MX2022005483A - Composiciones y uso de las mismas para tratar la enfermedad celiaca. - Google Patents

Composiciones y uso de las mismas para tratar la enfermedad celiaca.

Info

Publication number
MX2022005483A
MX2022005483A MX2022005483A MX2022005483A MX2022005483A MX 2022005483 A MX2022005483 A MX 2022005483A MX 2022005483 A MX2022005483 A MX 2022005483A MX 2022005483 A MX2022005483 A MX 2022005483A MX 2022005483 A MX2022005483 A MX 2022005483A
Authority
MX
Mexico
Prior art keywords
methods
compositions
seq
celiac sprue
treating celiac
Prior art date
Application number
MX2022005483A
Other languages
English (en)
Inventor
Justin Bloomfield Siegel
Ingrid Swanson Pultz
Lance Stewart
Clancey Wolf
Christine Elaine Tinberg
David Baker
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of MX2022005483A publication Critical patent/MX2022005483A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Los polipéptidos y métodos para su uso, se divulgan teniendo la secuencia de aminoácido por lo menos 75% idéntica a la secuencia de aminoácido de la SEQ ID NO:1, se proporcionan, en donde (a) el polipéptido degrada un PFQPQLPY (SEQ ID NO: 140) péptido y/o un PFPQPQQPF (SEQ ID NO: 68) a pH 4; (b) residuo 467 es Ser, residuo 267 es Glu y residuo 271 es Asp; y (c) el polipéptido comprende un cambio del aminoácido de la SEQ ID NO: 1 en uno o más residuos seleccionado del grupo que consistente en 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174 y 456.
MX2022005483A 2015-06-08 2017-12-05 Composiciones y uso de las mismas para tratar la enfermedad celiaca. MX2022005483A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562172557P 2015-06-08 2015-06-08

Publications (1)

Publication Number Publication Date
MX2022005483A true MX2022005483A (es) 2022-06-02

Family

ID=56194586

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017015786A MX2017015786A (es) 2015-06-08 2016-06-08 Composiciones y metodos para tratar la enfermedad celiaca.
MX2022005483A MX2022005483A (es) 2015-06-08 2017-12-05 Composiciones y uso de las mismas para tratar la enfermedad celiaca.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017015786A MX2017015786A (es) 2015-06-08 2016-06-08 Composiciones y metodos para tratar la enfermedad celiaca.

Country Status (24)

Country Link
US (4) US10793846B2 (es)
EP (1) EP3302518A1 (es)
JP (3) JP7325030B2 (es)
KR (1) KR102702879B1 (es)
CN (1) CN107873053A (es)
AU (2) AU2016276436C1 (es)
BR (1) BR112017026142A2 (es)
CA (1) CA2988651A1 (es)
CL (2) CL2017003097A1 (es)
CO (1) CO2017013720A2 (es)
CR (1) CR20170567A (es)
DO (1) DOP2017000286A (es)
EA (1) EA037603B1 (es)
EC (1) ECSP17080844A (es)
HK (1) HK1245129A1 (es)
IL (2) IL256103B (es)
MX (2) MX2017015786A (es)
MY (1) MY189160A (es)
PE (1) PE20180509A1 (es)
PH (1) PH12017502213A1 (es)
SA (1) SA517390479B1 (es)
SG (1) SG10201911867YA (es)
TN (1) TN2017000520A1 (es)
WO (1) WO2016200880A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015023728A1 (en) 2013-08-14 2015-02-19 University Of Washington Through Its Center For Commercialization Compositions and methods for treating celiac sprue disease
CR20170567A (es) 2015-06-08 2018-06-14 Univ California Composiciones y métodos para tratar la enfermedad celiaca.
WO2017218434A1 (en) 2016-06-12 2017-12-21 Millennium Pharmaceuticals, Inc. Method of treating inflammatory bowel disease
KR102553627B1 (ko) 2016-12-22 2023-07-07 에베 누트리찌온 게엠베하 안정한 프로테아제 변이체
JP2023548083A (ja) 2020-10-30 2023-11-15 ユニヴァーシティ オブ ワシントン セリアックスプルー病を治療するための組成物及び方法
JP7268910B2 (ja) * 2021-09-16 2023-05-08 株式会社ユニバーサルエンターテインメント 遊技機
JP7268911B2 (ja) * 2021-09-16 2023-05-08 株式会社ユニバーサルエンターテインメント 遊技機

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2688229B1 (fr) 1992-03-09 1995-06-23 Ulice Soc Procede de synthese enzymatique d'esters alkyliques de peptides, produits ainsi obtenus et utilisation desdits produits.
JP2002078489A (ja) * 2000-09-04 2002-03-19 Daiwa Kasei Kk セリン残基が活性発現に関与する新規酸性プロテアーゼ
US7320788B2 (en) 2002-02-14 2008-01-22 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for Celiac Sprue
DK1572127T4 (da) 2002-02-14 2014-11-24 Univ Leland Stanford Junior Enzymbehandling af fødevarer til cøliaki
US8143210B2 (en) 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
US7462688B2 (en) 2002-05-14 2008-12-09 The Board Of Trustees Of The Leland Stanford Junior University Peptides for diagnostic and therapeutic methods for celiac sprue
US7202216B2 (en) 2002-05-14 2007-04-10 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for celiac sprue
WO2004045392A2 (en) 2002-11-20 2004-06-03 The Board Of Trustees Of The Leland Stanford Junior University Diagnostic method for celiac sprue
US7265093B2 (en) 2002-05-14 2007-09-04 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for Celiac Sprue
CA2487247A1 (en) 2002-05-14 2003-11-27 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for celiac sprue
US7579313B2 (en) 2003-11-18 2009-08-25 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
US7628985B2 (en) 2004-04-26 2009-12-08 The Board Of Regents Of The Leland Stanford Junior University Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis
US7534426B2 (en) 2004-04-26 2009-05-19 The Board Of Trustees Of The Leland Stanford Junior University Glutenase enzyme assays
US7563864B2 (en) 2004-04-26 2009-07-21 Celiac Sprue Research Foundation Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten
EP1600141B1 (en) 2004-05-24 2013-04-17 3M Deutschland GmbH Collagenolytic active enzyme containing compositions for the treatment of dental caries
EP1726643A1 (en) 2005-05-27 2006-11-29 Direvo Biotech AG Method for the provision, identification and selection of proteases with altered sensitivity to activity-modulating substances
WO2010021752A1 (en) 2008-08-21 2010-02-25 Alvine Pharmaceuticals, Inc. Formulation for oral administration of proteins
HU0900199D0 (en) * 2009-04-01 2009-06-29 Debreceni Egyetem Diagnosis of gluten-induced autoimmune diseases
US20110200574A1 (en) * 2010-02-02 2011-08-18 Jolly James F Use of proteases for gluten intolerance
EP4023243A3 (en) * 2011-08-10 2022-09-14 University of Washington through its Center for Commercialization Compositions and methods for treating celiac sprue disease
CN104039345B (zh) 2011-12-06 2016-11-09 英萨博瑞克寻找生命基础研究所 来自放线菌放线异壁酸菌属(Actinoallomurus)的能在酸性pH水解谷蛋白肽和蛋白的新蛋白酶
WO2015023728A1 (en) 2013-08-14 2015-02-19 University Of Washington Through Its Center For Commercialization Compositions and methods for treating celiac sprue disease
US9914809B2 (en) * 2013-08-30 2018-03-13 Momentive Performance Materials Inc. Moisture curable composition with amino acids
CR20170567A (es) * 2015-06-08 2018-06-14 Univ California Composiciones y métodos para tratar la enfermedad celiaca.

Also Published As

Publication number Publication date
TN2017000520A1 (en) 2019-04-12
US20210171928A1 (en) 2021-06-10
EA201792362A8 (ru) 2018-12-28
US20200109387A1 (en) 2020-04-09
IL256103B (en) 2022-01-01
AU2016276436B2 (en) 2022-07-07
EP3302518A1 (en) 2018-04-11
EA201792362A1 (ru) 2018-05-31
IL288768A (en) 2022-02-01
DOP2017000286A (es) 2018-03-30
MX2017015786A (es) 2018-12-11
AU2022241520A1 (en) 2022-10-27
PE20180509A1 (es) 2018-03-09
JP7325030B2 (ja) 2023-08-14
JP2021151250A (ja) 2021-09-30
HK1245129A1 (zh) 2018-08-24
CA2988651A1 (en) 2016-12-15
US11485961B2 (en) 2022-11-01
US20230130764A1 (en) 2023-04-27
CL2023000752A1 (es) 2024-04-12
US10793846B2 (en) 2020-10-06
US10988748B2 (en) 2021-04-27
AU2016276436A1 (en) 2017-12-07
JP2024041995A (ja) 2024-03-27
KR20180023903A (ko) 2018-03-07
IL256103A (en) 2018-02-28
MY189160A (en) 2022-01-29
CL2017003097A1 (es) 2018-06-29
PH12017502213A1 (en) 2018-06-11
AU2016276436C1 (en) 2024-09-12
JP2018517409A (ja) 2018-07-05
KR102702879B1 (ko) 2024-09-04
ECSP17080844A (es) 2018-03-31
SG10201911867YA (en) 2020-01-30
SA517390479B1 (ar) 2022-11-10
JP7429907B2 (ja) 2024-02-09
BR112017026142A2 (pt) 2018-08-14
CR20170567A (es) 2018-06-14
CO2017013720A2 (es) 2018-04-10
EA037603B1 (ru) 2021-04-20
US20180142226A1 (en) 2018-05-24
WO2016200880A1 (en) 2016-12-15
CN107873053A (zh) 2018-04-03

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