CO5700748A2 - Derivados de 4-(2-fenilsulfanil-fenil)-piperidina como inhibidores de recaptacion de serotonina - Google Patents

Derivados de 4-(2-fenilsulfanil-fenil)-piperidina como inhibidores de recaptacion de serotonina

Info

Publication number
CO5700748A2
CO5700748A2 CO05112440A CO05112440A CO5700748A2 CO 5700748 A2 CO5700748 A2 CO 5700748A2 CO 05112440 A CO05112440 A CO 05112440A CO 05112440 A CO05112440 A CO 05112440A CO 5700748 A2 CO5700748 A2 CO 5700748A2
Authority
CO
Colombia
Prior art keywords
phenylsulphanyl
serotonine
piperidine
phenyl
derivatives
Prior art date
Application number
CO05112440A
Other languages
English (en)
Inventor
Ask Puschl
Morten Jorgensen
Thomas Ruhland
Stensbol Tine Bryan
Andersen Benny Bang
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of CO5700748A2 publication Critical patent/CO5700748A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached

Abstract

1.- Un compuesto representado por la fórmula general I en la cual R1, R2, R3, R4, R5 se seleccionan en forma independiente de hidrógeno, halógeno, ciano, alq(uen/uin)ilo C1-6, alq(uen/uin)iloxi C1-6, alq(uen/uin)il C1-6 sulfanilo, hidroxi, hidroxi-alq(uen/uin)ilo C1-6, haloalq(uen/uin)ilo C1-6, halo-alq(uen/uin)iloxi C1-6, o NRxRy en los cuales Rx y Ry se seleccionan en forma independiente de hidrógeno, alq(uen/uin)ilo C1-6, ciano-alq(uen/uin)ilo C1-6, cicloalq(uen)ilo C3-8, cicloalq(uen)il C3-8-alq(uen/uin)ilo C1-6, o NRzRw-alq(uen/uin)ilo C1-6, en los cuales Rz y Rw se seleccionan en forma independiente de hidrógeno, alq(uen/uin)ilo C1-6, cicloalq(uen)ilo C3-8, o cicloalq(uen)iI C3-8-alq(uen/uin)ilo C1-6; o Rx y Ry junto con el nitrógeno al cual están unidos forman un anillo de 3-7 miembros que contiene, en forma opcional, un heteroátomo adicional;R6, R7, R8, R9 se seleccionan en forma independiente de hidrógeno, halógeno, alq(uen/uin)ilo C1-6, alq(uen/uin)iloxi C1-6, alq(uen/uin)il C1-6 sulfanilo, hidroxi, hidroxi-alq(uen/uin)ilo C1-6, halo-alq(uen/uin)ilo C1-6, halo- alq(uen/uin)iloxi C1-6, o NRxRy en los cuales Rx y Ry se seleccionan en forma independiente de hidrógeno, alq(uen/uin)ilo C1-6, ciano-alq(uen/uin)ilo C1-6, cicloalq(uen)ilo C3-8, cicloalq(uen)il C3-8-alq(uen/uin)ilo C1-6, o NRzRw-alq(uen/uin)ilo C1-6, en los cuales Rz y Rw se seleccionan en forma independiente de hidrógeno, alq(uen/uin)ilo C1-6, cicloalq(uen)ilo C3-8, cicloalq(uen)il C3-8-alq(uen/uin)ilo C1-6; o Rx y Ry junto con el nitrógeno al cual están unidos forman un anillo de 3-7 miembros que contiene, en forma opcional, un heteroátomo adicional;siempre que por lo menos uno de R1, R2, R3, R4, R5, R6, R7, R8, y R9 sea distinto de hidrógeno; además, siempre que cuando R3 es metilo, entonces por lo menos uno de R1, R2, R4, R5, R6, R7, R8, R9 sea distinto de hidrógeno;o una de sus sales.
CO05112440A 2003-04-04 2005-11-03 Derivados de 4-(2-fenilsulfanil-fenil)-piperidina como inhibidores de recaptacion de serotonina CO5700748A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46052803P 2003-04-04 2003-04-04
DKPA200300520 2003-04-04

Publications (1)

Publication Number Publication Date
CO5700748A2 true CO5700748A2 (es) 2006-11-30

Family

ID=33132909

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05112440A CO5700748A2 (es) 2003-04-04 2005-11-03 Derivados de 4-(2-fenilsulfanil-fenil)-piperidina como inhibidores de recaptacion de serotonina

Country Status (19)

Country Link
US (1) US7732463B2 (es)
EP (1) EP1626720B1 (es)
JP (1) JP4667366B2 (es)
AT (1) ATE406894T1 (es)
AU (1) AU2004226838B8 (es)
CA (1) CA2521258C (es)
CO (1) CO5700748A2 (es)
CY (1) CY1108464T1 (es)
DE (1) DE602004016316D1 (es)
DK (1) DK1626720T3 (es)
ES (1) ES2309514T3 (es)
HR (1) HRP20080478T3 (es)
IL (1) IL171087A (es)
MX (1) MXPA05009592A (es)
NO (1) NO20055208L (es)
PL (1) PL1626720T3 (es)
PT (1) PT1626720E (es)
SI (1) SI1626720T1 (es)
WO (1) WO2004087156A1 (es)

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JP5173190B2 (ja) 2004-08-25 2013-03-27 武田薬品工業株式会社 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法
EP2018863B9 (en) 2006-05-16 2015-02-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
AR061481A1 (es) 2006-06-16 2008-08-27 Lundbeck & Co As H Compuestos con actividad combinada sobre sert, 5-ht3 y 5-ht1a
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EP2421534B1 (en) 2009-04-24 2014-09-03 H. Lundbeck A/S Liquid formulations of salts of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
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Also Published As

Publication number Publication date
ES2309514T3 (es) 2008-12-16
AU2004226838B2 (en) 2009-02-12
DE602004016316D1 (de) 2008-10-16
ATE406894T1 (de) 2008-09-15
AU2004226838B8 (en) 2009-06-11
CA2521258A1 (en) 2004-10-14
PT1626720E (pt) 2008-11-10
CA2521258C (en) 2009-12-01
SI1626720T1 (sl) 2008-12-31
HRP20080478T3 (en) 2009-02-28
AU2004226838A1 (en) 2004-10-14
WO2004087156A1 (en) 2004-10-14
EP1626720B1 (en) 2008-09-03
DK1626720T3 (da) 2008-12-01
PL1626720T3 (pl) 2009-02-27
NO20055208L (no) 2005-11-04
JP4667366B2 (ja) 2011-04-13
MXPA05009592A (es) 2005-10-18
JP2006522030A (ja) 2006-09-28
CY1108464T1 (el) 2014-04-09
US20060100242A1 (en) 2006-05-11
IL171087A (en) 2011-01-31
EP1626720A1 (en) 2006-02-22
US7732463B2 (en) 2010-06-08

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