BR9703276A - Novos derivados de benzimidazol com atividade anti-histamìnica - Google Patents

Novos derivados de benzimidazol com atividade anti-histamìnica

Info

Publication number
BR9703276A
BR9703276A BR9703276-0A BR9703276A BR9703276A BR 9703276 A BR9703276 A BR 9703276A BR 9703276 A BR9703276 A BR 9703276A BR 9703276 A BR9703276 A BR 9703276A
Authority
BR
Brazil
Prior art keywords
benzimidazole derivatives
antihistamine
novel benzimidazole
activity
antihistamine activity
Prior art date
Application number
BR9703276-0A
Other languages
English (en)
Inventor
Aurelio Orjales
Victor Rubio
Maravillas Bordell
Original Assignee
Espanola Prod Quimicos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Espanola Prod Quimicos filed Critical Espanola Prod Quimicos
Publication of BR9703276A publication Critical patent/BR9703276A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"NOVOS DERIVADOS DE BENZIMIDAZOL com ATIVIDADE ANTI-HISTAMìNICA". São descritos novos derivados de benzimidazol de fórmula: em que R~ 1~ é hidrogênio ou um grupo hidrocarboneto de cadeia curta, como metila, etila, isopropila, ciclopropila, vinila, e outros, e R~ 2~, é um grupo selecionado dentre CH~ 2~OH, COOH, COOR~ 3~ e 4,4-dimetil-2-oxazolinila, R~ 3~ sendo um grupo alquila de cadeia curta, como metila, etila, e outros. Também se descreve a preparação desses compostos, que têm uma alta atividade anti-histamínica H~ 1~ e antialérgica e que são livres de efeitos sobre os sistemas nervoso central e cardiovascular.
BR9703276-0A 1996-06-04 1997-06-04 Novos derivados de benzimidazol com atividade anti-histamìnica BR9703276A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (1)

Publication Number Publication Date
BR9703276A true BR9703276A (pt) 2004-08-17

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9703276-0A BR9703276A (pt) 1996-06-04 1997-06-04 Novos derivados de benzimidazol com atividade anti-histamìnica

Country Status (27)

Country Link
US (1) US5877187A (pt)
EP (1) EP0818454B1 (pt)
JP (1) JP4218991B2 (pt)
CN (1) CN1105716C (pt)
AR (1) AR008386A1 (pt)
AT (1) ATE264317T1 (pt)
AU (1) AU725700B2 (pt)
BR (1) BR9703276A (pt)
CA (1) CA2206754C (pt)
CZ (1) CZ289278B6 (pt)
DE (2) DE122011000006I1 (pt)
DK (1) DK0818454T3 (pt)
ES (1) ES2124167B1 (pt)
FR (1) FR11C0023I2 (pt)
HR (1) HRP970307B1 (pt)
HU (1) HU227598B1 (pt)
IN (1) IN186319B (pt)
LU (1) LU91798I2 (pt)
MX (1) MXPA97004127A (pt)
NO (2) NO313195B1 (pt)
PL (1) PL188908B1 (pt)
PT (1) PT818454E (pt)
RU (1) RU2182150C2 (pt)
SI (1) SI0818454T1 (pt)
TR (1) TR199700464A3 (pt)
TW (1) TW438794B (pt)
ZA (1) ZA974893B (pt)

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ID29247A (id) 1998-07-01 2001-08-16 Takeda Chemical Industries Ltd Bahan pengatur fungsi reseptor retinoid
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ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
BRPI0215703B8 (pt) * 2002-04-19 2021-05-25 Faes Farma Sa polimorfo de ácido 4-[2-[1-(2-etoxietil)-1h-benzidimazol-2-il]-1-piperidinil]etil]-a, a-dimetil-benzenoacético, preparado farmacêutico, e seu uso do polimorfo 1
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
CN101952273B (zh) 2008-02-12 2014-11-12 柳韩洋行 2-甲基2’-苯基丙酸衍生物的制备方法和中间体化合物
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
RU2671577C2 (ru) * 2013-03-15 2018-11-02 Геркулес Ллк Состав и способ получения композиций для личной гигиены, обладающих улучшенными характеристиками осаждения
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
ES2874577T3 (es) * 2015-07-24 2021-11-05 Urquima Sa Formas cristalinas de bilastina y procedimientos para su preparación
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
WO2017191651A1 (en) * 2016-05-05 2017-11-09 Msn Laboratories Private Limited, R & D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
EP3453384B1 (en) 2017-09-07 2020-05-27 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine
LT3681475T (lt) 2017-10-16 2021-02-25 Faes Farma, S.A. Vandeninės kompozicijos, apimančios bilastiną ir mometazoną
EP3470062B1 (en) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate
ES2773756R1 (es) 2017-12-18 2021-04-12 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende la forma 3 de bilastina y una carga soluble en agua
DK3740191T3 (da) 2018-01-18 2021-06-07 Faes Farma Sa Oftalmiske sammensætninger omfattende bilastin, et beta-cyclodextrin og mindst et geleringsmiddel
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
EP4247331A1 (en) 2020-11-18 2023-09-27 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
EP4267109A1 (en) 2020-12-23 2023-11-01 Noucor Health S.A. A non-micronized bilastine composition
WO2023156559A1 (en) 2022-02-17 2023-08-24 Faes Farma, S.A. Bilastine composition for once-daily parenteral administration

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
RO116043B1 (ro) * 1992-08-03 2000-10-30 Sepracor Inc Compozitie farmaceutica
JP3712208B2 (ja) * 1993-06-25 2005-11-02 メレルファーマスーティカルズ インコーポレイテッド 抗ヒスタミン性の４−ジフェニルメチル／ジフェニルメトキシピペリジン誘導体類を製造する新規な中間体

Also Published As

Publication number Publication date
HU227598B1 (en) 2011-09-28
US5877187A (en) 1999-03-02
JPH1059961A (ja) 1998-03-03
SI0818454T1 (en) 2004-08-31
FR11C0023I2 (fr) 2012-03-16
HUP9700997A1 (hu) 1999-09-28
CA2206754A1 (en) 1997-12-04
AR008386A1 (es) 2000-01-19
MXPA97004127A (es) 2005-07-25
FR11C0023I1 (pt) 2011-08-19
PL320358A1 (en) 1997-12-08
DE122011000006I1 (de) 2011-06-16
PL188908B1 (pl) 2005-05-31
HU9700997D0 (en) 1997-07-28
CZ289278B6 (cs) 2001-12-12
LU91798I2 (fr) 2011-05-23
ATE264317T1 (de) 2004-04-15
NO313195B1 (no) 2002-08-26
NO2011008I1 (no) 2011-06-06
NO972525D0 (no) 1997-06-03
IN186319B (pt) 2001-08-04
HRP970307B1 (en) 2002-02-28
ES2124167B1 (es) 1999-09-16
DK0818454T3 (da) 2004-07-12
EP0818454B1 (en) 2004-04-14
TW438794B (en) 2001-06-07
EP0818454A1 (en) 1998-01-14
RU2182150C2 (ru) 2002-05-10
DE69728608D1 (de) 2004-05-19
NO972525L (no) 1997-12-05
TR199700464A2 (xx) 1997-12-21
ZA974893B (en) 1997-12-30
PT818454E (pt) 2004-08-31
HRP970307A2 (en) 1998-04-30
CZ172397A3 (en) 1997-12-17
DE69728608T2 (de) 2005-04-21
AU2467297A (en) 1997-12-11
CA2206754C (en) 2007-01-23
TR199700464A3 (tr) 1997-12-21
CN1105716C (zh) 2003-04-16
AU725700B2 (en) 2000-10-19
NO2011008I2 (no) 2012-05-14
ES2124167A1 (es) 1999-01-16
CN1176964A (zh) 1998-03-25
JP4218991B2 (ja) 2009-02-04

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Legal Events

Date Code Title Description
FA12 Dismissal: dismissal - article 216, par. 2 of industrial property law
HKFN Application deemed withdrawn (deleted)
B03H Publication of an application: rectification [chapter 3.8 patent gazette]
B25D Requested change of name of applicant approved

Owner name: FAES FARMA, S.A. (ES)

Free format text: ALTERADO DE: FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS S.A. (FAES)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/10/2007, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]