TW438794B - New benzimidazole derivatives with antihistaminic activity - Google Patents

New benzimidazole derivatives with antihistaminic activity Download PDF

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Publication number
TW438794B
TW438794B TW086110371A TW86110371A TW438794B TW 438794 B TW438794 B TW 438794B TW 086110371 A TW086110371 A TW 086110371A TW 86110371 A TW86110371 A TW 86110371A TW 438794 B TW438794 B TW 438794B
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TW
Taiwan
Prior art keywords
ethyl
compound
scope
patent application
dimethyl
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Application number
TW086110371A
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English (en)
Chinese (zh)
Inventor
Aurelio Orjales
Victor Rubio
Maravillas Bordell
Original Assignee
Espanola Prod Quimicos
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Application filed by Espanola Prod Quimicos filed Critical Espanola Prod Quimicos
Application granted granted Critical
Publication of TW438794B publication Critical patent/TW438794B/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW086110371A 1996-06-04 1997-07-22 New benzimidazole derivatives with antihistaminic activity TW438794B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (1)

Publication Number Publication Date
TW438794B true TW438794B (en) 2001-06-07

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
TW086110371A TW438794B (en) 1996-06-04 1997-07-22 New benzimidazole derivatives with antihistaminic activity

Country Status (27)

Country Link
US (1) US5877187A (en, 2012)
EP (1) EP0818454B1 (en, 2012)
JP (1) JP4218991B2 (en, 2012)
CN (1) CN1105716C (en, 2012)
AR (1) AR008386A1 (en, 2012)
AT (1) ATE264317T1 (en, 2012)
AU (1) AU725700B2 (en, 2012)
BR (1) BR9703276A (en, 2012)
CA (1) CA2206754C (en, 2012)
CZ (1) CZ289278B6 (en, 2012)
DE (2) DE122011000006I1 (en, 2012)
DK (1) DK0818454T3 (en, 2012)
ES (1) ES2124167B1 (en, 2012)
FR (1) FR11C0023I2 (en, 2012)
HR (1) HRP970307B1 (en, 2012)
HU (1) HU227598B1 (en, 2012)
IN (1) IN186319B (en, 2012)
LU (1) LU91798I2 (en, 2012)
MX (1) MXPA97004127A (en, 2012)
NO (2) NO313195B1 (en, 2012)
PL (1) PL188908B1 (en, 2012)
PT (1) PT818454E (en, 2012)
RU (1) RU2182150C2 (en, 2012)
SI (1) SI0818454T1 (en, 2012)
TR (1) TR199700464A3 (en, 2012)
TW (1) TW438794B (en, 2012)
ZA (1) ZA974893B (en, 2012)

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EP1133477B1 (de) 1998-11-27 2004-02-18 Abbott GmbH & Co. KG Substituierte benzimidazole und ihre verwendung als parp inhibitoren
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
CZ305162B6 (cs) * 2002-04-19 2015-05-27 Faes Farma, S.A. Polymorf 1 bilastinu, způsob jeho přípravy a lékařské aplikace a farmaceutický přípravek s jeho obsahem
ES2277088T3 (es) * 2002-06-13 2007-07-01 Vertex Pharmaceuticals Incorporated Derivados del acido 2-ureido-6-heteroaril-3h-benzoimidazol-4-carboxilico y compuestos relacionados como inhibidores de girasa y/o topoisomerasa iv para el tratamiento de infecciones bacterianas.
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
CN104402773A (zh) 2008-02-12 2015-03-11 柳韩洋行 2-甲基-2’-苯基丙酸衍生物的制备方法和中间体化合物
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa 4−[2−[1−(2−エトキシエチル)−1H−ベンズイミダゾール−2−イル]−1−ピペリジニル]エチル]−α,α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
JP6284616B2 (ja) * 2013-03-15 2018-02-28 ハーキュリーズ・インコーポレーテッドHercules Incorporated 沈着特性が改善されたパーソナルケア組成物を生成する組成物及び方法
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
CA2993134A1 (en) * 2015-07-24 2017-02-02 Urquima, S.A. Crystalline forms of bilastine and preparation methods thereof
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
EP3452462A4 (en) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技(上海)有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
EP3453384B1 (en) 2017-09-07 2020-05-27 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine
AU2018353360B2 (en) 2017-10-16 2021-04-01 Faes Farma, S.A. Aqueous compositions comprising bilastine and mometasone
WO2019097091A1 (en) 2017-12-18 2019-05-23 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Pharmaceutical tablet composition comprising bilastine form 3 and a water-soluble filler
EP3470062B1 (en) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate
CA3088740A1 (en) 2018-01-18 2019-07-25 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
WO2022106923A1 (en) 2020-11-18 2022-05-27 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
EP4267109A1 (en) 2020-12-23 2023-11-01 Noucor Health S.A. A non-micronized bilastine composition
MX2024009978A (es) 2022-02-17 2024-08-26 Faes Farma Sa Composicion de bilastina para administracion parenteral una vez al dia.
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins

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GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
AU7759591A (en) * 1990-04-13 1991-11-11 Smithkline Beecham Corporation Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
AU675240B2 (en) * 1992-08-03 1997-01-30 Sepracor, Inc. Terfenadine metabolites and their optically pure isomers for treating allergic disorders
CN1275916C (zh) * 1993-06-25 2006-09-20 阿温蒂斯公司 用于制备抗组胺哌啶衍生物的新中间体

Also Published As

Publication number Publication date
ATE264317T1 (de) 2004-04-15
JP4218991B2 (ja) 2009-02-04
HRP970307B1 (en) 2002-02-28
JPH1059961A (ja) 1998-03-03
EP0818454A1 (en) 1998-01-14
HRP970307A2 (en) 1998-04-30
CA2206754C (en) 2007-01-23
LU91798I2 (fr) 2011-05-23
AR008386A1 (es) 2000-01-19
IN186319B (en, 2012) 2001-08-04
FR11C0023I1 (en, 2012) 2011-08-19
HUP9700997A1 (hu) 1999-09-28
NO972525L (no) 1997-12-05
PT818454E (pt) 2004-08-31
EP0818454B1 (en) 2004-04-14
BR9703276A (pt) 2004-08-17
ES2124167B1 (es) 1999-09-16
US5877187A (en) 1999-03-02
HU227598B1 (en) 2011-09-28
CA2206754A1 (en) 1997-12-04
TR199700464A2 (xx) 1997-12-21
NO313195B1 (no) 2002-08-26
FR11C0023I2 (fr) 2012-03-16
AU2467297A (en) 1997-12-11
CN1105716C (zh) 2003-04-16
HU9700997D0 (en) 1997-07-28
DE122011000006I1 (de) 2011-06-16
DE69728608D1 (de) 2004-05-19
ZA974893B (en) 1997-12-30
DE69728608T2 (de) 2005-04-21
SI0818454T1 (en) 2004-08-31
ES2124167A1 (es) 1999-01-16
DK0818454T3 (da) 2004-07-12
CZ172397A3 (en) 1997-12-17
CZ289278B6 (cs) 2001-12-12
RU2182150C2 (ru) 2002-05-10
AU725700B2 (en) 2000-10-19
NO972525D0 (no) 1997-06-03
NO2011008I1 (no) 2011-06-06
CN1176964A (zh) 1998-03-25
TR199700464A3 (tr) 1997-12-21
PL320358A1 (en) 1997-12-08
MXPA97004127A (es) 2005-07-25
NO2011008I2 (no) 2012-05-14
PL188908B1 (pl) 2005-05-31

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