HUP0300416A2 - Antibiotikus hatású oxazolidinon-származékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Antibiotikus hatású oxazolidinon-származékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0300416A2 HUP0300416A2 HU0300416A HUP0300416A HUP0300416A2 HU P0300416 A2 HUP0300416 A2 HU P0300416A2 HU 0300416 A HU0300416 A HU 0300416A HU P0300416 A HUP0300416 A HU P0300416A HU P0300416 A2 HUP0300416 A2 HU P0300416A2
- Authority
- HU
- Hungary
- Prior art keywords
- atom
- carbon atom
- nitrogen
- substituent
- ring member
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 7
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
A találmány (I) általános képletű vegyületekre, gyógyászatilagalkalmazható sóikra és in vivo körülmények között hidrolizálhatóésztereikre vonatkozik - a képletben HET a molekula további részéheznitrogénatomon keresztül kapcsolódó, (i) 1-3 további nitrogénheteroatomot vagy (ii) egy további oxigén vagy kén heteroatomot ésadott esetben egy további nitrogén heteroatomot tartalmazó, öttagúheteroaril-gyűrűt jelent, ami gyűrűtag-szénatomon adott esetben oxo-vagy tioxo-szubsztituenst hordoz, és/vagy gyűrűtag-szénatomon adottesetben egy vagy két 1-4 szénatomos alkil-szubsztituenst hordoz,és/vagy szubsztituálható gyűrűtag-nitrogénatomon adott esetben 1-4szénatomos alkil-szubsztituenst hordoz, feltéve, hogy ezáltal a gyűrűnem kvaternerizálódik; vagy HET a molekula további részéheznitrogénatomon keresztül kapcsolódó, a molekula további részéhezkapcsolódó nitrogénatomot is beleértve összesen legföljebb háromnitrogén heteroatomot tartalmazó hattagú heteroaril-gyűrűt jelent, amigyűrűtag-szénatomon oxo- vagy tioxo-szubsztituenst hordoz, és adottesetben bármely szubsztituálható szénatomon egy vagy két 1-4szénatomos alkil-szubsztituenst hordoz; és Q (Q1)-(Q9) általánosképletű csoportot jelent, - ahol A1 szénatomot vagy nitrogénatomotjelent; B1 oxigénatomot vagy kénatomot vagy a (Q9) csoportban NH-csoportot is jelenthet. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0009803.8A GB0009803D0 (en) | 2000-04-25 | 2000-04-25 | Chemical compounds |
PCT/GB2001/001815 WO2001081350A1 (en) | 2000-04-25 | 2001-04-23 | Oxazolidinone derivatives with antibiotic activity |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0300416A2 true HUP0300416A2 (hu) | 2003-06-28 |
Family
ID=9890314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0300416A HUP0300416A2 (hu) | 2000-04-25 | 2001-04-23 | Antibiotikus hatású oxazolidinon-származékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények |
Country Status (29)
Country | Link |
---|---|
US (1) | US7141583B2 (hu) |
EP (1) | EP1286998B2 (hu) |
JP (1) | JP2003531211A (hu) |
KR (1) | KR100858771B1 (hu) |
CN (1) | CN1277829C (hu) |
AT (1) | ATE268778T1 (hu) |
AU (1) | AU781784B2 (hu) |
BR (1) | BR0110240A (hu) |
CA (1) | CA2405349C (hu) |
CZ (1) | CZ20023527A3 (hu) |
DE (1) | DE60103754T3 (hu) |
DK (1) | DK1286998T4 (hu) |
EE (1) | EE200200598A (hu) |
ES (1) | ES2220759T5 (hu) |
GB (1) | GB0009803D0 (hu) |
HK (1) | HK1053114A1 (hu) |
HU (1) | HUP0300416A2 (hu) |
IL (2) | IL152284A0 (hu) |
IS (1) | IS6583A (hu) |
MX (1) | MXPA02010453A (hu) |
NO (1) | NO328549B1 (hu) |
NZ (1) | NZ521765A (hu) |
PL (1) | PL358326A1 (hu) |
PT (1) | PT1286998E (hu) |
RU (1) | RU2002131455A (hu) |
SI (1) | SI1286998T2 (hu) |
TR (1) | TR200402261T4 (hu) |
WO (1) | WO2001081350A1 (hu) |
ZA (1) | ZA200208187B (hu) |
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US7199143B2 (en) | 2002-02-28 | 2007-04-03 | Astrazeneca Ab | Chemical compounds |
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-
2000
- 2000-04-25 GB GBGB0009803.8A patent/GB0009803D0/en not_active Ceased
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2001
- 2001-04-23 SI SI200130129T patent/SI1286998T2/sl unknown
- 2001-04-23 CZ CZ20023527A patent/CZ20023527A3/cs unknown
- 2001-04-23 MX MXPA02010453A patent/MXPA02010453A/es active IP Right Grant
- 2001-04-23 AU AU48636/01A patent/AU781784B2/en not_active Ceased
- 2001-04-23 PL PL01358326A patent/PL358326A1/xx not_active Application Discontinuation
- 2001-04-23 DE DE60103754T patent/DE60103754T3/de not_active Expired - Lifetime
- 2001-04-23 EE EEP200200598A patent/EE200200598A/xx unknown
- 2001-04-23 US US10/258,355 patent/US7141583B2/en not_active Expired - Fee Related
- 2001-04-23 JP JP2001578439A patent/JP2003531211A/ja active Pending
- 2001-04-23 IL IL15228401A patent/IL152284A0/xx unknown
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- 2001-04-23 CN CNB01811640XA patent/CN1277829C/zh not_active Expired - Fee Related
- 2001-04-23 EP EP01921669A patent/EP1286998B2/en not_active Expired - Lifetime
- 2001-04-23 NZ NZ521765A patent/NZ521765A/en not_active IP Right Cessation
- 2001-04-23 HU HU0300416A patent/HUP0300416A2/hu unknown
- 2001-04-23 PT PT01921669T patent/PT1286998E/pt unknown
- 2001-04-23 AT AT01921669T patent/ATE268778T1/de active
- 2001-04-23 DK DK01921669T patent/DK1286998T4/da active
- 2001-04-23 CA CA2405349A patent/CA2405349C/en not_active Expired - Lifetime
- 2001-04-23 RU RU2002131455/04A patent/RU2002131455A/ru not_active Application Discontinuation
- 2001-04-23 BR BR0110240-0A patent/BR0110240A/pt not_active Application Discontinuation
- 2001-04-23 KR KR1020027014321A patent/KR100858771B1/ko not_active IP Right Cessation
- 2001-04-23 WO PCT/GB2001/001815 patent/WO2001081350A1/en active IP Right Grant
- 2001-04-23 ES ES01921669T patent/ES2220759T5/es not_active Expired - Lifetime
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- 2002-10-14 IL IL152284A patent/IL152284A/en not_active IP Right Cessation
- 2002-10-16 IS IS6583A patent/IS6583A/is unknown
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