SI9600036B - Paroksetin hidroklorid anhidrat brez vezanega organskega topila - Google Patents

Paroksetin hidroklorid anhidrat brez vezanega organskega topila Download PDF

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Publication number
SI9600036B
SI9600036B SI9600036A SI9600036A SI9600036B SI 9600036 B SI9600036 B SI 9600036B SI 9600036 A SI9600036 A SI 9600036A SI 9600036 A SI9600036 A SI 9600036A SI 9600036 B SI9600036 B SI 9600036B
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SI
Slovenia
Prior art keywords
paroxetine hydrochloride
hydrochloride anhydrate
organic solvent
bound organic
bound
Prior art date
Application number
SI9600036A
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English (en)
Other versions
SI9600036A (en
Inventor
Victor JACEWICZ
Neal Ward
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27267578&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI9600036(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9502297.6A external-priority patent/GB9502297D0/en
Priority claimed from GBGB9503112.6A external-priority patent/GB9503112D0/en
Priority claimed from GBGB9509807.5A external-priority patent/GB9509807D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of SI9600036A publication Critical patent/SI9600036A/sl
Publication of SI9600036B publication Critical patent/SI9600036B/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Predlozeni izum se nanasa na paroksetin hidroklorid anhidrat, v bistvu brez vezanega propan-2-ola, na stevilne njegove oblike, na postopke za njegovopripravo, na nove intermediate, koristne pri njegovi pripravi, in na postopke zdravljenja in/ali preprecevanja nekaterih bolezni z dajanjem spojin v smislu izuma trpecemu, ki jih potrebuje.

Claims (3)

1 PATENTNI ZAHTEVKI 1. Paroksetin hidroklorid anhidrat v obliki C, označen s tem, da ima tališče okoli 164 °C in ima signifikantne IR trakove (Nujol muli) pri okoli 540, 574, 615, 674, 720, 760, 779, 802, 829, 840, 886, 935, 965, 984, 1007, 1034, 1092, 1109, 1139, 1183, 1218, 1240, 1263, 1280, 1507, 1540, 1558, 1598, 1652 cm'1; DSC eksoterm, meijen pri 10 °C na minuto, kaže maksimum okoli 161 °C tako v odprti kot tudi v zaprti posodi; ima tudi rentgenski difraktogram, vključno s karakterističnimi piki pri 10,1, 12,1, 13,1, 14,3 stopinjah 2 theta, in NMR spekter trdnega stanja vključno s karakterističnimi piki pri 154,0, 148,5, 143,4, 140,4 ppm.
2. Paroksetin hidroklorid anhidrat po zahtevku 1, ki je v obliki igel ali prizem.
3. Postopek za pripravo paroksetin hidroklorid anhidrata oblike C, označen s tem, da kristaliziramo paroksetin hidroklorid v organskem topilu ali zmesi organskih topil, izbranih iz skupine, v kateri so butan-l-ol, etil acetat, 2-butanon in toluen.
SI9600036A 1995-02-06 1996-02-05 Paroksetin hidroklorid anhidrat brez vezanega organskega topila SI9600036B (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9502297.6A GB9502297D0 (en) 1995-02-06 1995-02-06 Novel compound
GBGB9503112.6A GB9503112D0 (en) 1995-02-17 1995-02-17 Novel compound
GBGB9509807.5A GB9509807D0 (en) 1995-05-15 1995-05-15 Novel compounds

Publications (2)

Publication Number Publication Date
SI9600036A SI9600036A (en) 1996-10-31
SI9600036B true SI9600036B (sl) 2006-12-31

Family

ID=27267578

Family Applications (2)

Application Number Title Priority Date Filing Date
SI9600036A SI9600036B (sl) 1995-02-06 1996-02-05 Paroksetin hidroklorid anhidrat brez vezanega organskega topila
SI9600378A SI21923B (sl) 1995-02-06 1996-02-05 Paroksetin hidroklorid anhidrat brez vezanega organskega topila

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI9600378A SI21923B (sl) 1995-02-06 1996-02-05 Paroksetin hidroklorid anhidrat brez vezanega organskega topila

Country Status (47)

Country Link
EP (3) EP1378508A1 (sl)
JP (2) JP2915338B2 (sl)
KR (1) KR100289885B1 (sl)
CN (3) CN1289496C (sl)
AR (2) AR001982A1 (sl)
AT (1) AT407528B (sl)
AU (2) AU4786496A (sl)
BE (1) BE1009112A3 (sl)
BG (1) BG62967B1 (sl)
BR (1) BR9600534A (sl)
CA (4) CA2210023C (sl)
CH (3) CH689229A5 (sl)
CZ (1) CZ297171B6 (sl)
DE (3) DE19603797C2 (sl)
DK (2) DK11996A (sl)
DZ (1) DZ1989A1 (sl)
ES (1) ES2114471B1 (sl)
FI (3) FI111544B (sl)
FR (1) FR2730232B1 (sl)
GR (1) GR1002466B (sl)
HK (1) HK59397A (sl)
HU (1) HUP9600255A1 (sl)
IE (1) IE80500B1 (sl)
IL (1) IL117035A (sl)
IT (1) IT1289532B1 (sl)
LU (1) LU88711A1 (sl)
LV (1) LV11618B (sl)
MA (1) MA23802A1 (sl)
MC (1) MC2411A1 (sl)
MX (1) MX9600484A (sl)
MY (1) MY132529A (sl)
NL (1) NL1002248C2 (sl)
NO (3) NO301009B1 (sl)
NZ (1) NZ280943A (sl)
OA (1) OA10261A (sl)
PL (1) PL189247B1 (sl)
PT (1) PT101827B (sl)
RO (1) RO112426B1 (sl)
RU (1) RU2125052C1 (sl)
SE (1) SE521084C2 (sl)
SG (1) SG43787A1 (sl)
SI (2) SI9600036B (sl)
SK (1) SK283608B6 (sl)
TR (1) TR199600096A2 (sl)
TW (1) TW503238B (sl)
UA (1) UA49796C2 (sl)
WO (1) WO1996024595A1 (sl)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3882224B2 (ja) 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
DE69739561D1 (de) 1996-06-13 2009-10-15 Sumitomo Chemical Co Piperidin Derivative als Zwischenprodukte zur Herstellung von Paroxetine und Verfahren zu ihrer Herstellung
EP0937152A2 (en) * 1996-07-15 1999-08-25 Smithkline Beecham Plc Screening for and use of an esterase for a stereospecific resolution
US5672612A (en) * 1996-09-09 1997-09-30 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
US6638948B1 (en) 1996-09-09 2003-10-28 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
CA2193939C (en) * 1996-12-24 2002-02-12 K.S. Keshava Murthy Useful form of anhydrous paroxetine hydrochloride
AU3108097A (en) * 1997-06-10 1998-12-30 Synthon B.V. 4-phenylpiperidine compounds
EP0987256B1 (de) * 1997-08-08 2001-10-17 Aventis Pharma Deutschland GmbH Kristallform von N-(4-Trifluormethylphenyl)-5-methylisoxazol-4-carbonsäureamid
GB9726907D0 (en) * 1997-12-19 1998-02-18 Smithkline Beecham Plc Novel compounds
AU2847199A (en) * 1998-03-16 1999-10-11 Smithkline Beecham Plc Crystalline form of paroxetine
AU2003200534B2 (en) * 1998-03-24 2004-12-02 Smithkline Beecham Plc Paroxetine compositions
GB9806312D0 (en) * 1998-03-24 1998-05-20 Smithkline Beecham Plc Novel formulations
US6699882B2 (en) 1998-03-24 2004-03-02 Smithkline Beecham P.L.C. Paroxetine compositions
JP3796351B2 (ja) 1998-04-13 2006-07-12 住友化学株式会社 パロキセチン塩酸塩無水和物の乾燥方法
GB9812941D0 (en) * 1998-06-16 1998-08-12 Smithkline Beecham Plc Method of treatment
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
ES2138937B1 (es) 1998-07-07 2000-10-01 Medichem Sa Polimorfo de maleato de paroxetina y formulaciones farmaceuticas que lo contienen.
IL141286A0 (en) * 1998-08-07 2002-03-10 Smithkline Beechmam Plc Process for the preparation of a non-crystalline anhydrate form of paroxetine hydrochloride
GB9824298D0 (en) * 1998-11-05 1998-12-30 Smithkline Beecham Plc Novel process
GB9826175D0 (en) * 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
GB9826176D0 (en) * 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
GB9826180D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9826242D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9826171D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel compounds
GB9826178D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
PT1135383E (pt) * 1998-11-30 2004-04-30 Smithkline Beecham Plc Solvatos mistos de propan-2-ol de paroxetina
GB9828767D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
EP1161241B1 (de) * 1999-03-12 2005-12-07 Aesica Pharmaceuticals Ltd. Stabile pharmazeutische anwendungsform für paroxetin-anhydrat
GB9914585D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
GB9914583D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
GB9919001D0 (en) * 1999-08-12 1999-10-13 Smithkline Beecham Plc Novel process
GB9923446D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
GB9923439D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
GB9923445D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
HU226912B1 (en) * 2000-04-07 2010-03-01 Richter Gedeon Nyrt New paroxetin salt and medicament containing it
JPWO2002022609A1 (ja) * 2000-09-14 2004-01-22 旭硝子株式会社 実質的に有機溶媒を含まないパロキセチン塩類の製造方法
EP1482939A4 (en) * 2002-02-22 2005-10-12 Teva Pharma PREPARATION OF PAROXETIN WITH NEW INTERMEDIATE PRODUCTS
KR20080055990A (ko) * 2005-11-22 2008-06-19 테바 파마슈티컬 인더스트리즈 리미티드 시나칼셋 ＨＣｌ의 결정형 및 이의 제조 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
GB8430581D0 (en) * 1984-12-04 1985-01-09 Ferrosan As Treatment
ES2058061T3 (es) * 1985-10-25 1994-11-01 Beecham Group Plc Derivado de piperidina, su preparacion y su uso como medicamento.
GB8626936D0 (en) * 1986-11-11 1986-12-10 Ferrosan As Treatment
DK716088D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Reduktion af piperidin-dion-derivater samt intermediat
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater
WO1992009281A2 (en) * 1990-11-24 1992-06-11 Beecham Group Plc Use of paroxetine for the treatment of senile dementia, bulimia, migraine or anorexia
GB9325644D0 (en) * 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation

Also Published As

Publication number Publication date
ITMI960203A1 (it) 1997-08-05
CN1216055C (zh) 2005-08-24
JP2915338B2 (ja) 1999-07-05
KR100289885B1 (ko) 2001-05-15
FR2730232A1 (fr) 1996-08-09
BG100333A (bg) 1996-08-30
NO301009B3 (sl) 2003-01-06
HUP9600255A1 (en) 1997-03-28
NO311519B1 (no) 2001-12-03
CA2210022C (en) 2005-09-13
KR960031409A (ko) 1996-09-17
CA2168829C (en) 1997-12-16
LU88711A1 (fr) 1996-08-23
CA2211522C (en) 1999-12-07
NO301009B1 (no) 1997-09-01
IT1289532B1 (it) 1998-10-15
FI20030370A (fi) 2003-03-12
LV11618B (en) 1997-04-20
AU4786496A (en) 1996-08-27
IE80500B1 (en) 1998-08-12
WO1996024595A1 (en) 1996-08-15
NO970939L (no) 1996-08-07
IL117035A0 (en) 1996-09-12
FI111544B (fi) 2003-08-15
AT407528B (de) 2001-04-25
GR1002466B (el) 1996-11-06
FI960519A (fi) 1996-08-07
PT101827B (pt) 1997-08-29
CN1143643A (zh) 1997-02-26
FI960519A0 (fi) 1996-02-05
AU4332896A (en) 1996-08-15
EP1136490B1 (en) 2004-01-07
NO960472L (no) 1996-08-07
SE521084C2 (sv) 2003-09-30
UA49796C2 (uk) 2002-10-15
NO20015070L (no) 1996-08-07
SG43787A1 (en) 1997-11-14
CN1090187C (zh) 2002-09-04
LV11618A (lv) 1996-12-20
CZ32096A3 (en) 1996-08-14
MY132529A (en) 2007-10-31
JPH11228571A (ja) 1999-08-24
MA23802A1 (fr) 1996-10-01
ATA21096A (de) 2000-08-15
NO960472D0 (no) 1996-02-05
BG62967B1 (bg) 2000-12-29
JPH08245620A (ja) 1996-09-24
CA2211522A1 (en) 1996-08-07
AU701518B2 (en) 1999-01-28
DK200100223A (sl) 2001-02-12
CH689229A5 (de) 1998-12-31
EP1378508A1 (en) 2004-01-07
ITMI960203A0 (sl) 1996-02-05
SK283608B6 (sk) 2003-10-07
FI20030162A (fi) 2003-02-03
HK59397A (en) 1997-05-16
BE1009112A3 (fr) 1996-11-05
MX198371B (sl) 2000-08-29
SE9600406L (sv) 1996-08-07
EP0808314A1 (en) 1997-11-26
RO112426B1 (ro) 1997-09-30
SI9600036A (en) 1996-10-31
TR199600096A2 (tr) 1996-08-21
CA2210023A1 (en) 1996-08-07
DE69631298D1 (de) 2004-02-12
TW503238B (en) 2002-09-21
HU9600255D0 (en) 1996-03-28
CH689804A5 (de) 1999-11-30
AR001982A1 (es) 1998-01-07
ES2114471A1 (es) 1998-05-16
MX9600484A (es) 1997-01-31
DK11996A (da) 1996-08-07
DZ1989A1 (fr) 2002-10-15
DE69621777D1 (de) 2002-07-18
DE19603797A1 (de) 1996-08-14
CN1636993A (zh) 2005-07-13
NL1002248C2 (nl) 1996-09-11
ES2114471B1 (es) 1999-08-16
DE69621777T2 (de) 2003-01-02
NZ280943A (en) 1997-01-29
DE69631298T2 (de) 2004-11-18
NL1002248A1 (nl) 1996-08-06
PL189247B1 (pl) 2005-07-29
SI21923A (sl) 2006-06-30
AR036856A2 (es) 2004-10-06
CA2210022A1 (en) 1996-08-07
CN1310180A (zh) 2001-08-29
SK14396A3 (en) 1996-11-06
NO20015070D0 (no) 2001-10-18
CA2210023C (en) 1999-02-09
SE9600406D0 (sv) 1996-02-05
RU2125052C1 (ru) 1999-01-20
AU701518C (en) 2006-12-07
NO970939D0 (no) 1997-02-28
IE960104A1 (en) 1996-08-07
PT101827A (pt) 1996-09-30
DE19603797C2 (de) 1998-11-12
OA10261A (en) 1997-09-19
PL312646A1 (en) 1996-08-19
CA2168829A1 (en) 1996-08-07
CH688353A5 (de) 1997-08-15
IL117035A (en) 2000-02-29
CN1289496C (zh) 2006-12-13
FR2730232B1 (fr) 1997-08-01
MC2411A1 (fr) 1996-12-02
EP0808314B1 (en) 2002-06-12
SI21923B (sl) 2006-12-31
EP1136490A1 (en) 2001-09-26
BR9600534A (pt) 1997-05-13
CZ297171B6 (cs) 2006-09-13

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Legal Events

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IF Valid on the event date
OU02 Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims

Effective date: 20061027

KO00 Lapse of patent

Effective date: 20140214