PE20070712A1 - Sulfonamidas biciclicas como moduladores del receptor de glucocorticoides en el tratamiento de enfermedades inflamatorias - Google Patents

Sulfonamidas biciclicas como moduladores del receptor de glucocorticoides en el tratamiento de enfermedades inflamatorias

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Publication number
PE20070712A1
PE20070712A1 PE2006001271A PE2006001271A PE20070712A1 PE 20070712 A1 PE20070712 A1 PE 20070712A1 PE 2006001271 A PE2006001271 A PE 2006001271A PE 2006001271 A PE2006001271 A PE 2006001271A PE 20070712 A1 PE20070712 A1 PE 20070712A1
Authority
PE
Peru
Prior art keywords
alkyl
glucocorticoid receptor
modulators
treatment
inflammatory diseases
Prior art date
Application number
PE2006001271A
Other languages
English (en)
Inventor
Hakan Bladh
Krister Henriksson
Matti Lepisto
Stinabritt Nilsson
Thomas Hansson
Jan Dahmen
Original Assignee
Astrazeneca Ab
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Bayer Schering Pharma Ag filed Critical Astrazeneca Ab
Publication of PE20070712A1 publication Critical patent/PE20070712A1/es

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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 ES H; R2 ES H, ALQUILO C1-C4, HALOALQUILO C1-C4; CICLOALQUILO C3-C7, ENTRE OTROS; R3 ES H, ALQUILO C1-C4, HALOALQUILO C1-C4; R3a ES H, ALQUILO C1-C4; R4 ES H, HALOGENO, ALQUILO C1-C4, ENTRE OTROS; T ES CH, N; A ES FENILO, NAFTILO, FURILO, ENTRE OTROS; Q1 ES CY1, N; Q2 ES CY2, N; W ES FENILO, CICLOALQUILO C3-C7, TIENILO, ENTRE OTROS; X ES CH2, O, S, ENTRE OTROS; Y, Y1 y Y2 SON CADA UNO H, HALO, ALQUILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-((1S)-2-{[1-(4-FLUOROFENIL)-1H-INDAZOL-4-IL]OXI}-1-METILETIL)-2,4,6-TRIMETILBENCENSULFONAMIDA; N-((1S)-2-{[1-(4-FLUOROFENIL)-1H-INDAZOL-4-IL]AMINO}-1-METILETIL)-2,4,6-TRIMETILBENCENSULFONAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS ACTUAN A NIVEL DEL RECEPTOR DE GLUCOCORTICOIDES SIENDO UTILES COMO AGENTES ANTIINFLAMATORIOS
PE2006001271A 2005-10-20 2006-10-19 Sulfonamidas biciclicas como moduladores del receptor de glucocorticoides en el tratamiento de enfermedades inflamatorias PE20070712A1 (es)

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