AU2001252419A1 - Thrombin inhibitors - Google Patents
Thrombin inhibitorsInfo
- Publication number
- AU2001252419A1 AU2001252419A1 AU2001252419A AU5241901A AU2001252419A1 AU 2001252419 A1 AU2001252419 A1 AU 2001252419A1 AU 2001252419 A AU2001252419 A AU 2001252419A AU 5241901 A AU5241901 A AU 5241901A AU 2001252419 A1 AU2001252419 A1 AU 2001252419A1
- Authority
- AU
- Australia
- Prior art keywords
- thrombin inhibitors
- dipeptides
- compounds
- mimetics
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229940122388 Thrombin inhibitor Drugs 0.000 title abstract 2
- 239000003868 thrombin inhibitor Substances 0.000 title abstract 2
- 108010016626 Dipeptides Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
The invention relates to compounds that are heterocyclic derivatives of dipeptides and dipeptides mimetics and pharmaceutically acceptable salts thereof. The compounds are used as thrombin inhibitors
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SIP-200000111 | 2000-05-05 | ||
SI200000111A SI20582A (en) | 2000-05-05 | 2000-05-05 | Novel thrombine inhibitors, their preparation and use |
PCT/GB2001/001997 WO2001085760A1 (en) | 2000-05-05 | 2001-05-04 | Thrombin inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001252419A1 true AU2001252419A1 (en) | 2001-11-20 |
Family
ID=20432649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001252419A Abandoned AU2001252419A1 (en) | 2000-05-05 | 2001-05-04 | Thrombin inhibitors |
Country Status (8)
Country | Link |
---|---|
US (1) | US7112590B2 (en) |
EP (1) | EP1287018B1 (en) |
AT (1) | ATE287416T1 (en) |
AU (1) | AU2001252419A1 (en) |
DE (1) | DE60108495T2 (en) |
ES (1) | ES2239134T3 (en) |
SI (1) | SI20582A (en) |
WO (1) | WO2001085760A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050282757A1 (en) * | 2002-09-09 | 2005-12-22 | Trigen Limited | Peptide boronic acid compounds useful in anticoagulation |
US20050119226A1 (en) * | 2003-09-09 | 2005-06-02 | Trigen Limited | Methods for synthesizing organoboronic compounds and products thereof |
US20050288253A1 (en) * | 2002-09-09 | 2005-12-29 | Trigen Limited | Boronic acid salts |
GB0405272D0 (en) * | 2004-03-09 | 2004-04-21 | Trigen Ltd | Compounds |
KR100735639B1 (en) * | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | Quinazoline derivatives inhibiting the growth of cancer cell and preparation thereof |
CN102796167B (en) * | 2011-05-26 | 2014-01-08 | 首都医科大学 | (S)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine-6-formyl-L-prolyl-L-alanyl-L-amino acid, and preparation method and application thereof |
CN102807600B (en) * | 2011-06-03 | 2014-08-13 | 首都医科大学 | Amino acid modified spinacin derivative and preparation method and application thereof |
MX2014014531A (en) * | 2012-05-31 | 2015-04-08 | Hoffmann La Roche | Aminoquinazoline and pyridopyrimidine derivatives. |
CN111848730B (en) * | 2019-04-30 | 2022-06-24 | 首都医科大学 | Preparation, activity and application of theanyl tetrahydroimidazopyridine-6-formyl polar amino acid |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5510369A (en) * | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
US5523308A (en) | 1995-06-07 | 1996-06-04 | Costanzo; Michael J. | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
US5827866A (en) | 1995-06-07 | 1998-10-27 | Ortho Pharmaceutical Corporation | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
US5811402A (en) | 1996-03-22 | 1998-09-22 | Eli Lilly And Company | Antithrombotic diamides |
IL123986A (en) | 1997-04-24 | 2011-10-31 | Organon Nv | Serine protease inhibiting antithrombotic agents and pharmaceutical compositions comprising them |
-
2000
- 2000-05-05 SI SI200000111A patent/SI20582A/en not_active IP Right Cessation
-
2001
- 2001-05-04 ES ES01925739T patent/ES2239134T3/en not_active Expired - Lifetime
- 2001-05-04 AT AT01925739T patent/ATE287416T1/en not_active IP Right Cessation
- 2001-05-04 AU AU2001252419A patent/AU2001252419A1/en not_active Abandoned
- 2001-05-04 US US10/275,215 patent/US7112590B2/en not_active Expired - Fee Related
- 2001-05-04 DE DE60108495T patent/DE60108495T2/en not_active Expired - Fee Related
- 2001-05-04 WO PCT/GB2001/001997 patent/WO2001085760A1/en active IP Right Grant
- 2001-05-04 EP EP01925739A patent/EP1287018B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2239134T3 (en) | 2005-09-16 |
US7112590B2 (en) | 2006-09-26 |
DE60108495T2 (en) | 2006-01-12 |
EP1287018B1 (en) | 2005-01-19 |
EP1287018A2 (en) | 2003-03-05 |
WO2001085760A8 (en) | 2002-03-14 |
US20030191139A1 (en) | 2003-10-09 |
SI20582A (en) | 2001-12-31 |
ATE287416T1 (en) | 2005-02-15 |
DE60108495D1 (en) | 2005-02-24 |
WO2001085760A1 (en) | 2001-11-15 |
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