CO5261551A1 - Nuevos derivados de biarileter utiles como inhibidores de la recaptacion de monoaminas - Google Patents

Nuevos derivados de biarileter utiles como inhibidores de la recaptacion de monoaminas

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Publication number
CO5261551A1
CO5261551A1 CO00077988A CO00077988A CO5261551A1 CO 5261551 A1 CO5261551 A1 CO 5261551A1 CO 00077988 A CO00077988 A CO 00077988A CO 00077988 A CO00077988 A CO 00077988A CO 5261551 A1 CO5261551 A1 CO 5261551A1
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CO
Colombia
Prior art keywords
ring
attached
nitrogen
independently selected
alkyl
Prior art date
Application number
CO00077988A
Other languages
English (en)
Inventor
Jr Harry Ralph Howard
Diane Adam Mavis
Original Assignee
Pfizer Prod Inc
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Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CO5261551A1 publication Critical patent/CO5261551A1/es

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Abstract

Un compuesto de Fórmula <EMI FILE="00077988_1" ID="1" IMF=JPEG >en la que el anillo fenilo A y el anillo fenilo B pueden estar, independientemente, reemplazados por un grupo naftilo, y en la que cuando el anillo fenilo A está reemplazado por un grupo naftilo, el oxígeno etéreo de la estructura I y el carbono al que R3, R4 y NR1R2 están unidos, están unidos átomos de carbono adyacentes del anillo del grupo naftilo y ninguno de los citados átomos de carbono adyacentes del anillo está también adyacente a un átomo de carbono del anillo condensado del citado grupo naftilo; n y m se seleccionan independientemente de uno, dos y tres; R1 y R2 se seleccionan independientemente de hidrógeno, alquilo (C1-C4), alquenilo (C2-C4) y alquinilo (C2-C4), o R1 y R2, junto con el nitrógeno al que están unidos, forman un anillo saturado de cuatro a ocho miembros que contiene uno o dos heteroátomos, incluyendo el nitrógeno al que R1 y R2 están ligados, estando seleccionado el segundo heteroátomo, cuando está presente, de oxígeno, nitrógeno y azufre, y pudiendo estar el citado anillo opcionalmente sustituido en los sitios de unión disponibles con de uno a tres sustituyentes seleccionados independientemente de hidroxi y alquilo (C1-C6); R3 y R4 se seleccionan independientemente de hidrógeno y alquilo (C1-C4) opcionalmente sustituido con de uno a tres átomos de flúor, o R3 y R4 junto con el carbono al que están unidos pueden formar un anillo carbocíclico saturado de cuatro a ocho miembros, y pudiendo estar el citado anillo opcionalmente sustituido en los sitios de unión disponibles con de uno a tres sustituyentes seleccionados independientemente de hidroxi y alquilo (C1-C6); o R2 y R3, junto con el nitrógeno al que R2 está unido y el carbono al que R3 está unido, forman un anillo saturado de cuatro a ocho miembros que contiene uno o dos heteroátomos, incluyendo el nitrógeno al que R2 está unido, estando seleccionado el segundo heteroátomo, cuando está presente, de oxígeno, nitrógeno y azufre, y pudiendo estar el citado anillo opcionalmente sustituido en los sitios de unión disponibles con de uno a tres sustituyentes seleccionados independientemente de hidroxi y alquilo (C1-C6); ...
CO00077988A 1999-10-13 2000-10-12 Nuevos derivados de biarileter utiles como inhibidores de la recaptacion de monoaminas CO5261551A1 (es)

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