BR112017015833A2 - compostos anti-senescência e usos dos mesmos - Google Patents

compostos anti-senescência e usos dos mesmos

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Publication number
BR112017015833A2
BR112017015833A2 BR112017015833-7A BR112017015833A BR112017015833A2 BR 112017015833 A2 BR112017015833 A2 BR 112017015833A2 BR 112017015833 A BR112017015833 A BR 112017015833A BR 112017015833 A2 BR112017015833 A2 BR 112017015833A2
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BR
Brazil
Prior art keywords
amino acid
senescence compounds
peptide
acid sequence
senescence
Prior art date
Application number
BR112017015833-7A
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English (en)
Inventor
Leonardus Josephus De Keizer Peterus
Original Assignee
Erasmus University Medical Center Rotterdam
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Publication date
Application filed by Erasmus University Medical Center Rotterdam filed Critical Erasmus University Medical Center Rotterdam
Publication of BR112017015833A2 publication Critical patent/BR112017015833A2/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)

Abstract

a presente invenção refere-se a um peptídeo compreendendo a sequência de aminoácidos ltlrkepaseiaqsileaysqngwanrrsggkrp, onde os aminoácidos na dita sequência de aminoácidos são resíduos de d-aminoácidos, e a métodos para a uso deste peptídeo no tratamento de distúrbios relacionados com a idade.
BR112017015833-7A 2015-01-23 2016-01-25 compostos anti-senescência e usos dos mesmos BR112017015833A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NL2014183 2015-01-23
NL2014183 2015-01-23
EP15193041.9 2015-11-04
EP15193041 2015-11-04
PCT/NL2016/050057 WO2016118014A2 (en) 2015-01-23 2016-01-25 Anti-senescence compounds and uses thereof

Publications (1)

Publication Number Publication Date
BR112017015833A2 true BR112017015833A2 (pt) 2018-03-27

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ID=55642804

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BR112017015833-7A BR112017015833A2 (pt) 2015-01-23 2016-01-25 compostos anti-senescência e usos dos mesmos

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Country Link
US (1) US11723947B2 (pt)
EP (2) EP3936141A3 (pt)
JP (1) JP6707549B2 (pt)
CN (1) CN107531768A (pt)
AU (1) AU2016209737A1 (pt)
BR (1) BR112017015833A2 (pt)
CA (1) CA2974623A1 (pt)
CL (1) CL2017001883A1 (pt)
MX (1) MX2017009595A (pt)
PE (1) PE20180128A1 (pt)
RU (1) RU2017128116A (pt)
SG (1) SG11201706029VA (pt)
WO (1) WO2016118014A2 (pt)

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EP3705109A1 (en) 2019-03-05 2020-09-09 Greenaltech, S.L. Carotenoids in the treatment of senescence-related diseases
WO2020201444A1 (en) * 2019-04-02 2020-10-08 Eternans Ltd Repurposing small molecules for senescence-related diseases and disorders
CN111346101B (zh) * 2019-04-16 2023-01-24 中山大学 Tamatinib在制备治疗胶质瘤的药物中的用途
WO2021016330A2 (en) 2019-07-22 2021-01-28 Oneskin, Inc. Polypeptides having anti-senescent effects and uses thereof
CN114981298B (zh) 2019-12-12 2024-08-20 听治疗有限责任公司 用于预防和治疗听力损失的组合物和方法
CN113144192A (zh) * 2020-01-22 2021-07-23 中国科学院上海营养与健康研究所 Mapk/erk通路抑制剂在拮抗皮肤老化与辐射性皮肤早衰中的应用
CA3168560A1 (en) 2020-02-21 2021-08-26 Peterus Leonardus Josephus DE KEIZER Improved anti-senescence compounds and uses thereof
BR112023012422A2 (pt) 2021-01-24 2023-12-12 Michael David Forrest Inibidores da atp sintase - usos cosmético e terapêutico
EP4249912A1 (en) 2022-03-24 2023-09-27 Cleara Biotech B.V. Phosphorylation of p53 as a prognostic or diagnostic marker for the treatment of senescent cells in a mammal
CN115466321B (zh) * 2022-09-23 2024-03-22 南方医科大学珠江医院 FOXO3a-DRI肽段、其药物组合物及应用

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US8227455B2 (en) * 2005-04-18 2012-07-24 Rigel Pharmaceuticals, Inc. Methods of treating cell proliferative disorders
AU2009322474A1 (en) * 2008-12-01 2011-07-21 Lifespan Extension Llc Methods and compositions for altering health, wellbeing, and lifespan
EP2660247A3 (en) * 2009-05-08 2014-09-03 Chongxi Yu High penetration prodrug compositions of peptides and peptide-related compounds
US20130288980A1 (en) 2012-04-02 2013-10-31 Buck Institute For Research On Aging Targeting senescent and cancer cells for selective killing by interference with foxo4
US20130288981A1 (en) 2012-04-02 2013-10-31 Buck Institute For Research On Aging Targeting senescent cells and cancer cells by interference with jnk and/or foxo4
EA201501080A1 (ru) 2013-06-26 2016-07-29 Ксижен Инфлемейшн Лтд. Новое применение обладающих способностью проникать в клетку пептидных ингибиторов пути трансдукции сигнала jnk для лечения различных заболеваний
CN110382543B (zh) 2017-01-03 2023-12-26 生物蛋白有限公司 用于治疗衰老细胞的蛋白治疗剂

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CA2974623A1 (en) 2016-07-28
SG11201706029VA (en) 2017-08-30
RU2017128116A (ru) 2019-02-26
PE20180128A1 (es) 2018-01-18
MX2017009595A (es) 2018-04-20
EP3247375A2 (en) 2017-11-29
CN107531768A (zh) 2018-01-02
RU2017128116A3 (pt) 2019-08-21
JP6707549B2 (ja) 2020-06-10
EP3936141A2 (en) 2022-01-12
AU2016209737A1 (en) 2017-08-17
EP3247375B1 (en) 2021-08-04
CL2017001883A1 (es) 2018-02-02
WO2016118014A2 (en) 2016-07-28
JP2018508196A (ja) 2018-03-29
US20180015137A1 (en) 2018-01-18
US11723947B2 (en) 2023-08-15
EP3936141A3 (en) 2022-03-23
WO2016118014A3 (en) 2016-11-17

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