TW438794B - New benzimidazole derivatives with antihistaminic activity - Google Patents

New benzimidazole derivatives with antihistaminic activity Download PDF

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Publication number
TW438794B
TW438794B TW086110371A TW86110371A TW438794B TW 438794 B TW438794 B TW 438794B TW 086110371 A TW086110371 A TW 086110371A TW 86110371 A TW86110371 A TW 86110371A TW 438794 B TW438794 B TW 438794B
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TW
Taiwan
Prior art keywords
ethyl
compound
scope
patent application
dimethyl
Prior art date
Application number
TW086110371A
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English (en)
Chinese (zh)
Inventor
Aurelio Orjales
Victor Rubio
Maravillas Bordell
Original Assignee
Espanola Prod Quimicos
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Application filed by Espanola Prod Quimicos filed Critical Espanola Prod Quimicos
Application granted granted Critical
Publication of TW438794B publication Critical patent/TW438794B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW086110371A 1996-06-04 1997-07-22 New benzimidazole derivatives with antihistaminic activity TW438794B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (1)

Publication Number Publication Date
TW438794B true TW438794B (en) 2001-06-07

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
TW086110371A TW438794B (en) 1996-06-04 1997-07-22 New benzimidazole derivatives with antihistaminic activity

Country Status (27)

Country Link
US (1) US5877187A (enExample)
EP (1) EP0818454B1 (enExample)
JP (1) JP4218991B2 (enExample)
CN (1) CN1105716C (enExample)
AR (1) AR008386A1 (enExample)
AT (1) ATE264317T1 (enExample)
AU (1) AU725700B2 (enExample)
BR (1) BR9703276A (enExample)
CA (1) CA2206754C (enExample)
CZ (1) CZ289278B6 (enExample)
DE (2) DE122011000006I1 (enExample)
DK (1) DK0818454T3 (enExample)
ES (1) ES2124167B1 (enExample)
FR (1) FR11C0023I2 (enExample)
HR (1) HRP970307B1 (enExample)
HU (1) HU227598B1 (enExample)
IN (1) IN186319B (enExample)
LU (1) LU91798I2 (enExample)
MX (1) MXPA97004127A (enExample)
NO (2) NO313195B1 (enExample)
PL (1) PL188908B1 (enExample)
PT (1) PT818454E (enExample)
RU (1) RU2182150C2 (enExample)
SI (1) SI0818454T1 (enExample)
TR (1) TR199700464A2 (enExample)
TW (1) TW438794B (enExample)
ZA (1) ZA974893B (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL140422A0 (en) 1998-07-01 2002-02-10 Retinoid Related Receptor Func Retinoid-related receptor function regulating agent
IL143303A0 (en) 1998-11-27 2002-04-21 Basf Ag Substituted benzimidazoles and their use as parp inhibitors
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
DE60216641T2 (de) * 2002-04-19 2007-09-27 Faes Farma S.A. Polymorph von 4-ä2-ä4-ä1-(2-ethoxyethyl)-1h-benzimidazol-2-ylü-1-piperidinylüethylü-alpha, alpha-dimethylbenzolessigsäure
CA2489128C (en) * 2002-06-13 2012-01-03 Vertex Pharmaceuticals Incorporated 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase iv inhibitors for the treatment of bacterial infections
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
EP2240464A4 (en) 2008-02-12 2011-09-14 Yuhan Corp PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
RU2671577C2 (ru) * 2013-03-15 2018-11-02 Геркулес Ллк Состав и способ получения композиций для личной гигиены, обладающих улучшенными характеристиками осаждения
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
LT3327012T (lt) * 2015-07-24 2021-09-10 Urquima, S.A. Bilastino kristalinės formos ir jų gamybos būdai
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
WO2017191651A1 (en) * 2016-05-05 2017-11-09 Msn Laboratories Private Limited, R & D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
HUE053233T2 (hu) 2017-10-16 2021-06-28 Faes Farma Sa Bilasztint és mometanzont tartalmazó vizes készítmények
WO2019097091A1 (en) 2017-12-18 2019-05-23 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Pharmaceutical tablet composition comprising bilastine form 3 and a water-soluble filler
ES2835287T3 (es) 2017-12-18 2021-06-22 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica de comprimido que comprende la forma polimórfica 3 de bilastina y aluminometasilicato de magnesio
KR102695627B1 (ko) 2018-01-18 2024-08-16 파에스 파마, 에스.에이. 빌라스틴, 베타-시클로덱스트린 및 적어도 하나의 겔화제를 포함하는 안과용 조성물
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
WO2022106923A1 (en) 2020-11-18 2022-05-27 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
WO2022135863A1 (en) 2020-12-23 2022-06-30 Biohorm, S.L. A non-micronized bilastine composition
JP2025508704A (ja) 2022-02-17 2025-04-10 ファエス・ファルマ・ソシエダッド・アノニマ １日１回非経口投与のためのビラスチン組成物
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
JPH05507469A (ja) * 1990-04-13 1993-10-28 スミスクライン・ビーチャム・コーポレイション 置換ベンズイミダゾール
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
PT1214937E (pt) * 1992-08-03 2007-07-25 Sepracor Inc Carboxilato de terfenadina e o tratamento de irritação dérmica.
DE69431954T2 (de) * 1993-06-25 2003-11-06 Merrell Pharmaceuticals Inc., Cincinnati Neue zwischenprodukte für die herstellung von antihistaminschen 4-diphenylmethyl/diphenylmethoxypiperidin-derivaten

Also Published As

Publication number Publication date
DE69728608T2 (de) 2005-04-21
HU9700997D0 (en) 1997-07-28
ES2124167B1 (es) 1999-09-16
IN186319B (enExample) 2001-08-04
EP0818454A1 (en) 1998-01-14
AU2467297A (en) 1997-12-11
NO972525L (no) 1997-12-05
CN1176964A (zh) 1998-03-25
MXPA97004127A (es) 2005-07-25
TR199700464A3 (tr) 1997-12-21
CA2206754C (en) 2007-01-23
BR9703276A (pt) 2004-08-17
JP4218991B2 (ja) 2009-02-04
PT818454E (pt) 2004-08-31
HUP9700997A1 (hu) 1999-09-28
JPH1059961A (ja) 1998-03-03
PL320358A1 (en) 1997-12-08
NO2011008I2 (no) 2012-05-14
HU227598B1 (en) 2011-09-28
ATE264317T1 (de) 2004-04-15
SI0818454T1 (en) 2004-08-31
FR11C0023I1 (enExample) 2011-08-19
NO2011008I1 (no) 2011-06-06
EP0818454B1 (en) 2004-04-14
CZ172397A3 (en) 1997-12-17
HRP970307B1 (en) 2002-02-28
DK0818454T3 (da) 2004-07-12
TR199700464A2 (xx) 1997-12-21
LU91798I2 (fr) 2011-05-23
HRP970307A2 (en) 1998-04-30
AU725700B2 (en) 2000-10-19
CZ289278B6 (cs) 2001-12-12
US5877187A (en) 1999-03-02
CN1105716C (zh) 2003-04-16
AR008386A1 (es) 2000-01-19
FR11C0023I2 (fr) 2012-03-16
NO313195B1 (no) 2002-08-26
RU2182150C2 (ru) 2002-05-10
NO972525D0 (no) 1997-06-03
CA2206754A1 (en) 1997-12-04
ZA974893B (en) 1997-12-30
DE69728608D1 (de) 2004-05-19
ES2124167A1 (es) 1999-01-16
PL188908B1 (pl) 2005-05-31
DE122011000006I1 (de) 2011-06-16

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