FR11C0023I2 - Derives de benzimidazole a activite antihistaminique - Google Patents

Derives de benzimidazole a activite antihistaminique

Info

Publication number
FR11C0023I2
FR11C0023I2 FR11C0023C FR11C0023C FR11C0023I2 FR 11C0023 I2 FR11C0023 I2 FR 11C0023I2 FR 11C0023 C FR11C0023 C FR 11C0023C FR 11C0023 C FR11C0023 C FR 11C0023C FR 11C0023 I2 FR11C0023 I2 FR 11C0023I2
Authority
FR
France
Prior art keywords
benzimidazole derivatives
antihistaminic activity
antihistaminic
activity
benzimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR11C0023C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fabrica Espanola De Productos Qui
Original Assignee
Fabrica Espanola De Productos Qui
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabrica Espanola De Productos Qui filed Critical Fabrica Espanola De Productos Qui
Publication of FR11C0023I1 publication Critical patent/FR11C0023I1/fr
Application granted granted Critical
Publication of FR11C0023I2 publication Critical patent/FR11C0023I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR11C0023C 1996-06-04 2011-07-08 Derives de benzimidazole a activite antihistaminique Active FR11C0023I2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (2)

Publication Number Publication Date
FR11C0023I1 FR11C0023I1 (fr) 2011-08-19
FR11C0023I2 true FR11C0023I2 (fr) 2012-03-16

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
FR11C0023C Active FR11C0023I2 (fr) 1996-06-04 2011-07-08 Derives de benzimidazole a activite antihistaminique

Country Status (27)

Country Link
US (1) US5877187A (fr)
EP (1) EP0818454B1 (fr)
JP (1) JP4218991B2 (fr)
CN (1) CN1105716C (fr)
AR (1) AR008386A1 (fr)
AT (1) ATE264317T1 (fr)
AU (1) AU725700B2 (fr)
BR (1) BR9703276A (fr)
CA (1) CA2206754C (fr)
CZ (1) CZ289278B6 (fr)
DE (2) DE122011000006I1 (fr)
DK (1) DK0818454T3 (fr)
ES (1) ES2124167B1 (fr)
FR (1) FR11C0023I2 (fr)
HR (1) HRP970307B1 (fr)
HU (1) HU227598B1 (fr)
IN (1) IN186319B (fr)
LU (1) LU91798I2 (fr)
MX (1) MXPA97004127A (fr)
NO (2) NO313195B1 (fr)
PL (1) PL188908B1 (fr)
PT (1) PT818454E (fr)
RU (1) RU2182150C2 (fr)
SI (1) SI0818454T1 (fr)
TR (1) TR199700464A2 (fr)
TW (1) TW438794B (fr)
ZA (1) ZA974893B (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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WO2000001679A1 (fr) 1998-07-01 2000-01-13 Takeda Chemical Industries, Ltd. Regulateurs du recepteur associe aux retinoides
TR200101498T2 (tr) 1998-11-27 2001-11-21 Basf Aktiengesellschaft İkameli benzimidazoller ve parp inhibitörleri olarak kullanımları
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
JP5142448B2 (ja) * 2002-04-19 2013-02-13 ファエス・ファルマ・ソシエダッド・アノニマ ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
CN104402773A (zh) 2008-02-12 2015-03-11 柳韩洋行 2-甲基-2’-苯基丙酸衍生物的制备方法和中间体化合物
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
US20140271504A1 (en) * 2013-03-15 2014-09-18 Hercules Incorporated Composition and method of producing personal care compositions with improved deposition properties
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
WO2014188453A2 (fr) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Nouveau procédé de préparation de l'acide 2-[4-(2-{4-[1-(2-éthoxyéthyl)-1h-benzimidazol-2-yl]-1-pipéridinyl}éthyl) phényl]-2-méthylpropanoïque
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (fr) 2014-12-29 2016-07-06 Faes Farma, S.A. Nouveaux dérivés de benzimidazole en tant qu'agents antihistaminiques
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
ES2600827B9 (es) * 2015-07-24 2018-03-28 Urquima, S.A Formas cristalinas de bilastina y procedimientos para su preparación
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170817A1 (fr) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-cristaux de composés de benzimidazole
EP3170816A1 (fr) 2015-11-20 2017-05-24 Faes Farma, S.A. Compositions sursaturées de composés de benzimidazole
WO2017167949A1 (fr) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Formes cristallines de bilastine
EP3452462A4 (fr) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center Formes à l'état solide d'acide 2-[4-(2-{4-[1-(2-éthoxyéthyl)-1h-benzimidazol-2-yl]-1-pipéridinyl}éthyl)phényl]-2-méthylpropanoïque et procédé de préparation associé
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
MA50247B1 (fr) 2017-10-16 2021-02-26 Faes Farma Sa Compositions aqueuses comprenant de la bilastine et du mométasone
WO2019097091A1 (fr) 2017-12-18 2019-05-23 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Composition de comprimé pharmaceutique comprenant une forme de bilastine 3 et une charge soluble dans l'eau
EP3470062B1 (fr) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Composition de comprimé pharmaceutique comprenant de la bilastine polymorphe forme 3 et de l'aluminométasilicate de magnésium
CN111727035B (zh) 2018-01-18 2024-05-28 费斯制药股份有限公司 包含比拉斯汀、β-环糊精和至少一种胶凝剂的眼用组合物
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (fr) 2019-04-16 2020-10-21 Faes Farma, S.A. Compositions pharmaceutiques stables et préservées de bilastine
EP4188339A1 (fr) 2020-07-30 2023-06-07 Faes Farma, S.A. Système d'administration de médicaments décongestionnants
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
EP4247331A1 (fr) 2020-11-18 2023-09-27 BioPharma Synergies, S. L. Composition de poudre orodispersible comprenant un composé antihistaminique
EP4267109A1 (fr) 2020-12-23 2023-11-01 Noucor Health S.A. Composition non micronisée de bilastine
WO2023156559A1 (fr) 2022-02-17 2023-08-24 Faes Farma, S.A. Composition de bilastine pour administration parentérale une fois par jour

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
ES2284740T3 (es) * 1992-08-03 2007-11-16 Sepracor Inc. Carboxilato de terfenadina y el tratamiento de la irritacion cutanea.
CN1275916C (zh) * 1993-06-25 2006-09-20 阿温蒂斯公司 用于制备抗组胺哌啶衍生物的新中间体

Also Published As

Publication number Publication date
CA2206754C (fr) 2007-01-23
CZ289278B6 (cs) 2001-12-12
CZ172397A3 (en) 1997-12-17
CA2206754A1 (fr) 1997-12-04
DE122011000006I1 (de) 2011-06-16
PL320358A1 (en) 1997-12-08
NO972525L (no) 1997-12-05
ES2124167B1 (es) 1999-09-16
FR11C0023I1 (fr) 2011-08-19
US5877187A (en) 1999-03-02
TR199700464A3 (tr) 1997-12-21
AU725700B2 (en) 2000-10-19
EP0818454A1 (fr) 1998-01-14
DK0818454T3 (da) 2004-07-12
HU9700997D0 (en) 1997-07-28
LU91798I2 (fr) 2011-05-23
AU2467297A (en) 1997-12-11
ES2124167A1 (es) 1999-01-16
MXPA97004127A (es) 2005-07-25
DE69728608T2 (de) 2005-04-21
TR199700464A2 (xx) 1997-12-21
HU227598B1 (en) 2011-09-28
ATE264317T1 (de) 2004-04-15
JPH1059961A (ja) 1998-03-03
NO313195B1 (no) 2002-08-26
IN186319B (fr) 2001-08-04
SI0818454T1 (en) 2004-08-31
EP0818454B1 (fr) 2004-04-14
NO972525D0 (no) 1997-06-03
RU2182150C2 (ru) 2002-05-10
HRP970307B1 (en) 2002-02-28
PT818454E (pt) 2004-08-31
PL188908B1 (pl) 2005-05-31
AR008386A1 (es) 2000-01-19
NO2011008I2 (no) 2012-05-14
BR9703276A (pt) 2004-08-17
CN1176964A (zh) 1998-03-25
NO2011008I1 (no) 2011-06-06
HRP970307A2 (en) 1998-04-30
JP4218991B2 (ja) 2009-02-04
CN1105716C (zh) 2003-04-16
HUP9700997A1 (hu) 1999-09-28
ZA974893B (en) 1997-12-30
TW438794B (en) 2001-06-07
DE69728608D1 (de) 2004-05-19

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