WO2005012334A8 - 生体内非分解性ペプチド、アンジオテンシン変換酵素阻害剤、医薬及び機能性食品 - Google Patents

生体内非分解性ペプチド、アンジオテンシン変換酵素阻害剤、医薬及び機能性食品

Info

Publication number
WO2005012334A8
WO2005012334A8 PCT/JP2004/010929 JP2004010929W WO2005012334A8 WO 2005012334 A8 WO2005012334 A8 WO 2005012334A8 JP 2004010929 W JP2004010929 W JP 2004010929W WO 2005012334 A8 WO2005012334 A8 WO 2005012334A8
Authority
WO
WIPO (PCT)
Prior art keywords
pro
drug
functional food
biologically non
peptide
Prior art date
Application number
PCT/JP2004/010929
Other languages
English (en)
French (fr)
Other versions
WO2005012334A1 (ja
Inventor
Naoyuki Yamamoto
Seiichi Mizuno
Shingo Nishimura
Takanobu Gotou
Keiichi Matsuura
Original Assignee
Calpis Co Ltd
Naoyuki Yamamoto
Seiichi Mizuno
Shingo Nishimura
Takanobu Gotou
Keiichi Matsuura
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK04771089.2T priority Critical patent/DK1661909T3/da
Priority to AT04771089T priority patent/ATE442855T1/de
Application filed by Calpis Co Ltd, Naoyuki Yamamoto, Seiichi Mizuno, Shingo Nishimura, Takanobu Gotou, Keiichi Matsuura filed Critical Calpis Co Ltd
Priority to NZ545341A priority patent/NZ545341A/en
Priority to JP2005512525A priority patent/JP4669396B2/ja
Priority to US10/566,057 priority patent/US20070122451A1/en
Priority to KR1020117005091A priority patent/KR101115560B1/ko
Priority to AU2004261522A priority patent/AU2004261522B2/en
Priority to BRPI0413242-4A priority patent/BRPI0413242A/pt
Priority to EP04771089A priority patent/EP1661909B1/en
Priority to CA002532537A priority patent/CA2532537A1/en
Priority to MXPA06000879A priority patent/MXPA06000879A/es
Priority to KR1020067000144A priority patent/KR101115557B1/ko
Priority to EA200600349A priority patent/EA010098B1/ru
Priority to DE602004023210T priority patent/DE602004023210D1/de
Publication of WO2005012334A1 publication Critical patent/WO2005012334A1/ja
Publication of WO2005012334A8 publication Critical patent/WO2005012334A8/ja
Priority to NO20060994A priority patent/NO20060994L/no
Priority to HK07100123.3A priority patent/HK1093991A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

　本発明は、経口投与等により投与した際に生体内において吸収され易く、且つ分解され難く、生体内において血圧降下作用等の機能を有効に発現することが期待できる新規な生体内非分解性ペプチド、該ペプチドを用いたACE阻害剤及び生体内において有効に血圧降下作用が期待できる医薬又は機能性食品を提供する。該生体内非分解性ペプチドは、Ile Pro、Glu Pro、Arg Pro、Gln Pro、Met Pro及びSer Pro Proからなる群より選択されるカルボキシ末端にProを有するジペプチド又はトリペプチドである。
PCT/JP2004/010929 2003-08-01 2004-07-30 生体内非分解性ペプチド、アンジオテンシン変換酵素阻害剤、医薬及び機能性食品 WO2005012334A1 (ja)

Priority Applications (16)

Application Number Priority Date Filing Date Title
EA200600349A EA010098B1 (ru) 2003-08-01 2004-07-30 Неперевариваемые in vivo пептиды, имеющие активность ингибитора ангиотензинпревращающего фермента, лекарственное средство и пищевой продукт
BRPI0413242-4A BRPI0413242A (pt) 2003-08-01 2004-07-30 peptìdeos não-degradáveis biologicamente, inibidor de enzima de conversão em angiotensina, alimentos medicinais e funcionais
NZ545341A NZ545341A (en) 2003-08-01 2004-07-30 Biologically non-degradable peptide, angiotensin converting enzyme inhibitor, drug and functional food
JP2005512525A JP4669396B2 (ja) 2003-08-01 2004-07-30 アンジオテンシン変換酵素阻害剤、医薬及び機能性食品
US10/566,057 US20070122451A1 (en) 2003-08-01 2004-07-30 Biogically non-degradable peptides, angiostensin converting enzyme inhibitor, drug and functional food
KR1020117005091A KR101115560B1 (ko) 2003-08-01 2004-07-30 생체내 비분해성 펩티드, 안지오텐신 변환효소 저해제, 의약 및 기능성 식품
AU2004261522A AU2004261522B2 (en) 2003-08-01 2004-07-30 Biologically non-degradable peptide, angiotensin converting enzyme inhibitor, drug and functional food
DK04771089.2T DK1661909T3 (da) 2003-08-01 2004-07-30 Biologisk ikke-nedbrydeligt peptid, angiotensinomdannende enzyminhibitor, medikament og funktionel fødevare
EP04771089A EP1661909B1 (en) 2003-08-01 2004-07-30 Biologically non-degradable peptide, angiotensin converting enzyme inhibitor, drug and functional food
MXPA06000879A MXPA06000879A (es) 2003-08-01 2004-07-30 Peptidos no degradables biologicamente, inhibidor de enzima convertidora de angiotensina, farmaco y alimento funcional.
CA002532537A CA2532537A1 (en) 2003-08-01 2004-07-30 Biologically non-degradable peptides and their use as angiotensin converting enzyme inhibitors, drugs and functional foods
KR1020067000144A KR101115557B1 (ko) 2003-08-01 2004-07-30 생체내 비분해성 펩티드, 안지오텐신 변환효소 저해제,의약 및 기능성 식품
AT04771089T ATE442855T1 (de) 2003-08-01 2004-07-30 Biologisch nicht-abbaubares peptid, inhibitor des angiotensinumwandelnden enzyms, arzneimittel und funktionelles nahrungsmittel
DE602004023210T DE602004023210D1 (de) 2003-08-01 2004-07-30 Biologisch nicht-abbaubares peptid, inhibitor des angiotensinumwandelnden enzyms, arzneimittel und funktionelles nahrungsmittel
NO20060994A NO20060994L (no) 2003-08-01 2006-02-28 Biologisk ikke-nedbrytbart peptid, angiotensinomdannende enzyminhibitor, medikament og funksjonell fode
HK07100123.3A HK1093991A1 (en) 2003-08-01 2007-01-04 Biologically non-degradable peptide, angiotensin converting enzyme inhibitor, drug and functional food

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003285007 2003-08-01
JP2003-285007 2003-08-01

Publications (2)

Publication Number Publication Date
WO2005012334A1 WO2005012334A1 (ja) 2005-02-10
WO2005012334A8 true WO2005012334A8 (ja) 2005-06-30

Family

ID=34113859

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/JP2004/010929 WO2005012334A1 (ja) 2003-08-01 2004-07-30 生体内非分解性ペプチド、アンジオテンシン変換酵素阻害剤、医薬及び機能性食品
PCT/JP2004/010928 WO2005012542A1 (ja) 2003-08-01 2004-07-30 カゼイン加水分解物、その製造法及びその用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/010928 WO2005012542A1 (ja) 2003-08-01 2004-07-30 カゼイン加水分解物、その製造法及びその用途

Country Status (23)

Country Link
US (3) US20070299014A1 (ja)
EP (2) EP1661909B1 (ja)
JP (3) JP5341300B2 (ja)
KR (3) KR101115557B1 (ja)
CN (3) CN100439393C (ja)
AT (2) ATE411035T1 (ja)
AU (2) AU2004261522B2 (ja)
BR (2) BRPI0413242A (ja)
CA (2) CA2532537A1 (ja)
DE (2) DE602004017202D1 (ja)
DK (2) DK1669463T3 (ja)
EA (2) EA011570B1 (ja)
ES (2) ES2313067T3 (ja)
HK (2) HK1094008A1 (ja)
MX (2) MXPA06000878A (ja)
NO (2) NO20060994L (ja)
NZ (2) NZ545341A (ja)
PL (1) PL1669463T3 (ja)
PT (2) PT1669463E (ja)
TW (2) TWI341866B (ja)
UA (2) UA87278C2 (ja)
WO (2) WO2005012334A1 (ja)
ZA (2) ZA200601746B (ja)

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TWI341866B (en) 2011-05-11
CA2546497A1 (en) 2005-02-10
US20070299014A1 (en) 2007-12-27
NZ545340A (en) 2010-04-30
CN100439393C (zh) 2008-12-03
UA89616C2 (ru) 2010-02-25
CN101381401A (zh) 2009-03-11
EP1661909A4 (en) 2006-08-30
KR101115560B1 (ko) 2012-03-13
DE602004023210D1 (de) 2009-10-29
CA2532537A1 (en) 2005-02-10
PT1661909E (pt) 2009-12-17
MXPA06000879A (es) 2006-03-30
JP2011102327A (ja) 2011-05-26
KR20110039379A (ko) 2011-04-15
HK1093991A1 (en) 2007-03-16
JPWO2005012542A1 (ja) 2007-09-27
DK1669463T3 (da) 2009-01-26
EA011570B1 (ru) 2009-04-28
EP1669463A4 (en) 2006-08-23
ATE411035T1 (de) 2008-10-15
NO20060995L (no) 2006-02-28
EP1661909B1 (en) 2009-09-16
DE602004017202D1 (de) 2008-11-27
BRPI0413238A (pt) 2006-10-03
PT1669463E (pt) 2009-01-23
ZA200601739B (en) 2007-05-30
ZA200601746B (en) 2007-05-30
AU2004261522B2 (en) 2010-09-16
EA200600349A1 (ru) 2006-08-25
WO2005012334A1 (ja) 2005-02-10
WO2005012542A1 (ja) 2005-02-10
AU2004261522A1 (en) 2005-02-10
AU2004261855B2 (en) 2010-09-16
CN100398661C (zh) 2008-07-02
EA010098B1 (ru) 2008-06-30
KR101115557B1 (ko) 2012-03-13
NZ545341A (en) 2009-06-26
DK1661909T3 (da) 2010-01-18
ES2331312T3 (es) 2009-12-29
EP1669463B1 (en) 2008-10-15
BRPI0413242A (pt) 2006-10-03
CN1833031A (zh) 2006-09-13
NO20060994L (no) 2006-02-28
TW200505471A (en) 2005-02-16
JP5341300B2 (ja) 2013-11-13
US20110082281A1 (en) 2011-04-07
US20070122451A1 (en) 2007-05-31
AU2004261855A1 (en) 2005-02-10
EP1661909A1 (en) 2006-05-31
PL1669463T3 (pl) 2009-02-27
KR20060118395A (ko) 2006-11-23
EP1669463A1 (en) 2006-06-14
TWI349676B (en) 2011-10-01
TW200507869A (en) 2005-03-01
MXPA06000878A (es) 2006-03-30
JP4669396B2 (ja) 2011-04-13
KR20060120567A (ko) 2006-11-27
HK1094008A1 (en) 2007-03-16
US8580557B2 (en) 2013-11-12
EA200600352A1 (ru) 2006-08-25
CN1832958A (zh) 2006-09-13
ATE442855T1 (de) 2009-10-15
ES2313067T3 (es) 2009-03-01
KR101174299B1 (ko) 2012-08-16
UA87278C2 (ru) 2009-07-10
JPWO2005012334A1 (ja) 2008-01-17

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