DK0818454T3 - Benzimidazolderivater med antihistamin-aktivitet - Google Patents

Benzimidazolderivater med antihistamin-aktivitet

Info

Publication number
DK0818454T3
DK0818454T3 DK97500099T DK97500099T DK0818454T3 DK 0818454 T3 DK0818454 T3 DK 0818454T3 DK 97500099 T DK97500099 T DK 97500099T DK 97500099 T DK97500099 T DK 97500099T DK 0818454 T3 DK0818454 T3 DK 0818454T3
Authority
DK
Denmark
Prior art keywords
benzimidazole derivatives
antihistamine activity
antihistamine
activity
benzimidazole
Prior art date
Application number
DK97500099T
Other languages
Danish (da)
English (en)
Inventor
Aurelio Orjales
Victor Rubio
Maravillas Bordell
Original Assignee
Faes Farma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faes Farma Sa filed Critical Faes Farma Sa
Application granted granted Critical
Publication of DK0818454T3 publication Critical patent/DK0818454T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK97500099T 1996-06-04 1997-06-03 Benzimidazolderivater med antihistamin-aktivitet DK0818454T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (1)

Publication Number Publication Date
DK0818454T3 true DK0818454T3 (da) 2004-07-12

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97500099T DK0818454T3 (da) 1996-06-04 1997-06-03 Benzimidazolderivater med antihistamin-aktivitet

Country Status (27)

Country Link
US (1) US5877187A (pt)
EP (1) EP0818454B1 (pt)
JP (1) JP4218991B2 (pt)
CN (1) CN1105716C (pt)
AR (1) AR008386A1 (pt)
AT (1) ATE264317T1 (pt)
AU (1) AU725700B2 (pt)
BR (1) BR9703276A (pt)
CA (1) CA2206754C (pt)
CZ (1) CZ289278B6 (pt)
DE (2) DE69728608T2 (pt)
DK (1) DK0818454T3 (pt)
ES (1) ES2124167B1 (pt)
FR (1) FR11C0023I2 (pt)
HR (1) HRP970307B1 (pt)
HU (1) HU227598B1 (pt)
IN (1) IN186319B (pt)
LU (1) LU91798I2 (pt)
MX (1) MXPA97004127A (pt)
NO (2) NO313195B1 (pt)
PL (1) PL188908B1 (pt)
PT (1) PT818454E (pt)
RU (1) RU2182150C2 (pt)
SI (1) SI0818454T1 (pt)
TR (1) TR199700464A3 (pt)
TW (1) TW438794B (pt)
ZA (1) ZA974893B (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1314899A (zh) 1998-07-01 2001-09-26 武田药品工业株式会社 视黄酸类相关的受体机能调节剂
IL143303A0 (en) 1998-11-27 2002-04-21 Basf Ag Substituted benzimidazoles and their use as parp inhibitors
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
CA2484460C (en) * 2002-04-19 2009-09-29 Faes Farma, S.A. Polymorph of 4-[2-[4-[1-(2-ethoxyethyl)-1h-benzimidazole-2-yl]-1-piperidinyl]ethyl]-.alpha..alpha. dimethyl-benzeneacetic acid
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
KR101123903B1 (ko) 2008-02-12 2012-03-23 주식회사유한양행 2-메틸-2'-페닐프로피온산 유도체의 제조 방법 및 이에 사용되는 신규한 중간체 화합물
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
WO2014149019A1 (en) * 2013-03-15 2014-09-25 Hercules Incorporated Composition and method of producing personal care compositions with improved deposition properties
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
SI3327012T1 (sl) * 2015-07-24 2021-10-29 Urquima Sa Kristalinične oblike bilastina in postopki za pripravo le-teh
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
WO2017191651A1 (en) * 2016-05-05 2017-11-09 Msn Laboratories Private Limited, R & D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
EP3453384B1 (en) 2017-09-07 2020-05-27 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine
US11642309B2 (en) 2017-10-16 2023-05-09 Faes Farma, S.A. Aqueous compositions comprising bilastine and mometasone
ES2864176T3 (es) 2017-12-18 2021-10-13 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende la forma 3 de bilastina y una carga soluble en agua
EP3470062B1 (en) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate
MA51612B1 (fr) 2018-01-18 2021-06-30 Faes Farma Sa Compositions ophtalmiques comprenant de la bilastine, une bêta-cyclodextrine et au moins un agent gélifiant
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
JP2023549381A (ja) 2020-11-18 2023-11-24 バイオファーマ・シナジーズ，エス．エル． 抗ヒスタミン活性化合物を含む口内分散性粉末組成物
EP4267109A1 (en) 2020-12-23 2023-11-01 Noucor Health S.A. A non-micronized bilastine composition
WO2023156559A1 (en) 2022-02-17 2023-08-24 Faes Farma, S.A. Bilastine composition for once-daily parenteral administration

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
PT815860E (pt) * 1992-08-03 2006-08-31 Sepracor Inc Carboxilato de terfenadina e tratamento de desordens alergicas.
CN1168717C (zh) * 1993-06-25 2004-09-29 默里尔药物公司 用于制备抗组胺哌啶衍生物的新中间体

Also Published As

Publication number Publication date
TW438794B (en) 2001-06-07
FR11C0023I1 (pt) 2011-08-19
DE69728608D1 (de) 2004-05-19
CN1176964A (zh) 1998-03-25
CZ172397A3 (en) 1997-12-17
HRP970307A2 (en) 1998-04-30
TR199700464A2 (xx) 1997-12-21
ES2124167A1 (es) 1999-01-16
BR9703276A (pt) 2004-08-17
ES2124167B1 (es) 1999-09-16
NO972525L (no) 1997-12-05
LU91798I2 (fr) 2011-05-23
NO972525D0 (no) 1997-06-03
JP4218991B2 (ja) 2009-02-04
DE122011000006I1 (de) 2011-06-16
HU227598B1 (en) 2011-09-28
CA2206754A1 (en) 1997-12-04
MXPA97004127A (es) 2005-07-25
PL188908B1 (pl) 2005-05-31
EP0818454B1 (en) 2004-04-14
JPH1059961A (ja) 1998-03-03
FR11C0023I2 (fr) 2012-03-16
NO313195B1 (no) 2002-08-26
CN1105716C (zh) 2003-04-16
CZ289278B6 (cs) 2001-12-12
DE69728608T2 (de) 2005-04-21
SI0818454T1 (en) 2004-08-31
US5877187A (en) 1999-03-02
PL320358A1 (en) 1997-12-08
NO2011008I1 (no) 2011-06-06
PT818454E (pt) 2004-08-31
AU725700B2 (en) 2000-10-19
RU2182150C2 (ru) 2002-05-10
NO2011008I2 (no) 2012-05-14
IN186319B (pt) 2001-08-04
AU2467297A (en) 1997-12-11
EP0818454A1 (en) 1998-01-14
HU9700997D0 (en) 1997-07-28
HUP9700997A1 (hu) 1999-09-28
CA2206754C (en) 2007-01-23
TR199700464A3 (tr) 1997-12-21
ZA974893B (en) 1997-12-30
ATE264317T1 (de) 2004-04-15
HRP970307B1 (en) 2002-02-28
AR008386A1 (es) 2000-01-19

Similar Documents

Publication Publication Date Title
DK0818454T3 (da) Benzimidazolderivater med antihistamin-aktivitet
PT900210E (pt) Derivados azahexano heterociclicos com actividade antviral
ATE246700T1 (de) Benzimidazolderivate
DE69525418T2 (de) Benzimidazol-derivate
NO994791D0 (no) Nikotinamid-derivater
ATE236155T1 (de) Naphthyridin-derivate
DE69716266T2 (de) Sprachaktivitätsdetektor
NO970088L (no) Acylazolonderivater med anti-Helicobacteraktivitet
DE69720051T2 (de) Harnstoffderivate
DE69721347D1 (de) Sprachaktivitätserkennung
DK0779887T3 (da) Hidtil ukendte benzimidazolderivater med CGMP-phosphodiesteraseinhiberende aktivitet
NO932146D0 (no) Benzimidazolderivater
NO970086D0 (no) Heterocykliske azolonderivater med anti-Helicobacteraktivitet
KR970703765A (ko) 약리학적 활성을 갖는 2- 메르캅토벤조이미다졸 유도체(2-mercaptobenzimidazole derivatives possessing the pharmacological activity)
DK1030850T3 (da) Azolinderivater
ATE214063T1 (de) Heterocyclische substituierte pyrrolidinamid- derivate
NO970498D0 (no) Benzimidazolderivater med dopaminergisk aktivitet