SMT201700360T1 - Derivati di arilmetossi isoindolina, composizioni comprendenti i medesimi e metodi per usare i medesimi - Google Patents

Derivati di arilmetossi isoindolina, composizioni comprendenti i medesimi e metodi per usare i medesimi

Info

Publication number
SMT201700360T1
SMT201700360T1 SM20170360T SMT201700360T SMT201700360T1 SM T201700360 T1 SMT201700360 T1 SM T201700360T1 SM 20170360 T SM20170360 T SM 20170360T SM T201700360 T SMT201700360 T SM T201700360T SM T201700360 T1 SMT201700360 T1 SM T201700360T1
Authority
SM
San Marino
Prior art keywords
compositions
methods
same
isoindoline derivatives
arylmethoxy isoindoline
Prior art date
Application number
SM20170360T
Other languages
English (en)
Italian (it)
Inventor
George W Muller
Hon-Wah Man
Alexander Ruchelman
Ehab M Khalil
Roger Shen-Chu Chen
Weihong Zhang
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of SMT201700360T1 publication Critical patent/SMT201700360T1/it

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • AIDS & HIV (AREA)
  • Anesthesiology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
SM20170360T 2010-02-11 2011-02-10 Derivati di arilmetossi isoindolina, composizioni comprendenti i medesimi e metodi per usare i medesimi SMT201700360T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30361810P 2010-02-11 2010-02-11
PCT/US2011/024269 WO2011100380A1 (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
EP11704156.6A EP2536706B1 (en) 2010-02-11 2011-02-10 Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

Publications (1)

Publication Number Publication Date
SMT201700360T1 true SMT201700360T1 (it) 2017-09-07

Family

ID=43708752

Family Applications (3)

Application Number Title Priority Date Filing Date
SM20170360T SMT201700360T1 (it) 2010-02-11 2011-02-10 Derivati di arilmetossi isoindolina, composizioni comprendenti i medesimi e metodi per usare i medesimi
SM20190155T SMT201900155T1 (it) 2010-02-11 2011-02-10 Derivati di arilmetossi isoindolina, composizioni comprendenti i medesimi e metodi per usare i medesimi
SM20190420T SMT201900420T1 (it) 2010-02-11 2011-02-10 Derivati di arilmetossi isoindolina, composizioni comprendenti i medesimi e metodi per usare i medesimi

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Application Number Title Priority Date Filing Date
SM20190155T SMT201900155T1 (it) 2010-02-11 2011-02-10 Derivati di arilmetossi isoindolina, composizioni comprendenti i medesimi e metodi per usare i medesimi
SM20190420T SMT201900420T1 (it) 2010-02-11 2011-02-10 Derivati di arilmetossi isoindolina, composizioni comprendenti i medesimi e metodi per usare i medesimi

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US (8) US8518972B2 (enExample)
EP (6) EP3106460B1 (enExample)
JP (5) JP2013519675A (enExample)
KR (2) KR101812356B1 (enExample)
CN (2) CN104693193B (enExample)
AR (1) AR081058A1 (enExample)
AU (1) AU2011215877C1 (enExample)
CA (1) CA2787823C (enExample)
CO (1) CO6571916A2 (enExample)
CR (1) CR20120414A (enExample)
CY (3) CY1119177T1 (enExample)
DK (3) DK3202460T3 (enExample)
EC (1) ECSP12012098A (enExample)
ES (5) ES2738776T3 (enExample)
HR (3) HRP20171078T1 (enExample)
HU (3) HUE044652T2 (enExample)
IL (2) IL220992A (enExample)
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ME (2) ME03441B (enExample)
MX (3) MX2012009237A (enExample)
NI (1) NI201200132A (enExample)
NZ (3) NZ717149A (enExample)
PH (2) PH12012501607A1 (enExample)
PL (3) PL3202460T3 (enExample)
PT (3) PT3202461T (enExample)
RS (3) RS59275B1 (enExample)
RU (1) RU2567753C2 (enExample)
SG (3) SG10201501062SA (enExample)
SI (3) SI3202461T1 (enExample)
SM (3) SMT201700360T1 (enExample)
TR (1) TR201903027T4 (enExample)
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EP2436387B1 (en) 2009-05-25 2018-07-25 Celgene Corporation Pharmaceutical composition comprising crbn for use in treating a disease of the cerebral cortex
SG10201501062SA (en) 2010-02-11 2015-04-29 Celgene Corp Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
EP2699091B1 (en) * 2011-03-28 2017-06-21 DeuteRx, LLC 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
US9365640B2 (en) 2011-04-29 2016-06-14 Celgene Corporation Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
ES2872967T3 (es) 2012-06-29 2021-11-03 Celgene Corp Métodos para determinar la eficacia de fármacos usando IKZF3 (AIOLOS)
US20150038511A1 (en) * 2012-08-09 2015-02-05 Celgene Corporation Treatment of immune-related and inflammatory diseases
US20140343058A1 (en) * 2012-08-09 2014-11-20 Celgene Corporation Treatment of systemic lupus erythematosus
HRP20190398T1 (hr) * 2012-08-09 2019-05-17 Celgene Corporation Čvrsti oblik (s)-3-(4-((4-morfolinometil)benzil)oksi)-1-oksoizoindolin-2-il)piperidin-2,6-dion hidroklorida
CN114939119A (zh) * 2012-08-09 2022-08-26 细胞基因公司 免疫相关和炎性疾病的治疗
SI2882442T1 (sl) * 2012-08-09 2021-11-30 Celgene Corporation Metode zdravljenja raka z uporabo 3-(4-((4-(morfolinometil)benzil)oksi)-1-oksoizoindolin-2-il)piperidin- 2,6-diona
EP2882736B1 (en) * 2012-08-09 2019-01-09 Celgene Corporation Processes for the preparation of (s)-3-4-((4-(morpholinomethyl) benzyl)oxy)-1-oxoisoindolin-2-yl) piperidine-2,6-dione and pharmaceutically acceptable forms thereof
US9587281B2 (en) 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
US9694015B2 (en) * 2012-09-10 2017-07-04 Celgene Corporation Methods for the treatment of locally advanced breast cancer
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
US9540340B2 (en) 2013-01-14 2017-01-10 Deuterx, Llc 3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same
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US20110196150A1 (en) 2011-08-11
US8518972B2 (en) 2013-08-27
JP2016106106A (ja) 2016-06-16
EP2536706A1 (en) 2012-12-26

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