ATE264317T1 - Benzimidazol-derivate mit antihistaminischer wirkung - Google Patents

Benzimidazol-derivate mit antihistaminischer wirkung

Info

Publication number
ATE264317T1
ATE264317T1 AT97500099T AT97500099T ATE264317T1 AT E264317 T1 ATE264317 T1 AT E264317T1 AT 97500099 T AT97500099 T AT 97500099T AT 97500099 T AT97500099 T AT 97500099T AT E264317 T1 ATE264317 T1 AT E264317T1
Authority
AT
Austria
Prior art keywords
benzimidazole derivatives
antihistaminic effect
antihistaminic
effect
benzimidazole
Prior art date
Application number
AT97500099T
Other languages
English (en)
Inventor
Aurelio Orjales
Victor Rubio
Maravillas Bordell
Original Assignee
Espanola Prod Quimicos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Espanola Prod Quimicos filed Critical Espanola Prod Quimicos
Application granted granted Critical
Publication of ATE264317T1 publication Critical patent/ATE264317T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT97500099T 1996-06-04 1997-06-03 Benzimidazol-derivate mit antihistaminischer wirkung ATE264317T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (1)

Publication Number Publication Date
ATE264317T1 true ATE264317T1 (de) 2004-04-15

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97500099T ATE264317T1 (de) 1996-06-04 1997-06-03 Benzimidazol-derivate mit antihistaminischer wirkung

Country Status (27)

Country Link
US (1) US5877187A (de)
EP (1) EP0818454B1 (de)
JP (1) JP4218991B2 (de)
CN (1) CN1105716C (de)
AR (1) AR008386A1 (de)
AT (1) ATE264317T1 (de)
AU (1) AU725700B2 (de)
BR (1) BR9703276A (de)
CA (1) CA2206754C (de)
CZ (1) CZ289278B6 (de)
DE (2) DE69728608T2 (de)
DK (1) DK0818454T3 (de)
ES (1) ES2124167B1 (de)
FR (1) FR11C0023I2 (de)
HR (1) HRP970307B1 (de)
HU (1) HU227598B1 (de)
IN (1) IN186319B (de)
LU (1) LU91798I2 (de)
MX (1) MXPA97004127A (de)
NO (2) NO313195B1 (de)
PL (1) PL188908B1 (de)
PT (1) PT818454E (de)
RU (1) RU2182150C2 (de)
SI (1) SI0818454T1 (de)
TR (1) TR199700464A2 (de)
TW (1) TW438794B (de)
ZA (1) ZA974893B (de)

Families Citing this family (40)

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HUP0102470A3 (en) 1998-07-01 2002-05-28 Takeda Chemical Industries Ltd 1,3-azole derivatives as retinoid-associated receptor regulators and their use
CZ300148B6 (cs) 1998-11-27 2009-02-25 Abbott Gmbh & Co. Kg Derivát substituovaného benzimidazolu, zpusob jeho prípravy a jeho použití
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
PT1505066E (pt) * 2002-04-19 2007-03-30 Faes Farma Sa Polimorfo do ácido 4-[2-[4-[1-(2-etoxietil)-1h-benzimidazol-2-il]-1-piperidinil]etil]-alfa,alfa-dimetil-benzenoacético
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
CN101952273B (zh) * 2008-02-12 2014-11-12 柳韩洋行 2-甲基2’-苯基丙酸衍生物的制备方法和中间体化合物
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
KR102066476B1 (ko) * 2013-03-15 2020-01-15 허큘레스 엘엘씨 개선된 침적 특성을 가진 조성물 및 개선된 침적 특성을 가진 개인 관리 조성물의 제조 방법
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (de) 2014-12-29 2016-07-06 Faes Farma, S.A. Neue Benzimidazolderivate als Antihistaminmittel
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
KR102657147B1 (ko) * 2015-07-24 2024-04-12 울퀴마, 에스. 에이. 빌라스틴의 결정형 및 그의 제조 방법
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170817A1 (de) 2015-11-20 2017-05-24 Faes Farma, S.A. Cokristalle von benzimidazolverbindungen
EP3170816A1 (de) 2015-11-20 2017-05-24 Faes Farma, S.A. Übersättigte zusammensetzungen von benzimidazolverbindungen
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
EP3452462A4 (de) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center Feststoffformen von 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methyl-propansäure und verfahren zur herstellung davon
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
CA3079303A1 (en) 2017-10-16 2019-04-25 Faes Farma, S.A. Aqueous compositions comprising bilastine and mometasone
EP3641735B1 (de) 2017-12-18 2021-02-24 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmazeutische tablettenzusammensetzung mit bilastinform 3 und wasserlöslichem füllstoff
ES2835287T3 (es) 2017-12-18 2021-06-22 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica de comprimido que comprende la forma polimórfica 3 de bilastina y aluminometasilicato de magnesio
PL3740191T3 (pl) 2018-01-18 2021-11-29 Faes Farma, S.A. Kompozycje oftalmiczne zawierające bilastynę, beta-cyklodektrynę i co najmniej jeden środek żelatujący
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (de) 2019-04-16 2020-10-21 Faes Farma, S.A. Stabile und konservierte pharmazeutische zusammensetzungen von bilastin
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
US20230414597A1 (en) 2020-11-18 2023-12-28 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
EP4267109A1 (de) 2020-12-23 2023-11-01 Noucor Health S.A. Nichtmikronisierte bilastinzusammensetzung
AU2023221541A1 (en) 2022-02-17 2024-08-08 Faes Farma, S.A. Bilastine composition for once-daily parenteral administration

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
DK0815860T3 (da) * 1992-08-03 2006-08-14 Sepracor Inc Terfenadincarboxylat og behandlingen af allergiske lidelser
CN1275916C (zh) * 1993-06-25 2006-09-20 阿温蒂斯公司 用于制备抗组胺哌啶衍生物的新中间体

Also Published As

Publication number Publication date
ES2124167B1 (es) 1999-09-16
HRP970307B1 (en) 2002-02-28
PL320358A1 (en) 1997-12-08
JP4218991B2 (ja) 2009-02-04
US5877187A (en) 1999-03-02
HU227598B1 (en) 2011-09-28
CZ289278B6 (cs) 2001-12-12
DK0818454T3 (da) 2004-07-12
MXPA97004127A (es) 2005-07-25
PT818454E (pt) 2004-08-31
PL188908B1 (pl) 2005-05-31
CN1176964A (zh) 1998-03-25
AU725700B2 (en) 2000-10-19
CA2206754C (en) 2007-01-23
NO972525D0 (no) 1997-06-03
AU2467297A (en) 1997-12-11
CN1105716C (zh) 2003-04-16
ZA974893B (en) 1997-12-30
IN186319B (de) 2001-08-04
TR199700464A3 (tr) 1997-12-21
CZ172397A3 (en) 1997-12-17
TR199700464A2 (xx) 1997-12-21
NO2011008I1 (no) 2011-06-06
FR11C0023I2 (fr) 2012-03-16
LU91798I2 (fr) 2011-05-23
TW438794B (en) 2001-06-07
DE122011000006I1 (de) 2011-06-16
NO972525L (no) 1997-12-05
HUP9700997A1 (hu) 1999-09-28
NO2011008I2 (no) 2012-05-14
EP0818454A1 (de) 1998-01-14
HRP970307A2 (en) 1998-04-30
JPH1059961A (ja) 1998-03-03
EP0818454B1 (de) 2004-04-14
DE69728608T2 (de) 2005-04-21
ES2124167A1 (es) 1999-01-16
NO313195B1 (no) 2002-08-26
AR008386A1 (es) 2000-01-19
FR11C0023I1 (de) 2011-08-19
DE69728608D1 (de) 2004-05-19
SI0818454T1 (en) 2004-08-31
CA2206754A1 (en) 1997-12-04
RU2182150C2 (ru) 2002-05-10
HU9700997D0 (en) 1997-07-28
BR9703276A (pt) 2004-08-17

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