MX2022002171A - Dominios fc variantes y usos de estos. - Google Patents

Dominios fc variantes y usos de estos.

Info

Publication number
MX2022002171A
MX2022002171A MX2022002171A MX2022002171A MX2022002171A MX 2022002171 A MX2022002171 A MX 2022002171A MX 2022002171 A MX2022002171 A MX 2022002171A MX 2022002171 A MX2022002171 A MX 2022002171A MX 2022002171 A MX2022002171 A MX 2022002171A
Authority
MX
Mexico
Prior art keywords
variant
domain monomers
kda
domain
domains
Prior art date
Application number
MX2022002171A
Other languages
English (en)
Inventor
Leslie W Tari
Original Assignee
Cidara Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cidara Therapeutics Inc filed Critical Cidara Therapeutics Inc
Publication of MX2022002171A publication Critical patent/MX2022002171A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

La presente descripción hace referencia a monómeros de dominios Fc variantes, proteínas de fusión, conjugados, composiciones y métodos relacionados para el tratamiento o la prevención de enfermedades. En particular, la invención presenta monómeros de dominios Fc variantes que incluyen mutaciones en las posiciones (220), y (252, 254), y/o (256) o (309, 311), y/o (434) de acuerdo con la numeración del índice de Kabat. La invención también presenta monómeros de dominios de Fc variantes que incluyen mutaciones en la posición (220) de acuerdo con el número del índice de Kabat, donde el monómero de dominio Fc variante tiene una longitud de 200 a 300 residuos de aminoácidos y/o una masa de alrededor de 20 kDa a alrededor de 40 kDa.
MX2022002171A 2019-08-22 2020-08-21 Dominios fc variantes y usos de estos. MX2022002171A (es)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US201962890475P 2019-08-22 2019-08-22
US201962897036P 2019-09-06 2019-09-06
US201962941405P 2019-11-27 2019-11-27
US201962948143P 2019-12-13 2019-12-13
US202062959857P 2020-01-10 2020-01-10
US202062966500P 2020-01-27 2020-01-27
US202062970491P 2020-02-05 2020-02-05
US202062984705P 2020-03-03 2020-03-03
US202062988304P 2020-03-11 2020-03-11
US202062988821P 2020-03-12 2020-03-12
US202063032488P 2020-05-29 2020-05-29
US202063032316P 2020-05-29 2020-05-29
US202063062377P 2020-08-06 2020-08-06
PCT/US2020/047490 WO2021035177A2 (en) 2019-08-22 2020-08-21 Variant fc domains and uses thereof

Publications (1)

Publication Number Publication Date
MX2022002171A true MX2022002171A (es) 2022-05-13

Family

ID=74660747

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022002171A MX2022002171A (es) 2019-08-22 2020-08-21 Dominios fc variantes y usos de estos.

Country Status (9)

Country Link
US (1) US20220175943A1 (es)
EP (1) EP4017529A4 (es)
JP (1) JP2022545106A (es)
KR (1) KR20220066276A (es)
CN (1) CN114599389A (es)
AU (1) AU2020333967A1 (es)
CA (1) CA3152009A1 (es)
MX (1) MX2022002171A (es)
WO (1) WO2021035177A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021045836A1 (en) 2020-04-02 2021-03-11 Regeneron Pharmaceuticals, Inc. Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ581395A (en) * 2007-05-14 2012-08-31 Biogen Idec Inc Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto
ES2826894T3 (es) * 2010-02-19 2021-05-19 Xencor Inc Nuevas inmunoadhesinas CTLA4-IG
US9409987B2 (en) * 2011-04-15 2016-08-09 Compugen Ltd Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer
TW201817745A (zh) * 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
WO2018128826A1 (en) * 2017-01-06 2018-07-12 Cidara Therapeutics, Inc. Compositions and methods for the treatment of bacterial infections
KR20200012907A (ko) * 2017-05-25 2020-02-05 브리스톨-마이어스 스큅 컴퍼니 변형된 IgG1 Fc 도메인 및 그와의 항-CD40 도메인 항체 융합체
KR20200035972A (ko) * 2017-08-11 2020-04-06 리서치 디벨럽먼트 파운데이션 증강된 혈청 반감기를 위한 조작된 항체 fc 변이체
WO2019125732A1 (en) * 2017-12-19 2019-06-27 Xencor, Inc. Engineered il-2 fc fusion proteins
EP3982993A1 (en) * 2019-06-13 2022-04-20 Cidara Therapeutics, Inc. Compositions and methods for the treatment of human immunodeficiency virus

Also Published As

Publication number Publication date
WO2021035177A3 (en) 2021-05-06
WO2021035177A2 (en) 2021-02-25
CN114599389A (zh) 2022-06-07
KR20220066276A (ko) 2022-05-24
AU2020333967A1 (en) 2022-03-17
JP2022545106A (ja) 2022-10-25
US20220175943A1 (en) 2022-06-09
EP4017529A4 (en) 2024-03-13
EP4017529A2 (en) 2022-06-29
CA3152009A1 (en) 2021-02-25

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