MX2017009595A - Compuestos antisenescentes y usos de los mismos. - Google Patents

Compuestos antisenescentes y usos de los mismos.

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Publication number
MX2017009595A
MX2017009595A MX2017009595A MX2017009595A MX2017009595A MX 2017009595 A MX2017009595 A MX 2017009595A MX 2017009595 A MX2017009595 A MX 2017009595A MX 2017009595 A MX2017009595 A MX 2017009595A MX 2017009595 A MX2017009595 A MX 2017009595A
Authority
MX
Mexico
Prior art keywords
amino acid
senescence compounds
peptide
acid sequence
senescence
Prior art date
Application number
MX2017009595A
Other languages
English (en)
Inventor
Leonardus Josephus De Keizer Peterus
Original Assignee
Univ Erasmus Med Ct Rotterdam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Erasmus Med Ct Rotterdam filed Critical Univ Erasmus Med Ct Rotterdam
Publication of MX2017009595A publication Critical patent/MX2017009595A/es

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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)

Abstract

La invención se refiere a péptido que comprende la secuencia de aminoácidos LTLRKEPASEIAQSILEAYSQNGWANRRSGGKRP, en la que los aminoácidos en la secuencia de aminoácidos son residuos de D-aminoácido, y a métodos para el uso de este péptido en el tratamiento de trastornos relacionados con la edad.
MX2017009595A 2015-01-23 2016-01-25 Compuestos antisenescentes y usos de los mismos. MX2017009595A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2014183 2015-01-23
EP15193041 2015-11-04
PCT/NL2016/050057 WO2016118014A2 (en) 2015-01-23 2016-01-25 Anti-senescence compounds and uses thereof

Publications (1)

Publication Number Publication Date
MX2017009595A true MX2017009595A (es) 2018-04-20

Family

ID=55642804

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017009595A MX2017009595A (es) 2015-01-23 2016-01-25 Compuestos antisenescentes y usos de los mismos.

Country Status (13)

Country Link
US (1) US11723947B2 (es)
EP (2) EP3247375B1 (es)
JP (1) JP6707549B2 (es)
CN (1) CN107531768A (es)
AU (1) AU2016209737A1 (es)
BR (1) BR112017015833A2 (es)
CA (1) CA2974623A1 (es)
CL (1) CL2017001883A1 (es)
MX (1) MX2017009595A (es)
PE (1) PE20180128A1 (es)
RU (1) RU2017128116A (es)
SG (1) SG11201706029VA (es)
WO (1) WO2016118014A2 (es)

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WO2020201444A1 (en) * 2019-04-02 2020-10-08 Eternans Ltd Repurposing small molecules for senescence-related diseases and disorders
CN111346101B (zh) * 2019-04-16 2023-01-24 中山大学 Tamatinib在制备治疗胶质瘤的药物中的用途
WO2021016330A2 (en) 2019-07-22 2021-01-28 Oneskin, Inc. Polypeptides having anti-senescent effects and uses thereof
JP7769388B2 (ja) 2019-12-12 2025-11-13 ティン セラピューティクス，インコーポレイテッド 聴覚損失の予防及び治療のための組成物及び方法
CN113144192A (zh) * 2020-01-22 2021-07-23 中国科学院上海营养与健康研究所 Mapk/erk通路抑制剂在拮抗皮肤老化与辐射性皮肤早衰中的应用
EP4106878A1 (en) 2020-02-21 2022-12-28 Cleara Biotech B.V. Improved anti-senescence compounds and uses thereof
WO2022157548A1 (en) 2021-01-24 2022-07-28 Forrest Michael David Inhibitors of atp synthase - cosmetic and therapeutic uses
EP4249912A1 (en) 2022-03-24 2023-09-27 Cleara Biotech B.V. Phosphorylation of p53 as a prognostic or diagnostic marker for the treatment of senescent cells in a mammal
CN115466321B (zh) * 2022-09-23 2024-03-22 南方医科大学珠江医院 FOXO3a-DRI肽段、其药物组合物及应用
CN116832049A (zh) * 2023-04-18 2023-10-03 复旦大学附属中山医院 一种清除衰老细胞的核酸药物、药物组合物及其制备方法和应用
EP4613274A1 (en) 2024-03-06 2025-09-10 Freie Universität Berlin Senolytic compounds
CN119587553A (zh) * 2024-12-02 2025-03-11 衢州市复大生物医药创新研究院 一种小分子化合物r406在制备防治帕金森病的产品中的应用

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CN105307670A (zh) 2013-06-26 2016-02-03 埃克西金炎症有限公司 Jnk信号转导途径的细胞渗透肽抑制剂用于治疗多种疾病的新用途
AU2018205629B2 (en) 2017-01-03 2025-02-06 Bioatla Llc Protein therapeutics for treatment of senescent cells

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