HU227598B1 - Benzimidazole derivatives and antihistaminic pharmaceutical compositions containing them - Google Patents

Benzimidazole derivatives and antihistaminic pharmaceutical compositions containing them Download PDF

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Publication number
HU227598B1
HU227598B1 HU9700997A HUP9700997A HU227598B1 HU 227598 B1 HU227598 B1 HU 227598B1 HU 9700997 A HU9700997 A HU 9700997A HU P9700997 A HUP9700997 A HU P9700997A HU 227598 B1 HU227598 B1 HU 227598B1
Authority
HU
Hungary
Prior art keywords
ethyl
pharmaceutically acceptable
addition salts
base
acid
Prior art date
Application number
HU9700997A
Other languages
English (en)
Hungarian (hu)
Inventor
Maravillas Bordell
Aurelio Orjales
Victor Rubio
Original Assignee
Faes Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faes Farma filed Critical Faes Farma
Publication of HU9700997D0 publication Critical patent/HU9700997D0/hu
Publication of HUP9700997A1 publication Critical patent/HUP9700997A1/hu
Publication of HU227598B1 publication Critical patent/HU227598B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU9700997A 1996-06-04 1997-06-04 Benzimidazole derivatives and antihistaminic pharmaceutical compositions containing them HU227598B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (3)

Publication Number Publication Date
HU9700997D0 HU9700997D0 (en) 1997-07-28
HUP9700997A1 HUP9700997A1 (hu) 1999-09-28
HU227598B1 true HU227598B1 (en) 2011-09-28

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700997A HU227598B1 (en) 1996-06-04 1997-06-04 Benzimidazole derivatives and antihistaminic pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US5877187A (enExample)
EP (1) EP0818454B1 (enExample)
JP (1) JP4218991B2 (enExample)
CN (1) CN1105716C (enExample)
AR (1) AR008386A1 (enExample)
AT (1) ATE264317T1 (enExample)
AU (1) AU725700B2 (enExample)
BR (1) BR9703276A (enExample)
CA (1) CA2206754C (enExample)
CZ (1) CZ289278B6 (enExample)
DE (2) DE122011000006I1 (enExample)
DK (1) DK0818454T3 (enExample)
ES (1) ES2124167B1 (enExample)
FR (1) FR11C0023I2 (enExample)
HR (1) HRP970307B1 (enExample)
HU (1) HU227598B1 (enExample)
IN (1) IN186319B (enExample)
LU (1) LU91798I2 (enExample)
MX (1) MXPA97004127A (enExample)
NO (2) NO313195B1 (enExample)
PL (1) PL188908B1 (enExample)
PT (1) PT818454E (enExample)
RU (1) RU2182150C2 (enExample)
SI (1) SI0818454T1 (enExample)
TR (1) TR199700464A3 (enExample)
TW (1) TW438794B (enExample)
ZA (1) ZA974893B (enExample)

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BR9911752A (pt) 1998-07-01 2001-04-03 Takeda Chemical Industries Ltd Agente de regulagem da função do receptor relacionado com a retinóide, derivados de oxazol, de imidazol e de tiazol, composto, processo para regular uma função de receptor relacionado com a retinóide, e, uso de um derivado
SK285529B6 (sk) 1998-11-27 2007-03-01 Basf Aktiengesellschaft Substituované benzimidazoly, farmaceutická kompozícia s ich obsahom a ich použitie ako inhibítorov PARP
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
NZ536551A (en) * 2002-04-19 2006-08-31 Faes Farma S Preparation of polymorphous cyrstalline form, known as bilastine, and its antihistaminic and antiallergenic use
WO2003105846A1 (en) * 2002-06-13 2003-12-24 Vertex Pharmaceuticals Incorporated 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase iv inhibitors for the treatment of bacterial infections
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
CN101952273B (zh) * 2008-02-12 2014-11-12 柳韩洋行 2-甲基2’-苯基丙酸衍生物的制备方法和中间体化合物
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
EP2969019A1 (en) * 2013-03-15 2016-01-20 Hercules Incorporated Composition and method of producing personal care compositions with improved deposition properties
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
SI3327012T1 (sl) * 2015-07-24 2021-10-29 Urquima Sa Kristalinične oblike bilastina in postopki za pripravo le-teh
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
EP3452462A4 (en) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
MX2020003834A (es) 2017-10-16 2020-08-06 Faes Farma Sa Composiciones acuosas que comprenden bilastina y mometasona.
ES2864176T3 (es) 2017-12-18 2021-10-13 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende la forma 3 de bilastina y una carga soluble en agua
EP3470062B1 (en) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate
EA202091725A1 (ru) 2018-01-18 2020-10-12 Фаэс Фарма С.А. Офтальмические композиции, содержащие биластин, бета-циклодекстрин и по крайней мере одно желатинирующее вещество
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
PE20231844A1 (es) 2020-07-30 2023-11-21 Faes Farma Sa Sistema de liberacion de farmacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
US20230414597A1 (en) 2020-11-18 2023-12-28 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
CA3200779A1 (en) 2020-12-23 2022-06-30 Strusi ORAZIO LUCA A non-micronized bilastine composition
WO2023156559A1 (en) 2022-02-17 2023-08-24 Faes Farma, S.A. Bilastine composition for once-daily parenteral administration
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
CA2077897A1 (en) * 1990-04-13 1991-10-14 Robert G. Franz Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
ES2257757T3 (es) * 1992-08-03 2006-08-01 Sepracor Inc. Carboxilato de terfenadina y el tratamiento de trastornos alergicos.
EP0705245B1 (en) * 1993-06-25 2003-01-02 Merrell Pharmaceuticals Inc. Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives

Also Published As

Publication number Publication date
CZ172397A3 (en) 1997-12-17
NO2011008I2 (no) 2012-05-14
NO2011008I1 (no) 2011-06-06
JP4218991B2 (ja) 2009-02-04
PL320358A1 (en) 1997-12-08
DE122011000006I1 (de) 2011-06-16
ATE264317T1 (de) 2004-04-15
ES2124167A1 (es) 1999-01-16
CA2206754A1 (en) 1997-12-04
AU725700B2 (en) 2000-10-19
TR199700464A2 (xx) 1997-12-21
HRP970307B1 (en) 2002-02-28
AU2467297A (en) 1997-12-11
TW438794B (en) 2001-06-07
NO972525L (no) 1997-12-05
NO313195B1 (no) 2002-08-26
LU91798I2 (fr) 2011-05-23
PL188908B1 (pl) 2005-05-31
EP0818454B1 (en) 2004-04-14
DK0818454T3 (da) 2004-07-12
CN1105716C (zh) 2003-04-16
BR9703276A (pt) 2004-08-17
ES2124167B1 (es) 1999-09-16
FR11C0023I2 (fr) 2012-03-16
ZA974893B (en) 1997-12-30
HUP9700997A1 (hu) 1999-09-28
IN186319B (enExample) 2001-08-04
US5877187A (en) 1999-03-02
HU9700997D0 (en) 1997-07-28
CA2206754C (en) 2007-01-23
DE69728608T2 (de) 2005-04-21
HRP970307A2 (en) 1998-04-30
PT818454E (pt) 2004-08-31
RU2182150C2 (ru) 2002-05-10
FR11C0023I1 (enExample) 2011-08-19
CZ289278B6 (cs) 2001-12-12
NO972525D0 (no) 1997-06-03
CN1176964A (zh) 1998-03-25
AR008386A1 (es) 2000-01-19
TR199700464A3 (tr) 1997-12-21
JPH1059961A (ja) 1998-03-03
EP0818454A1 (en) 1998-01-14
MXPA97004127A (es) 2005-07-25
SI0818454T1 (en) 2004-08-31
DE69728608D1 (de) 2004-05-19

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Legal Events

Date Code Title Description
AA1S Information on application for a supplementary protection certificate

Free format text: PRODUCT NAME: BILASTIN AND IT'S PHARMACEUTICALLY ACCEPTABLE ALKALINE OR ACID ADDITION SALTS; REG. NO/DATE: OGYI-T-21640/01-03 20110224; FIRST REG. NO: IS/1/10/002/01 20100923

Spc suppl protection certif: S1100021

Filing date: 20111013

Expiry date: 20170604

Free format text: PRODUCT NAME: BILASTIN AND IT'S PHARMACEUTICALLY ACCEPTABLE ALKALINE OR ACID ADDITION SALTS; REG. NO/DATE: OGYI-T-21640/01-03 20110224; FIRST REG.: EU IS/1/10/002/01 20100923

Spc suppl protection certif: S1100021

Filing date: 20111013

Expiry date: 20170604

FG4S Grant of supplementary protection certificate

Free format text: PRODUCT NAME: BILASTIN AND IT'S PHARMACEUTICALLY ACCEPTABLE ALKALINE OR ACID ADDITION SALTS; REG. NO/DATE: OGYI-T-21640/01-03 20110224; FIRST REG. NO: IS/1/10/002/01 20100923

Spc suppl protection certif: S1100021

Filing date: 20111013

Expiry date: 20170604

Extension date: 20220604