WO2008123095A1 - 心不全予防剤 - Google Patents

心不全予防剤 Download PDF

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Publication number
WO2008123095A1
WO2008123095A1 PCT/JP2008/055072 JP2008055072W WO2008123095A1 WO 2008123095 A1 WO2008123095 A1 WO 2008123095A1 JP 2008055072 W JP2008055072 W JP 2008055072W WO 2008123095 A1 WO2008123095 A1 WO 2008123095A1
Authority
WO
WIPO (PCT)
Prior art keywords
heart failure
prophylactic agent
thickening
agent capable
heart
Prior art date
Application number
PCT/JP2008/055072
Other languages
English (en)
French (fr)
Inventor
Tatsuhiko Hirota
Kohji Ohki
Teppei Nakamura
Toshiaki Takano
Original Assignee
Calpis Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calpis Co., Ltd. filed Critical Calpis Co., Ltd.
Priority to MX2009010427A priority Critical patent/MX2009010427A/es
Priority to JP2009509045A priority patent/JP5292632B2/ja
Priority to EP08722459A priority patent/EP2130546B1/en
Priority to BRPI0809319-9A priority patent/BRPI0809319A2/pt
Priority to EA200970893A priority patent/EA016808B1/ru
Priority to CA2681746A priority patent/CA2681746C/en
Priority to TW097110324A priority patent/TWI412372B/zh
Publication of WO2008123095A1 publication Critical patent/WO2008123095A1/ja
Priority to US12/567,322 priority patent/US20100022747A1/en
Priority to US13/293,993 priority patent/US8673854B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

　本発明により、心臓壁の肥厚抑制作用を有する剤、ならびに前記剤を含む心不全の予防剤や、心不全の予防効果が期待できる機能性食品が提供される。本発明の心臓壁肥厚抑制剤は有効成分としてＸａａ Ｐｒｏ Ｐｒｏを含有する。
PCT/JP2008/055072 2007-03-27 2008-03-19 心不全予防剤 WO2008123095A1 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
MX2009010427A MX2009010427A (es) 2007-03-27 2008-03-19 Agente profilactico para la insuficiencia cardiaca.
JP2009509045A JP5292632B2 (ja) 2007-03-27 2008-03-19 心不全予防剤
EP08722459A EP2130546B1 (en) 2007-03-27 2008-03-19 Tripeptides for use in treating heart wall thickening
BRPI0809319-9A BRPI0809319A2 (pt) 2007-03-27 2008-03-19 Agente para suprimir espessamento de parede de coração, agente profilático para hipertrofia cardíaca, agente profilático para insuficiência cardíaca, e, alimento funcional
EA200970893A EA016808B1 (ru) 2007-03-27 2008-03-19 ПРИМЕНЕНИЕ ТРИПЕПТИДОВ Val Pro Pro И Ile Pro Pro ДЛЯ СУПРЕССИИ УТОЛЩЕНИЯ СТЕНКИ СЕРДЦА
CA2681746A CA2681746C (en) 2007-03-27 2008-03-19 Prophylactic agent for heart failure
TW097110324A TWI412372B (zh) 2007-03-27 2008-03-24 心衰竭預防劑
US12/567,322 US20100022747A1 (en) 2007-03-27 2009-09-25 Prophylactic agent for heart failure
US13/293,993 US8673854B2 (en) 2007-03-27 2011-11-10 Prophylactic agent for heart failure

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-081638 2007-03-27
JP2007081638 2007-03-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/567,322 Continuation US20100022747A1 (en) 2007-03-27 2009-09-25 Prophylactic agent for heart failure

Publications (1)

Publication Number Publication Date
WO2008123095A1 true WO2008123095A1 (ja) 2008-10-16

Family

ID=39830596

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/JP2008/055073 WO2008123096A1 (ja) 2007-03-27 2008-03-19 腎不全予防剤
PCT/JP2008/055072 WO2008123095A1 (ja) 2007-03-27 2008-03-19 心不全予防剤

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/055073 WO2008123096A1 (ja) 2007-03-27 2008-03-19 腎不全予防剤

Country Status (10)

Country Link
US (4) US20100022747A1 (ja)
EP (2) EP2138184B1 (ja)
JP (2) JP5292633B2 (ja)
KR (2) KR20090130303A (ja)
CN (2) CN101641113A (ja)
BR (1) BRPI0809319A2 (ja)
CA (2) CA2681746C (ja)
EA (1) EA016808B1 (ja)
MX (2) MX2009010427A (ja)
WO (2) WO2008123096A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012176659A1 (ja) * 2011-06-24 2012-12-27 カルピス株式会社 乳酸菌発酵によるカゼイン由来ペプチドの製造方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090130303A (ko) * 2007-03-27 2009-12-22 칼피스가부시키가이샤 신부전 예방제

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2782142B2 (ja) 1992-07-23 1998-07-30 カルピス株式会社 アンジオテンシン変換酵素阻害剤及びその製造法
WO1999016862A1 (fr) * 1997-09-26 1999-04-08 Calpis Co., Ltd. Bacterie du genre lactobacillus helveticus ayant une grande capacite de production de tripeptides, produit laitier fermente et son procede de preparation
WO2007013426A1 (ja) * 2005-07-26 2007-02-01 Calpis Co., Ltd. 発酵乳の製造方法及び発酵乳飲食品
WO2007094342A1 (ja) * 2006-02-14 2007-08-23 Calpis Co., Ltd. 動脈硬化予防剤、血管内膜の肥厚抑制剤及び血管内皮機能改善剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI113741B (fi) * 1999-11-01 2004-06-15 Valio Oy Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi
CA2523410A1 (en) 2003-05-05 2004-11-18 Unilever Plc Hydrolysed casein product comprising tripeptides ipp and/or vpp
KR101115560B1 (ko) * 2003-08-01 2012-03-13 칼피스가부시키가이샤 생체내 비분해성 펩티드, 안지오텐신 변환효소 저해제, 의약 및 기능성 식품
BRPI0513237A (pt) * 2004-07-12 2008-04-29 Dsm Assets B V hidrolisados de proteìna para diminuição de pressão sanguìnea
US20080085914A1 (en) * 2004-10-08 2008-04-10 David Louis Feldman Use Of Organic Compounds
US20060205642A1 (en) * 2005-03-08 2006-09-14 Vesely David L Oral methods of treatment using proANF peptides
US20100167979A1 (en) * 2006-02-09 2010-07-01 Calpis Co. Ltd Rheumatoid arthritis-preventive agent for oral intake
BRPI0707827A2 (pt) * 2006-02-14 2011-05-10 Calpis Co Ltd vasodilatador
KR20090130303A (ko) * 2007-03-27 2009-12-22 칼피스가부시키가이샤 신부전 예방제

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2782142B2 (ja) 1992-07-23 1998-07-30 カルピス株式会社 アンジオテンシン変換酵素阻害剤及びその製造法
WO1999016862A1 (fr) * 1997-09-26 1999-04-08 Calpis Co., Ltd. Bacterie du genre lactobacillus helveticus ayant une grande capacite de production de tripeptides, produit laitier fermente et son procede de preparation
WO2007013426A1 (ja) * 2005-07-26 2007-02-01 Calpis Co., Ltd. 発酵乳の製造方法及び発酵乳飲食品
WO2007094342A1 (ja) * 2006-02-14 2007-08-23 Calpis Co., Ltd. 動脈硬化予防剤、血管内膜の肥厚抑制剤及び血管内皮機能改善剤

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
AM J HYPERTENS., vol. 10, no. 8, August 1997 (1997-08-01), pages 913 - 20
AM. J. CLIN. NUTR., vol. 64, 1996, pages 767 - 771
J. CLIN. INVEST., vol. 77, 1986, pages 1993 - 2000
J. DAIRY SCI., vol. 78, 1995, pages 777 - 78
J. DAIRY SCI., vol. 78, 1995, pages 777 - 783
J.DAIRY SCI., vol. 78, 1995, pages 1253 - 1257
SAISHIN IGAKU, vol. 48, 1993, pages 1404 - 1409
See also references of EP2130546A4 *
TWINING, S., ANAL. BIOCHEM., vol. 143, 1984, pages 3410
YAMAMOTO Y.: "Koatsuzai no Ichizuke 6) Angiotensin Henkan Koso (ACE) Sogaizai", MEDICINE AND DRUG JOURNAL, vol. 33, no. 2, 1997, pages 646 - 650 *
YAMAMOTO, N. ET AL., BIOCHEM., vol. 114, 1993, pages 740

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012176659A1 (ja) * 2011-06-24 2012-12-27 カルピス株式会社 乳酸菌発酵によるカゼイン由来ペプチドの製造方法

Also Published As

Publication number Publication date
KR20090127174A (ko) 2009-12-09
EA016808B1 (ru) 2012-07-30
EP2138184A4 (en) 2010-04-07
JP5292633B2 (ja) 2013-09-18
US20120058947A1 (en) 2012-03-08
BRPI0809319A2 (pt) 2014-09-23
US20100022747A1 (en) 2010-01-28
CN101641113A (zh) 2010-02-03
MX2009010427A (es) 2009-10-20
CA2681746C (en) 2014-04-29
KR20090130303A (ko) 2009-12-22
MX2009010428A (es) 2009-12-01
JPWO2008123095A1 (ja) 2010-07-15
JPWO2008123096A1 (ja) 2010-07-15
US20100022748A1 (en) 2010-01-28
US8673854B2 (en) 2014-03-18
CA2681551C (en) 2014-06-10
EA200970893A1 (ru) 2010-04-30
US20120077735A1 (en) 2012-03-29
CA2681551A1 (en) 2008-10-16
CN101678071A (zh) 2010-03-24
CA2681746A1 (en) 2008-10-16
EP2138184A1 (en) 2009-12-30
EP2130546A1 (en) 2009-12-09
EP2130546B1 (en) 2013-02-27
EP2138184B1 (en) 2013-09-18
WO2008123096A1 (ja) 2008-10-16
EP2130546A4 (en) 2010-03-31
JP5292632B2 (ja) 2013-09-18

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