HUE038055T2 - Eljárás szulforafán szintetizálására - Google Patents

Eljárás szulforafán szintetizálására

Info

Publication number
HUE038055T2
HUE038055T2 HUE13726846A HUE13726846A HUE038055T2 HU E038055 T2 HUE038055 T2 HU E038055T2 HU E13726846 A HUE13726846 A HU E13726846A HU E13726846 A HUE13726846 A HU E13726846A HU E038055 T2 HUE038055 T2 HU E038055T2
Authority
HU
Hungary
Prior art keywords
sulforaphane
synthesising
synthesising sulforaphane
Prior art date
Application number
HUE13726846A
Other languages
English (en)
Inventor
Sahadeva Reddy Damireddi
Kpakpo Ambroise Akue
Jared K Nelson
Albert Roger Frisbee
Peter Wyatt Newsome
Original Assignee
Pharmagra Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmagra Labs Inc filed Critical Pharmagra Labs Inc
Publication of HUE038055T2 publication Critical patent/HUE038055T2/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/26Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/724Cyclodextrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/16Isothiocyanates
    • C07C331/18Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms
    • C07C331/20Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/16Cyclodextrin; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Catalysts (AREA)
HUE13726846A 2012-06-01 2013-05-31 Eljárás szulforafán szintetizálására HUE038055T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261654277P 2012-06-01 2012-06-01

Publications (1)

Publication Number Publication Date
HUE038055T2 true HUE038055T2 (hu) 2018-10-29

Family

ID=48576452

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE13726846A HUE038055T2 (hu) 2012-06-01 2013-05-31 Eljárás szulforafán szintetizálására

Country Status (14)

Country Link
US (4) US9567405B2 (hu)
EP (1) EP2854861B1 (hu)
JP (2) JP6130910B2 (hu)
CN (1) CN104703628B (hu)
AU (1) AU2013269340B9 (hu)
BR (1) BR112014029841B1 (hu)
CA (1) CA2875063C (hu)
DK (1) DK2854861T3 (hu)
ES (1) ES2653248T3 (hu)
HU (1) HUE038055T2 (hu)
IN (1) IN2014DN10764A (hu)
NO (1) NO2882932T3 (hu)
PL (1) PL2854861T3 (hu)
WO (1) WO2013179057A1 (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105001135B (zh) * 2015-07-10 2017-04-12 北京化工大学 一种莱菔子素的化学合成方法
CN108503568A (zh) * 2017-02-27 2018-09-07 无锡杰西医药股份有限公司 一种适用于工业化生产的高纯度异硫氰酸酯类化合物制备方法
CN107468666B (zh) * 2017-08-18 2021-01-01 赣州华汉生物科技有限公司 一种可稳定保存的萝卜硫素胶囊及其制备方法
WO2020068525A1 (en) 2018-09-24 2020-04-02 Chevron Phillips Chemical Company Lp Methods for making supported chromium catalysts with increased polymerization activity
GB202005238D0 (en) * 2020-04-08 2020-05-20 Evgen Pharma Plc Crystalline complexes
WO2022140409A1 (en) 2020-12-23 2022-06-30 Church & Dwight Co., Inc. Compositions and methods to increase production of isothiocyanates

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US135618A (en) 1873-02-11 Improvement in printing-presses
JP3604172B2 (ja) 1994-03-22 2004-12-22 株式会社白元 除菌組成物、及び除菌方法
FR2776666B1 (fr) 1998-03-31 2002-09-06 Commissariat Energie Atomique Complexes d'inclusion dans des cyclodextrines d'isothiocyanates organiques, en particulier bacteriostatiques, bactericides et/ou fongicides ou de leurs precurseurs naturels, et leur preparation
US6048736A (en) 1998-04-29 2000-04-11 Kosak; Kenneth M. Cyclodextrin polymers for carrying and releasing drugs
KR20020063914A (ko) 1999-12-20 2002-08-05 코니스 프랑스, 에스.에이. 화장용 및/또는 약학용 제제
US6737441B2 (en) 2000-08-21 2004-05-18 Jed W. Fahey Treatment of helicobacter with isothiocyanates
JP2002187842A (ja) 2000-12-19 2002-07-05 Toyo Shinyaku:Kk ケール加工品およびその加工方法
JP2003146803A (ja) 2001-11-13 2003-05-21 Carex Inc 抗菌性粉末組成物およびその製造方法
FR2845599B1 (fr) 2002-10-11 2005-01-07 Lmd Medicament comprenant une thiouree pour son utilisation en tant que depigmentant
CA2603235A1 (en) 2005-03-28 2006-10-05 Bioresponse, Llc Diindolylmethane-based compositions and methods of use thereof for promoting oral mucosal and bone health
FR2888235B1 (fr) 2005-07-07 2007-09-14 Nutrinov Sa Procede d'extraction de sulforaphane a partir de broyat de crucifere contenant de la glucoraphanine
US20080312164A1 (en) 2006-07-14 2008-12-18 Rajski Scott R Isothiocyanates and glucosinolate compounds and anti-tumor compositions containing same
WO2008015315A1 (fr) 2006-08-03 2008-02-07 Lmd Compositions medicinales contenant une thiouree pour le traitement du cancer en association avec des agents chimiotherapeutiques ou des rayonnements ionisants ou non ionisants
CN101120948A (zh) 2006-08-08 2008-02-13 普文英 一种具有化学保护、癌症预防和治疗用途的化合物组合物
HUE046151T2 (hu) 2007-01-23 2020-02-28 Pharmagra Labs Inc Stabilizált szulforafán
CN102249968B (zh) * 2011-06-17 2013-07-17 常州大学 萝卜硫素的合成方法
CN102423492A (zh) * 2011-12-31 2012-04-25 肖广惠 一种莱菔硫烷的包合物及其制备方法
CN102688219A (zh) 2012-02-03 2012-09-26 马建华 萝卜硫素的微胶囊包埋方法

Also Published As

Publication number Publication date
CN104703628B (zh) 2017-09-08
US20210212978A1 (en) 2021-07-15
JP6130910B2 (ja) 2017-05-17
US10864186B2 (en) 2020-12-15
US9567405B2 (en) 2017-02-14
JP2015518041A (ja) 2015-06-25
CA2875063A1 (en) 2013-12-05
JP2017141288A (ja) 2017-08-17
AU2013269340B2 (en) 2017-02-16
US20190282534A1 (en) 2019-09-19
EP2854861B1 (en) 2017-10-04
WO2013179057A1 (en) 2013-12-05
ES2653248T3 (es) 2018-02-06
US20150191551A1 (en) 2015-07-09
US11571406B2 (en) 2023-02-07
BR112014029841B1 (pt) 2021-01-19
JP6385511B2 (ja) 2018-09-05
US20170112796A1 (en) 2017-04-27
AU2013269340B9 (en) 2017-08-17
NO2882932T3 (hu) 2018-08-04
PL2854861T3 (pl) 2018-02-28
CA2875063C (en) 2021-01-12
EP2854861A1 (en) 2015-04-08
DK2854861T3 (en) 2018-01-02
BR112014029841A2 (pt) 2017-06-27
AU2013269340A1 (en) 2015-01-22
IN2014DN10764A (hu) 2015-09-04
US10307390B2 (en) 2019-06-04
AU2013269340A8 (en) 2015-03-12
CN104703628A (zh) 2015-06-10

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