PE20180509A1 - Composiciones y metodos para tratar la enfermedad celiaca - Google Patents
Composiciones y metodos para tratar la enfermedad celiacaInfo
- Publication number
- PE20180509A1 PE20180509A1 PE2017002543A PE2017002543A PE20180509A1 PE 20180509 A1 PE20180509 A1 PE 20180509A1 PE 2017002543 A PE2017002543 A PE 2017002543A PE 2017002543 A PE2017002543 A PE 2017002543A PE 20180509 A1 PE20180509 A1 PE 20180509A1
- Authority
- PE
- Peru
- Prior art keywords
- residue
- celiac disease
- amino acid
- compositions
- methods
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Se refiere a un polipeptido que comprende una secuencia de aminoacidos por lo menos 75% identica a la secuencia de aminoacidos de SEQ ID NO: 1, en donde: A) residuos 467 es Ser, residuo 267 es Glu y residuo 271 es Asp; y B) el polipeptido comprende un cambio de aminoacidos de SEQ ID NO: 1 en uno o mas residuos seleccionados del grupo que consiste en 463, 221, 262E, 268, 268, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F Q, 399, 402, 406, 424, 449, 461, 105, 171, 172, 173, 174 Y 456. La presente invencion tambien se refiere a una composicion farmaceutica que comprende un acido nucleico, un vector de expresion del acido nucleico y una celula huesped recombinante. La presente invencion es util para el tratamiento de la celiaquia o sensibilidad de gluten no celiaco (NCGS).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562172557P | 2015-06-08 | 2015-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20180509A1 true PE20180509A1 (es) | 2018-03-09 |
Family
ID=56194586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2017002543A PE20180509A1 (es) | 2015-06-08 | 2016-06-08 | Composiciones y metodos para tratar la enfermedad celiaca |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US10793846B2 (es) |
| EP (1) | EP3302518A1 (es) |
| JP (3) | JP7325030B2 (es) |
| KR (1) | KR20180023903A (es) |
| CN (1) | CN107873053A (es) |
| AU (2) | AU2016276436B2 (es) |
| BR (1) | BR112017026142A2 (es) |
| CA (1) | CA2988651A1 (es) |
| CL (2) | CL2017003097A1 (es) |
| CO (1) | CO2017013720A2 (es) |
| CR (1) | CR20170567A (es) |
| DO (1) | DOP2017000286A (es) |
| EA (1) | EA037603B1 (es) |
| EC (1) | ECSP17080844A (es) |
| HK (1) | HK1245129A1 (es) |
| IL (2) | IL256103B (es) |
| MX (2) | MX2017015786A (es) |
| MY (1) | MY189160A (es) |
| PE (1) | PE20180509A1 (es) |
| PH (1) | PH12017502213A1 (es) |
| SA (1) | SA517390479B1 (es) |
| SG (1) | SG10201911867YA (es) |
| TN (1) | TN2017000520A1 (es) |
| WO (1) | WO2016200880A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3033100B1 (en) | 2013-08-14 | 2018-10-03 | University Of Washington Through Its Center For Commercialization | Compositions for treating celiac sprue disease |
| KR20180023903A (ko) * | 2015-06-08 | 2018-03-07 | 유니버시티 오브 워싱턴 | 셀리악 스프루 질환 치료용 조성물 및 방법 |
| US11389533B2 (en) | 2016-06-12 | 2022-07-19 | Takeda Pharmaceutical Company Limited | Method of treating inflammatory bowel disease |
| BR112019012980A2 (pt) * | 2016-12-22 | 2020-05-26 | Ew Nutrition Gmbh | Variantes estáveis de protease |
| WO2022094177A1 (en) | 2020-10-30 | 2022-05-05 | University Of Washington | Compositions and methods for treating celiac sprue disease |
| JP7268911B2 (ja) * | 2021-09-16 | 2023-05-08 | 株式会社ユニバーサルエンターテインメント | 遊技機 |
| JP7268910B2 (ja) * | 2021-09-16 | 2023-05-08 | 株式会社ユニバーサルエンターテインメント | 遊技機 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2688229B1 (fr) | 1992-03-09 | 1995-06-23 | Ulice Soc | Procede de synthese enzymatique d'esters alkyliques de peptides, produits ainsi obtenus et utilisation desdits produits. |
| JP2002078489A (ja) * | 2000-09-04 | 2002-03-19 | Daiwa Kasei Kk | セリン残基が活性発現に関与する新規酸性プロテアーゼ |
| US7320788B2 (en) | 2002-02-14 | 2008-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
| US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| EP2409711B1 (en) | 2002-02-14 | 2018-11-21 | The Board of Trustees of the Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| CA2487247A1 (en) | 2002-05-14 | 2003-11-27 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| US7265093B2 (en) | 2002-05-14 | 2007-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
| US7202216B2 (en) | 2002-05-14 | 2007-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| US7462688B2 (en) | 2002-05-14 | 2008-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for diagnostic and therapeutic methods for celiac sprue |
| ES2383595T3 (es) | 2002-11-20 | 2012-06-22 | The Board Of Trustees Of The Leland Stanford Junior University | Procedimiento de diagnóstico de la celiaquía |
| US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
| US7563864B2 (en) | 2004-04-26 | 2009-07-21 | Celiac Sprue Research Foundation | Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten |
| US7628985B2 (en) | 2004-04-26 | 2009-12-08 | The Board Of Regents Of The Leland Stanford Junior University | Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis |
| US7534426B2 (en) | 2004-04-26 | 2009-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Glutenase enzyme assays |
| EP1600141B1 (en) * | 2004-05-24 | 2013-04-17 | 3M Deutschland GmbH | Collagenolytic active enzyme containing compositions for the treatment of dental caries |
| EP1726643A1 (en) | 2005-05-27 | 2006-11-29 | Direvo Biotech AG | Method for the provision, identification and selection of proteases with altered sensitivity to activity-modulating substances |
| DK2321640T3 (en) | 2008-08-21 | 2017-02-27 | Immunogenics Llc | FORMULATION FOR ORAL ADMINISTRATION OF PROTEINS |
| HU0900199D0 (en) * | 2009-04-01 | 2009-06-29 | Debreceni Egyetem | Diagnosis of gluten-induced autoimmune diseases |
| US20110200574A1 (en) * | 2010-02-02 | 2011-08-18 | Jolly James F | Use of proteases for gluten intolerance |
| JP6342802B2 (ja) * | 2011-08-10 | 2018-06-13 | ザ ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーションＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｗａｓｈｉｎｇｔｏｎ Ｔｈｒｏｕｇｈ Ｉｔｓ Ｃｅｎｔｅｒ Ｆｏｒ Ｃｏｍｍｅｒｃｉａｌｉｚａｔｉｏｎ | セリアックスプルー病を治療するための組成物および方法 |
| IN2014CN04131A (es) | 2011-12-06 | 2015-07-17 | Fond Istituto Insubrico Di Ricerca Per La Vita | |
| EP3033100B1 (en) * | 2013-08-14 | 2018-10-03 | University Of Washington Through Its Center For Commercialization | Compositions for treating celiac sprue disease |
| EP3039068B1 (en) * | 2013-08-30 | 2020-12-16 | Momentive Performance Materials Inc. | Moisture curable compound with amino acids |
| KR20180023903A (ko) * | 2015-06-08 | 2018-03-07 | 유니버시티 오브 워싱턴 | 셀리악 스프루 질환 치료용 조성물 및 방법 |
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2016
- 2016-06-08 KR KR1020177036246A patent/KR20180023903A/ko active IP Right Grant
- 2016-06-08 BR BR112017026142A patent/BR112017026142A2/pt active Search and Examination
- 2016-06-08 JP JP2017560984A patent/JP7325030B2/ja active Active
- 2016-06-08 EP EP16731724.7A patent/EP3302518A1/en active Pending
- 2016-06-08 SG SG10201911867YA patent/SG10201911867YA/en unknown
- 2016-06-08 MY MYPI2017704393A patent/MY189160A/en unknown
- 2016-06-08 PE PE2017002543A patent/PE20180509A1/es unknown
- 2016-06-08 CN CN201680032977.9A patent/CN107873053A/zh active Pending
- 2016-06-08 EA EA201792362A patent/EA037603B1/ru not_active IP Right Cessation
- 2016-06-08 WO PCT/US2016/036356 patent/WO2016200880A1/en active Application Filing
- 2016-06-08 TN TNP/2017/000520A patent/TN2017000520A1/en unknown
- 2016-06-08 MX MX2017015786A patent/MX2017015786A/es unknown
- 2016-06-08 CR CR20170567A patent/CR20170567A/es unknown
- 2016-06-08 AU AU2016276436A patent/AU2016276436B2/en active Active
- 2016-06-08 US US15/575,159 patent/US10793846B2/en active Active
- 2016-06-08 CA CA2988651A patent/CA2988651A1/en active Pending
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2017
- 2017-12-04 PH PH12017502213A patent/PH12017502213A1/en unknown
- 2017-12-04 SA SA517390479A patent/SA517390479B1/ar unknown
- 2017-12-04 CL CL2017003097A patent/CL2017003097A1/es unknown
- 2017-12-04 IL IL256103A patent/IL256103B/en unknown
- 2017-12-05 MX MX2022005483A patent/MX2022005483A/es unknown
- 2017-12-07 DO DO2017000286A patent/DOP2017000286A/es unknown
- 2017-12-07 EC ECIEPI201780844A patent/ECSP17080844A/es unknown
- 2017-12-28 CO CONC2017/0013720A patent/CO2017013720A2/es unknown
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2018
- 2018-04-12 HK HK18104793.1A patent/HK1245129A1/zh unknown
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2019
- 2019-12-18 US US16/719,183 patent/US10988748B2/en active Active
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2020
- 2020-09-14 US US17/019,497 patent/US11485961B2/en active Active
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2021
- 2021-06-15 JP JP2021099361A patent/JP7429907B2/ja active Active
- 2021-12-07 IL IL288768A patent/IL288768A/en unknown
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2022
- 2022-09-13 US US17/931,704 patent/US20230130764A1/en active Pending
- 2022-09-28 AU AU2022241520A patent/AU2022241520A1/en active Pending
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2023
- 2023-03-16 CL CL2023000752A patent/CL2023000752A1/es unknown
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2024
- 2024-01-19 JP JP2024007072A patent/JP2024041995A/ja active Pending
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