ATE406894T1 - 4-(2-phenylsulfanyl-phenyl)-piperidin-derivate als serotonin-wiederaufnahme-hemmer - Google Patents
4-(2-phenylsulfanyl-phenyl)-piperidin-derivate als serotonin-wiederaufnahme-hemmerInfo
- Publication number
- ATE406894T1 ATE406894T1 AT04725291T AT04725291T ATE406894T1 AT E406894 T1 ATE406894 T1 AT E406894T1 AT 04725291 T AT04725291 T AT 04725291T AT 04725291 T AT04725291 T AT 04725291T AT E406894 T1 ATE406894 T1 AT E406894T1
- Authority
- AT
- Austria
- Prior art keywords
- reuppost
- phenylsulfanyl
- serotonin
- inhibitors
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46052803P | 2003-04-04 | 2003-04-04 | |
| DKPA200300520 | 2003-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE406894T1 true ATE406894T1 (de) | 2008-09-15 |
Family
ID=33132909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04725291T ATE406894T1 (de) | 2003-04-04 | 2004-04-02 | 4-(2-phenylsulfanyl-phenyl)-piperidin-derivate als serotonin-wiederaufnahme-hemmer |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7732463B2 (de) |
| EP (1) | EP1626720B1 (de) |
| JP (1) | JP4667366B2 (de) |
| AT (1) | ATE406894T1 (de) |
| AU (1) | AU2004226838B8 (de) |
| CA (1) | CA2521258C (de) |
| CO (1) | CO5700748A2 (de) |
| CY (1) | CY1108464T1 (de) |
| DE (1) | DE602004016316D1 (de) |
| DK (1) | DK1626720T3 (de) |
| ES (1) | ES2309514T3 (de) |
| HR (1) | HRP20080478T3 (de) |
| IL (1) | IL171087A (de) |
| MX (1) | MXPA05009592A (de) |
| NO (1) | NO20055208L (de) |
| PL (1) | PL1626720T3 (de) |
| PT (1) | PT1626720E (de) |
| SI (1) | SI1626720T1 (de) |
| WO (1) | WO2004087156A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| EP1792629A4 (de) | 2004-08-25 | 2010-08-25 | Takeda Pharmaceutical | Mittel zur prävention/behandlung von stressbedingter harninkontinenz und vorsorgeuntersuchungsverfahren dafür |
| EP2018863B9 (de) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Kondensierte, heterocyclische Verbindung und ihre Verwendung |
| EP2439201B1 (de) | 2006-06-16 | 2013-08-07 | H. Lundbeck A/S | Verbindungen mit kombinierter sert, 5-ht3 und 5-ht1a-aktivität |
| TWI405588B (zh) * | 2007-03-20 | 2013-08-21 | Lundbeck & Co As H | ４-〔２-（４-甲苯基硫基）-苯基〕哌啶之鹽類的液體調配物 |
| TWI432194B (zh) * | 2007-03-20 | 2014-04-01 | Lundbeck & Co As H | ４-〔２-（４-甲基苯硫基）苯基〕哌啶之新穎治療用途 |
| TW200932233A (en) | 2007-11-13 | 2009-08-01 | Lundbeck & Co As H | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity |
| US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
| TW200938194A (en) * | 2007-12-14 | 2009-09-16 | Lundbeck & Co As H | Therapeutic uses of compounds having affinity to the serotonin transporter, serotonin receptors and noradrenalin transporter |
| TW200932225A (en) * | 2007-12-14 | 2009-08-01 | Lundbeck & Co As H | 4-[2,3-difluoro-6-(2-fluoro-4-methyl-phenylsulfanyl)-phenyl]-piperidine |
| UA98698C2 (en) * | 2008-03-03 | 2012-06-11 | Х. Луннбек А/С | Phenylsulfanylphenyl-piperidines and process for the preparation thereof |
| KR101779214B1 (ko) | 2009-04-24 | 2017-09-18 | 하. 룬드벡 아크티에셀스카브 | １―［２―（２，４―디메틸페닐술파닐）페닐］피페라진 염의 액체 제형 |
| JPWO2011071136A1 (ja) | 2009-12-11 | 2013-04-22 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
| CN102970982B (zh) * | 2010-04-30 | 2015-01-14 | 武田药品工业株式会社 | 肠溶片剂 |
| JP5787881B2 (ja) * | 2010-04-30 | 2015-09-30 | 武田薬品工業株式会社 | 腸溶性錠剤 |
| JPWO2019131902A1 (ja) | 2017-12-27 | 2020-12-10 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
| EP3762379A1 (de) | 2018-03-07 | 2021-01-13 | Bayer Aktiengesellschaft | Identifizierung und verwendung von erk5-inhibitoren |
| WO2023218484A1 (en) | 2022-05-11 | 2023-11-16 | Pi Industries Ltd. | Bicyclic compounds and their use as pest control agents |
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| US3803143A (en) | 1969-09-08 | 1974-04-09 | Eisai Co Ltd | 6-amino alkylene 6,7-dihydro-5h-dibenzo (b,g),(1,5)thiazocines |
| US4018830A (en) | 1969-09-22 | 1977-04-19 | Merck & Co., Inc. | Phenylthioaralkylamines |
| US4055665A (en) | 1974-11-25 | 1977-10-25 | Merck & Co., Inc. | Treating arrythmia with phenylthioaralkylamines |
| US4066654A (en) | 1975-04-16 | 1978-01-03 | G. D. Searle & Co. | 1-triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives |
| US4056632A (en) | 1975-07-21 | 1977-11-01 | Burroughs Wellcome Co. | 2-Hydroxymethyl-2'-aminomethyl-diphenylsulfides and method of use |
| DE2802306A1 (de) * | 1977-01-27 | 1978-08-10 | Hoechst Ag | Azacycloalkane, azacycloalkene und ihre derivate |
| US4241071A (en) * | 1977-01-27 | 1980-12-23 | American Hoechst Corporation | Antidepressant (α-phenyl-2-tolyl)azacycloalkanes |
| US4198417A (en) | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Phenoxyphenylpiperidines |
| US4198419A (en) * | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Phenylthiophenylpiperidines |
| DE3640475A1 (de) | 1986-11-27 | 1988-06-09 | Hoechst Sa Lab | Arzneimittel auf basis von derivaten des 3,4-diphenylpiperidins, die verwendung der derivate als arzneimittel sowie neue 3,4-diphenylpiperidinderivate und verfahren zu ihrer herstellung |
| EP0396827A1 (de) | 1989-05-09 | 1990-11-14 | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu | 2-Phenylthiobenzylamin-Derivate und Säureadditionssalze davon |
| GB8912971D0 (en) * | 1989-06-06 | 1989-07-26 | Wellcome Found | Halogen substituted diphenylsulfides |
| GB9126311D0 (en) | 1991-12-11 | 1992-02-12 | Wellcome Found | Substituted diphenylsulfides |
| EP0755923B1 (de) | 1995-01-23 | 2005-05-04 | Daiichi Suntory Pharma Co., Ltd. | Verbesserung oder heilung von durch ischämischen krankheiten hervorgerufenen symtomen und dafür verwendbare phenylpiperidinverbingungen |
| AU7567596A (en) | 1995-11-06 | 1997-05-29 | Gist-Brocades B.V. | De-esterification process |
| CZ293595A3 (cs) | 1995-11-09 | 1999-12-15 | Farmak A. S. | Deriváty N,N-dimethyl-2-(arylthio)benzylaminu, jejich soli, způsoby jejich přípravy a jejich použití v léčivých přípravcích |
| US5912256A (en) | 1996-06-20 | 1999-06-15 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| JP2000516936A (ja) | 1996-08-27 | 2000-12-19 | アメリカン・ホーム・プロダクツ・コーポレイション | ドパミンｄ２作動薬としておよび５―ｈｔ１ａリガンドとしての４―アミノエトキシインドール |
| US6297239B1 (en) | 1997-10-08 | 2001-10-02 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| GB9725953D0 (en) | 1997-12-08 | 1998-02-04 | Pfizer Ltd | Compounds useful in therapy |
| YU56301A (sh) | 1999-02-23 | 2004-05-12 | Pfizer Products Inc. | Inhibitori resorpcije monoamina za tretiranje poremećaja cns |
| CN1351588A (zh) | 1999-04-02 | 2002-05-29 | 伊科斯公司 | 白细胞功能相关抗原与细胞间粘着分子结合的抑制剂及其用途 |
| ES2264259T3 (es) | 1999-04-30 | 2006-12-16 | Trustees Of The University Of Pennsylvania | Agentes de obtencion de imagenes por spect (tomografia por emision de foton unico) para transportador de serotonina. |
| AU6621600A (en) | 1999-08-04 | 2001-03-05 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| US6410736B1 (en) | 1999-11-29 | 2002-06-25 | Pfizer Inc. | Biaryl ether derivatives useful as monoamine reuptake inhibitors |
| KR100524159B1 (ko) | 1999-10-13 | 2005-10-25 | 화이자 프로덕츠 인코포레이티드 | 모노아민 재흡수 억제제로서 유용한 비아릴 에테르 유도체 |
| JP2003519227A (ja) | 1999-12-30 | 2003-06-17 | ハー・ルンドベック・アクチエゼルスカベット | 置換されたベンゼン誘導体の製造方法 |
| CZ20022319A3 (cs) * | 1999-12-30 | 2002-10-16 | H. Lundbeck A/S | Substituovaná fenylpiperazinová sloučenina a farmaceutický prostředek, který ji obsahuje |
| US6436938B1 (en) | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
| US20020107244A1 (en) * | 2001-02-02 | 2002-08-08 | Howard Harry R. | Combination treatment for depression |
| EP1363890A4 (de) | 2001-02-07 | 2009-06-10 | Ore Pharmaceuticals Inc | Melanocortin-4-rezeptor bindende verbindungen und verfahren zu deren anwendung |
| NZ529631A (en) | 2001-06-07 | 2006-08-31 | F | Indole derivatives with 5-hydroxytryptamine (5-HT) 5-HT6 receptor affinity in the treatment of disorders of the CNS |
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| CA2467337A1 (en) | 2001-12-21 | 2003-07-10 | H. Lundbeck A/S | Aminoindane derivatives as serotonin and norepinephrine uptake inhibitors |
| AR043633A1 (es) | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
| PL1635828T3 (pl) | 2003-04-04 | 2008-10-31 | H Lundbeck As | Pochodne 4-(2-fenyloksyfenylo)-piperydyny lub 1,2,3,6-tetrahydropirydyny jako inhibitory wychwytu zwrotnego serotoniny |
| UA81300C2 (en) | 2003-04-04 | 2007-12-25 | Lundbeck & Co As H | Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture |
| WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
-
2004
- 2004-04-02 JP JP2006504349A patent/JP4667366B2/ja not_active Expired - Fee Related
- 2004-04-02 WO PCT/DK2004/000244 patent/WO2004087156A1/en active IP Right Grant
- 2004-04-02 PT PT04725291T patent/PT1626720E/pt unknown
- 2004-04-02 MX MXPA05009592A patent/MXPA05009592A/es active IP Right Grant
- 2004-04-02 DK DK04725291T patent/DK1626720T3/da active
- 2004-04-02 US US10/551,883 patent/US7732463B2/en not_active Expired - Fee Related
- 2004-04-02 CA CA002521258A patent/CA2521258C/en not_active Expired - Fee Related
- 2004-04-02 DE DE602004016316T patent/DE602004016316D1/de not_active Expired - Lifetime
- 2004-04-02 AU AU2004226838A patent/AU2004226838B8/en not_active Ceased
- 2004-04-02 SI SI200430864T patent/SI1626720T1/sl unknown
- 2004-04-02 PL PL04725291T patent/PL1626720T3/pl unknown
- 2004-04-02 ES ES04725291T patent/ES2309514T3/es not_active Expired - Lifetime
- 2004-04-02 EP EP04725291A patent/EP1626720B1/de not_active Expired - Lifetime
- 2004-04-02 AT AT04725291T patent/ATE406894T1/de active
-
2005
- 2005-09-25 IL IL171087A patent/IL171087A/en not_active IP Right Cessation
- 2005-11-03 CO CO05112440A patent/CO5700748A2/es not_active Application Discontinuation
- 2005-11-04 NO NO20055208A patent/NO20055208L/no not_active Application Discontinuation
-
2008
- 2008-09-26 HR HR20080478T patent/HRP20080478T3/xx unknown
- 2008-10-30 CY CY20081101225T patent/CY1108464T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1626720A1 (de) | 2006-02-22 |
| HRP20080478T3 (en) | 2009-02-28 |
| NO20055208L (no) | 2005-11-04 |
| US20060100242A1 (en) | 2006-05-11 |
| PT1626720E (pt) | 2008-11-10 |
| EP1626720B1 (de) | 2008-09-03 |
| WO2004087156A1 (en) | 2004-10-14 |
| AU2004226838B8 (en) | 2009-06-11 |
| PL1626720T3 (pl) | 2009-02-27 |
| CA2521258C (en) | 2009-12-01 |
| SI1626720T1 (sl) | 2008-12-31 |
| JP2006522030A (ja) | 2006-09-28 |
| IL171087A (en) | 2011-01-31 |
| MXPA05009592A (es) | 2005-10-18 |
| CA2521258A1 (en) | 2004-10-14 |
| AU2004226838A1 (en) | 2004-10-14 |
| CO5700748A2 (es) | 2006-11-30 |
| DK1626720T3 (da) | 2008-12-01 |
| AU2004226838B2 (en) | 2009-02-12 |
| JP4667366B2 (ja) | 2011-04-13 |
| ES2309514T3 (es) | 2008-12-16 |
| CY1108464T1 (el) | 2014-04-09 |
| US7732463B2 (en) | 2010-06-08 |
| DE602004016316D1 (de) | 2008-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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