DE69619067D1 - Verfahren zur Herstellung von 3-Amino-2-oxo-1-Halogenpropan-Derivaten - Google Patents

Verfahren zur Herstellung von 3-Amino-2-oxo-1-Halogenpropan-Derivaten

Info

Publication number
DE69619067D1
DE69619067D1 DE69619067T DE69619067T DE69619067D1 DE 69619067 D1 DE69619067 D1 DE 69619067D1 DE 69619067 T DE69619067 T DE 69619067T DE 69619067 T DE69619067 T DE 69619067T DE 69619067 D1 DE69619067 D1 DE 69619067D1
Authority
DE
Germany
Prior art keywords
halopropane
oxo
derivatives
amino
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69619067T
Other languages
English (en)
Other versions
DE69619067T2 (de
Inventor
Yutaka Honda
Satoshi Katayama
Kunisuke Izawa
Masakazu Nakazawa
Takayuki Suzuki
Naoko Kanno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Application granted granted Critical
Publication of DE69619067D1 publication Critical patent/DE69619067D1/de
Publication of DE69619067T2 publication Critical patent/DE69619067T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
DE69619067T 1995-11-17 1996-11-18 Verfahren zur Herstellung von 3-Amino-2-oxo-1-Halogenpropan-Derivaten Expired - Fee Related DE69619067T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29982795 1995-11-17

Publications (2)

Publication Number Publication Date
DE69619067D1 true DE69619067D1 (de) 2002-03-21
DE69619067T2 DE69619067T2 (de) 2002-10-02

Family

ID=17877407

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69619067T Expired - Fee Related DE69619067T2 (de) 1995-11-17 1996-11-18 Verfahren zur Herstellung von 3-Amino-2-oxo-1-Halogenpropan-Derivaten

Country Status (4)

Country Link
US (3) US5767316A (de)
EP (2) EP1097919A3 (de)
CA (1) CA2190570C (de)
DE (1) DE69619067T2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1097919A3 (de) * 1995-11-17 2003-08-06 Ajinomoto Co., Inc. Verfahren zur Herstellung eines 4-Amino-3-oxo-butansäureesters
JPH11100363A (ja) * 1997-07-29 1999-04-13 Kanegafuchi Chem Ind Co Ltd アミノ基が保護された（２ｓ，３ｒ）−１−ハロ−２−ヒドロキシ−３−アミノ−４−フェニルチオブタン又はその光学対掌体の精製、単離方法
EP1067125B1 (de) * 1999-01-29 2006-07-26 Kaneka Corporation VERFAHREN ZUR HERSTELLUNG VON threo-1,2-EPOXY-3-AMINO-4-PHENYLBUTAN-DERIVATEN
KR100708221B1 (ko) * 1999-08-31 2007-04-17 아지노모토 가부시키가이샤 에폭사이드 결정의 제조방법
ATE401298T1 (de) * 1999-12-23 2008-08-15 Ampac Fine Chemicals Llc Verbessertes verfahren zur herstellung von 2s,3s- n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)- - nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin
US6399793B1 (en) * 2000-08-16 2002-06-04 Bristol-Myers Squibb Company Process for the preparation of α' chloroketones
JPWO2002044136A1 (ja) * 2000-11-30 2004-04-02 味の素株式会社 Ｎ保護−β−アミノアルコールの製造法およびＮ保護−β−アミノエポキシドの製造法
DE10143742A1 (de) * 2001-09-06 2003-03-27 Consortium Elektrochem Ind Verfahren zur Herstellung von alpha-Halogenketonen
CN1329373C (zh) * 2003-12-11 2007-08-01 上海安基生物科技股份有限公司 （2s.3r）－n－苄氧羰基－3－氨基－1－氯－4－苯硫基－2－丁醇的生产方法
US20050244816A1 (en) * 2003-12-19 2005-11-03 Ark Diagnostics, Inc. Immunoassays, haptens, immunogens and antibodies for anti-HIV therapeutics
US7772411B2 (en) 2003-12-23 2010-08-10 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
DE602008005462D1 (de) * 2007-06-22 2011-04-21 Bristol Myers Squibb Co Tablettierte atazanavirhaltige zusammensetzungen
DE602008005896D1 (de) * 2007-06-22 2011-05-12 Bristol Myers Squibb Co Tablettierte atazanavirhaltige zusammensetzungen
DK2170292T3 (da) * 2007-06-22 2014-04-07 Bristol Myers Squibb Holdings Ireland Atazanavirholdige sammensætninger i tabletform
KR20100033378A (ko) * 2007-06-22 2010-03-29 브리스톨-마이어스 스큅 컴퍼니 아타자나비르를 함유하는 정제 조성물
CN101508664B (zh) * 2009-02-25 2012-08-22 江阴希迪医药科技有限公司 N-苄氧羰基-3-氨基-1-氯-4-苯硫基-2-丁醇合成方法
EP2380871B1 (de) * 2010-04-15 2013-01-09 Indena S.p.A. Verfahren zur Herstellung von Isoserinderivaten
CN106380412A (zh) * 2016-08-31 2017-02-08 中国科学院新疆生态与地理研究所 一种合成利托那韦中间体的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1529913A (en) 1976-02-04 1978-10-25 Beecham Group Ltd Beta-lactam compounds
CA1340588C (en) 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
DE3820492A1 (de) 1988-06-16 1989-12-28 Diehl Gmbh & Co Rohrwaffe mit chemisch-elektrischem hybridantrieb mittels regenerativer treibmitteleinspritzung
US5021454A (en) * 1989-10-06 1991-06-04 Rohm And Haas Company Benzoylaminoalkanoic acids and esters
US5101068A (en) 1990-02-16 1992-03-31 Prototek Inc. Magnesium fluoromalonates
US5648511A (en) * 1990-11-19 1997-07-15 G.D. Searle & Co. Method for making intermediates useful in the synthesis of retroviral protease inhibitors
AU4253193A (en) 1992-05-20 1993-12-13 G.D. Searle & Co. Urea-containing hydroxyethylamine compounds as retroviral protease inhibitors
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5461154A (en) 1994-02-02 1995-10-24 Eli Lilly And Company Intermediate and process for making
US5929284A (en) 1995-02-03 1999-07-27 Kaneka Corporation Processes for producing α-halo ketones, α-halohydrins and epoxides
EP1097919A3 (de) * 1995-11-17 2003-08-06 Ajinomoto Co., Inc. Verfahren zur Herstellung eines 4-Amino-3-oxo-butansäureesters

Also Published As

Publication number Publication date
EP1097919A3 (de) 2003-08-06
US5902887A (en) 1999-05-11
EP0774453B1 (de) 2002-02-06
DE69619067T2 (de) 2002-10-02
US5767316A (en) 1998-06-16
CA2190570C (en) 2005-05-03
CA2190570A1 (en) 1997-05-18
USRE38796E1 (en) 2005-09-13
EP0774453A1 (de) 1997-05-21
EP1097919A2 (de) 2001-05-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee