DE69631298D1 - Verfahren zur Herstellung von Paroxetinhydrochloridanhydrat - Google Patents

Verfahren zur Herstellung von Paroxetinhydrochloridanhydrat

Info

Publication number
DE69631298D1
DE69631298D1 DE69631298T DE69631298T DE69631298D1 DE 69631298 D1 DE69631298 D1 DE 69631298D1 DE 69631298 T DE69631298 T DE 69631298T DE 69631298 T DE69631298 T DE 69631298T DE 69631298 D1 DE69631298 D1 DE 69631298D1
Authority
DE
Germany
Prior art keywords
preparation
paroxetine hydrochloride
hydrochloride anhydrate
anhydrate
paroxetine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69631298T
Other languages
English (en)
Other versions
DE69631298T2 (de
Inventor
Victor Witold Jacewicz
Neal Ward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27267578&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69631298(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9502297.6A external-priority patent/GB9502297D0/en
Priority claimed from GBGB9503112.6A external-priority patent/GB9503112D0/en
Priority claimed from GBGB9509807.5A external-priority patent/GB9509807D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of DE69631298D1 publication Critical patent/DE69631298D1/de
Publication of DE69631298T2 publication Critical patent/DE69631298T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE1996631298 1995-02-06 1996-02-02 Paroxetinhydrochloridanhydrat Expired - Lifetime DE69631298T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9502297 1995-02-06
GBGB9502297.6A GB9502297D0 (en) 1995-02-06 1995-02-06 Novel compound
GBGB9503112.6A GB9503112D0 (en) 1995-02-17 1995-02-17 Novel compound
GB9503112 1995-02-17
GBGB9509807.5A GB9509807D0 (en) 1995-05-15 1995-05-15 Novel compounds
GB9509807 1995-05-15

Publications (2)

Publication Number Publication Date
DE69631298D1 true DE69631298D1 (de) 2004-02-12
DE69631298T2 DE69631298T2 (de) 2004-11-18

Family

ID=27267578

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69621777T Expired - Lifetime DE69621777T2 (de) 1995-02-06 1996-02-02 Formen von paroxetin hydrochlorid
DE1996631298 Expired - Lifetime DE69631298T2 (de) 1995-02-06 1996-02-02 Paroxetinhydrochloridanhydrat
DE19603797A Revoked DE19603797C2 (de) 1995-02-06 1996-02-02 Neue Formen von Paroxetin-Hydrochlorid

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69621777T Expired - Lifetime DE69621777T2 (de) 1995-02-06 1996-02-02 Formen von paroxetin hydrochlorid

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19603797A Revoked DE19603797C2 (de) 1995-02-06 1996-02-02 Neue Formen von Paroxetin-Hydrochlorid

Country Status (47)

Country Link
EP (3) EP0808314B1 (de)
JP (2) JP2915338B2 (de)
KR (1) KR100289885B1 (de)
CN (3) CN1090187C (de)
AR (2) AR001982A1 (de)
AT (1) AT407528B (de)
AU (2) AU701518C (de)
BE (1) BE1009112A3 (de)
BG (1) BG62967B1 (de)
BR (1) BR9600534A (de)
CA (4) CA2210022C (de)
CH (3) CH688353A5 (de)
CZ (1) CZ297171B6 (de)
DE (3) DE69621777T2 (de)
DK (2) DK11996A (de)
DZ (1) DZ1989A1 (de)
ES (1) ES2114471B1 (de)
FI (3) FI111544B (de)
FR (1) FR2730232B1 (de)
GR (1) GR1002466B (de)
HK (1) HK59397A (de)
HU (1) HUP9600255A1 (de)
IE (1) IE80500B1 (de)
IL (1) IL117035A (de)
IT (1) IT1289532B1 (de)
LU (1) LU88711A1 (de)
LV (1) LV11618B (de)
MA (1) MA23802A1 (de)
MC (1) MC2411A1 (de)
MX (1) MX9600484A (de)
MY (1) MY132529A (de)
NL (1) NL1002248C2 (de)
NO (3) NO301009B1 (de)
NZ (1) NZ280943A (de)
OA (1) OA10261A (de)
PL (1) PL189247B1 (de)
PT (1) PT101827B (de)
RO (1) RO112426B1 (de)
RU (1) RU2125052C1 (de)
SE (1) SE521084C2 (de)
SG (1) SG43787A1 (de)
SI (2) SI21923B (de)
SK (1) SK283608B6 (de)
TR (1) TR199600096A2 (de)
TW (1) TW503238B (de)
UA (1) UA49796C2 (de)
WO (1) WO1996024595A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3882224B2 (ja) 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
EP0812827B1 (de) 1996-06-13 2009-09-02 Sumitomo Chemical Company, Limited Piperidin Derivative als Zwischenprodukte zur Herstellung von Paroxetine und Verfahren zu ihrer Herstellung
JP2000514653A (ja) * 1996-07-15 2000-11-07 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 立体特異的分割のためのエステラーゼのスクリーニングおよびその使用
US5672612A (en) * 1996-09-09 1997-09-30 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
US6638948B1 (en) 1996-09-09 2003-10-28 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
CA2193939C (en) * 1996-12-24 2002-02-12 K.S. Keshava Murthy Useful form of anhydrous paroxetine hydrochloride
EE03970B1 (et) * 1997-06-10 2003-02-17 Synthon B.V. 4-fenüülpiperidiinühend, selle valmistamine ja kasutamine ning seda sisaldav ravim
ATE207065T1 (de) * 1997-08-08 2001-11-15 Aventis Pharma Gmbh Kristallform von n-(4-trifluormethylphenyl)-5- methylisoxazol-4-carbonsäureamid
GB9726907D0 (en) * 1997-12-19 1998-02-18 Smithkline Beecham Plc Novel compounds
KR20010041947A (ko) * 1998-03-16 2001-05-25 피터 기딩스 결정 형태의 파록세틴
GB9806312D0 (en) * 1998-03-24 1998-05-20 Smithkline Beecham Plc Novel formulations
AU2003200534B2 (en) * 1998-03-24 2004-12-02 Smithkline Beecham Plc Paroxetine compositions
US6699882B2 (en) 1998-03-24 2004-03-02 Smithkline Beecham P.L.C. Paroxetine compositions
JP3796351B2 (ja) 1998-04-13 2006-07-12 住友化学株式会社 パロキセチン塩酸塩無水和物の乾燥方法
GB9812941D0 (en) * 1998-06-16 1998-08-12 Smithkline Beecham Plc Method of treatment
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
ES2138937B1 (es) 1998-07-07 2000-10-01 Medichem Sa Polimorfo de maleato de paroxetina y formulaciones farmaceuticas que lo contienen.
ATE239016T1 (de) * 1998-08-07 2003-05-15 Smithkline Beecham Plc Verfahren zur herstellung von einer nicht- kristallinen wasswerfreien form von paroxetin hydrochlorid
GB9824298D0 (en) * 1998-11-05 1998-12-30 Smithkline Beecham Plc Novel process
GB9826176D0 (en) * 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
GB9826175D0 (en) * 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
GB9826178D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9826242D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9826171D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel compounds
JP2002531452A (ja) * 1998-11-30 2002-09-24 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 混合パロキセチンプロパン−２−オール溶媒和物
GB9826180D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9828767D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
AU3810100A (en) * 1999-03-12 2000-10-04 Basf Aktiengesellschaft Stable pharmaceutical application form for paroxetin anhydrate
GB9914583D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
GB9914585D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
GB9919001D0 (en) * 1999-08-12 1999-10-13 Smithkline Beecham Plc Novel process
GB9923445D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
GB9923439D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
GB9923446D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
HU226912B1 (en) * 2000-04-07 2010-03-01 Richter Gedeon Nyrt New paroxetin salt and medicament containing it
AU2001286232A1 (en) * 2000-09-14 2002-03-26 Asahi Glass Company, Limited Process for producing paroxetine salt containing substantially no organic solvent
WO2003072104A1 (en) * 2002-02-22 2003-09-04 Teva Pharmaceutical Industries Ltd. Preparation of paroxetine involving novel intermediates
JP2009516655A (ja) * 2005-11-22 2009-04-23 テバ ファーマシューティカル インダストリーズ リミティド シナカルセット塩酸塩の結晶形フォーム（Ｆｏｒｍ）、およびそれらの調製方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
GB8430581D0 (en) * 1984-12-04 1985-01-09 Ferrosan As Treatment
EP0223403B1 (de) * 1985-10-25 1993-08-04 Beecham Group Plc Piperidinderivat, seine Herstellung und seine Verwendung als Arzneimittel
GB8626936D0 (en) * 1986-11-11 1986-12-10 Ferrosan As Treatment
DK716088D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Reduktion af piperidin-dion-derivater samt intermediat
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater
CA2096853A1 (en) * 1990-11-24 1992-05-25 Anthony Michael Johnson Use of paroxetine for the treatment of senile dementia, bulimia, migraine or anorexia
GB9325644D0 (en) * 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation

Also Published As

Publication number Publication date
SK283608B6 (sk) 2003-10-07
SI9600036B (sl) 2006-12-31
BG62967B1 (bg) 2000-12-29
CN1289496C (zh) 2006-12-13
PT101827B (pt) 1997-08-29
DE69631298T2 (de) 2004-11-18
IL117035A0 (en) 1996-09-12
SI21923A (sl) 2006-06-30
RU2125052C1 (ru) 1999-01-20
BE1009112A3 (fr) 1996-11-05
KR960031409A (ko) 1996-09-17
FR2730232A1 (fr) 1996-08-09
PT101827A (pt) 1996-09-30
NO20015070D0 (no) 2001-10-18
EP1136490B1 (de) 2004-01-07
CA2210023A1 (en) 1996-08-07
HK59397A (en) 1997-05-16
AR036856A2 (es) 2004-10-06
AT407528B (de) 2001-04-25
GR1002466B (el) 1996-11-06
KR100289885B1 (ko) 2001-05-15
FI20030370A (fi) 2003-03-12
CZ297171B6 (cs) 2006-09-13
NL1002248C2 (nl) 1996-09-11
CH689804A5 (de) 1999-11-30
CA2168829C (en) 1997-12-16
CA2210022A1 (en) 1996-08-07
JPH08245620A (ja) 1996-09-24
DE69621777D1 (de) 2002-07-18
HUP9600255A1 (en) 1997-03-28
BG100333A (bg) 1996-08-30
MC2411A1 (fr) 1996-12-02
AU701518C (en) 2006-12-07
ES2114471B1 (es) 1999-08-16
RO112426B1 (ro) 1997-09-30
HU9600255D0 (en) 1996-03-28
PL189247B1 (pl) 2005-07-29
IL117035A (en) 2000-02-29
NO301009B3 (de) 2003-01-06
SI21923B (sl) 2006-12-31
DE19603797A1 (de) 1996-08-14
NO20015070L (no) 1996-08-07
MA23802A1 (fr) 1996-10-01
TR199600096A2 (tr) 1996-08-21
NO960472D0 (no) 1996-02-05
CN1216055C (zh) 2005-08-24
CA2168829A1 (en) 1996-08-07
FR2730232B1 (fr) 1997-08-01
CZ32096A3 (en) 1996-08-14
DE19603797C2 (de) 1998-11-12
EP1378508A1 (de) 2004-01-07
AU701518B2 (en) 1999-01-28
MX9600484A (es) 1997-01-31
MY132529A (en) 2007-10-31
SG43787A1 (en) 1997-11-14
JPH11228571A (ja) 1999-08-24
WO1996024595A1 (en) 1996-08-15
SE9600406L (sv) 1996-08-07
EP0808314A1 (de) 1997-11-26
CN1143643A (zh) 1997-02-26
FI960519A0 (fi) 1996-02-05
ITMI960203A0 (de) 1996-02-05
MX198371B (de) 2000-08-29
CN1310180A (zh) 2001-08-29
IE80500B1 (en) 1998-08-12
ES2114471A1 (es) 1998-05-16
DK11996A (da) 1996-08-07
DZ1989A1 (fr) 2002-10-15
DK200100223A (de) 2001-02-12
TW503238B (en) 2002-09-21
EP1136490A1 (de) 2001-09-26
AU4786496A (en) 1996-08-27
FI20030162A (fi) 2003-02-03
JP2915338B2 (ja) 1999-07-05
SE9600406D0 (sv) 1996-02-05
NZ280943A (en) 1997-01-29
EP0808314B1 (de) 2002-06-12
CA2210023C (en) 1999-02-09
NO960472L (no) 1996-08-07
ATA21096A (de) 2000-08-15
BR9600534A (pt) 1997-05-13
NO970939D0 (no) 1997-02-28
AU4332896A (en) 1996-08-15
IT1289532B1 (it) 1998-10-15
AR001982A1 (es) 1998-01-07
NO970939L (no) 1996-08-07
CA2211522C (en) 1999-12-07
LU88711A1 (fr) 1996-08-23
CN1090187C (zh) 2002-09-04
SE521084C2 (sv) 2003-09-30
UA49796C2 (uk) 2002-10-15
SK14396A3 (en) 1996-11-06
ITMI960203A1 (it) 1997-08-05
OA10261A (en) 1997-09-19
PL312646A1 (en) 1996-08-19
CH689229A5 (de) 1998-12-31
IE960104A1 (en) 1996-08-07
DE69621777T2 (de) 2003-01-02
NL1002248A1 (nl) 1996-08-06
NO311519B1 (no) 2001-12-03
FI960519A (fi) 1996-08-07
FI111544B (fi) 2003-08-15
SI9600036A (en) 1996-10-31
CA2211522A1 (en) 1996-08-07
LV11618B (en) 1997-04-20
CA2210022C (en) 2005-09-13
LV11618A (lv) 1996-12-20
CN1636993A (zh) 2005-07-13
CH688353A5 (de) 1997-08-15
NO301009B1 (no) 1997-09-01

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