SI9300423A - Peg-interferon conjugates - Google Patents
Peg-interferon conjugates Download PDFInfo
- Publication number
- SI9300423A SI9300423A SI9300423A SI9300423A SI9300423A SI 9300423 A SI9300423 A SI 9300423A SI 9300423 A SI9300423 A SI 9300423A SI 9300423 A SI9300423 A SI 9300423A SI 9300423 A SI9300423 A SI 9300423A
- Authority
- SI
- Slovenia
- Prior art keywords
- interferon
- conjugate
- conjugates
- peg
- lower alkyl
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
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US07/935,770 US5382657A (en) | 1992-08-26 | 1992-08-26 | Peg-interferon conjugates |
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US (1) | US5382657A (fr) |
EP (1) | EP0593868B1 (fr) |
JP (1) | JP2859105B2 (fr) |
KR (1) | KR100295520B1 (fr) |
CN (3) | CN1039015C (fr) |
AT (1) | ATE165102T1 (fr) |
AU (1) | AU668742B2 (fr) |
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EE (1) | EE9400151A (fr) |
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-
1993
- 1993-08-03 HR HR07/935,770A patent/HRP931094A2/hr not_active Application Discontinuation
- 1993-08-06 SI SI9300423A patent/SI9300423A/sl unknown
- 1993-08-11 CA CA002103829A patent/CA2103829C/fr not_active Expired - Lifetime
- 1993-08-13 EP EP93112983A patent/EP0593868B1/fr not_active Expired - Lifetime
- 1993-08-13 AT AT93112983T patent/ATE165102T1/de active
- 1993-08-13 DK DK93112983T patent/DK0593868T3/da active
- 1993-08-13 DE DE69317979T patent/DE69317979T2/de not_active Expired - Lifetime
- 1993-08-13 ES ES93112983T patent/ES2116376T3/es not_active Expired - Lifetime
- 1993-08-16 MW MW7693A patent/MW7693A1/xx unknown
- 1993-08-18 HU HU9302366A patent/HUT67013A/hu unknown
- 1993-08-18 CZ CZ931693A patent/CZ169393A3/cs unknown
- 1993-08-19 ZA ZA936098A patent/ZA936098B/xx unknown
- 1993-08-20 NZ NZ248452A patent/NZ248452A/en unknown
- 1993-08-20 IL IL106750A patent/IL106750A0/xx unknown
- 1993-08-20 AU AU44780/93A patent/AU668742B2/en not_active Ceased
- 1993-08-20 NZ NZ264872A patent/NZ264872A/en unknown
- 1993-08-20 SK SK898-93A patent/SK89893A3/sk unknown
- 1993-08-20 PH PH46719A patent/PH30460A/en unknown
- 1993-08-23 RO RO93-01141A patent/RO112730B1/ro unknown
- 1993-08-23 JP JP5229504A patent/JP2859105B2/ja not_active Expired - Lifetime
- 1993-08-23 BG BG98067A patent/BG98067A/xx unknown
- 1993-08-24 MY MYPI93001695A patent/MY131445A/en unknown
- 1993-08-24 UY UY23635A patent/UY23635A1/es unknown
- 1993-08-25 PL PL93300194A patent/PL300194A1/xx unknown
- 1993-08-25 CN CN93116479A patent/CN1039015C/zh not_active Expired - Lifetime
- 1993-08-25 FI FI933740A patent/FI109765B/fi not_active IP Right Cessation
- 1993-08-25 LT LTIP888A patent/LT3174B/lt not_active IP Right Cessation
- 1993-08-25 BR BR9303469A patent/BR9303469A/pt not_active Application Discontinuation
- 1993-08-25 NO NO933028A patent/NO933028D0/no unknown
- 1993-08-25 MX MX9305146A patent/MX9305146A/es active IP Right Grant
- 1993-08-25 KR KR1019930016550A patent/KR100295520B1/ko not_active IP Right Cessation
- 1993-08-25 LV LVP-93-1040A patent/LV10907B/en unknown
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- 1993-08-25 CN CNB971054339A patent/CN1183112C/zh not_active Expired - Lifetime
- 1993-08-25 YU YU56693A patent/YU56693A/sh unknown
- 1993-08-26 OA OA60405A patent/OA09850A/fr unknown
- 1993-08-26 ZW ZW11193A patent/ZW11193A1/xx unknown
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1994
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1997
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