AR071386A1 - Compuestos heterociclicos nitrogenados, inhibidores carbamato y urea de la 11-beta-hidroxiesteroide deshidrogenasa tipo 1(11 beta-hsd1),composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de la obesidad,hipertension,trastornos cognitivos y otras enfermedades. - Google Patents

Compuestos heterociclicos nitrogenados, inhibidores carbamato y urea de la 11-beta-hidroxiesteroide deshidrogenasa tipo 1(11 beta-hsd1),composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de la obesidad,hipertension,trastornos cognitivos y otras enfermedades.

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AR071386A1
AR071386A1 ARP090101394A ARP090101394A AR071386A1 AR 071386 A1 AR071386 A1 AR 071386A1 AR P090101394 A ARP090101394 A AR P090101394A AR P090101394 A ARP090101394 A AR P090101394A AR 071386 A1 AR071386 A1 AR 071386A1
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Argentina
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optionally substituted
alkyl
represented
cycloalkyl
heteroaryl
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ARP090101394A
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Vitae Pharmaceuticals Inc
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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Abstract

Composiciones farmacéuticas que los contienen y su uso en la reduccion o control de la produccion de cortisol en una célula o la inhibicion de la conversion de cortisona en cortisol en una célula. Reivindicacion 1: Un compuesto de formula (1), en la que Cy bicicloalquilo C7-12 o tricicloalquilo C9-12, donde 1-2 átomos de carbono se reemplazan opcionalmente por heteroátomos seleccionados independientemente entre N y O, y que está opcionalmente sustituido con 1-3 grupos seleccionados independientemente entre halogeno, nitro, (CH2)xCN, alquilo C1-3, haloalquilo C1-3, hidroxialquilo C1-3, (CH2)xOR4, haloalcoxi C1-3, (CH2)xN(R4)2, (CH2)xC(=NOH)NH2, (CH2)xNR4CON(R4)2, (CH2)xCON(R4)2, (CH2)xCO2R4, (CH2)xSO2N(R4)2, (CH2)xSO2R4, (CH2)xNR4COR4, (CH2)xNR4CO2R4, (CH2)xNR4SO2R4, (CH2)xOC(=O)N(R4)2, arilo opcionalmente sustituido representado por Ar1, heteroarilo opcionalmente sustituido representado por HetAr1, heterociclilo opcionalmente sustituido representado por HetCy1 y cicloalquilo opcionalmente sustituido representado por Cy1, donde Ar1, HetAr1, HetCy1 y Cy1 están opcionalmente sustituidos con uno a tres grupos representados por R7; B es (a) -C(O)OR1 o (b) arilo o heteroarilo, cada uno opcionalmente sustituido con 1-4 grupos representados por R6; R1 es alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-8, heterociclilo, cicloalquil C3-8-alquilo C1-3, heterociclilalquilo C1-3, arilo, arilalquilo C1-3 o heteroarilalquilo C1-3, cada uno opcionalmente sustituido con 1-4 grupos seleccionados independientemente entre halogeno, nitro, (CH2)xCN, alquilo C1-3, haloalquilo C1-3, hidroxialquilo C1-3, (CH2)xOR4, haloalcoxi C1-3, (CH2)xN(R4)2, (CH2)xC(=NOH)NH2, (CH2)xNR4CON(R4)2, (CH2)xCON(R4)2, (CH2)xCO2R4, (CH2)xSO2N(R4)2, (CH2)xSO2R4, (CH2)xNR4COR4, (CH2)xNR4CO2R4, (CH2)xNR4SO2R4, (CH2)xOC(=O)N(R4)2, arilo opcionalmente sustituido representado por Ar1, heteroarilo opcionalmente sustituido representado por HetAr1, heterociclilo opcionalmente sustituido representado por HetCy1 y cicloalquilo opcionalmente sustituido representado por Cy1, donde Ar1, HetAr1, HetCy1 y Cy1 están opcionalmente sustituidos con uno a tres grupos representados por R7; donde el alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-8, heterociclilo, cicloalquil C3-8-alquilo C1-3, heterociclilalquilo C1-3, la porcion alquilo de arilalquilo C1-3, heteroarilo y heteroarilalquilo C1-3 están opcionalmente sustituidos además con oxo; R2 y R3 son independientemente (a) hidrogeno; o (b) alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-8, heterociclilo, arilo, heteroarilo, cicloalquil C3-8-alquilo C1-3, heterociclilalquilo C1-3, arilalquilo C1-3, heteroarilalquilo C1-3 o (CH2)xCO2R4, cada uno opcionalmente sustituido con 1-4 grupos seleccionados independientemente entre halogeno, nitro, (CH2)xCN, alquilo C1-3, haloalquilo C1-3, haloalcoxi C1-3, hidroxialquilo C1-3, (CH2)xOR4, (CH2)xN(R4)2, (CH2)xC(=NOH)NH2, (CH2)xNR4CON(R4)2, (CH2)xCON(R4)2, (CH2)xCO2R4, (CH2)xSO2N(R4)2, (CH2)xSO2R4, (CH2)xNR4COR4, (CH2)xNR4CO2R4, (CH2)xNR4SO2R4, (CH2)xOC(=O)N(R4)2, arilo opcionalmente sustituido representado por Ar1, heteroarilo opcionalmente sustituido representado por HetAr1, heterociclilo opcionalmente sustituido representado por HetCy1 y cicloalquilo opcionalmente sustituido representado por Cy1, donde Ar1, HetAr1, HetCy1 y Cy1 están opcionalmente sustituidos con uno a tres grupos representados por R7; donde el alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-8, heterociclilo, heteroarilo, cicloalquil C3-8-alquilo C1-3, heterociclilalquilo C1-3, la porcion alquilo de arilalquilo C1-3, heteroarilo y heteroarilalquilo C1-3 están opcionalmente sustituidos además con oxo; o R2 y R3 tomados juntos forman alquileno C1-4 opcionalmente sustituido hasta con 2 grupos alquilo C1-3; cada R4 es independientemente (a) hidrogeno; o (b) alquilo C1-10, cicloalquilo C3-8, arilo o arilalquilo C1-3, cada uno opcionalmente sustituido con halogeno, alcoxi C1-3, alquilo C1-3, haloalquilo C1-3, haloalcoxi C1-3, ciano o nitro; R5 es hidrogeno o alquilo C1-6; cada R6 se selecciona independientemente entre halogeno, nitro, (CH2)xCN, alquilo C1-3, haloalquilo C1-3, hidroxialquilo C1-3, (CH2)xOR4, haloalcoxi C1-3, (CH2)xN(R4)2, (CH2)xC(=NOH)NH2, (CH2)xNR4CON(R4)2, (CH2)xCON(R4)2, (CH2)xCO2R4, (CH2)xSO2N(R4)2, (CH2)xSO2R4, (CH2)xNR4COR4, (CH2)xNR4CO2R4, (CH2)xNR4SO2R4, (CH2)xOC(=O)N(R4)2, arilo opcionalmente sustituido representado por Ar1, heteroarilo opcionalmente sustituido representado por HetAr1, heterociclilo opcionalmente sustituido representado por HetCy1 y cicloalquilo opcionalmente sustituido representado por Cy1, donde Ar1, HetAr1, HetCy1 y Cy1 están opcionalmente sustituidos con uno a tres grupos representados por R7, donde, cuando B es heteroarilo, R6 también puede ser oxo; cada R7 se selecciona independientemente entre halogeno, nitro, ciano, alquilo C1-3, haloalquilo C1-3, alcoxi C1-3, haloalcoxi C1-3, y CON(R4)2, con la condicion de que R7 también incluya oxo cuando HetAr1, HetCy1 y Cy1 están sustituidos con R7; x es 0, 1, 2 o 3; A es un enlace o CH2; m es 0,1, 2, 3 o 4; n es 1, 2, 3 o 4; y Q es O o NR5; o una sal farmacéuticamente aceptable del mismo.
ARP090101394A 2008-04-22 2009-04-21 Compuestos heterociclicos nitrogenados, inhibidores carbamato y urea de la 11-beta-hidroxiesteroide deshidrogenasa tipo 1(11 beta-hsd1),composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de la obesidad,hipertension,trastornos cognitivos y otras enfermedades. AR071386A1 (es)

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