TW201326209A - 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 - Google Patents
具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A61P19/00—Drugs for skeletal disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/526—CH3 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
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- Immunology (AREA)
- Organic Chemistry (AREA)
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- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| JP2011218736 | 2011-09-30 | ||
| PCT/JP2012/058603 WO2012133782A1 (ja) | 2011-03-30 | 2012-03-30 | 抗原結合分子の血漿中滞留性と免疫原性を改変する方法 |
| JP2012123773 | 2012-05-30 | ||
| JP2012123781 | 2012-05-30 | ||
| JP2012123782 | 2012-05-30 | ||
| JP2012139211 | 2012-06-20 | ||
| JP2012177311 | 2012-08-09 |
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| TW107101834A TW201817744A (zh) | 2011-09-30 | 2012-09-27 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
| TW107101835A TW201817745A (zh) | 2011-09-30 | 2012-09-27 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
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| TW107101835A TW201817745A (zh) | 2011-09-30 | 2012-09-27 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
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| CA2647846C (en) | 2006-03-31 | 2016-06-21 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| PL2202245T3 (pl) | 2007-09-26 | 2017-02-28 | Chugai Seiyaku Kabushiki Kaisha | Sposób modyfikowania punktu izoelektrycznego przeciwciała poprzez podstawienie aminokwasu w cdr |
| WO2009041613A1 (ja) | 2007-09-26 | 2009-04-02 | Chugai Seiyaku Kabushiki Kaisha | 抗体定常領域改変体 |
| KR102269708B1 (ko) | 2008-04-11 | 2021-06-25 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| EP4231014A3 (en) | 2010-11-30 | 2024-08-14 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| KR20230005405A (ko) | 2011-02-25 | 2023-01-09 | 추가이 세이야쿠 가부시키가이샤 | ＦｃγＲＩＩｂ 특이적 Ｆｃ 항체 |
| CN103827300A (zh) | 2011-06-30 | 2014-05-28 | 中外制药株式会社 | 异源二聚化多肽 |
| TW201326209A (zh) * | 2011-09-30 | 2013-07-01 | Chugai Pharmaceutical Co Ltd | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
| TWI681970B (zh) | 2011-09-30 | 2020-01-11 | 日商中外製藥股份有限公司 | 包含依離子濃度之條件對抗原之結合活性會改變之抗原結合分域、及於pH中性之條件下對FcRn有結合活性之FcRn結合分域、且誘導對標的抗原的免疫反應之抗原結合分子 |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| RU2739792C1 (ru) * | 2011-11-30 | 2020-12-28 | Чугаи Сейяку Кабусики Кайся | Содержащий лекарственное средство переносчик в клетку для формирования иммунного комплекса |
| CN113480639A (zh) | 2012-02-09 | 2021-10-08 | 中外制药株式会社 | 抗体的Fc区变异体 |
| US20150353630A1 (en) * | 2012-05-30 | 2015-12-10 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for eliminating aggregated antigens |
| CN107964042B (zh) | 2012-05-30 | 2022-04-19 | 中外制药株式会社 | 靶组织特异性抗原结合分子 |
| EP2889376A4 (en) | 2012-08-24 | 2016-11-02 | Chugai Pharmaceutical Co Ltd | ANTIBODIES Fc SPECIFIC TO FCTRII OF MOUSE |
| SG10201709559PA (en) | 2012-08-24 | 2017-12-28 | Chugai Pharmaceutical Co Ltd | Fcγriib-specific fc region variant |
| CN105121465B (zh) | 2013-03-13 | 2020-09-08 | 普罗塞纳生物科技公司 | Tau免疫疗法 |
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2012
- 2012-09-27 TW TW101135493A patent/TW201326209A/zh unknown
- 2012-09-27 TW TW107101834A patent/TW201817744A/zh unknown
- 2012-09-27 TW TW107101835A patent/TW201817745A/zh unknown
- 2012-09-28 MX MX2014003891A patent/MX2014003891A/es unknown
- 2012-09-28 CN CN201280058760.7A patent/CN103958547B/zh not_active Expired - Fee Related
- 2012-09-28 JP JP2014514947A patent/JP6204350B2/ja active Active
- 2012-09-28 SG SG10201808187TA patent/SG10201808187TA/en unknown
- 2012-09-28 KR KR1020147011698A patent/KR20140069332A/ko not_active Withdrawn
- 2012-09-28 CN CN201810780566.9A patent/CN108948197A/zh not_active Withdrawn
- 2012-09-28 EP EP19150272.3A patent/EP3549956A3/en not_active Withdrawn
- 2012-09-28 RU RU2018118993A patent/RU2018118993A/ru not_active Application Discontinuation
- 2012-09-28 SG SG11201401098TA patent/SG11201401098TA/en unknown
- 2012-09-28 RU RU2014117500/10A patent/RU2014117500A/ru unknown
- 2012-09-28 WO PCT/JP2012/006218 patent/WO2013046704A2/en not_active Ceased
- 2012-09-28 AU AU2012313670A patent/AU2012313670B2/en not_active Ceased
- 2012-09-28 US US14/347,187 patent/US10253100B2/en active Active
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- 2012-09-28 EP EP23210057.8A patent/EP4324850A3/en active Pending
- 2012-09-28 BR BR112014007290A patent/BR112014007290A2/pt active Search and Examination
- 2012-09-28 CA CA2850035A patent/CA2850035A1/en not_active Abandoned
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2017
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- 2017-08-31 JP JP2017166638A patent/JP6541730B2/ja active Active
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2019
- 2019-01-09 HK HK19100308.6A patent/HK1257946A1/zh unknown
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