US20060264967A1 - Hydraulic device for the injection of bone cement in percutaneous vertebroplasty - Google Patents

Hydraulic device for the injection of bone cement in percutaneous vertebroplasty Download PDF

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Publication number
US20060264967A1
US20060264967A1 US10/549,409 US54940905A US2006264967A1 US 20060264967 A1 US20060264967 A1 US 20060264967A1 US 54940905 A US54940905 A US 54940905A US 2006264967 A1 US2006264967 A1 US 2006264967A1
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Prior art keywords
viscous material
syringe
tube
pressure
bone cement
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Abandoned
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US10/549,409
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English (en)
Inventor
Roque Ferreyro
Mario Marquez Miranda
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DePuy Spine LLC
DePuy Synthes Products Inc
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Disc O Tech Medical Technologies Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32986007&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20060264967(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Disc O Tech Medical Technologies Ltd filed Critical Disc O Tech Medical Technologies Ltd
Priority to IL174347A priority Critical patent/IL174347A0/en
Publication of US20060264967A1 publication Critical patent/US20060264967A1/en
Assigned to DISC-O-TECH MEDICAL TECHNOLOGIES, LTD. reassignment DISC-O-TECH MEDICAL TECHNOLOGIES, LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FERREYRO IRIGOYEN, ROQUE HUMBERTO, MIRANDA, MARIO MARQUEZ
Assigned to DEPUY SPINE, INC. reassignment DEPUY SPINE, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DISC-O-TECH MEDICAL TECHNOLOGIES LTD.
Assigned to DEPUY SPINE, LLC reassignment DEPUY SPINE, LLC CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: DEPUY SPINE, INC.
Assigned to HAND INNOVATIONS LLC reassignment HAND INNOVATIONS LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DEPUY SPINE, LLC
Assigned to DePuy Synthes Products, LLC reassignment DePuy Synthes Products, LLC CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: HAND INNOVATIONS LLC
Priority to US14/091,638 priority patent/US8992541B2/en
Priority to US14/614,818 priority patent/US9186194B2/en
Assigned to DePuy Synthes Products, Inc. reassignment DePuy Synthes Products, Inc. CONVERSION Assignors: DePuy Synthes Products, LLC
Priority to US14/929,628 priority patent/US10799278B2/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
    • A61B17/8819—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by the introducer proximal part, e.g. cannula handle, or by parts which are inserted inside each other, e.g. stylet and cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
    • A61B17/8822—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by means facilitating expulsion of fluid from the introducer, e.g. a screw pump plunger, hydraulic force transmissions, application of vibrations or a vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2002/4635—Special tools for implanting artificial joints using minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31586—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle

Definitions

  • This invention in a general way relates to the medical area in procedures where it is required to inject a dense or viscous fluid through a needle, in a particular way the viscous material is the polymethylmethacrylate. It is used in procedures like percutaneous vertebroplasty, kyphoplasty or other surgical events of the field. It has applications in other areas where it is required to apply at distance a dense and viscous liquid.
  • Percutaneous vertebroplasty is a minimally invasive interventional radiological procedure that consists on injecting bone cement (Polymethylmethacrylate, PMMA) in the vertebral body, by trans-pedicular or oblique approach through a bone biopsy needle.
  • bone cement Polymethylmethacrylate, PMMA
  • Vertebroplasty is a procedure that is carried out in hospital facilities that requires specialized medical personnel. It is performed in a hemodinamia room or cath lab, and it requires of the use of radiological equipment with high resolution fluoroscopy, mounted in a C arm. Currently, this injection is carried out in a manual and direct way and the operator is exposed to ionizing radiation every time that he/she practices a vertebroplasty. The injection of bone cement is made with fluoroscopic control, connecting an insulin syringe to the needle. This implies that the surgeon is in direct contact with the patient and therefore, overexposed to primary or secondary ionizing radiation during the lapse of the procedure of the vertebroplasty.
  • the primary radiation is the X ray beam coming from the X ray tube and received by the patient in a direct way
  • the secondary radiation it the one resulting on the deviation of the primary beam in the patient's body tissues and doesn't contribute to the formation of a diagnostic image, it is spread in all directions and it is the main source of exposure of medical personnel.
  • each syringe is filled approximately in half or two thirds of its capacity to avoid bending or breaking the plunger when exercising the required injecting pressure that may be considerable.
  • the volume needed to obtain the expected results varies from 3 ml up to 9 ml, therefore, 5 to 18 syringe exchanges are necessary, this favors the solidification of the polymethylmethacrylate and it can prevent to inject the wanted quantity.
  • the syringe In most of these devices the syringe is not interchangeable, it is loaded with the total volume to inject and therefore, are of larger diameter and the increased resistance to the flow of the cement becomes worse with time due to solidification of cement.
  • the conventional hypodermic syringes are not designed for high pressure injection, the plunger and the fingers supporting wings bend easily.
  • the devices of the previous technique solve only the mechanical problem of injecting the dense and viscous cement through the needle but they are focused on exercising the necessary pressure directly on the patient or at a very short distance of the radiation source. They don't allow the operator to maintain an appropriate distance to reduced exposure to secondary radiation at acceptable levels according with the international radiological protection norms.
  • the first camera that has a first transverse section and a second smaller camera than the first one. Both cameras communicate to each other.
  • the first camera includes a gate to receive the material inside the filling instrument, the second camera includes a gate to discharge the contained material.
  • a first plunger suited to pass through the first camera and displace the material.
  • a second plunger to pass through the interior of the first plunger's concentric hole and reach the interior of the second camera to displace the material through the exit in the second camera to inject into the needle toward the interior of the vertebral body.
  • the injection devices have a bolster that impels the viscous fluid by means of a manual trigger moved by a screw mechanism (inclined plane), there are others that have a gun like body such as the device of the Patent Application of the United States of America. 2002/0049448, for Sand et al, published Apr.
  • 25th, 2002 It has a tubular body that stores a viscous flowing material (bone cement), it is a longitudinal body with a providing end and a driving end, a plunger housed inside the tubular body that displaces the flowing material along the longitudinal axis of the tubular body, the driving mechanism has a handle like a gun to hold with a hand, while injecting with the other hand by means of the plunger that advances due the pressure exerted by a threaded mechanism.
  • These mechanisms with big deposits have the inconvenience that the cement can end up solidifying in the conduit at the time of application and impede to apply the total amount of cement inside the affected vertebral body.
  • the cement could leak outside of the vertebral body, since the fluid (PMMA), for its viscosity, possesses a remaining flowing memory that may be difficult to control.
  • the invention facilitates the injection of viscous filler in trabecular bone or a cavity formed in the vertebral body.
  • Another object of the present invention is to provide a hydraulic device to treat vertebral fractures and reduce the pain, stabilize the vertebral body, to obtain higher resistance to compression, avoid further collapse and at the same time, to allow early mobilization of the patients and improve their quality of life.
  • PMMA polymethylmethacrylate
  • FIG. 1 represents the connection outline of the novel hydraulic press like device for injection at distance, of the present invention.
  • FIG. 2 represents an injection device with a screw type threaded plunger of the previous technique.
  • FIG. 3 represents a device of injection of the previous technique, which has a recipient to make the mixture, another to exercise the injecting pressure.
  • each recipient contains a check valve in their exit holes to avoid re-flow
  • FIG. 4 represents a device of injection of the previous technique, which contains a larger capacity syringe in which the total amount of bone cement mixture is placed to inject, impelled by a threaded plunger.
  • FIG. 5 represents the device object of the present invention corresponding to the transverse view of the piston together with the rubber cap.
  • FIG. 6 represents the smaller, manual syringe for control of the device with the plunger and rubber cap.
  • FIG. 7 it represents the syringe of force, the conduit ( 7 ) that transmits the pressure to the larger diameter device (B) and the way to place the plunger (A) of the injecting syringe that contains the material and the injection needle.
  • FIG. 8 represents a hydraulic press, theoretical basic principles of the present invention.
  • FIG. 9 represents the pressure transmitted in the tube and the exit force generated, which pushes the plunger that injects the material through the needle.
  • the present describes a new device and method to treat affections of the bones, specifically, in the treatment of osteoporotic or fractured vertebral bodies.
  • bone structures have different pathological states of diverse ethiology (trauma, osteoporosis, primary bone tumors or metastasys, etc.).
  • An alternative of treatment to stabilize and to consolidate this structures consists on the injection of a bio-materials such polymethylmethacrylate in the interior of the vertebral body for healing purpose.
  • biomaterials such as bone cement
  • a hydraulic device exerting pressure on small caliber conventional syringes connected directly to the needle; since the cement has the property of becoming hard quickly.
  • the theoretical basic principle for the operation of the device of the present invention consists on the amplification of the hydraulic pressure generated at distance and transmitted by the hydraulic tube.
  • FIG. 9 that describes the body (B) and area ( 95 ) of the piston of larger area of the present invention, it is also represented the entrance of the pressure P 1 that is transmitted through the incompressible fluid, either water or oil, content in the flexible tube (not shown) that generates an exit force F 0 .
  • the attachment ( 2 ) for the lateral wings of the injecting syringe that contains the bone cement acts as coupler to the device, the wings enter tightly in the internal peripheral groove ( 70 ) diametrically opposed inside the bolster (header) of the body of the device object of the present invention, with a turn of 90° either clockwise or counterclockwise.
  • the plunger of the syringe enters in the longitudinal central space ( 95 ) of the body (B).
  • the hydraulic device consists of four main parts arranged one after another in such a way that allows to inject at distance and in a controlled way (regarding the pressure) viscous materials such as polymehylmethacrylate used in percutaneous vertebroplasty for the reestablishment (without surgery) of patient with osteoporotic fractures.
  • the device here described is designed to inject at distance a polymethylmethacrylate suspension with viscous consistency, directly in the cancellous bone of the vertebral bodies by means of a syringe loaded with the bone cement attached to a bone biopsy needle.
  • the device consists of four main parts, “injecting syringe” in vicinity to the patient, “pressure” exerting body, “hydraulic transmission tube” and “manual syringe”. In this, the fingers of the operator exercise the controlled force. This control is carried out by the operator's tact sensitivity.
  • This device conforms a hydraulic system for polymethylmethacrylate injection at a variable distance from the patient (usually 1 m to 1.5 m).
  • the injection part is a commercially available, disposable 3 ml. hypodermic syringe (a) that is placed next to the patient, loaded with the bone cement that consists of a plunger ( 11 ) that pushes the material (CO) to be injected in the vertebral body trough a bone needle (CA), (not shown).
  • This syringe couples tightly in a revolved way, by means of the opposed wings of support (b), in a peripheral groove in the internal face of the bolster ( 2 ) of the body of pressure, it is coupled by means of the opposed wings (b) used as support for the fingers in an act of usual injection, these wings (b) are placed in the entrance guide and rotated, either clockwise or counterclockwise an angle of 90° to stay in tightly fixed to avoid inadvertent detachment and loss of the pressure.
  • the injection needle is coupled rotating the threaded distal end (CA) in the usual way of common plastic syringes in order to avoid spillage of the material to be injected due to the high pressure exercised on the plunger (c) and its end ( 3 ).
  • the empty syringe is detached from the needle, and then from the pressure device by means of a 90° rotation, discarded ( 2 ) and replaced with another loaded syringe prepared in advance and stored in a cold environment to delay curing and hardening of the cement.
  • the syringe (a) is of 3 or 5 ml capacity.
  • the part of pressure consists of distal inverted syringe body ( 1 ) of larger diameter that the syringe at the proximal end of the complete device, It has a bolster ( 2 ) open to the atmospheric pressure that contains an internal peripheral groove where the opposed supporting wings of the injecting disposable hypodermic syringe are coupled (b) with a turn of 90°.
  • the piston moves tightly with respect of the internal wall of the device ( 1 ) by means of a rubber cap ( 4 ), to maintain a closed hydraulic space ( 5 )
  • the distal pressure is transmitted to the piston through the opening or mouthpiece ( 6 ) connected to the flexible tube of polyethylene or similar material ( 7 ) by means of the hydraulic fluid ( 10 ).
  • the rigid surface of the piston ( 3 ) exercises pressure (which has been increased by the device) on the plunger ( 1 ) of the injecting syringe.
  • the body ( 1 ) is manufactured of transparent plastic, aluminum or any other suitable light-weighted and rigid material. Other characteristics of the body will be described ( 1 ) with more detail in the FIGS. 5, 7 and 9 .
  • the hydraulic tube for pressure transmission (the Pascal's Principle), is a tube or flexible hose of polyethylene or similar material of little weight, with appropriate diameter to couple in the distant and proximal ends of the syringes, the longitude is variable, most commonly of 1.0 m to 1.50 m, it is resistant to the internal pressure.
  • the tube is loaded of water, oil or other non-compress fluid ( 10 ) to integrate together with the manual proximal syringe and the body of pressure closed hydraulic system.
  • the manual syringe ( 8 ) has a smaller diameter than the body of pressure ( 1 ) in a 2/1, 3/1 or 4/1 ratio that may vary according to the necessity of each case.
  • the longitude of the manual syringe should be larger than that of the body of pressure ( 1 ) with the purpose of containing enough volume to displace the piston the distance required to impel the plunger of the injecting syringe. this way, the quantity required of bone cement is deposited in the vertebral body.
  • the device works in the following way: a manual force is exercised on the plunger ( 9 ) of the manual syringe ( 8 ) in its extended position, the force exercises a pressure that is transmitted through the incompressible fluid ( 10 ) content in the flexible tube and in the camera ( 5 ) of the body of pressure ( 1 ).
  • This pressure exercises an increased force on the plunger of the injecting syringe, due to the mechanical advantage of the relationship of areas or displacements formerly described.
  • the plunger of the injecting syringe in turn, exert a force that impels (to) the material or cement to be injected in the patient's vertebral body through the bone biopsy needle.
  • the plunger of the manual syringe is retracted to generate space inside the body of pressure ( 1 ) by retracting the piston to replace the emptied syringe with a loaded new syringe to continue the injection.
  • up to 10 ml. of bone cement is required to achieve an suitable filling of the fractured vertebral body, therefore, 3 to 4 syringe exchanges may be necessary.
  • the bone needle stays in place during the procedure that is to say, the movements or abnormal displacements of the needle during the injection are avoided, situation that implies several advantages: For the patient, since additional punctures are less frequent and for the operator with less problems of solidification of the cement.
  • Another advantage of the device is that the transmission of the pressure is immediate, that is to say, doesn't have a dynamic memory by effects of the increasing viscosity due to the solidification in the injection conduit specially with prolonged injections, prone to happen in the injecting devices of the previous technique that are loaded with the complete volume of cement to be placed.
  • the threaded plunger doesn't allow tact sensibility regarding the exercised pressure and therefore favors unwanted leakage of the bone cement due to the dynamic memory of the material.
  • FIG. 2 that consists of a threaded plunger ( 23 ) that impels the contained cement in the camera ( 24 ) and a refilling deposit ( 22 ) that in turn feeds the camera by means of a plunger ( 21 );
  • a handle ( 25 ) that serves for support to the other hand of the operator to facilitate exercise the intense force so that the cement flows in a short tube ( 26 ) and it is injected through the needle ( 27 ).
  • the device ( 30 ) of the previous technique of the FIG. 3 contains two cameras ( 35 ) ( 32 ) connected by a valve check in the conduit ( 37 ).
  • the bone cement is mixed In the camera ( 35 ) and impelled to the injection camera ( 32 ) by means of a plunger ( 36 ), once in the injection camera the cement is impelled by the piston ( 38 ) of a plunger ( 34 ) moved by a lever that provides the required force ( 33 ), forcing the cement through the opening ( 31 ) that in turn contains a valve check that closes in the recharge operation.
  • FIG. 4 illustrate another device ( 40 ) of the previous technique for injection of polymethylmethacrylate.
  • the threaded plunger ( 41 ) has a crank ( 42 ) in the end to facilitate impel the total content of the syringe ( 45 ), and supporting elements ( 43 ) ( 44 ) for the other hand of the operator in the action of injection of the bone cement.
  • FIG. 5 represents a cut profile and front view the body of pressure ( 50 ) that shows the groove of the bolster ( 2 ) where the injecting syringe that contains the bone cement is secured. Also presents the front view and profile of the piston ( 51 ) and the rubber cap ( 52 ) that avoids spillage of the hydraulic fluid in the action of transmission of the pressure.
  • This body of pressure complies with the characteristic of being light-weighted, may be disposable or reusable, manufactured of plastic, aluminum or other suitable material able to support sterilization.
  • FIG. 6 represents frontal and lateral views of the manual or impulsion syringe ( 60 ), and plunger ( 61 ) where the rubber cap is placed ( 62 ) to avoid leakage of the hydraulic fluid.
  • the bone cement should be kept in a cold environment before it is applied so it is maintain fluid to avoid solidification in the needle.
  • the transverse cut of the cylindrical hollow body of pressure is described (B) that houses the plunger (A) of the injecting syringe secured in the peripheral groove ( 70 ) of this body of pressure, it is connected to the flexible tube ( 7 ) that transmits the hydraulic pressure ( 10 ), exercised from the manual or impulsion syringe (C) by means of its plunger ( 9 ).
  • the way the injecting syringe is attached to the body of pressure Once introduced the plunger (A) in the opening of the body of pressure (B) the syringe is turned 90° in such a way that the body of the syringe is tightly secured to proceed with the injection of the bone cement.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Surgical Instruments (AREA)
  • Medicinal Preparation (AREA)
US10/549,409 2003-03-14 2003-03-14 Hydraulic device for the injection of bone cement in percutaneous vertebroplasty Abandoned US20060264967A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IL174347A IL174347A0 (en) 2005-07-31 2006-03-16 Bone cement and methods of use thereof
US14/091,638 US8992541B2 (en) 2003-03-14 2013-11-27 Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
US14/614,818 US9186194B2 (en) 2003-03-14 2015-02-05 Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
US14/929,628 US10799278B2 (en) 2003-03-14 2015-11-02 Hydraulic device for the injection of bone cement in percutaneous vertebroplasty

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/MX2003/000027 WO2004080357A1 (fr) 2003-03-14 2003-03-14 Dispositif hydraulique d'injecton de ciment osseux utilise dans le domaine de la vertebroplastie percutanee

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PCT/MX2003/000027 A-371-Of-International WO2004080357A1 (fr) 2003-03-14 2003-03-14 Dispositif hydraulique d'injecton de ciment osseux utilise dans le domaine de la vertebroplastie percutanee

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US14/091,638 Continuation US8992541B2 (en) 2003-03-14 2013-11-27 Hydraulic device for the injection of bone cement in percutaneous vertebroplasty

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US20060264967A1 true US20060264967A1 (en) 2006-11-23

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US10/549,409 Abandoned US20060264967A1 (en) 2003-03-14 2003-03-14 Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
US14/091,638 Expired - Lifetime US8992541B2 (en) 2003-03-14 2013-11-27 Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
US14/614,818 Expired - Fee Related US9186194B2 (en) 2003-03-14 2015-02-05 Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
US14/929,628 Expired - Fee Related US10799278B2 (en) 2003-03-14 2015-11-02 Hydraulic device for the injection of bone cement in percutaneous vertebroplasty

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US14/091,638 Expired - Lifetime US8992541B2 (en) 2003-03-14 2013-11-27 Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
US14/614,818 Expired - Fee Related US9186194B2 (en) 2003-03-14 2015-02-05 Hydraulic device for the injection of bone cement in percutaneous vertebroplasty
US14/929,628 Expired - Fee Related US10799278B2 (en) 2003-03-14 2015-11-02 Hydraulic device for the injection of bone cement in percutaneous vertebroplasty

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US (4) US20060264967A1 (fr)
EP (3) EP2311408B1 (fr)
AT (1) ATE488205T1 (fr)
AU (1) AU2003214708A1 (fr)
DE (1) DE60335037D1 (fr)
ES (2) ES2353689T5 (fr)
MX (1) MXPA05009651A (fr)
WO (1) WO2004080357A1 (fr)

Cited By (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050180806A1 (en) * 2004-02-12 2005-08-18 Lawrence Green Manual pump mechanism and delivery system
US20060089715A1 (en) * 2004-06-07 2006-04-27 Csaba Truckai Implants and methods for treating bone
US20060264965A1 (en) * 2004-11-05 2006-11-23 Shadduck John H Bone treatment systems and methods
US20070118142A1 (en) * 2005-11-18 2007-05-24 Krueger John A Device, system and method for delivering a curable material into bone
US20070142842A1 (en) * 2005-11-18 2007-06-21 Krueger John A Device, system and method for delivering a curable material into bone
US20070185496A1 (en) * 2004-02-18 2007-08-09 Lorne Beckman Device for injecting a viscous material into a hard tissue
US20070197971A1 (en) * 2006-02-22 2007-08-23 Krueger John A Curable material delivery device with a rotatable supply section
US20070233250A1 (en) * 2006-02-07 2007-10-04 Shadduck John H Systems for treating bone
US20080027456A1 (en) * 2006-07-19 2008-01-31 Csaba Truckai Bone treatment systems and methods
US20080144428A1 (en) * 2005-02-23 2008-06-19 Biomet Manufacturing Corp. Method and Apparatus for Mixing Bone Cement
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US9186194B2 (en) 2015-11-17
DE60335037D1 (de) 2010-12-30
ATE488205T1 (de) 2010-12-15
US8992541B2 (en) 2015-03-31
US10799278B2 (en) 2020-10-13
ES2545328T3 (es) 2015-09-10
US20160051302A1 (en) 2016-02-25
EP2314259B1 (fr) 2015-07-29
MXPA05009651A (es) 2005-10-20
ES2353689T3 (es) 2011-03-04
US20140088605A1 (en) 2014-03-27
AU2003214708A1 (en) 2004-09-30
EP2311408A1 (fr) 2011-04-20
EP1614403A1 (fr) 2006-01-11
EP2314259A1 (fr) 2011-04-27
US20150148777A1 (en) 2015-05-28
ES2353689T5 (es) 2014-08-18
EP1614403B2 (fr) 2014-06-18
EP2311408B1 (fr) 2019-02-20
WO2004080357A1 (fr) 2004-09-23
EP1614403B1 (fr) 2010-11-17

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