DE602005021871D1 - 4-aminopiperidinderivate als inhibitoren der monoamin-aufnahme - Google Patents

4-aminopiperidinderivate als inhibitoren der monoamin-aufnahme

Info

Publication number
DE602005021871D1
DE602005021871D1 DE602005021871T DE602005021871T DE602005021871D1 DE 602005021871 D1 DE602005021871 D1 DE 602005021871D1 DE 602005021871 T DE602005021871 T DE 602005021871T DE 602005021871 T DE602005021871 T DE 602005021871T DE 602005021871 D1 DE602005021871 D1 DE 602005021871D1
Authority
DE
Germany
Prior art keywords
inhibitors
monoamine
intrusion
aminopiperidine derivatives
aminopiperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005021871T
Other languages
English (en)
Inventor
Serge Louis Boulet
Barry Peter Clark
John Fairhurst
Peter Thaddeus Gallagher
Anette Margareta Johansson
Maria Ann Whatton
Virginia Ann Wood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE602005021871D1 publication Critical patent/DE602005021871D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE602005021871T 2004-02-27 2005-02-11 4-aminopiperidinderivate als inhibitoren der monoamin-aufnahme Active DE602005021871D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54867904P 2004-02-27 2004-02-27
PCT/US2005/004174 WO2005092885A1 (en) 2004-02-27 2005-02-11 4-amino-piperidine derivatives as monoamine uptake inhibitors

Publications (1)

Publication Number Publication Date
DE602005021871D1 true DE602005021871D1 (de) 2010-07-29

Family

ID=34961148

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005021871T Active DE602005021871D1 (de) 2004-02-27 2005-02-11 4-aminopiperidinderivate als inhibitoren der monoamin-aufnahme

Country Status (6)

Country Link
US (1) US7521462B2 (de)
EP (1) EP1735302B1 (de)
AT (1) ATE471320T1 (de)
DE (1) DE602005021871D1 (de)
ES (1) ES2345261T3 (de)
WO (1) WO2005092885A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0716532A2 (pt) 2006-09-11 2013-09-24 Glaxo Group Ltd compostos azabicÍclios como inidores de reabsorÇço de monoaminas
WO2008103615A1 (en) * 2007-02-21 2008-08-28 Kalypsys, Inc. Isoquinolines useful as inducible nitric oxide synthase inhibitors
EP2008996A1 (de) * 2007-06-27 2008-12-31 Syngeta Participations AG Verfahren zur Herstellung von Pyrazolen
EP2224923A4 (de) 2007-11-28 2013-05-15 Sequoia Pharmaceuticals Inc Zusammensetzungen und verfahren zur hemmung von zytochrom p450 2d6
CN109526218B (zh) * 2016-03-31 2021-07-06 富士胶片富山化学株式会社 5-溴甲基-1-苯并噻吩的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
US4861785A (en) * 1984-12-03 1989-08-29 Janssen Pharmaceutica N.V. Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents
GB9226111D0 (en) 1992-12-15 1993-02-10 Smithkline Beecham Plc Madicaments
US6303627B1 (en) 1998-06-19 2001-10-16 Eli Lilly And Company Inhibitors of serotonin reuptake
ES2157148B1 (es) 1998-11-18 2002-03-01 Faes Fabrica Espanola De Produ Nuevas piperidinas 4-sustituidas.
US6498161B1 (en) 1999-04-06 2002-12-24 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
MXPA02002115A (es) 1999-09-14 2002-10-31 Abbott Lab Compuestos de eter 3-pirrolidiniloxi-3'-piridilico, utiles para controlar la transmision sinaptica quimica. .
GB0011838D0 (en) 2000-05-17 2000-07-05 Astrazeneca Ab Chemical compounds
KR20030029978A (ko) 2000-09-25 2003-04-16 액테리온 파마슈티칼 리미티드 말라리아에 유용한 치환된 아미노-아자-사이클로알칸
US7812035B2 (en) 2001-12-11 2010-10-12 Sepracor Inc. 4-substituted piperidines, and methods of use thereof
CN1326519C (zh) 2001-12-14 2007-07-18 诺沃挪第克公司 化合物及其降低激素－敏感性脂肪酶活性的用途
MY134200A (en) 2002-04-12 2007-11-30 Kowa Co Method for treating cancer
US20060079554A1 (en) 2002-12-06 2006-04-13 Barry Peter C Inhibitors of monomine uptake
WO2005000811A1 (en) 2003-06-11 2005-01-06 Eli Lilly And Company 3-aminopyrrolidines as inhibitors of monoamine uptake
EP1638560A1 (de) 2003-06-20 2006-03-29 Eli Lilly And Company 3-aminopiperidine und 3-aminochinuclidine als hemmer der monoamin-aufname

Also Published As

Publication number Publication date
WO2005092885A1 (en) 2005-10-06
ES2345261T3 (es) 2010-09-20
EP1735302A1 (de) 2006-12-27
US7521462B2 (en) 2009-04-21
US20070093526A1 (en) 2007-04-26
ATE471320T1 (de) 2010-07-15
EP1735302B1 (de) 2010-06-16

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Legal Events

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8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN