no) 2009-04-06
HUP0401005A3 (en) 2007-11-28
CN1639136A (zh) 2005-07-13
RU2004111285A (ru) 2005-10-10
IL160739A0 (en) 2004-08-31
NZ531621A (en) 2005-06-24
AU2002329393B2 (en) 2008-06-12
US20050107435A1 (en) 2005-05-19
EP1427711A1 (de) 2004-06-16
US20100137243A1 (en) 2010-06-03
US7396847B2 (en) 2008-07-08
AR036778A1 (es) 2004-10-06
DE60205030T2 (de) 2006-04-20
CO5560609A2 (es) 2005-09-30
PT1427711E (pt) 2005-11-30
BR0212458A (pt) 2004-10-19
HUP0401005A2 (hu) 2004-08-30
DE60205030D1 (de) 2005-08-18
IS7175A (is) 2004-03-10
MXPA04002303A (es) 2004-06-29
JP2005507386A (ja) 2005-03-17
EP1427711B1 (de) 2005-07-13
KR20040044886A (ko) 2004-05-31
WO2003022824A1 (en) 2003-03-20
HK1065789A1 (en) 2005-03-04
PL369183A1 (en) 2005-04-18
SI1427711T1 (sl) 2005-12-31
CA2459766A1 (en) 2003-03-20
DK1427711T3 (da) 2005-10-17
NO20041428L (no) 2004-06-08

Similar Documents

Publication Publication Date Title
DE60205030D1 (de) Oxazolidinon- und/oder isoxazolinderivate als antibakterielle mittel
IL168747A0 (en) Oxazolidinone and/or isoxazoline derivatives as antibacterial agents
ATE398110T1 (de) 3-aminochinazolin-2,4-dione als antibakterielle mittel
DE60131138D1 (de) Antibakterielle mittel
DE60214413D1 (de) Thiophen- und thiazolsulfonamide als antineoplastische mittel
DE602004012891D1 (de) Pyrido- und pyrimidopyrimidinderivate als anti-proliferative mittel
ATE457641T1 (de) Synergistische herbizide mittel
DE60026540D1 (de) Mutilin-derivate und ihre anwendung als antibakterielle mittel
FR14C0066I2 (fr) 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles
DE60238194D1 (de) Isoxazolinderivate und herbizide
ATE391531T1 (de) Schweisshemmende mittel
DE60317711D1 (de) Kationische porphyrin-derivate als antibakterielle mittel
GB0303836D0 (en) Oxazolidinones and their use as antibacterial agents
DE60304188D1 (de) Ä1,4ÜDIAZOCINOÄ7,8,1-hiÜINDOLDERIVATE ALS ANTIPSYCHOTISCHE MITTEL UND MITTEL GEGEN OBESITÄT
EE200400004A (et) Oksasolidinoonide derivaadid kui antibakteriaalsed ained
ATE437860T1 (de) 2-hydroxy-mutilin-carbamat derivate und ihre anwendung als antibakterielle mittel
ATE246189T1 (de) Bizyklische oxazolidinone als antibakterielle mittel
AU2003292422A1 (en) Oxazolidinone derivatives and their use as antibacterial agents
ATE326452T1 (de) Piperidinyloxy- und pyrrolidinyloxyphenyloxazolidinone als antibakterielle mittel
FR2813777B1 (fr) Gant reversible jetable
ATE399523T1 (de) Haarbehandlungszusammensetzung
ATE337322T1 (de) Isoxazolin-derivate als antidepressiva
DE60207318D1 (de) Festes kosmetisches Mittel
DE60010425D1 (de) Mittel gegen medikamentenresistente bakterienstämme und anti-chlamydiamittel
ATE321761T1 (de) Indolylpiperidinderivate als antihistaminische und antiallergische mittel

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1427711

Country of ref document: EP

REN Ceased due to non-payment of the annual fee