FR2730232B1 - Anhydrate de chlorhydrate de paroxetine pratiquement depourvu de propane-2-ol lie, son application en therapeutique - Google Patents

Anhydrate de chlorhydrate de paroxetine pratiquement depourvu de propane-2-ol lie, son application en therapeutique

Info

Publication number
FR2730232B1
FR2730232B1 FR9601297A FR9601297A FR2730232B1 FR 2730232 B1 FR2730232 B1 FR 2730232B1 FR 9601297 A FR9601297 A FR 9601297A FR 9601297 A FR9601297 A FR 9601297A FR 2730232 B1 FR2730232 B1 FR 2730232B1
Authority
FR
France
Prior art keywords
propane
lie
substantially free
therapeutic application
paroxetine hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9601297A
Other languages
English (en)
Other versions
FR2730232A1 (fr
Inventor
Victor Witold Jacewicz
Neal Ward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27267578&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2730232(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9502297.6A external-priority patent/GB9502297D0/en
Priority claimed from GBGB9503112.6A external-priority patent/GB9503112D0/en
Priority claimed from GBGB9509807.5A external-priority patent/GB9509807D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of FR2730232A1 publication Critical patent/FR2730232A1/fr
Application granted granted Critical
Publication of FR2730232B1 publication Critical patent/FR2730232B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9601297A 1995-02-06 1996-02-02 Anhydrate de chlorhydrate de paroxetine pratiquement depourvu de propane-2-ol lie, son application en therapeutique Expired - Fee Related FR2730232B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9502297.6A GB9502297D0 (en) 1995-02-06 1995-02-06 Novel compound
GBGB9503112.6A GB9503112D0 (en) 1995-02-17 1995-02-17 Novel compound
GBGB9509807.5A GB9509807D0 (en) 1995-05-15 1995-05-15 Novel compounds

Publications (2)

Publication Number Publication Date
FR2730232A1 FR2730232A1 (fr) 1996-08-09
FR2730232B1 true FR2730232B1 (fr) 1997-08-01

Family

ID=27267578

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9601297A Expired - Fee Related FR2730232B1 (fr) 1995-02-06 1996-02-02 Anhydrate de chlorhydrate de paroxetine pratiquement depourvu de propane-2-ol lie, son application en therapeutique

Country Status (47)

Country Link
EP (3) EP0808314B1 (fr)
JP (2) JP2915338B2 (fr)
KR (1) KR100289885B1 (fr)
CN (3) CN1090187C (fr)
AR (2) AR001982A1 (fr)
AT (1) AT407528B (fr)
AU (2) AU701518C (fr)
BE (1) BE1009112A3 (fr)
BG (1) BG62967B1 (fr)
BR (1) BR9600534A (fr)
CA (4) CA2210023C (fr)
CH (3) CH688353A5 (fr)
CZ (1) CZ297171B6 (fr)
DE (3) DE19603797C2 (fr)
DK (2) DK11996A (fr)
DZ (1) DZ1989A1 (fr)
ES (1) ES2114471B1 (fr)
FI (3) FI111544B (fr)
FR (1) FR2730232B1 (fr)
GR (1) GR1002466B (fr)
HK (1) HK59397A (fr)
HU (1) HUP9600255A1 (fr)
IE (1) IE80500B1 (fr)
IL (1) IL117035A (fr)
IT (1) IT1289532B1 (fr)
LU (1) LU88711A1 (fr)
LV (1) LV11618B (fr)
MA (1) MA23802A1 (fr)
MC (1) MC2411A1 (fr)
MX (1) MX9600484A (fr)
MY (1) MY132529A (fr)
NL (1) NL1002248C2 (fr)
NO (3) NO301009B1 (fr)
NZ (1) NZ280943A (fr)
OA (1) OA10261A (fr)
PL (1) PL189247B1 (fr)
PT (1) PT101827B (fr)
RO (1) RO112426B1 (fr)
RU (1) RU2125052C1 (fr)
SE (1) SE521084C2 (fr)
SG (1) SG43787A1 (fr)
SI (2) SI21923B (fr)
SK (1) SK283608B6 (fr)
TR (1) TR199600096A2 (fr)
TW (1) TW503238B (fr)
UA (1) UA49796C2 (fr)
WO (1) WO1996024595A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3882224B2 (ja) 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
EP1384720A1 (fr) * 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Procédé de séchage pour le chlorhydrate de paroxetine
JP2000514653A (ja) * 1996-07-15 2000-11-07 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 立体特異的分割のためのエステラーゼのスクリーニングおよびその使用
US6638948B1 (en) 1996-09-09 2003-10-28 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
US5672612A (en) * 1996-09-09 1997-09-30 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
CA2193939C (fr) * 1996-12-24 2002-02-12 K.S. Keshava Murthy Forme utile de chlorhydrate de paroxetine anhydre
ES2155995T3 (es) * 1997-06-10 2001-06-01 Synthon Bv Compuestos de 4-fenilpiperidina.
EP0903345B1 (fr) * 1997-08-08 2000-10-04 Aventis Pharma Deutschland GmbH Forme cristalline de N-(4-trifluorométhylphényl)-5-méthylisoxazole-4-carboxamid
GB9726907D0 (en) * 1997-12-19 1998-02-18 Smithkline Beecham Plc Novel compounds
SK13622000A3 (sk) * 1998-03-16 2001-03-12 Smithkline Beecham Plc Kryštalická forma paroxetínu, farmaceutický prostriedok a použitie
AU2003200534B2 (en) * 1998-03-24 2004-12-02 Smithkline Beecham Plc Paroxetine compositions
US6699882B2 (en) 1998-03-24 2004-03-02 Smithkline Beecham P.L.C. Paroxetine compositions
GB9806312D0 (en) * 1998-03-24 1998-05-20 Smithkline Beecham Plc Novel formulations
JP3796351B2 (ja) 1998-04-13 2006-07-12 住友化学株式会社 パロキセチン塩酸塩無水和物の乾燥方法
GB9812941D0 (en) * 1998-06-16 1998-08-12 Smithkline Beecham Plc Method of treatment
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
ES2138937B1 (es) 1998-07-07 2000-10-01 Medichem Sa Polimorfo de maleato de paroxetina y formulaciones farmaceuticas que lo contienen.
ID27914A (id) * 1998-08-07 2001-05-03 Smithkline Beecham Plc Proses untuk penyiapan bentuk anhidrat paroksetina hidroklorida bukan kristal
GB9824298D0 (en) * 1998-11-05 1998-12-30 Smithkline Beecham Plc Novel process
GB9826175D0 (en) * 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
GB9826176D0 (en) * 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
GB9826178D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
DE69913377T2 (de) * 1998-11-30 2004-12-30 Smithkline Beecham P.L.C., Brentford Gemischte Paroxetin-Propan-2-ol-Solvate
GB9826171D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel compounds
GB9826180D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9826242D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9828767D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
ATE311883T1 (de) * 1999-03-12 2005-12-15 Aesica Pharmaceuticals Ltd Stabile pharmazeutische anwendungsform für paroxetin-anhydrat
GB9914583D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
GB9914585D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
GB9919001D0 (en) * 1999-08-12 1999-10-13 Smithkline Beecham Plc Novel process
GB9923446D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
GB9923445D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
GB9923439D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
HU226912B1 (en) * 2000-04-07 2010-03-01 Richter Gedeon Nyrt New paroxetin salt and medicament containing it
AU2001286232A1 (en) * 2000-09-14 2002-03-26 Asahi Glass Company, Limited Process for producing paroxetine salt containing substantially no organic solvent
AU2002259114A1 (en) * 2002-02-22 2003-09-09 Teva Pharmaceutical Industries Ltd. Preparation of paroxetine involving novel intermediates
WO2007062147A1 (fr) * 2005-11-22 2007-05-31 Teva Pharmaceutical Industries Ltd. FORMES CRISTALLINES DE CINACALCET HCl ET LEURS PROCÉDÉS DE SYNTHÈSE

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
GB8430581D0 (en) * 1984-12-04 1985-01-09 Ferrosan As Treatment
DE3688827T2 (de) * 1985-10-25 1994-03-31 Beecham Group Plc Piperidinderivat, seine Herstellung und seine Verwendung als Arzneimittel.
GB8626936D0 (en) * 1986-11-11 1986-12-10 Ferrosan As Treatment
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater
DK716088D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Reduktion af piperidin-dion-derivater samt intermediat
EP0558679A1 (fr) * 1990-11-24 1993-09-08 BEECHAM GROUP plc Utilisation de paroxetine pour le traitement de la demence senile, la boulimie, la migraine ou l'anorexie
GB9325644D0 (en) * 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation

Also Published As

Publication number Publication date
PT101827B (pt) 1997-08-29
NO20015070L (no) 1996-08-07
NO970939D0 (no) 1997-02-28
ATA21096A (de) 2000-08-15
SE9600406D0 (sv) 1996-02-05
SI21923B (sl) 2006-12-31
MX198371B (fr) 2000-08-29
LU88711A1 (fr) 1996-08-23
BG100333A (bg) 1996-08-30
HU9600255D0 (en) 1996-03-28
SE9600406L (sv) 1996-08-07
PL189247B1 (pl) 2005-07-29
DE69631298T2 (de) 2004-11-18
SK283608B6 (sk) 2003-10-07
FI20030370A (fi) 2003-03-12
NL1002248C2 (nl) 1996-09-11
IE80500B1 (en) 1998-08-12
CZ32096A3 (en) 1996-08-14
EP1378508A1 (fr) 2004-01-07
FI111544B (fi) 2003-08-15
SG43787A1 (en) 1997-11-14
CA2211522A1 (fr) 1996-08-07
DK200100223A (fr) 2001-02-12
AU4332896A (en) 1996-08-15
CN1216055C (zh) 2005-08-24
SI9600036A (en) 1996-10-31
ES2114471B1 (es) 1999-08-16
RU2125052C1 (ru) 1999-01-20
BG62967B1 (bg) 2000-12-29
CA2210023A1 (fr) 1996-08-07
NO301009B3 (fr) 2003-01-06
CA2210023C (fr) 1999-02-09
TR199600096A2 (tr) 1996-08-21
CA2168829C (fr) 1997-12-16
IL117035A (en) 2000-02-29
RO112426B1 (ro) 1997-09-30
OA10261A (en) 1997-09-19
CN1289496C (zh) 2006-12-13
FI960519A (fi) 1996-08-07
CA2210022C (fr) 2005-09-13
NL1002248A1 (nl) 1996-08-06
CH689229A5 (de) 1998-12-31
NO960472L (no) 1996-08-07
JP2915338B2 (ja) 1999-07-05
MX9600484A (es) 1997-01-31
FR2730232A1 (fr) 1996-08-09
MC2411A1 (fr) 1996-12-02
EP1136490B1 (fr) 2004-01-07
EP0808314B1 (fr) 2002-06-12
ES2114471A1 (es) 1998-05-16
EP0808314A1 (fr) 1997-11-26
CA2168829A1 (fr) 1996-08-07
HUP9600255A1 (en) 1997-03-28
DE69621777D1 (de) 2002-07-18
FI960519A0 (fi) 1996-02-05
NO301009B1 (no) 1997-09-01
BR9600534A (pt) 1997-05-13
DE19603797A1 (de) 1996-08-14
CN1310180A (zh) 2001-08-29
MY132529A (en) 2007-10-31
LV11618B (en) 1997-04-20
NZ280943A (en) 1997-01-29
FI20030162A (fi) 2003-02-03
AU701518B2 (en) 1999-01-28
CH688353A5 (de) 1997-08-15
SI9600036B (sl) 2006-12-31
NO960472D0 (no) 1996-02-05
ITMI960203A1 (it) 1997-08-05
CA2211522C (fr) 1999-12-07
DE19603797C2 (de) 1998-11-12
IT1289532B1 (it) 1998-10-15
PT101827A (pt) 1996-09-30
MA23802A1 (fr) 1996-10-01
AR036856A2 (es) 2004-10-06
AT407528B (de) 2001-04-25
GR1002466B (el) 1996-11-06
NO970939L (no) 1996-08-07
NO311519B1 (no) 2001-12-03
CA2210022A1 (fr) 1996-08-07
JPH08245620A (ja) 1996-09-24
CN1143643A (zh) 1997-02-26
DE69631298D1 (de) 2004-02-12
AU701518C (en) 2006-12-07
CH689804A5 (de) 1999-11-30
NO20015070D0 (no) 2001-10-18
AU4786496A (en) 1996-08-27
DE69621777T2 (de) 2003-01-02
SE521084C2 (sv) 2003-09-30
UA49796C2 (uk) 2002-10-15
DK11996A (da) 1996-08-07
DZ1989A1 (fr) 2002-10-15
HK59397A (en) 1997-05-16
AR001982A1 (es) 1998-01-07
SK14396A3 (en) 1996-11-06
WO1996024595A1 (fr) 1996-08-15
IE960104A1 (en) 1996-08-07
CN1090187C (zh) 2002-09-04
TW503238B (en) 2002-09-21
JPH11228571A (ja) 1999-08-24
CZ297171B6 (cs) 2006-09-13
IL117035A0 (en) 1996-09-12
PL312646A1 (en) 1996-08-19
KR100289885B1 (ko) 2001-05-15
KR960031409A (ko) 1996-09-17
EP1136490A1 (fr) 2001-09-26
SI21923A (sl) 2006-06-30
LV11618A (lv) 1996-12-20
CN1636993A (zh) 2005-07-13
BE1009112A3 (fr) 1996-11-05
ITMI960203A0 (fr) 1996-02-05

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Effective date: 20131031