ATE264114T1 - Zyklodexrinpolymere zum gebrauch als medikamententräger - Google Patents

Zyklodexrinpolymere zum gebrauch als medikamententräger

Info

Publication number
ATE264114T1
ATE264114T1 AT99970862T AT99970862T ATE264114T1 AT E264114 T1 ATE264114 T1 AT E264114T1 AT 99970862 T AT99970862 T AT 99970862T AT 99970862 T AT99970862 T AT 99970862T AT E264114 T1 ATE264114 T1 AT E264114T1
Authority
AT
Austria
Prior art keywords
biocleavable
cyclodexrine
polymers
compositions
drugs
Prior art date
Application number
AT99970862T
Other languages
English (en)
Inventor
Ken M Kosak
Original Assignee
Ken M Kosak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ken M Kosak filed Critical Ken M Kosak
Application granted granted Critical
Publication of ATE264114T1 publication Critical patent/ATE264114T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5161Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AT99970862T 1998-12-30 1999-12-27 Zyklodexrinpolymere zum gebrauch als medikamententräger ATE264114T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/223,055 US6048736A (en) 1998-04-29 1998-12-30 Cyclodextrin polymers for carrying and releasing drugs
PCT/US1999/030820 WO2000040962A1 (en) 1998-12-30 1999-12-27 Cyclodextrin polymers for use as drug carriers

Publications (1)

Publication Number Publication Date
ATE264114T1 true ATE264114T1 (de) 2004-04-15

Family

ID=22834827

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99970862T ATE264114T1 (de) 1998-12-30 1999-12-27 Zyklodexrinpolymere zum gebrauch als medikamententräger

Country Status (6)

Country Link
US (3) US6048736A (de)
EP (1) EP1183538B1 (de)
AT (1) ATE264114T1 (de)
AU (1) AU3468900A (de)
DE (1) DE69916504D1 (de)
WO (1) WO2000040962A1 (de)

Families Citing this family (468)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6501188B1 (en) * 1997-07-03 2002-12-31 Micron Technology, Inc. Method for improving a stepper signal in a planarized surface over alignment topography
US7091192B1 (en) * 1998-07-01 2006-08-15 California Institute Of Technology Linear cyclodextrin copolymers
US6509323B1 (en) 1998-07-01 2003-01-21 California Institute Of Technology Linear cyclodextrin copolymers
GB9814507D0 (en) * 1998-07-03 1998-09-02 Univ Southampton A method and apparatus for controlling pests
US7343710B2 (en) * 1998-07-03 2008-03-18 I.D.A Limited Method and apparatus for controlling pests
US20030190740A1 (en) 1998-10-13 2003-10-09 The University Of Georgia Research Foundation, Inc Stabilized bioactive peptides and methods of identification, synthesis, and use
US7375096B1 (en) * 1998-12-04 2008-05-20 California Institute Of Technology Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network
US6740643B2 (en) * 1999-01-21 2004-05-25 Mirus Corporation Compositions and methods for drug delivery using amphiphile binding molecules
US6716452B1 (en) * 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US7060708B2 (en) * 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
CA2381846A1 (en) * 1999-08-11 2001-02-15 Josef Pitha Potentiation of inclusion complex formation of cyclodextrin derivatives
DE19941769A1 (de) * 1999-09-02 2001-03-08 Beiersdorf Ag Wirkstoffkombinationen bzw. Addukte aus Biotin und/oder Biotinderivaten und Cyclodextrinen und Verwendung solcher Wirkstoffkombinationen in kosmetischen Zubereitungen
US20070219363A1 (en) * 1999-11-29 2007-09-20 Budker Vladimir G Chelating Compound for Drug Delivery
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
US20030148996A1 (en) * 2000-03-31 2003-08-07 Joseph Rubinfeld Camptothecin complexes
WO2001074401A2 (en) * 2000-03-31 2001-10-11 Supergen, Inc. Camptothecin complexes
DK1272161T3 (da) * 2000-04-12 2008-05-19 Liplasome Pharma As Lipid-baserede system til afgivelse af lægemidler mod parasitiske infektioner
JP2003531930A (ja) * 2000-04-28 2003-10-28 ユニバーシティ・カレッジ・ダブリン 両親媒性大環状誘導体およびそれらの類似体
SG98393A1 (en) 2000-05-19 2003-09-19 Inst Materials Research & Eng Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
DE10029185A1 (de) * 2000-06-19 2002-01-03 Henkel Kgaa Verfahren zur antimikrobiellen Behandlung von durch mikrobiellen Befallgefährdeten Materialien
US20020099013A1 (en) * 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
US7163918B2 (en) 2000-08-22 2007-01-16 New River Pharmaceuticals Inc. Iodothyronine compositions
WO2003020200A2 (en) * 2000-11-16 2003-03-13 New River Pharmaceuticals Inc. A novel pharmaceutical compound and methods of making and using same
WO2002051432A1 (en) * 2001-11-16 2002-07-04 New River Pharmaceuticals Inc. A novel pharmaceutical compound and methods of making and using same
EP1315777B1 (de) * 2000-09-06 2007-10-31 AP Pharma, Inc. Abbaubare polyacetal-polymere
WO2002032459A2 (en) * 2000-10-17 2002-04-25 Massachusetts Institute Of Technology Method of increasing the efficacy of antibiotics by complexing with cyclodextrins
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
WO2002044336A2 (en) * 2000-11-30 2002-06-06 Diversa Corporation Method of making a protein polymer and uses of the polymer
RU2288921C2 (ru) * 2000-12-19 2006-12-10 Калифорниа Инститьют оф Текнолоджи Композиции, содержащие комплексы включения
TWI321054B (en) * 2000-12-19 2010-03-01 California Inst Of Techn Compositions containing inclusion complexes
US6566556B2 (en) * 2000-12-19 2003-05-20 Nippon Shokubai Co., Ltd. Method for production of alkanolamine and apparatus therefor
EP1363594B1 (de) * 2001-03-02 2007-11-21 MERCK PATENT GmbH Kosmetische formulierung enthaltend flavonoid-derivate
WO2002100326A2 (en) * 2001-05-01 2002-12-19 The General Hospital Corporation Photoimmunotherapies for cancer using photosensitizer immunoconjugates and combination therapies
US20020187178A1 (en) * 2001-05-04 2002-12-12 Roe R. Michael Polymer conjugates of insecticidal peptides or nucleic acids and methods of use thereof
US20030108585A1 (en) * 2001-05-04 2003-06-12 Roe R. Michael Polymer conjugates of insecticidal peptides or nucleic acids or insecticides and methods of use thereof
CA2451511A1 (en) 2001-06-22 2003-01-03 The University Of British Columbia Antimitotic eleuthesides
US7375082B2 (en) * 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
US7338939B2 (en) * 2003-09-30 2008-03-04 New River Pharmaceuticals Inc. Abuse-resistant hydrocodone compounds
US20070066537A1 (en) * 2002-02-22 2007-03-22 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US7169752B2 (en) * 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
WO2003032916A2 (en) * 2001-10-16 2003-04-24 Structural Bioinformatics Inc. Organosulfur inhibitors of tyrosine phosphatases
US7141540B2 (en) * 2001-11-30 2006-11-28 Genta Salus Llc Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
AU2002359855B2 (en) * 2001-12-21 2008-08-21 David S. Soane Use of oligomers and polymers for drug solublization, stabilization, and delivery
CN1646501A (zh) * 2002-02-07 2005-07-27 科瓦伦特合伙责任有限公司 纳米膜和薄膜组合物
US20040034223A1 (en) * 2002-02-07 2004-02-19 Covalent Partners, Llc. Amphiphilic molecular modules and constructs based thereon
JP2006502695A (ja) * 2002-02-15 2006-01-26 ダイヴァーサ コーポレイション キメラカニューレタンパク質、それをコードする核酸、その製造方法およびその使用方法
US20050222064A1 (en) * 2002-02-20 2005-10-06 Sirna Therapeutics, Inc. Polycationic compositions for cellular delivery of polynucleotides
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US7659253B2 (en) * 2002-02-22 2010-02-09 Shire Llc Abuse-resistant amphetamine prodrugs
US7700561B2 (en) * 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
US7105486B2 (en) * 2002-02-22 2006-09-12 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds
EP1481078A4 (de) * 2002-02-22 2006-08-16 New River Pharmaceuticals Inc Verwendung einer peptid-arzneistoff-konjugation zur reduzierung der variabilität von arzneistoff-serumspiegeln zwischen patienten
KR100822498B1 (ko) * 2002-02-22 2008-04-16 샤이어 엘엘씨 규제된 물질의 남용을 방지하기 위한 새로운 서방성 약학화합물
JP2005518470A (ja) * 2002-02-22 2005-06-23 インサート セラピューティクス インコーポレイテッド 炭水化物−修飾ポリマー組成物及びその使用法
AU2002249486A1 (en) * 2002-03-26 2003-10-08 Council Of Scientific And Industrial Research Macromolecular compounds as potential anti-inflammatory agents
US8829198B2 (en) * 2007-10-31 2014-09-09 Proteotech Inc Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies
AU2003248747A1 (en) 2002-06-27 2004-01-19 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
AU2003249742A1 (en) * 2002-07-02 2004-01-23 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
US10004729B2 (en) 2002-07-05 2018-06-26 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US8557291B2 (en) * 2002-07-05 2013-10-15 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opioids and other drugs
US8840928B2 (en) 2002-07-05 2014-09-23 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
EP1594467A4 (de) * 2002-07-05 2008-10-22 Collegium Pharmaceutical Inc Missbrauch verhindernde pharmazeutische zusammensetzungen von opioiden und anderen medikamenten
FR2842106B1 (fr) * 2002-07-11 2006-07-14 Centre Nat Rech Scient Dispersions aqueuses de particules nanometriques ou micrometriques pour l'encapsulation de composes chimiques
CN100519643C (zh) 2002-07-19 2009-07-29 奥默罗斯公司 可生物降解的三嵌段共聚物,它们的合成方法和从它制得的水凝胶和生物材料
US20040034336A1 (en) * 2002-08-08 2004-02-19 Neal Scott Charged liposomes/micelles with encapsulted medical compounds
KR20120104412A (ko) 2002-09-06 2012-09-20 인설트 테라페틱스, 인코퍼레이티드 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체
US20040106741A1 (en) * 2002-09-17 2004-06-03 Kriesel Joshua W. Nanofilm compositions with polymeric components
JP4602085B2 (ja) * 2002-10-09 2010-12-22 セルリアン・ファーマ・インコーポレイテッド シクロデキストリンを基材とした物質、組成物及びこれらと関連する用途
WO2004041310A1 (en) * 2002-11-08 2004-05-21 Danmarks Fødevareforskning Preparation of chemically well-defined carbohydrate dendrimer conjugates
US8133881B2 (en) 2003-01-13 2012-03-13 Shire Llc Carbohydrate conjugates to prevent abuse of controlled substances
SG129240A1 (en) * 2003-01-23 2007-02-26 Agency Science Tech & Res Biodegradable copolymer and nucleic acid delivery system
US20070020272A1 (en) * 2003-04-30 2007-01-25 Tayyaba Hasan Indirectly linked photosensitizer immunoconjugates, processes for the production thereof and methods of use thereof
WO2004099162A1 (en) * 2003-04-30 2004-11-18 Ricerca Biosciences, Llc. Polycyclic diazodioxide-based bcl-2 protein antagonist
WO2004110350A2 (en) * 2003-05-14 2004-12-23 Torreypines Therapeutics, Inc. Compouds and uses thereof in modulating amyloid beta
US7332527B2 (en) * 2003-05-16 2008-02-19 Board Of Regents Of The University Of Nebraska Cross-linked ionic core micelles
KR101159477B1 (ko) * 2003-05-29 2012-07-02 샤이어 엘엘씨 남용 방지성 암페타민 화합물
US20100331380A1 (en) * 2009-06-29 2010-12-30 Esposito Luke A Compounds, Compositions, and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies
US20090227647A1 (en) * 2008-03-05 2009-09-10 Thomas Lake Compounds, Compositions and Methods for the Treatment of Islet Amyloid Polypeptide (IAPP) Accumulation in Diabetes
US8916598B2 (en) 2003-05-30 2014-12-23 Proteotech Inc Compounds, compositions, and methods for the treatment of β-amyloid diseases and synucleinopathies
US7057100B2 (en) * 2003-06-26 2006-06-06 The J.C. Robinson Seed Co. Inbred corn line W23129
AU2004277400B2 (en) * 2003-09-30 2009-01-22 Shire Llc Pharmaceutical compositions for prevention of overdose or abuse
WO2005047242A2 (en) * 2003-11-07 2005-05-26 Molecular Probes, Inc. Compounds containing thiosulfate moieties
WO2005090370A1 (en) 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
WO2005089106A2 (en) * 2004-02-27 2005-09-29 Molecular Therapeutics, Inc. Degradable nanoparticles
EP1735333A2 (de) * 2004-03-24 2006-12-27 Diversa Corporation Chimärische cannulae-proteine, diese codierende nukleinsäuren und verfahren zu deren herstellung und verwendung
KR100771411B1 (ko) 2004-04-01 2007-10-30 에프. 호프만-라 로슈 아게 피리미딘-2,4,6-트리온의 시클로덱스트린 포접 복합체
US20050255161A1 (en) * 2004-05-10 2005-11-17 Servet Buyuktimkin Method for the long term stabilization of labile compounds at room temperature in pharmaceutical preparations containing water
EP1768968A1 (de) 2004-05-20 2007-04-04 Foldrx Pharmaceuticals, Inc. 2-((hetero) aryl)-benzoxazolverbindungen und derivate, zusammensetzungen und verfahren zur stabilisierung von transthyretin und zur vermeidung von fehlern beim falten von transthyretin
GB2414479A (en) * 2004-05-27 2005-11-30 Croda Int Plc Reactive cyclodextrins derivatised with proteins
CA2569958C (en) 2004-06-12 2016-03-22 Jane C. Hirsh Abuse-deterrent drug formulations
EP1765332A2 (de) * 2004-06-17 2007-03-28 Cengent Therapeutics, Inc. Trisubstituierte stickstoffmodulatoren von tyrosin-phosphatasen
WO2006010083A2 (en) * 2004-07-08 2006-01-26 Molecular Therapeutics, Inc. Biodegradable nanoparticles
JP2008505916A (ja) * 2004-07-09 2008-02-28 メタバシス・セラピューティクス・インコーポレイテッド チロシンホスファターゼの酸素/窒素複素環阻害剤
US20060040879A1 (en) * 2004-08-21 2006-02-23 Kosak Kenneth M Chloroquine coupled nucleic acids and methods for their synthesis
EP1841749A1 (de) * 2004-09-02 2007-10-10 Metabasis Therapeutics, Inc. Thiazol- und thiadiazolderivate als inhibitoren von tyrosinphosphatasen
AU2005282241B2 (en) * 2004-09-08 2011-03-03 Chelsea Therapeutics, Inc. Quinazoline derivatives as metabolically inert antifolate compounds.
US8440705B2 (en) 2004-09-17 2013-05-14 Whitehead Institute For Biomedical Research Compounds, compositions and methods of inhibiting alpha-synuclein toxicity
US20060067889A1 (en) * 2004-09-27 2006-03-30 Light Sciences Corporation Singlet oxygen photosensitizers activated by target binding enhancing the selectivity of targeted PDT agents
TW200640493A (en) * 2005-02-16 2006-12-01 Insert Therapeutics Inc Cyclodextrin-based polymers for therapeutics delivery
ES2310948B2 (es) * 2005-02-25 2009-09-16 Universidade De Santiago De Compostela Procedimiento de obtencion de hidrogeles de ciclodextrinas con glicidileteres, las composiciones obtenidas y sus aplicaciones.
CN101189249B (zh) 2005-04-01 2013-04-17 加利福尼亚大学董事会 膦酰基-戊-2-烯-1-基核苷和类似物
WO2006130217A2 (en) * 2005-04-01 2006-12-07 The Regents Of The University Of California Substituted phosphate esters of nucleoside phosphonates
US20100098640A1 (en) * 2005-06-20 2010-04-22 Cohen Seth M Multidentate Pyrone-Derived Chelators for Medicinal Imaging and Chelation
US20080095699A1 (en) * 2006-10-20 2008-04-24 Shiying Zheng Imaging contrast agents using nanoparticles
WO2008051197A2 (en) * 2005-09-20 2008-05-02 Mayo Foundation For Medical Education And Research Small-molecule botulinum toxin inhibitors
US7781572B2 (en) * 2005-10-05 2010-08-24 Nse Products, Inc. Nanosized carotenoid cyclodextrin complexes
WO2007047253A2 (en) * 2005-10-11 2007-04-26 Eastman Chemical Company Pharmaceutical formulations of cyclodextrins and antifungal azole compounds
US8685478B2 (en) * 2005-11-21 2014-04-01 Philip Morris Usa Inc. Flavor pouch
WO2007076160A2 (en) * 2005-12-28 2007-07-05 Acidophil Llc C-10 carbamates of taxanes
KR100750320B1 (ko) * 2006-01-04 2007-08-17 학교법인 포항공과대학교 쿠커비투릴을 포함하는 젤
EP1808181A1 (de) * 2006-01-17 2007-07-18 B. Braun Melsungen Ag Polysaccharid-Cyclodextrin-Konjugate
CN101443314B (zh) 2006-03-13 2014-04-09 杏林制药株式会社 作为gsk-3抑制剂的氨基喹诺酮类
EA200870385A1 (ru) * 2006-03-29 2009-04-28 Фолдркс Фармасьютикалз, Инк. Ингибирование токсичности альфа-синуклеина
WO2008005479A2 (en) * 2006-07-06 2008-01-10 University Of Wyoming Charge reversible polymers
FR2903987B1 (fr) * 2006-07-21 2012-12-21 Centre Nat Rech Scient Nouveaux derives de cyclodextrines amphiphiles, leur utilisation dans les domaines pharmaceutiques,cosmetiques, alimentaires et leur application a la production de nouveaux nanosystemes
CA2659600A1 (en) * 2006-08-02 2008-02-07 Board Of Regents Of The University Of Nebraska Drug carriers, their synthesis, and methods of use thereof
WO2008024435A2 (en) 2006-08-23 2008-02-28 Vanderbilt University Dendritic molecular intracellular transporters and methods of making and using same
EA021255B1 (ru) 2006-08-28 2015-05-29 Киова Хакко Кирин Ко., Лимитед Антагонистические моноклональные антитела человека, специфичные в отношении light человека
ZA200902091B (en) 2006-09-21 2010-07-28 Activx Biosciences Inc Serine hydrolase inhibitors
AU2007310949A1 (en) 2006-10-19 2008-04-24 Auspex Pharmaceuticals, Inc. Substituted indoles
FR2907456B1 (fr) * 2006-10-20 2009-01-16 Biocydex Soc Par Actions Simpl Procede de preparation d'oligomeres ou polymeres de cyclodestrines.
US20100137421A1 (en) * 2006-11-08 2010-06-03 Emmanuel Theodorakis Small molecule therapeutics, synthesis of analogues and derivatives and methods of use
KR100785913B1 (ko) * 2006-11-29 2007-12-17 한국과학기술연구원 경화된 β-사이클로덱스트린 중합체 분말과 그의 제조방법
CA2673566A1 (en) 2006-12-19 2008-06-26 Auspex Pharmaceuticals, Inc. Preparation and utility of ccr5 inhibitors
EP2125739A1 (de) * 2006-12-22 2009-12-02 Encysive Pharmaceuticals, Inc. Modulatoren des c3a-rezeptors und verfahren zu deren anwendung
ES2674052T3 (es) * 2007-01-23 2018-06-27 Pharmagra Labs, Inc. Sulforafano estabilizado
JP2010516625A (ja) 2007-01-24 2010-05-20 インサート セラピューティクス, インコーポレイテッド 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート
ATE525068T1 (de) 2007-02-28 2011-10-15 Conatus Pharmaceuticals Inc Verfahren zur behandlung von chronischer viraler hepatitis c mithilfe von ro 113-0830
WO2008106167A1 (en) * 2007-02-28 2008-09-04 Conatus Pharmaceuticals, Inc. Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases
US8372834B2 (en) * 2007-03-02 2013-02-12 University Of Wollongong Compositions and methods for delivery of anti-cancer agents
PL2125698T3 (pl) 2007-03-15 2017-03-31 Auspex Pharmaceuticals, Inc. Deuterowana wenlafaksyna-d9
FR2914306B1 (fr) * 2007-04-02 2009-07-03 Biocydex Soc Par Actions Simpl Oligomeres de cyclodextrines, vecteurs de molecules actives
US7892776B2 (en) 2007-05-04 2011-02-22 The Regents Of The University Of California Screening assay to identify modulators of protein kinase A
WO2008150996A1 (en) * 2007-05-30 2008-12-11 University Of Wyoming Degradable thermoresponsive poly(ethylene glycol) analogue materials
US20100226987A1 (en) * 2007-06-28 2010-09-09 Capsutech Ltd. Targeting conjugates comprising active agents encapsulated in cyclodextrin-containing polymers
ITMI20071321A1 (it) * 2007-07-04 2009-01-05 Sea Marconi Technologies Di Va Nanospugne a base di ciclodestrine come veicolo per farmaci antitumorali
AU2008274941A1 (en) * 2007-07-12 2009-01-15 Tragara Pharmaceuticals, Inc. Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders
US8124147B2 (en) * 2007-07-16 2012-02-28 Philip Morris Usa Inc. Oral pouch products with immobilized flavorant particles
US8424541B2 (en) 2007-07-16 2013-04-23 Philip Morris Usa Inc. Tobacco-free oral flavor delivery pouch product
WO2009013770A1 (en) * 2007-07-26 2009-01-29 Humanitas Mirasole S.P.A. Derivatised polysaccharide material for the transdermal administration of drugs
ES2316292B1 (es) * 2007-08-01 2010-02-05 Consejo Superior De Investigaciones Cientificas Material hibrido organico-inorganico para almacenamiento y liberacion de principios activos.
CN102351880B (zh) * 2007-09-11 2014-11-12 杏林制药株式会社 作为gsk-3 抑制剂的氰基氨基喹诺酮和四唑并氨基喹诺酮
KR101597841B1 (ko) 2007-09-12 2016-02-26 교린 세이야꾸 가부시키 가이샤 Gsk-3 억제제로서의 스피로시클릭 아미노퀴놀론
US20090264421A1 (en) * 2007-10-05 2009-10-22 Bible Keith C Methods and Compositions for Treating Cancer
US20130142733A1 (en) 2007-11-05 2013-06-06 Vanderbilt University Multifunctional degradable nanoparticles with control over size and functionalities
US11254786B2 (en) 2007-11-05 2022-02-22 Vanderbilt University Multifunctional degradable nanoparticles with control over size and functionalities
US20110274620A1 (en) * 2007-11-05 2011-11-10 Harth Eva M Multifunctional degradable nanoparticles with control over size and functionalities
JP2011504485A (ja) * 2007-11-21 2011-02-10 ファーマクシス リミテッド Ssao/vap−1のハロアリルアミン阻害剤およびその用途
US9259398B1 (en) * 2007-11-26 2016-02-16 Abbott Cardiovascular Systems Inc. Bioactive agent-loaded targeting micelles
US7842475B2 (en) * 2008-01-08 2010-11-30 Siemens Healthcare Diagnostics Inc. Stabilization of solid support assay reagents
US8114818B2 (en) 2008-01-16 2012-02-14 Halliburton Energy Services, Inc. Methods and compositions for altering the viscosity of treatment fluids used in subterranean operations
HUE025197T2 (en) 2008-03-17 2016-02-29 Ambit Biosciences Corp Quinazoline derivatives as RAF kinase modulators and methods for their use
MX2010010999A (es) * 2008-04-07 2011-02-22 Chelsea Therapeutics Inc Formas de sal cristalinas de compuestos antifolatos y metodos de fabricacion de las mismas.
US8207264B2 (en) * 2008-07-11 2012-06-26 Tyco Healthcare Group Lp Functionalized inclusion complexes as crosslinkers
WO2010009087A1 (en) * 2008-07-15 2010-01-21 Eyegate Pharmaceuticals, Inc. Iontophoretic delivery of a controlled-release formulation in the eye
US20110092961A1 (en) * 2008-08-13 2011-04-21 Searete Llc Artificial cells
KR101661746B1 (ko) 2008-08-13 2016-09-30 캘리포니아 인스티튜트 오브 테크놀로지 캐리어 나노입자, 그리고 관련된 조성물, 방법 및 시스템
CN101658533A (zh) * 2008-08-29 2010-03-03 首都医科大学宣武医院 抗肿瘤药物的干细胞递送
WO2010088450A2 (en) 2009-01-30 2010-08-05 Celladon Corporation Methods for treating diseases associated with the modulation of serca
US8568793B2 (en) 2009-02-11 2013-10-29 Hope Medical Enterprises, Inc. Sodium nitrite-containing pharmaceutical compositions
WO2010099379A1 (en) 2009-02-27 2010-09-02 Ambit Biosciences Corporation Jak kinase modulating quinazoline derivatives and methods of use thereof
US8193372B2 (en) 2009-03-04 2012-06-05 Idenix Pharmaceuticals, Inc. Phosphothiophene and phosphothiazole HCV polymerase inhibitors
WO2010105016A1 (en) 2009-03-11 2010-09-16 Ambit Biosciences Corp. Combination of an indazolylaminopyrrolotriazine and taxane for cancer treatment
AU2010221990B2 (en) * 2009-03-11 2015-06-04 Kyorin Pharmaceutical Co., Ltd. 7-cycloalkylaminoquinolones as GSK-3 inhibitors
WO2010110686A1 (en) 2009-03-27 2010-09-30 Pathway Therapeutics Limited Pyrimidinyl and 1,3,5 triazinyl benzimidazoles and their use in cancer therapy
JP5766177B2 (ja) 2009-03-27 2015-08-19 ベトディーシー,インコーポレイテッド ピリミジニル及び1,3,5−トリアジニルベンゾイミダゾールスルホンアミド及びガンの療法におけるその使用
ES2543754T3 (es) 2009-04-22 2015-08-21 Axikin Pharmaceuticals, Inc. Antagonistas de CCR3 de arilsulfonamida
DK2421829T3 (en) 2009-04-22 2016-01-04 Axikin Pharmaceuticals Inc 2,5-disubstituted aryl sulfonamide CCR3 antagonists
US8318747B2 (en) 2009-04-22 2012-11-27 Axikin Pharmaceuticals, Inc. 2,5-disubstituted arylsulfonamide CCR3 antagonists
US8569463B2 (en) * 2009-04-23 2013-10-29 Syracuse University Method of covalently modifying proteins with organic molecules to prevent aggregation
US11020363B2 (en) 2009-05-29 2021-06-01 Cydex Pharmaceuticals, Inc. Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
JP5914328B2 (ja) 2009-05-29 2016-05-11 サイデックス・ファーマシューティカルズ・インコーポレイテッド シクロデキストリン誘導体を含む注射用メルファラン組成物並びにその製造及び使用方法
WO2011003870A2 (en) 2009-07-06 2011-01-13 Creabilis S.A. Mini-pegylated corticosteroids, compositions including same, and methods of making and using same
EP2451802A1 (de) 2009-07-07 2012-05-16 Pathway Therapeutics, Inc. Pyrimidinyl- und 1,3,5-triazinyl-benzimidazole und ihre verwendung in der krebstherapie
US20110124650A1 (en) * 2009-07-08 2011-05-26 Chelsea Therapeutics, Inc. Stable crystalline salts of antifolate compounds
EP2451435B2 (de) 2009-07-08 2021-12-01 Hope Medical Enterprises, Inc. d.b.a. Hope Pharmaceuticals Natriumthiosulfathaltige pharmazeutische zusammensetzungen
US8404728B2 (en) 2009-07-30 2013-03-26 Mayo Foundation For Medical Education And Research Small-molecule botulinum toxin inhibitors
JP2013501068A (ja) 2009-08-05 2013-01-10 アイディニックス ファーマシューティカルズ インコーポレイテッド 大環状セリンプロテアーゼ阻害剤
KR20120059558A (ko) 2009-08-19 2012-06-08 암비트 바이오사이언시즈 코포레이션 바이아릴 화합물 및 이의 사용 방법
US20120225834A1 (en) * 2009-09-29 2012-09-06 Eyegate Pharmaceuticals, Inc. Ocular iontophoresis of charged micelles containing bioactive agents
US8747562B2 (en) 2009-10-09 2014-06-10 Philip Morris Usa Inc. Tobacco-free pouched product containing flavor beads providing immediate and long lasting flavor release
WO2011050319A2 (en) * 2009-10-23 2011-04-28 Oregon Health & Science University Inhibiting the deleterious effect of anthracyclines
WO2011056566A2 (en) 2009-10-26 2011-05-12 Sunesis Pharmaceuticals, Inc. Compounds and methods for treatment of cancer
WO2011056764A1 (en) 2009-11-05 2011-05-12 Ambit Biosciences Corp. Isotopically enriched or fluorinated imidazo[2,1-b][1,3]benzothiazoles
KR20120103604A (ko) * 2009-11-06 2012-09-19 첼시 쎄라퓨틱스, 인코포레이티드 효소 저해성 화합물
WO2011057214A2 (en) 2009-11-09 2011-05-12 Neurogenetic Pharmaceuticals, Inc. Gamma-secretase modulatory compounds, methods for identifying same, and uses therefor
US20110237540A1 (en) * 2009-11-23 2011-09-29 Crawford Thomas C Cyclodextrin-based polymers for therapeutic delivery
US20110301235A1 (en) 2009-12-02 2011-12-08 Alquest Therapeutics, Inc. Organoselenium compounds and uses thereof
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
MX2012006877A (es) 2009-12-18 2012-08-31 Idenix Pharmaceuticals Inc Inhibidores de virus de hepatitis c de arileno o heteroarileno 5, 5 - fusionado.
SG181896A1 (en) * 2009-12-23 2012-07-30 Map Pharmaceuticals Inc Novel ergoline analogs
FR2954771B1 (fr) 2010-04-23 2013-09-13 Mohamed Skiba Nouveau procede de synthese de copolymeres, terpolymeres et tetrapolymeres de cyclodextrines et leurs utilisations
FR2954770B1 (fr) 2009-12-31 2013-02-01 Mohamed Skiba Nouveau procede de synthese de copolymeres, terpolymeres, et tetrapolymeres de cyclodextrines et leurs utilisations
WO2011094890A1 (en) 2010-02-02 2011-08-11 Argusina Inc. Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators
US20110196474A1 (en) * 2010-02-11 2011-08-11 Abbott Cardiovascular Systems Inc. Magnetically sensitive drug carriers for treatment or targeted delivery
EP2542542B1 (de) 2010-03-02 2015-04-22 Axikin Pharmaceuticals, Inc. Isotopisch angereicherte arylsulfonamid-ccr3-antagonisten
WO2011112689A2 (en) 2010-03-11 2011-09-15 Ambit Biosciences Corp. Saltz of an indazolylpyrrolotriazine
TW201134820A (en) 2010-03-17 2011-10-16 Axikin Pharmaceuticals Inc Arylsulfonamide CCR3 antagonists
US20110237609A1 (en) * 2010-03-29 2011-09-29 Chelsea Therapeutics, Inc. Antifolate compositions
IT1400323B1 (it) * 2010-05-07 2013-05-24 Univ Degli Studi Torino Metodo per il rilascio controllato di un principio attivo
WO2011150201A2 (en) 2010-05-27 2011-12-01 Ambit Biosciences Corporation Azolyl amide compounds and methods of use thereof
US9296722B2 (en) 2010-05-27 2016-03-29 Ambit Biosciences Corporation Azolyl urea compounds and methods of use thereof
EP2576513A1 (de) 2010-06-01 2013-04-10 Biotheryx Inc. Hydroxypyridonderivate, pharmazeutische zusammensetzungen daraus und ihre therapeutische verwendung zur behandlung von proliferativen erkrankungen
MX342465B (es) 2010-06-01 2016-09-30 Biotheryx Inc * Metodos para tratar enfermedades hematologicas usando 6-ciclohexil-1-hidroxi-4-metil-2(1h)-piridona.
MX367469B (es) 2010-06-07 2019-08-23 Novomedix Llc Compuestos furanilo y su uso.
EP2595615A1 (de) 2010-07-19 2013-05-29 Summa Health System Vitamin c und chromfreies vitamin k sowie zusammensetzungen daraus zur behandlung von nfkb-induzierten leiden oder erkrankungen
EP2600900A4 (de) 2010-08-06 2014-11-19 Univ Illinois Supramolekulare multiplex-aggregate zur nicht-viralen ausgabe eines genetischen materials
WO2012030917A1 (en) 2010-09-01 2012-03-08 Ambit Biosciences Corporation An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof
US20130303533A1 (en) 2010-09-01 2013-11-14 Ambit Biosciences Corporation Azolopyridine and azolopyrimidine compounds and methods of use thereof
WO2012030944A2 (en) 2010-09-01 2012-03-08 Ambit Biosciences Corporation Quinoline and isoquinoline compounds and methods of use thereof
EP2611812A1 (de) 2010-09-01 2013-07-10 Ambit Biosciences Corporation Thienopyridin- und thienopyrimidinverbindungen sowie verfahren zu ihrer verwendung
AU2011296046B2 (en) 2010-09-01 2015-05-14 Ambit Biosciences Corporation Hydrobromide salts of a pyrazolylaminoquinazoline
WO2012030918A1 (en) 2010-09-01 2012-03-08 Ambit Biosciences Corporation Adenosine a3 receptor modulating compounds and methods of use thereof
US20130225578A1 (en) 2010-09-01 2013-08-29 Ambit Biosciences Corporation 7-cyclylquinazoline derivatives and methods of use thereof
EP2611793A1 (de) 2010-09-01 2013-07-10 Ambit Biosciences Corporation 2-cyclochinazolinderivate und verwendungsverfahren dafür
US20130225614A1 (en) 2010-09-01 2013-08-29 Ambit Biosciences Corporation 4-azolylaminoquinazoline derivatives and methods of use thereof
JP5901634B2 (ja) 2010-09-01 2016-04-13 アムビト ビオスシエンセス コルポラチオン キナゾリン化合物及びその使用方法
WO2012044641A1 (en) 2010-09-29 2012-04-05 Pathway Therapeutics Inc. 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
MX2013003954A (es) 2010-10-11 2013-08-01 Axikin Pharmaceuticals Inc Sales de arilsulfonamida antagonistas de ccr3.
CA2819859A1 (en) 2010-12-06 2012-06-14 Follica, Inc. Methods for treating baldness and promoting hair growth
US8658652B2 (en) 2010-12-07 2014-02-25 Chelsea Therapeutics, Inc. Antifolate combinations
WO2012080050A1 (en) 2010-12-14 2012-06-21 F. Hoffmann-La Roche Ag Solid forms of a phenoxybenzenesulfonyl compound
EP2658567A4 (de) 2010-12-28 2014-09-24 Univ Rochester Verfahren zur modifikation einer insulinsignalübertragung mittels biliverdinreduktase (bvr) und bvr-abgeleiteten peptiden
WO2012100142A2 (en) * 2011-01-20 2012-07-26 Cornell University Treatments for retinal disorders
WO2012103165A2 (en) 2011-01-26 2012-08-02 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies and uses thereof
US9393255B2 (en) 2011-01-31 2016-07-19 Celgene Corporation Pharmaceutical compositions of cytidine analogs and methods of use thereof
TW201309690A (zh) 2011-02-10 2013-03-01 Idenix Pharmaceuticals Inc 巨環絲胺酸蛋白酶抑制劑,其醫藥組合物及其於治療hcv感染之用途
AU2012236722A1 (en) 2011-03-28 2013-10-17 Mei Pharma, Inc. (alpha-substituted cycloalkylamino and heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
WO2012135166A1 (en) 2011-03-28 2012-10-04 Pathway Therapeutics Inc. (fused ring arylamino and heterocyclylamino) pyrimidynyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
BR112013024907A2 (pt) 2011-03-28 2016-12-20 Mei Pharma Inc composto, composição farmacêutica, método para o tratamento, prevenção ou atenuação de um ou mais sintomas de um distúrbio, doença ou condição mediada por pi3k em um sujeito, método para modular a atividade enzimática de pi3k
US20120252721A1 (en) 2011-03-31 2012-10-04 Idenix Pharmaceuticals, Inc. Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
WO2012177962A1 (en) 2011-06-23 2012-12-27 Map Pharmaceuticals, Inc. Novel fluoroergoline analogs
CN102302786A (zh) * 2011-08-01 2012-01-04 扬州大学 β-环糊精聚合物-紫杉醇包合物的制备方法
CN102331414B (zh) * 2011-08-29 2014-06-11 西南大学 黄曲霉毒素b1的荧光增敏剂及其运用
EP2750662A4 (de) 2011-08-31 2015-06-24 Univ Georgia Auf apoptose abzielende nanopartikel
WO2013037482A1 (en) 2011-09-15 2013-03-21 Phenex Pharmaceuticals Ag Farnesoid x receptor agonists for cancer treatment and prevention
CN103857385B (zh) * 2011-09-23 2016-06-29 艾黙罗德希尔顿戴维斯公司 自组装纳米结构颗粒和制备方法
US10988618B2 (en) 2011-09-23 2021-04-27 Dystar Hilton Davis Corp. Self-assembled nano-structured particle and methods for preparing
ES2371898B2 (es) * 2011-09-29 2012-06-13 Universidade De Santiago De Compostela Nanogeles de ciclodextrina.
EP2766359B9 (de) 2011-10-14 2017-04-05 Ambit Biosciences Corporation Heterocyclische verbindungen und ihren anwendung als typ iii rezeptor tyrosin kinasen
US9163173B2 (en) 2011-12-15 2015-10-20 Halliburton Energy Services, Inc. Wellbore servicing compositions and methods of making and using same
SG11201403434YA (en) 2011-12-19 2014-09-26 Map Pharmaceuticals Inc Novel iso-ergoline derivatives
AU2012355983A1 (en) 2011-12-21 2015-01-22 Map Pharmaceuticals, Inc. Novel neuromodulatory compounds
ES2669561T3 (es) 2012-02-17 2018-05-28 University Of Georgia Research Foundation, Inc. Nanopartículas para el transporte mitocondrial de agentes
US9611253B2 (en) 2012-02-29 2017-04-04 Ambit Biosciences Corporation Solid forms comprising optically active pyrazolylaminoquinazoline, compositions thereof, and uses therewith
JP6134376B2 (ja) 2012-03-16 2017-05-24 アクシキン ファーマシューティカルズ インコーポレーテッド 3,5−ジアミノピラゾールキナーゼ阻害剤
KR20200030126A (ko) 2012-05-02 2020-03-19 베링거 인겔하임 인터내셔날 게엠베하 Ssao의 치환된 3-할로알릴아민 억제제들 및 그 용도들
US11406595B2 (en) * 2012-05-21 2022-08-09 University Of Maryland, College Park Highly stable colloid from aqueous solutions of small organic molecules
JP6130910B2 (ja) 2012-06-01 2017-05-17 ファームアグラ・ラブズ,インコーポレイテッド スルフォラファンを合成する方法
EP2861562B1 (de) 2012-06-14 2018-05-09 Mayo Foundation For Medical Education And Research Pyrazolderivate als hemmer von stat3
US9012640B2 (en) 2012-06-22 2015-04-21 Map Pharmaceuticals, Inc. Cabergoline derivatives
US9334332B2 (en) 2012-07-25 2016-05-10 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies
CN104769127A (zh) 2012-08-14 2015-07-08 10X基因组学有限公司 微胶囊组合物及方法
US10323279B2 (en) * 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9074186B2 (en) 2012-08-15 2015-07-07 Boston Medical Center Corporation Production of red blood cells and platelets from stem cells
AR093763A1 (es) 2012-09-07 2015-06-24 Axikin Pharmaceuticals Inc Antagonistas de ccr3 de arilsulfonamida isotopicamente enriquecidas
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
WO2014055647A1 (en) 2012-10-03 2014-04-10 Mei Pharma, Inc. (sulfinyl and sulfonyl benzimidazolyl) pyrimidines and triazines, pharmaceutical compositions thereof, and their use for treating proliferative diseases
EP2908853B1 (de) 2012-10-21 2018-12-05 University Of Rochester Thy1 (cd90) als therapie zur steuerung von fettgewebeakkumulation
WO2014074765A2 (en) 2012-11-08 2014-05-15 Summa Health System Vitamin c, vitamin k, a polyphenol, and combinations thereof for wound healing
ES2689921T3 (es) 2012-11-30 2018-11-16 Novomedix, Llc Biarilsulfonamidas sustituidas y sus usos
WO2014100354A1 (en) 2012-12-21 2014-06-26 Map Pharmaceuticals, Inc. Novel methysergide derivatives
US9169214B2 (en) 2012-12-21 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
EP2943188A1 (de) 2013-01-11 2015-11-18 Mayo Foundation for Medical Education and Research Vitamine c und k zur behandlung polyzystischer erkrankungen
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
EP3714903A1 (de) 2013-03-01 2020-09-30 California Institute of Technology Mit nitrophenylborsäurezusammensetzungen stabilisierte nanopartikel
US20160101188A1 (en) * 2013-05-31 2016-04-14 University Of Cincinnati Novel nanocarrier delivered cancer chemotherapeutic agents
ES2891755T3 (es) 2013-06-06 2022-01-31 Pf Medicament Anticuerpos anti-C10orf54 y utilizaciones de los mismos
ES2864667T3 (es) 2013-08-16 2021-10-14 Univ Rochester Péptidos diseñados para la modulación de la barrera de unión estrecha
SG11201601341QA (en) 2013-08-30 2016-03-30 Ambit Biosciences Corp Biaryl acetamide compounds and methods of use thereof
US9751974B2 (en) * 2013-09-06 2017-09-05 Honeywell Federal Manufacturing & Technologies, Llc Aminoanthracene—epoxy nanocomposite containing free anthracene
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
WO2015042375A1 (en) 2013-09-20 2015-03-26 Idenix Pharmaceuticals, Inc. Hepatitis c virus inhibitors
EP3110974A4 (de) 2014-02-24 2018-01-24 Celgene Corporation Verfahren zur verwendung eines aktivators von cereblon für neuronale zellexpansion und behandlung von erkrankungen des zentralnervensystems
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US20170066779A1 (en) 2014-03-05 2017-03-09 Idenix Pharmaceuticals Llc Solid forms of a flaviviridae virus inhibitor compound and salts thereof
US10398663B2 (en) 2014-03-14 2019-09-03 University Of Georgia Research Foundation, Inc. Mitochondrial delivery of 3-bromopyruvate
EP3119784B1 (de) 2014-03-20 2020-07-22 Capella Therapeutics, Inc. Benzimidazolderivate als erbb-tyrosinkinasehemmer zur behandlung von krebs
CA2943220C (en) 2014-03-20 2024-01-16 Capella Therapeutics, Inc. Benzimidazole derivatives as erbb tyrosine kinase inhibitors for the treatment of cancer
WO2015175381A1 (en) 2014-05-12 2015-11-19 Conatus Pharmaceuticals, Inc. Treatment of the complications of chronic liver disease with caspase inhibitors
PH12022550194A1 (en) 2014-05-28 2022-09-19 Agenus Inc Anti-gitr antibodies and methods of use thereof
US9527815B2 (en) 2014-06-18 2016-12-27 Biotheryx, Inc. Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating inflammatory, neurodegenerative, or immune-mediated diseases
US9499514B2 (en) 2014-07-11 2016-11-22 Celgene Corporation Antiproliferative compounds and methods of use thereof
WO2016025129A1 (en) 2014-08-14 2016-02-18 Alhamadsheh Mamoun M Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life
US9982250B2 (en) 2014-08-21 2018-05-29 Illumina Cambridge Limited Reversible surface functionalization
WO2016040860A1 (en) 2014-09-12 2016-03-17 Tobira Therapeutics, Inc. Cenicriviroc combination therapy for the treatment of fibrosis
WO2016065264A1 (en) 2014-10-24 2016-04-28 Biogen Ma Inc. Diterpenoid derivatives and methods of use thereof
CN114230664B (zh) 2014-12-11 2025-01-03 皮埃尔法布雷医药公司 抗c10orf54抗体及其用途
US10221248B2 (en) 2014-12-22 2019-03-05 The Rockefeller University Anti-MERTK agonistic antibodies and uses thereof
AU2015369690B2 (en) 2014-12-23 2019-01-17 SMA Therapeutics Inc. 3,5-diaminopyrazole kinase inhibitors
JP6856532B2 (ja) 2015-01-20 2021-04-07 エックスオーシー ファーマシューティカルズ インコーポレイテッドXoc Pharmaceuticals, Inc エルゴリン化合物およびその使用
BR112017015510A2 (pt) 2015-01-20 2018-01-30 Xoc Pharmaceuticals Inc composto de fórmula estrutural (i), método de tratamento e/ou prevenção, método de agonização do receptor d2 em um indivíduo, método de antagonização do receptor d3 em um indivíduo, método de agonização do receptor 5-ht1d em um indivíduo, método de agonização do receptor 5-ht1a em um indivíduo, método de agonização seletiva do receptor 5-ht1d em vez do receptor 5-ht1b em um indivíduo, método de agonização seletiva do re-ceptor 5-ht2c em vez do receptor 5-ht2a ou 5-ht2b em um indivíduo, método de agonização do receptor 5-ht2c em um indivíduo, método de fornecimento de atividade antagonista funcional no receptor 5-ht2b ou receptor 5-ht7, e, método de fornecimento de atividade antagonista funcional nos receptores adrenérgicos em um indivíduo
AU2016212526B2 (en) 2015-01-28 2020-11-05 Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd Substituted imidazo (1, 2-a) pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof
WO2016126910A1 (en) * 2015-02-04 2016-08-11 University Of South Florida Self-assembled targeted inclusion complexes for drug delivery
KR20250005465A (ko) 2015-03-03 2025-01-09 키맵 리미티드 항체, 용도 및 방법
LT3303394T (lt) 2015-05-29 2020-10-12 Agenus Inc. Anti-ctla-4 antikūnai ir jų naudojimo būdai
JP6919099B2 (ja) 2015-06-23 2021-08-18 ニューロクライン バイオサイエンシーズ,インコーポレイテッド 神経学的疾患または障害を処置するためのvmat2阻害剤
WO2017003668A1 (en) 2015-07-01 2017-01-05 California Institute Of Technology Cationic mucic acid polymer-based delivery systems
WO2017006279A1 (en) * 2015-07-08 2017-01-12 Aten Porus Lifesciences Cyclodextrin-polymer complexes and compostions and methods of making and using the same
JP7063804B2 (ja) * 2015-08-28 2022-05-09 カリウェイ バイオファーマシューティカルズ カンパニー リミテッド 局所脂肪減少に用いられる医薬組成物及びその用途
US11318110B2 (en) 2015-08-28 2022-05-03 Caliway Biopharmaceuticals Co., Ltd. Pharmaceutical composition for reducing local fat and uses thereof
WO2017040790A1 (en) 2015-09-01 2017-03-09 Agenus Inc. Anti-pd-1 antibodies and methods of use thereof
HUE053872T2 (hu) 2015-10-30 2021-07-28 Neurocrine Biosciences Inc Valbenazin-ditozilát és polimorfjai
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
EP3383390A4 (de) 2015-12-02 2019-11-20 Astraea Therapeutics, LLC Piperidinyl-nociceptin-rezeptorverbindungen
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
MA44127A (fr) 2015-12-23 2018-10-31 Neurocrine Biosciences Inc Procédés de synthèse pour la préparation de di(4-méthylbenzènesulfonate) de 2-amino-3-méthylbutanoate de (s)-(2r,3r,11br)-3-isobutyl-9,10-diméthoxy-2,3,4,6,7,11b-hexahydro-1h-pyrido[2,1,-a]isoquinoléin-2-yl
CA3010286A1 (en) 2015-12-31 2017-07-06 Conatus Pharmaceuticals Inc. Methods of using caspase inhibitors in treatment of liver disease
US10189808B2 (en) 2016-01-08 2019-01-29 Celgene Corporation Solid forms of 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide, and their pharmaceutical compositions and uses
BR112018013761A2 (pt) 2016-01-08 2018-12-11 Celgene Corp compostos antiproliferativos e suas composições farmacêuticas e usos
CR20180451A (es) 2016-02-19 2019-10-11 Hazel Tech Inc Composiciones para la liberación controlada de ingredientes activos y métodos de preparación de las mismas
WO2017151836A1 (en) 2016-03-04 2017-09-08 East Carolina University J-series prostaglandin-ethanolamides as novel therapeutics for skin and/or oral disorders
US10407437B2 (en) 2016-03-08 2019-09-10 Los Gatos Pharmaceuticals, Inc. Camptothecin derivatives and uses thereof
EP3426301A4 (de) 2016-03-08 2019-11-06 Los Gatos Pharmaceuticals, Inc. Verbundnanopartikel und verwendungen davon
CA3020681A1 (en) 2016-04-11 2017-10-19 Clexio Biosciences Ltd. Deuterated ketamine derivatives
US10047077B2 (en) 2016-04-13 2018-08-14 Skyline Antiinfectives, Inc. Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams
EP3454904B1 (de) 2016-05-13 2022-12-14 Institut Pasteur Hemmung von beta-2-nicotinischen acetylcholinrezeptoren zur behandlung von morbus alzheimer
TWI753910B (zh) 2016-05-16 2022-02-01 美商拜歐斯瑞克斯公司 吡啶硫酮、其醫藥組合物及其治療增生性、炎性、神經退化性或免疫介導疾病之治療用途
GB201608936D0 (en) 2016-05-20 2016-07-06 Polytherics Ltd Novel conjugates and novel conjugating reagents
MY195089A (en) 2016-05-27 2023-01-10 Agenus Inc Anti-Tim-3 Antibodies and Methods of use thereof
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
JP2019525772A (ja) 2016-07-08 2019-09-12 スターテン・バイオテクノロジー・ベー・フェー 抗apoc3抗体およびその使用方法
US10919904B2 (en) 2016-08-17 2021-02-16 North Carolina State University Northern-southern route to synthesis of bacteriochlorins
MX390121B (es) 2016-09-19 2025-03-20 Mei Pharma Inc Combinaciones de un inhibidor de btk y un inhibidor de pi3k para tratar neoplasias malignas hematológicas.
CN117586403A (zh) 2016-10-11 2024-02-23 艾吉纳斯公司 抗lag-3抗体及其使用方法
EP3534947A1 (de) 2016-11-03 2019-09-11 Kymab Limited Antikörper, kombinationen mit antikörpern, biomarker, verwendungen und verfahren
US11332521B2 (en) 2016-11-07 2022-05-17 Neuracle Science Co., Ltd. Anti-family with sequence similarity 19, member A5 antibodies and method of use thereof
US10106521B2 (en) 2016-11-09 2018-10-23 Phloronol, Inc. Eckol derivatives, methods of synthesis and uses thereof
TW201828932A (zh) 2016-11-09 2018-08-16 美商諾沃麥迪斯有限責任公司 1,1-二甲基雙胍之亞硝酸鹽、醫藥組合物及使用方法
WO2018102252A1 (en) 2016-11-30 2018-06-07 North Carolina State University Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds
CN110191705A (zh) 2016-12-01 2019-08-30 亚尼塔公司 治疗癌症的方法
EP4400171A3 (de) 2016-12-02 2024-09-11 Neurocrine Biosciences, Inc. Verwendung von valbenazin zur behandlung von schizophrenie oder schizoaffektiver störung
JP6992068B2 (ja) 2016-12-07 2022-02-03 アジェナス インコーポレイテッド 抗ctla-4抗体およびそれらの使用方法
CN110300599B (zh) 2016-12-07 2024-07-02 艾吉纳斯公司 抗体和其使用方法
KR20200066662A (ko) 2017-01-27 2020-06-10 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
WO2018151815A1 (en) 2017-02-17 2018-08-23 Eidos Therapeutics, Inc. Processes for preparing ag-10, its intermediates, and salts thereof
EP3582798B1 (de) 2017-02-17 2025-07-23 DayLife LLC Universelles gegengift
WO2018164996A1 (en) 2017-03-06 2018-09-13 Neurocrine Biosciences, Inc. Dosing regimen for valbenazine
EP3601351A1 (de) 2017-03-27 2020-02-05 Celgene Corporation Verfahren und zusammensetzungen zur reduzierung der immunogenität
CN108653747B (zh) * 2017-03-29 2023-04-07 中国科学院上海药物研究所 一种基因与疏水药物共输送的可降解纳米载体及其制法和应用
WO2018191502A2 (en) 2017-04-13 2018-10-18 Agenus Inc. Anti-cd137 antibodies and methods of use thereof
EP3612560A1 (de) 2017-04-21 2020-02-26 Staten Biotechnology B.V. Anti-apoc3-antikörper und verfahren zur verwendung davon
US20200179352A1 (en) 2017-04-26 2020-06-11 Neurocrine Biosciences, Inc. Use of valbenazine for treating levodopa-induced dyskinesia
MA50957A (fr) 2017-05-01 2020-10-14 Agenus Inc Anticorps anti-tigit et leurs méthodes d'utilisation
JOP20190219A1 (ar) 2017-05-09 2019-09-22 Cardix Therapeutics LLC تركيبات صيدلانية وطرق لعلاج أمراض القلب والأوعية الدموية
US10085999B1 (en) 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
WO2018223065A1 (en) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine
KR102327698B1 (ko) 2017-06-27 2021-11-17 주식회사 뉴라클사이언스 녹내장의 치료를 위한 항-서열 유사성 19를 가진 패밀리, 멤버 a5 항체의 용도
US11618783B2 (en) 2017-06-27 2023-04-04 Neuracle Science Co., Ltd. Anti-FAM19A5 antibodies and uses thereof
US11155613B2 (en) 2017-06-27 2021-10-26 Neuracle Science Co., Ltd. Use of anti-FAM19A5 antibodies for treating fibrosis
KR20220031738A (ko) 2017-06-27 2022-03-11 주식회사 뉴라클사이언스 암 치료를 위한 항-fam19a5 항체의 용도
US11571401B2 (en) 2017-09-01 2023-02-07 East Carolina University Compounds, compositions, kits, and methods for activating immune cells and/or an immune system response
IL309802A (en) 2017-09-21 2024-02-01 Neurocrine Biosciences Inc High dose valbenazine formulation and related preparations, methods and kits
CN111263820B (zh) 2017-10-02 2024-07-02 纽洛可科学有限公司 抗序列相似家族19成员a5抗体用于治疗和诊断情绪障碍的用途
MX2020004133A (es) 2017-10-04 2020-08-13 Univ California Oligosacaridos inmunomoduladores.
MY198713A (en) 2017-10-10 2023-09-19 Neurocrine Biosciences Inc Methods for the administration of certain vmat2 inhibitors
KR20250070134A (ko) 2017-10-10 2025-05-20 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
JP7039694B2 (ja) 2017-10-31 2022-03-22 スターテン・バイオテクノロジー・ベー・フェー 抗apoc3抗体およびその使用方法
TW202406538A (zh) 2018-01-10 2024-02-16 美商克拉治療有限責任公司 包含苯基磺醯胺之醫藥組合物及其治療應用
WO2019139871A1 (en) 2018-01-10 2019-07-18 Cura Therapeutics Llc Pharmaceutical compositions comprising dicarboxylic acids and their therapeutic applications
KR20200135996A (ko) 2018-03-23 2020-12-04 에이도스 테라퓨틱스, 인코포레이티드 Ag10을 사용하여 ttr 아밀로이드증을 치료하는 방법
US11634484B2 (en) 2018-04-24 2023-04-25 Neuracle Science Co., Ltd. Use of anti-family with sequence similarity 19, member A5 antibodies for the treatment of neuropathic pain
EA202092457A1 (ru) 2018-05-08 2021-08-10 Ньюракл Сайенс Ко., Лтд. Доставка антител к fam19a5 с помощью аденоассоциированного вируса (aav)
WO2019215702A1 (en) 2018-05-10 2019-11-14 Neuracle Science Co., Ltd. Anti-family with sequence similarity 19, member a5 antibodies and method of use thereof
WO2019241327A1 (en) 2018-06-13 2019-12-19 California Institute Of Technology Nanoparticles for crossing the blood brain barrier and methods of treatment using the same
EA202092750A1 (ru) 2018-06-14 2021-05-13 Ньюрокрайн Байосайенсиз, Инк. Соединения ингибиторы vmat2, композиции и способы, относящиеся к ним
CA3105352A1 (en) 2018-06-29 2020-01-02 Histogen, Inc. (s)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases
CN108774290B (zh) * 2018-07-10 2020-09-04 宁夏蓝博思化学技术有限公司 白藜芦醇-羧烷基型环糊精衍生物及其制备方法
JP2021531007A (ja) 2018-07-20 2021-11-18 ピエール、ファーブル、メディカマン Vistaに対する受容体
MA53239A (fr) 2018-08-15 2022-05-04 Neurocrine Biosciences Inc Procédés d'administration de certains inhibiteurs de vmat2
SMT202500463T1 (it) 2018-08-17 2026-01-12 Eidos Therapeutics Inc Formulazioni di ag10
JP2022504287A (ja) 2018-10-03 2022-01-13 スターテン・バイオテクノロジー・ベー・フェー ヒト及びカニクイザルapoc3に特異的な抗体、並びにその使用の方法
CN119185536A (zh) 2018-10-16 2024-12-27 纽洛可科学有限公司 抗fam19a5抗体的用途
CN109364262A (zh) * 2018-11-07 2019-02-22 西南大学 一种氧化还原双响应型高分子喜树碱前药的制备方法
AU2019379325B2 (en) 2018-11-16 2025-04-24 Genexine, Inc. Method of treating a tumor with a combination of IL-7 protein and an immune checkpoint inhibitor
CN109172824A (zh) * 2018-11-26 2019-01-11 中南大学湘雅三医院 一种用于治疗皮肤鳞状细胞癌的药物组合物及其制备方法
KR20200071198A (ko) 2018-12-10 2020-06-19 네오이뮨텍, 인코퍼레이티드 Nrf2 발현 조절 기반 T 세포 항암면역치료법
US12391705B2 (en) 2018-12-19 2025-08-19 Shy Therapeutics, Llc Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
KR102757347B1 (ko) 2018-12-27 2025-01-23 주식회사 뉴라클사이언스 죽상경화증을 치료하기 위한 항-fam19a5 항체의 사용
BR112021008114A2 (pt) 2019-01-02 2021-08-31 Neuracle Science Co., Ltd. Anti-família com similaridade de sequência 19, membro a5, anticorpos e método de uso dos mesmos
IL284435B2 (en) 2019-01-03 2025-09-01 Cyclarity Therapeutics Inc Cyclodextrin dimers, their preparations and uses
CN113874080B (zh) 2019-02-06 2024-09-27 戴斯阿尔法公司 Il-17a调节剂及其用途
PL3930847T3 (pl) 2019-02-26 2024-07-08 Inspirna, Inc. Przeciwciała anty-mertk o wysokim powinowactwie i ich zastosowania
TW202100506A (zh) 2019-03-07 2021-01-01 美商柯納特斯製藥公司 半胱天冬酶(caspase)抑制劑及其使用方法
ES3036313T3 (en) 2019-05-20 2025-09-17 Nirvana Sciences Inc Narrow emission dyes, compositions comprising same, and methods for making and using same
CA3138403A1 (en) 2019-05-20 2020-11-26 Christopher J. MACNEVIN Narrow emission dyes, compositions comprising same, and methods for making and using same
CN110124050B (zh) * 2019-05-24 2022-05-24 西南大学 基于共价自组装策略的电荷翻转型聚合物载体的制备方法
WO2020247347A1 (en) 2019-06-05 2020-12-10 University Of Rochester New designed inhibitors of tight junction formation
WO2021007474A1 (en) 2019-07-11 2021-01-14 Cura Therapeutics, Llc Phenyl compounds and pharmaceutical compositions thereof, and their therapeutic applications
EP3997068A1 (de) 2019-07-11 2022-05-18 Cura Therapeutics, LLC Sulfonverbindungen und pharmazeutische zusammensetzungen daraus sowie ihre therapeutischen anwendungen zur behandlung von neurodegenerativen erkrankungen
US10940141B1 (en) 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
AU2020335928A1 (en) 2019-08-30 2022-02-17 Agenus Inc. Anti-CD96 antibodies and methods of use thereof
RU2740287C1 (ru) * 2019-08-30 2021-01-12 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) 3д-матриксная структура для доставки лекарственных препаратов
CN115103835B (zh) 2019-09-16 2024-12-10 戴斯阿尔法公司 Il-17a调节剂及其用途
KR20220150274A (ko) 2020-01-13 2022-11-10 네오이뮨텍, 인코퍼레이티드 Il-7 단백질과 이중특이적 항체의 조합물을 사용한 종양의 치료 방법
WO2021151001A1 (en) 2020-01-22 2021-07-29 Outpace Bio, Inc. Chimeric polypeptides
US20230210952A1 (en) 2020-02-05 2023-07-06 Washington University Method of treating a solid tumor with a combination of an il-7 protein and car-bearing immune cells
US11974982B2 (en) * 2020-04-03 2024-05-07 The Board Of Trustees Of The University Of Illinois Stimulus-responsive antioxidant crystals and method for their preparation
CA3179635A1 (en) 2020-05-29 2021-12-02 Boulder Bioscience Llc Methods for improved endovascular thrombectomy using 3,3'-diindolylmethane
EP4168414A1 (de) 2020-06-18 2023-04-26 Shy Therapeutics LLC Substituierte thienopyrimidine zur interaktion mit der ras-superfamilie zur behandlung von krebs, entzündlichen erkrankungen, rasopathien und fibrotischen erkrankungen
JP2023532312A (ja) 2020-06-30 2023-07-27 プロセッタ バイオサイエンシズ, インク. イソキノリン誘導体、合成の方法及びそれらの使用
WO2022061348A1 (en) 2020-09-16 2022-03-24 Biotheryx, Inc. Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
CN112263566B (zh) * 2020-09-24 2022-06-24 中国药科大学 白蛋白结合型缺氧氧化双响应性复合纳米粒、制备方法及用途
CN112229991B (zh) * 2020-10-16 2022-08-16 厦门圣科环保科技股份有限公司 一种纳米捕获器件及其制备方法和用途
WO2022087335A1 (en) 2020-10-23 2022-04-28 Biotheryx, Inc. Kras protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
WO2022094475A1 (en) 2020-11-02 2022-05-05 Neoimmunetech, Inc. Use of interleukin-7 for the treatment of coronavirus
IL302482A (en) 2020-11-05 2023-06-01 Neoimmunetech Inc Method of treating a tumor with a combination of an il-7 protein and a nucleotide vaccine
CA3201965A1 (en) 2020-12-14 2022-06-23 Kyle W.H. Chan Pde4 degraders, pharmaceutical compositions, and therapeutic applications
WO2022164997A1 (en) 2021-01-27 2022-08-04 Shy Therapeutics, Llc Methods for the treatment of fibrotic disease
US20240309015A1 (en) 2021-01-27 2024-09-19 Shy Therapeutics, Llc Methods for the Treatment of Fibrotic Disease
CA3211505A1 (en) 2021-03-10 2022-09-15 Lalit Kumar Sharma Alpha v beta 6 and alpha v beta 1 integrin inhibitors and uses thereof
WO2022226166A1 (en) 2021-04-22 2022-10-27 Protego Biopharma, Inc. Spirocyclic imidazolidinones and imidazolidinediones for treatment of light chain amyloidosis
WO2022251533A1 (en) 2021-05-27 2022-12-01 Protego Biopharma, Inc. Heteroaryl diamide ire1/xbp1s activators
WO2022251644A1 (en) 2021-05-28 2022-12-01 Lyell Immunopharma, Inc. Nr4a3-deficient immune cells and uses thereof
KR20240027676A (ko) 2021-06-02 2024-03-04 라이엘 이뮤노파마, 인크. Nr4a3-결핍 면역 세포 및 이의 용도
CN118696057A (zh) 2021-06-14 2024-09-24 阿根思有限公司 抗il-9抗体及其使用方法
EP4355741B1 (de) 2021-06-16 2025-12-10 Biotheryx, Inc. Sos1-proteinabbauer, pharmazeutische zusammensetzungen daraus und ihre therapeutischen anwendungen
WO2022266249A1 (en) 2021-06-16 2022-12-22 Biotheryx, Inc. Kras protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
JP2024530856A (ja) 2021-09-29 2024-08-27 エヌビオス,インコーポレイテッド コイルドコイル融合タンパク質
US12017997B2 (en) 2021-10-22 2024-06-25 Prosetta Biosciences, Inc. Host-targeted pan-respiratory antiviral small molecule therapeutics
CA3237696A1 (en) 2021-11-08 2023-05-11 Progentos Therapeutics, Inc. Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
EP4456907A1 (de) 2021-12-30 2024-11-06 NeoImmuneTech, Inc. Verfahren zur behandlung eines tumors mit einer kombination aus il-7-protein und vegf-antagonist
WO2023129576A2 (en) 2022-01-03 2023-07-06 Lilac Therapeutics, Inc. Acyclic thiol prodrugs
WO2023129577A1 (en) 2022-01-03 2023-07-06 Lilac Therapeutics, Inc. Cyclic thiol prodrugs
WO2023157989A1 (ko) 2022-02-17 2023-08-24 주식회사 노벨티노빌리티 항체-약물 접합체
US12168673B2 (en) 2022-03-02 2024-12-17 Mitopower, Inc. Prodrugs derived from nicotinic acid and ribose
US20230348909A1 (en) 2022-03-30 2023-11-02 Biomarin Pharmaceutical Inc. Dystrophin exon skipping oligonucleotides
GB2619907A (en) 2022-04-01 2023-12-27 Kanna Health Ltd Novel crystalline salt forms of mesembrine
JP2025513877A (ja) 2022-04-14 2025-04-30 ブリストル-マイヤーズ スクイブ カンパニー 新規なgspt1化合物およびその新規な化合物の使用方法
WO2023215781A1 (en) 2022-05-05 2023-11-09 Biomarin Pharmaceutical Inc. Method of treating duchenne muscular dystrophy
CN120092003A (zh) 2022-05-10 2025-06-03 拜欧斯瑞克斯公司 Cdk蛋白降解剂、药物组合物和治疗应用
JP2025516823A (ja) 2022-05-19 2025-05-30 ライエル・イミュノファーマ・インコーポレイテッド Nr4a3を標的とするポリヌクレオチド及びその使用
CN114794098A (zh) * 2022-06-30 2022-07-29 山东百农思达生物科技有限公司 一种茼蒿素与藜芦碱的微囊悬浮剂的制备方法
CN115340615B (zh) * 2022-08-12 2023-05-02 同济大学 一种基于环糊精-氨基酸的荧光分子及其合成方法与应用
WO2024054832A1 (en) 2022-09-09 2024-03-14 Innovo Therapeutics, Inc. CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS
CA3268510A1 (en) 2022-09-30 2024-04-04 Boulder Bioscience Llc Compositions containing 3,3'-diindolmythane for treating a closed, non-bleeding head wound
AU2023364731A1 (en) 2022-10-21 2025-04-03 Diagonal Therapeutics Inc. Heteromeric agonistic antibodies to il-18 receptor
US20240174672A1 (en) 2022-10-26 2024-05-30 Protego Biopharma, Inc. Spirocycle Containing Pyridone Compounds
US20240174695A1 (en) 2022-10-26 2024-05-30 Protego Biopharma, Inc. Spirocycle Containing Bicyclic Heteroaryl Compounds
US20240174673A1 (en) 2022-10-26 2024-05-30 Protego Biopharma, Inc. Spirocycle Containing Pyridine Compounds
WO2024092211A1 (en) * 2022-10-27 2024-05-02 Nurettin Sahiner Fabrication of cyclodextrin particles and cryogels and methods of using and making thereof
KR20250089492A (ko) 2022-11-07 2025-06-18 네오이뮨텍, 인코퍼레이티드 비메틸화된 mgmt 프로모터를 갖는 종양의 치료 방법
EP4626865A1 (de) 2022-11-30 2025-10-08 Protego Biopharma, Inc. Cyclische pyrazoldiamid-ire1/xbp1s-aktivatoren
EP4626864A1 (de) 2022-11-30 2025-10-08 Protego Biopharma, Inc. Lineare heteroaryldiamid-ire1/xbp1s-aktivatoren
KR102868101B1 (ko) * 2023-01-13 2025-10-01 한림대학교 산학협력단 CGTase를 이용한 피세틴 포접 복합체 생산 방법
EP4680632A2 (de) 2023-03-17 2026-01-21 Oxitope Pharma B.V. Anti-phosphocholin-antikörper und verfahren zur verwendung davon
WO2024194685A2 (en) 2023-03-17 2024-09-26 Oxitope Pharma B.V. Anti-phosphocholine antibodies and methods of use thereof
CN121127500A (zh) 2023-04-07 2025-12-12 达科纳治疗有限公司 针对激活素a受体样1型(alk1)的双特异性激动性抗体
US20240383990A1 (en) 2023-04-07 2024-11-21 Diagonal Therapeutics Inc. Hinge-modified bispecific antibodies
WO2024226471A2 (en) 2023-04-24 2024-10-31 Biomarin Pharmaceutical Inc. Compositions and methods for treating stxbp1 disorders
WO2024233303A1 (en) 2023-05-05 2024-11-14 Biomarin Pharmaceutical Inc. Dystrophin exon skipping oligonucleotides
CN121263415A (zh) 2023-05-09 2026-01-02 普罗根托斯治疗公司 杂环化合物及其用途
CN121219320A (zh) 2023-05-19 2025-12-26 达科纳治疗有限公司 针对il12受体的双特异性激动性抗体
WO2025010272A1 (en) 2023-07-03 2025-01-09 Neoimmunetech, Inc. Heterodimeric fc molecules and uses thereof
US20250101101A1 (en) 2023-09-01 2025-03-27 iTeos Belgium SA Anti-trem2 antibodies and methods of use
WO2025063888A1 (en) 2023-09-19 2025-03-27 Kancure Pte. Ltd. Survivin-targeted compounds
TW202530223A (zh) 2023-09-27 2025-08-01 美商艾索司特瑞克斯公司 Myst抑制劑
WO2025085416A1 (en) 2023-10-16 2025-04-24 Bristol-Myers Squibb Company Gspt1 compounds and methods of use of the compounds
WO2025090519A1 (en) 2023-10-23 2025-05-01 Diagonal Therapeutics Inc. Heteromeric agonistic antibodies to il-18 receptor
GB2636969A (en) 2023-11-24 2025-07-09 Ontrack Therapeutics Ltd Novel crystalline salt forms
CN117598306A (zh) * 2023-12-06 2024-02-27 安徽省农业科学院植物保护与农产品质量安全研究所 一种高效杀菌剂及其应用
WO2025133707A1 (en) 2023-12-19 2025-06-26 Vectory Therapeutics B.V. Anti-tdp-43 antibodies and uses thereof
WO2025147691A1 (en) 2024-01-04 2025-07-10 Innovo Therapeutics, Inc. Compositions and methods for degrading aryl hydrocarbon receptor nuclear translocator protein
WO2025179161A1 (en) 2024-02-21 2025-08-28 Innovo Therapeutics, Inc. Protein degrading compounds
WO2025201633A1 (en) 2024-03-26 2025-10-02 Chen Gefei An agent for reducing amyloid formation
WO2025255341A1 (en) 2024-06-05 2025-12-11 Protego Biopharma, Inc. Tetrahydrofuranyl ire1/xbp1s activators

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH445129A (fr) * 1964-04-29 1967-10-15 Nestle Sa Procédé pour la préparation de composés d'inclusion à poids moléculaire élevé
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US5997856A (en) * 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
US5068227A (en) * 1989-01-18 1991-11-26 Cyclex, Inc. Cyclodextrins as carriers
WO1991005605A1 (en) * 1989-10-10 1991-05-02 Kosak Kenneth M Cyclodextrin labels for immunoassay and biochemical analysis
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
IT1241417B (it) * 1990-03-06 1994-01-14 Vectorpharma Int Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione
EP0586524B2 (de) * 1991-06-03 2000-11-02 Nycomed Imaging As Verbesserungen im bezug auf kontrastmittel

Also Published As

Publication number Publication date
WO2000040962A1 (en) 2000-07-13
US20010021703A1 (en) 2001-09-13
US20010034333A1 (en) 2001-10-25
US6048736A (en) 2000-04-11
EP1183538B1 (de) 2004-04-14
DE69916504D1 (de) 2004-05-19
US6835718B2 (en) 2004-12-28
EP1183538A4 (de) 2003-07-16
AU3468900A (en) 2000-07-24
EP1183538A1 (de) 2002-03-06

Similar Documents

Publication Publication Date Title
ATE264114T1 (de) Zyklodexrinpolymere zum gebrauch als medikamententräger
MXPA05003591A (es) Materiales basados en ciclodextrina, composiciones y usos relacionados a los mismos.
Chen et al. Synthesis and biological evaluation of dimeric RGD peptide− paclitaxel conjugate as a model for integrin-targeted drug delivery
MY167123A (en) Conveniently implantable sustained release drug compositions
DK1296647T3 (da) Polymermicellepræparater
WO2007040469A3 (en) Chloroquine coupled compositions and methods for their synthesis
ATE377048T1 (de) Abbaubare polyacetal-polymere
MD20070267A (en) Gastroresistant pharmaceutical formulation containing rifaximin
ATE533493T1 (de) Schäumende pharmazeutische zusammensetzungen und verfahren zur behandlung einer erkrankung
BRPI0414017A8 (pt) pró-fármacos poliméricos de múltiplos braços
DK1392254T3 (da) Micelle-lægemiddelindgivelsessystem for hydrofobe lægemidler
DK1318788T3 (da) Nanopartikulær fastdosissammensætninger
AU2273302A (en) Compositions for sustained delivery of hydrophobic drugs and process for the preparation thereof
ATE235895T1 (de) Arzneistoff-abgabesystem enthaltend eine festgepackte, feste arzneistoffbasis
EP1988910A4 (de) Acryloyloxyethylphosphorylcholin-haltige polymerkonjugate und ihre zubereitung
BR0013948A (pt) Prodroga, composição farmacêutica, e, método de tratamento de um paciente mamìfero
BR9405798A (pt) Métodos para liberação in vivo de material biológico e composições úteis dos mesmos
MX2009003504A (es) Dispositivo para suministro local y/o regional que utiliza formulaciones liquidas de agentes terapeuticos.
DE69934337D1 (de) Konjugate zur Behandlung von Entzündungskrankheiten und von assozierter Gewebeschädigung
Huang et al. pH-sensitive nanocarrier-mediated codelivery of simvastatin and noggin siRNA for synergistic enhancement of osteogenesis
DE60141567D1 (de) Freisetzungssysteme zur behandlung von restenose und anastomotischer intimaler hyperplasie
Zhong et al. New progress in improving the delivery methods of bisphosphonates in the treatment of bone tumors
TW200509998A (en) Controlled release of highly soluble agents
Hu et al. Mechanisms of hydrogel-based microRNA delivery systems and its application strategies in targeting inflammatory diseases
SE9603480L (sv) Beredningsform för svårlösliga läkemedel

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties