PE20120811A1 - Antagonistas ccr3 arilsulfonamida - Google Patents

Antagonistas ccr3 arilsulfonamida

Info

Publication number
PE20120811A1
PE20120811A1 PE2011001844A PE2011001844A PE20120811A1 PE 20120811 A1 PE20120811 A1 PE 20120811A1 PE 2011001844 A PE2011001844 A PE 2011001844A PE 2011001844 A PE2011001844 A PE 2011001844A PE 20120811 A1 PE20120811 A1 PE 20120811A1
Authority
PE
Peru
Prior art keywords
ccr3
antagonists
arylsulfonamide
cyane
piperazin
Prior art date
Application number
PE2011001844A
Other languages
English (en)
Inventor
Jared Andrew Forrester
Tai Wei Ly
Original Assignee
Axikin Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42301162&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120811(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Axikin Pharmaceuticals Inc filed Critical Axikin Pharmaceuticals Inc
Publication of PE20120811A1 publication Critical patent/PE20120811A1/es

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
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    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P35/00Antineoplastic agents
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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D285/01Five-membered rings
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    • C07D295/22Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26Sulfur atoms
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    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
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  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
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  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE R1, R2, R3, R4, R5 Y R6 SON CADA UNO H, HALO, CIANO, NITRO ALQUILO C1-C6, ARILO C6-C14HETEROARILO, ENTRE OTROS; R7 ES HALO, CIANO, OXO, CICLOALQUILO C3-C7, ARILO C6-C14, HETEROCICLILO, ENTRE OTROS; X ES O, S; RYa ES CH3-SO2, 4-METIL-FENIL-SULFONIL, FENILMETANONA, ENTRE OTROS; m ES 0-3; n ES 1-3; p ES 0-4. SON COMPUESTOS PREFERIDOS: 1-(4-(2-(2,5-DICLOROFENILTIO)-5-NITROFENILSULFONIL)PIPERAZIN-1-IL)ETANONA; 4-CLORO-1-(4-(2-(2,5-DILCLOROFENILTIO)-5-NITROFENILSULFONIL)PIPERAZIN-1-IL)BUTAN-1-ONA; ENTRE OTROS. DICHOS COMPUESTOS SON ANTAGONISTAS CCR3 UTILES EN EL TRATAMIENTO O TRASTORNO DE ASMA, RINITIS ALERGICA, GASTROENTERITIS EOSINOFILICO, ENTRE OTROS
PE2011001844A 2009-04-22 2010-04-21 Antagonistas ccr3 arilsulfonamida PE20120811A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17178009P 2009-04-22 2009-04-22

Publications (1)

Publication Number Publication Date
PE20120811A1 true PE20120811A1 (es) 2012-07-08

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ID=42301162

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PE2015000493A PE20150759A1 (es) 2009-04-22 2010-04-21 Antagonistas ccr3 arilsulfonamida
PE2011001844A PE20120811A1 (es) 2009-04-22 2010-04-21 Antagonistas ccr3 arilsulfonamida

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US (2) US8420639B2 (es)
EP (2) EP2421838A2 (es)
JP (1) JP2012524791A (es)
KR (1) KR20120034627A (es)
CN (1) CN102459210B (es)
AR (1) AR076363A1 (es)
AU (1) AU2010239341B2 (es)
BR (1) BRPI1014668A2 (es)
CA (1) CA2758729A1 (es)
CL (1) CL2011002619A1 (es)
CO (1) CO6470793A2 (es)
CR (1) CR20110536A (es)
DK (1) DK2502921T3 (es)
EC (1) ECSP11011474A (es)
ES (1) ES2543754T3 (es)
HK (1) HK1176927A1 (es)
HU (1) HUE025647T2 (es)
IL (1) IL215843A0 (es)
MX (1) MX2011011141A (es)
MY (1) MY184048A (es)
NI (1) NI201100185A (es)
NZ (2) NZ620092A (es)
PE (2) PE20150759A1 (es)
RU (1) RU2539591C2 (es)
SG (2) SG175277A1 (es)
TW (1) TWI473793B (es)
UA (1) UA107660C2 (es)
WO (1) WO2010123960A2 (es)

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NZ620074A (en) 2009-04-22 2015-09-25 Axikin Pharmaceuticals Inc 2,5-disubstituted arylsulfonamide ccr3 antagonists
EP2727908A3 (en) * 2009-04-22 2014-08-20 Axikin Pharmaceuticals, Inc. 2,5-disubstituted arylsulfonamide CCR3 antagonists
DK2542542T3 (en) * 2010-03-02 2015-07-20 Axikin Pharmaceuticals Inc ISOTOPIC ENRICHED ARYL SULPHONAMIDE CCR3 ANTAGONISTS
JP2013543512A (ja) * 2010-10-11 2013-12-05 アクシキン ファーマシューティカルズ インコーポレーテッド アリールスルホンアミドccr3アンタゴニストの塩
WO2014039748A1 (en) 2012-09-07 2014-03-13 Axikin Pharmaceuticals, Inc. Isotopically enriched arylsulfonamide ccr3 antagonists
GB2560713A (en) * 2017-03-20 2018-09-26 Eternygen Gmbh Inhibitor of citrate transporter

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