SI2254586T1 - Delci mezenhimske matične celice - Google Patents

Delci mezenhimske matične celice

Info

Publication number
SI2254586T1
SI2254586T1 SI200931203T SI200931203T SI2254586T1 SI 2254586 T1 SI2254586 T1 SI 2254586T1 SI 200931203 T SI200931203 T SI 200931203T SI 200931203 T SI200931203 T SI 200931203T SI 2254586 T1 SI2254586 T1 SI 2254586T1
Authority
SI
Slovenia
Prior art keywords
stem cell
mesenchymal stem
cell particles
particles
mesenchymal
Prior art date
Application number
SI200931203T
Other languages
English (en)
Inventor
Sai Kiang Lim
Original Assignee
Agency For Science, Technology And Research (A*Star)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency For Science, Technology And Research (A*Star) filed Critical Agency For Science, Technology And Research (A*Star)
Publication of SI2254586T1 publication Critical patent/SI2254586T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
SI200931203T 2008-02-22 2009-02-21 Delci mezenhimske matične celice SI2254586T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6667108P 2008-02-22 2008-02-22
PCT/SG2009/000062 WO2009105044A1 (en) 2008-02-22 2009-02-21 Mesenchymal stem cell particles
EP09712571.0A EP2254586B1 (en) 2008-02-22 2009-02-21 Mesenchymal stem cell particles

Publications (1)

Publication Number Publication Date
SI2254586T1 true SI2254586T1 (sl) 2015-07-31

Family

ID=40688500

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200931203T SI2254586T1 (sl) 2008-02-22 2009-02-21 Delci mezenhimske matične celice

Country Status (14)

Country Link
US (3) US20110003008A1 (sl)
EP (1) EP2254586B1 (sl)
JP (1) JP5718648B2 (sl)
KR (1) KR101640381B1 (sl)
CN (2) CN102014934B (sl)
AU (1) AU2009215934C1 (sl)
DK (1) DK2254586T3 (sl)
ES (1) ES2537516T3 (sl)
HR (1) HRP20150510T1 (sl)
HU (1) HUE026536T2 (sl)
PL (1) PL2254586T3 (sl)
PT (1) PT2254586E (sl)
SI (1) SI2254586T1 (sl)
WO (1) WO2009105044A1 (sl)

Families Citing this family (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
GB0818725D0 (en) 2008-10-13 2008-11-19 Habib Nagy A Pharmaceutical composition
US20120107413A1 (en) * 2009-07-23 2012-05-03 Singapore Health Services Pte Ltd Pre-natal mesenchymal stem cells
CN102596179A (zh) 2009-08-27 2012-07-18 工业研究与发展基金会有限公司 脂质体组合物及其用途
CA2773619C (en) 2009-09-10 2019-11-12 Svend Lindenberg Method for the preparation of micro-rna and its therapeutic application
WO2011043524A1 (ko) * 2009-10-08 2011-04-14 주식회사 알앤엘바이오 인간 유래 성체 줄기세포를 함유하는 항암용 조성물
EP2333047A1 (en) * 2009-12-09 2011-06-15 Fresenius Medical Care Deutschland GmbH Adult stem cell derived conditioned medium and/or adult stem cells for use in the therapeutic treatment of a tumor disease
US20110171323A1 (en) * 2010-01-09 2011-07-14 The Translational Genomics Research Institute Methods and kits to predict prognostic and therapeutic outcome in small cell lung cancer
EP2363136A1 (en) * 2010-03-02 2011-09-07 Fresenius Medical Care Deutschland GmbH Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
CN101890050B (zh) * 2010-07-14 2012-07-04 江苏大学 脐带间质干细胞来源膜性囊泡及其应用
SG189438A1 (en) * 2010-10-18 2013-05-31 Agency Science Tech & Res Use of exosomes to promote or enhance hair growth
SG190450A1 (en) * 2010-12-20 2013-06-28 Agency Science Tech & Res Method of purifying exosomes
SG183579A1 (en) * 2011-02-11 2012-09-27 Agency Science Tech & Res Methods of detecting therapeutic exosomes
KR101947699B1 (ko) * 2011-03-11 2019-02-14 칠드런'즈 메디컬 센터 코포레이션 중간엽 줄기 세포 엑소솜에 관련된 방법 및 조성물
CN102225054B (zh) * 2011-06-20 2013-01-16 河北科技大学 一种载有抗肿瘤药物微粒的制剂及其制备方法
ITRM20110403A1 (it) 2011-07-28 2013-01-29 Ospedale Pediatrico Bambino Gesu Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori.
KR101405437B1 (ko) * 2011-08-16 2014-06-11 사회복지법인 삼성생명공익재단 줄기세포 유래 미세소포를 포함하는 신경 생성 촉진용 조성물
EP2756847A1 (en) * 2011-09-13 2014-07-23 Takahiro Ochiya Pharmaceutical product for preventing or treating alzheimer's disease
CN104053668B (zh) 2011-11-30 2020-09-11 新加坡科技研究局 用于生物学检测的gm1神经节苷脂与膜联蛋白v的微粒多肽比例
WO2013082458A1 (en) 2011-12-02 2013-06-06 The Regents Of The University Of California Reperfusion protection solution and uses thereof
ITRM20110685A1 (it) * 2011-12-23 2013-06-24 Internat Ct For Genetic En Gineering And Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci
WO2013122950A1 (en) * 2012-02-13 2013-08-22 Wuyi Kong Nprcps, pfdncs and uses thereof
US11286463B2 (en) 2012-03-08 2022-03-29 Advanced ReGen Medical Technologies, LLC Reprogramming of aged adult stem cells
WO2013150303A1 (en) 2012-04-03 2013-10-10 Reneuron Limited Stem cell microparticles
GB201302468D0 (en) 2013-02-12 2013-03-27 Reneuron Ltd Stem cell product
US20150297639A1 (en) * 2012-04-18 2015-10-22 Rhode Island Hospital, A Lifespan-Partner Treating cancer
US20150104455A1 (en) * 2012-04-25 2015-04-16 Genera Istrazivanja D.O.O. Methods and compositions for treating and diagnosing acute myocardial infarction
WO2013172793A1 (en) * 2012-05-18 2013-11-21 Agency For Science, Technology & Research Umbilical cord mesenchymal stem cell exosomes
WO2013184527A1 (en) 2012-06-05 2013-12-12 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
EP2687219A1 (en) * 2012-07-18 2014-01-22 Universität Duisburg-Essen Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions
JP2015529450A (ja) 2012-07-19 2015-10-08 リニューロン・リミテッドＲｅＮｅｕｒｏｎ Ｌｉｍｉｔｅｄ 幹細胞微粒子
EP2879682B1 (en) 2012-08-01 2018-03-21 United Therapeutics Corporation Treatment of pulmonary arterial hypertension with mesenchymal stem cells
ES2869701T3 (es) 2012-08-01 2021-10-25 United Therapeutics Corp Tratamiento de hipertensión arterial pulmonar con células progenitoras endoteliales tratadas con prostaciclina
EP3563859B1 (en) * 2012-08-13 2021-10-13 Cedars-Sinai Medical Center Cardiosphere-derived exosomes for tissue regeneration
US10231997B2 (en) 2012-08-15 2019-03-19 The University Of Chicago Exosome-based therapeutics against neurodegenerative disorders
US20190178879A1 (en) * 2012-08-23 2019-06-13 Stemcell Technologies Canada Inc. Compositions and methods for rapid and reversible biomolecular labeling
CN103865873B (zh) * 2012-12-12 2017-04-05 中国医学科学院基础医学研究所 亚全能干细胞分泌的外来体及其应用
US10080730B2 (en) * 2013-01-09 2018-09-25 United Therapeutics Corporation Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
CA2900454A1 (en) * 2013-02-07 2014-08-14 Glaxosmithkline Biologicals Sa Pharmaceutical compositions comprising vesicles
SG11201506284RA (en) 2013-02-12 2015-09-29 Reneuron Ltd Method of producing microparticles
DE112014000822T5 (de) * 2013-02-14 2015-10-29 Metanomics Health Gmbh Mittel und Verfahren zur Beurteilung der Qualität einer biologischen Probe
US10500231B2 (en) 2013-03-13 2019-12-10 University Of Miami Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids
US20140314872A1 (en) * 2013-04-22 2014-10-23 Hans Klingemann Methods of Use of Culture Supernatant Obtained from Mesenchymal Stem Cells from Dogs and Cats for Treatment of Organ Dysfunction
WO2014197421A1 (en) 2013-06-05 2014-12-11 Biotime, Inc. Compositions and methods for induced tissue regeneration in mammalian species
EP3016665B1 (en) 2013-07-05 2019-09-18 Université Catholique de Louvain Conditioned medium from human adult liver stem cells and its use in the treatment of liver disorders
CN103409369A (zh) * 2013-07-31 2013-11-27 江苏大学 一种快速建立间质干细胞衰老模型的方法
PT3027738T (pt) * 2013-08-01 2022-05-11 Swedish Stromabio Ab Mscs no tratamento de doenças pulmonares inflamatórias
WO2015022545A2 (en) * 2013-08-14 2015-02-19 Reneuron Limited Stem cell microparticles and mirna
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
SG11201601939VA (en) * 2013-09-16 2016-04-28 Agency Science Tech & Res Method
GB201317889D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product and use
CN105848662A (zh) 2013-11-01 2016-08-10 南克维斯特公司 杀肿瘤和抗微生物组合物和方法
US9309314B2 (en) 2013-12-03 2016-04-12 Agency For Science, Technology And Research (A*Star) Polypeptides, nucleic acids and uses thereof
US20150174166A1 (en) 2013-12-20 2015-06-25 Advanced ReGen Medical Technologies, LLC Compositions for Cellular Restoration and Methods of Making and Using Same
US10772911B2 (en) 2013-12-20 2020-09-15 Advanced ReGen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
TWI558421B (zh) * 2014-03-06 2016-11-21 芯芮生技開發股份有限公司 幹細胞條件培養基用於製備抑制氧化作用達到皮膚抗老化之組成物的用途
US9284528B2 (en) 2014-04-18 2016-03-15 Growgene Biotech Inc. Use of stem cell conditioned medium to inhibit oxidation for anti-aging skin
US10568945B2 (en) 2014-04-25 2020-02-25 University Of Cincinnati Compositions and methods for inducing liver regeneration by administering hepatocyte-derived exosomes
CN106714781B (zh) 2014-05-18 2021-08-10 儿童医学中心公司 涉及外排体的方法和组合物
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
SG11201701982QA (en) 2014-09-15 2017-04-27 Agency Science Tech & Res Methods of treating graft versus host disease (gvhd) or epidermolysis bullosa (eb) with exosomes
WO2016051983A1 (ja) * 2014-09-29 2016-04-07 株式会社カネカ 細胞培養培地及びそれを用いた培養方法
EP3200808A4 (en) 2014-10-03 2018-05-16 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
KR101673059B1 (ko) * 2014-11-26 2016-11-07 가톨릭관동대학교산학협력단 중간엽줄기세포 유래 미세소포체를 포함하는 발모촉진 또는 창상 치료용 약제학적 조성물
RU2644650C2 (ru) 2014-12-01 2018-02-13 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток и способ его получения
KR101784050B1 (ko) * 2014-12-23 2017-10-10 영남대학교 산학협력단 엑소솜을 유효성분으로 함유하는 피부 노화 예방 또는 치료용 약학조성물
CN104673749B (zh) * 2015-02-12 2017-10-20 江苏大学 一种粒细胞样髓源性抑制细胞来源exosomes及其应用
WO2016149358A1 (en) * 2015-03-16 2016-09-22 Duncan Ross Method of treatment comprising membrane-enclosed vesicle
EP3277296B1 (en) * 2015-04-02 2020-03-11 Stegi-Ra Trust Composition for use in treating celiac disease
GB201505747D0 (en) * 2015-04-02 2015-05-20 Univ Bristol Exosomes
US20160324898A1 (en) * 2015-05-04 2016-11-10 Stemedica International, Sa Compositions and methods for the treatment of alzheimer's disease
US11291689B2 (en) 2015-06-03 2022-04-05 Aelan Cell Technologies, Inc. Methods and devices for the production and delivery of beneficial factors from adipose-derived stem cells
WO2016196774A1 (en) * 2015-06-03 2016-12-08 Aelan Cell Technologies, Inc. Methods and devices for the production and delivery of beneficial factors from stem cells
KR101751513B1 (ko) * 2015-06-23 2017-06-27 한국과학기술연구원 인 비트로 섬유증 모델, 그의 제조방법 및 용도
EP3328397B1 (en) * 2015-07-31 2023-07-12 Exotropin, LLC Exosome compositions and methods for preparation and use thereof for regulating and conditioning skin and hair
WO2017022809A1 (ja) 2015-08-03 2017-02-09 国立大学法人大阪大学 間葉系幹細胞由来エキソソーム
DE102015115158B4 (de) * 2015-09-09 2017-07-13 Fresenius Medical Care Deutschland Gmbh Verfahren und Kit zur Diagnose von epithelial-mesenchymaler Transition (EMT) des Peritoneums
WO2017054086A1 (en) * 2015-10-01 2017-04-06 Exerkine Corporation Treatment of genetic myopathies using bioengineered exosomes
US20170121685A1 (en) * 2015-11-02 2017-05-04 Tigenix S.A.U. Mesenchymal stem cell-derived exosomes and their uses
US11857575B2 (en) 2015-11-02 2024-01-02 Takeda Pharmaceutical Company Limited Mesenchymal stem cell-derived exosomes and their uses
WO2017123662A1 (en) 2016-01-11 2017-07-20 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
CN108699519A (zh) * 2016-01-12 2018-10-23 康干细胞生物技术有限公司 干细胞衍生的含有大量生长因子的外来体
WO2017139357A1 (en) 2016-02-08 2017-08-17 Orbusneich Medical, Inc. Drug eluting balloon
US10792477B2 (en) 2016-02-08 2020-10-06 Orbusneich Medical Pte. Ltd. Drug eluting balloon
EP3427060A4 (en) 2016-03-07 2019-12-18 CFGenome, LLC NON-INVASIVE MOLECULAR WITNESSES
US11672830B2 (en) 2016-04-15 2023-06-13 Temple University-Of The Commonwealth System Of Higher Education MicroRNA-294 and Lin28A as a driver of cardiac tissue proliferation in response to pathological injury
JP6999575B2 (ja) 2016-04-29 2022-01-18 アドヴァンスド リジェン メディカル テクノロジーズ，エルエルシー マイクロｒｎａ組成物並びにその作製及び使用方法
JP7011605B2 (ja) * 2016-05-06 2022-01-26 ユニシテ エーファウ アクチェンゲゼルシャフト 高血糖症によって引き起こされる線維性疾患の処置における使用のためのｍｉＲＮＡを含有する薬学的担体
CN109477072A (zh) * 2016-05-16 2019-03-15 埃克森蒂姆生物技术公司 间充质干细胞及其用于治疗肌肉损伤和肌肉相关疾病的用途
RU2708329C2 (ru) 2016-05-31 2019-12-05 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток, композиции и способы применения
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
TWI601741B (zh) * 2016-07-11 2017-10-11 財團法人國家衛生研究院 利用前列腺素受體ｅｐ４－拮抗劑誘導幹細胞製造含有高囊泡含物之外泌體囊泡的方法及其應用
EP3496730B1 (en) 2016-08-14 2022-05-25 Ramot at Tel-Aviv University Ltd. Mesenchymal cell-derived exosomes to treat neurological disorders
WO2018057542A1 (en) 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
CN106265899A (zh) * 2016-09-30 2017-01-04 广州赛莱拉干细胞科技股份有限公司 一种组合物及其在制备改善慢性鼻炎的产品中的应用
EP3308795A1 (en) 2016-10-12 2018-04-18 Unicyte EV AG A composition of extracellular vesicles (evs) and medical uses thereof
US20190231694A1 (en) * 2016-10-12 2019-08-01 Agency For Science, Technology And Research Method for lyophilising an exosome
AU2017350732B2 (en) 2016-10-24 2023-07-27 United Therapeutics Corporation Enhancement of MSC immunomodulatory properties by treprostinil
CN106636305A (zh) * 2016-11-16 2017-05-10 宁夏医科大学总医院 一种检测人胎盘胎儿侧间充质干细胞抗氧化能力的方法
WO2018109525A1 (en) * 2016-12-14 2018-06-21 Università Degli Studi Di Padova New anti-angiogenic extracellurlar vesicles
WO2018186505A1 (ko) * 2017-04-03 2018-10-11 ㈜프로스테믹스 줄기세포 유래 엑소좀을 포함하는 상처 치료, 피부 개선 및 탈모 방지 또는 치료용 조성물 및 그 제조방법
US11759482B2 (en) 2017-04-19 2023-09-19 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
WO2018208728A1 (en) 2017-05-08 2018-11-15 Flagship Pioneering, Inc. Compositions for facilitating membrane fusion and uses thereof
US20200171092A1 (en) * 2017-06-09 2020-06-04 Osaka University Therapeutic agent for dilated cardiomyopathy
KR102045188B1 (ko) * 2017-06-30 2019-11-14 주식회사 엑소코바이오 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부염 개선 용도
WO2019004738A2 (ko) * 2017-06-30 2019-01-03 주식회사 엑소코바이오 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 피부염 개선 용도
KR20190003316A (ko) 2017-06-30 2019-01-09 주식회사 엑소코바이오 지방줄기세포 유래의 엑소좀 및/또는 세포외 소포체를 유효성분으로 포함하는 조성물의 피부염 개선 용도
KR102147169B1 (ko) * 2017-06-30 2020-08-24 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 가려움증 억제 또는 개선 용도
WO2019016799A1 (en) * 2017-07-16 2019-01-24 Ramot At Tel-Aviv University Ltd. SECRETEOME OF HUMAN MUCOSAL MUCOSAL STEM CELLS
CN107189985B (zh) * 2017-07-24 2021-02-02 中国人民解放军军事医学科学院基础医学研究所 miRNA分子及其抑制剂在调控骨间充质干细胞成脂分化中的应用
CA3072562A1 (en) * 2017-08-15 2019-02-21 Children's Medical Center Corporation Purified mesenchymal stem cell exosomes and uses thereof
KR102197562B1 (ko) * 2017-09-07 2020-12-31 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 포함하는 엑소좀 키트의 새로운 용도
WO2019083201A2 (ko) * 2017-10-24 2019-05-02 주식회사 엑소코바이오 지방줄기세포 유래의 엑소좀을 유효성분으로 포함하는 조성물의 신장 기능 개선 용도
WO2019088545A1 (ko) * 2017-10-31 2019-05-09 주식회사 엑소코바이오 엑소좀 키트 및 이를 이용한 엑소좀의 경피 투과 증진 방법
KR101964991B1 (ko) * 2017-12-10 2019-04-02 주식회사 엑소코바이오 줄기세포 유래의 엑소좀을 포함하는 엑소좀 키트의 새로운 용도
EP3727351A4 (en) 2017-12-20 2021-10-06 Cedars-Sinai Medical Center MODIFIED EXTRACELLULAR VESICLES FOR IMPROVED TISSUE DELIVERY
KR102096150B1 (ko) * 2018-01-05 2020-04-02 재단법인 아산사회복지재단 인터페론 감마로 전처리된 유도만능 줄기세포 유래 중간엽 줄기세포 및 이로부터 유래된 엑소좀을 포함하는 피부질환의 개선, 예방 또는 치료용 조성물
KR102095628B1 (ko) * 2018-01-05 2020-04-01 재단법인 아산사회복지재단 유도만능 줄기세포 유래 중간엽 줄기세포 및 이로부터 유래된 엑소좀을 포함하는 피부질환의 개선, 예방 또는 치료용 조성물
US10717981B2 (en) 2018-01-18 2020-07-21 Advanced ReGen Medical Technologies, LLC Therapeutic compositions and methods of making and using the same
CN110141577A (zh) * 2018-02-13 2019-08-20 上海三炬生物科技有限公司 miRNA-24-3p核苷酸类似物在制备药物中的应用
CN108414334A (zh) * 2018-02-23 2018-08-17 中山大学附属第医院 一种从精液中分离提纯外泌体的方法
WO2019168281A1 (ko) * 2018-03-02 2019-09-06 주식회사 엑소코바이오 피부에 대한 레이저 빔 조사와 줄기세포 유래의 엑소좀 처리를 병용한 피부 미용방법
KR20210005031A (ko) 2018-03-29 2021-01-13 테크니온 리서치 엔드 디벨로프먼트 화운데이션 엘티디. Pten 억제제를 포함하는 소포 및 이의 용도
IL277447B2 (en) * 2018-04-10 2024-04-01 Brainstorm Cell Therapeutics Ltd Cell-adapted exosomes and their uses
RU2710368C2 (ru) * 2018-05-29 2019-12-26 Станислав Евгеньевич Волчков Способ получения и концентрирования микроРНК-содержащих экзосом мультипотентных мезенхимально-стромальных клеток для применения в косметических и лекарственных средствах для стимуляции регенеративных процессов и замедления процессов старения
CN108865976B (zh) * 2018-07-19 2022-06-28 复旦大学附属中山医院 一种离散汲取收集外泌体(exosome)的方法及试剂
CN109125349A (zh) * 2018-09-27 2019-01-04 天津欣普赛尔生物医药科技有限公司 一种具有外伤修复和抗衰老功能的凝胶的制备方法
CN109543883A (zh) * 2018-10-26 2019-03-29 上海城市交通设计院有限公司 一种基于多源数据融合的枢纽客流时空分布预测建模方法
RS62863B1 (sr) * 2018-11-16 2022-02-28 Codiak Biosciences Inc Konstruisane vanćelijske vezikule i njihove upotrebe
RU2720812C1 (ru) * 2018-11-28 2020-05-13 Общество с ограниченной ответственностью "НОВИСТЕМ" Способ получения средства, обладающего противовоспалительной, регенеративной, иммуномодулирующей, детоксикационной, адаптогенной активностью и способного регулировать метаболизм
RU2720800C1 (ru) * 2018-11-28 2020-05-13 Общество с ограниченной ответственностью "НОВИСТЕМ" Средство для крупного рогатого скота, обладающее противовоспалительной, регенеративной, иммуномодулирующей, детоксикационной, адаптогенной активностью и способное регулировать метаболизм
JP2022535178A (ja) * 2019-01-30 2022-08-05 ダイレクト バイオロジクス エルエルシー 標的特異的エクソソームおよび増殖因子生成物を開発するための方法および組成物
AU2020225364A1 (en) * 2019-02-19 2021-09-16 Direct Biologics, Llc Acellular intravenous infusion including mesenchymal stem cell growth factors and exosomes
EP3950060A4 (en) 2019-04-04 2023-04-19 Nissan Chemical Corporation COMPOSITION TO PROMOTE THE SECRETION OF EXTRACELLULAR VESICLES
US10758571B1 (en) 2019-04-09 2020-09-01 Combangio, Inc. Processes for making and using a mesenchymal stem cell derived secretome
WO2021009778A2 (en) * 2019-07-18 2021-01-21 Pandorum Technologies Private Limited Methods for culturing mesenchymal stem cells, products thereof, and applications thereof
CN110447601A (zh) * 2019-08-09 2019-11-15 南京医科大学 一种靶向巨噬细胞过表达基因小鼠模型的制备方法
CN110693912A (zh) * 2019-11-18 2020-01-17 深圳市人民医院 干细胞外泌体在制备促进创面愈合的产品中的应用
WO2021146616A1 (en) * 2020-01-17 2021-07-22 Codiak Biosciences, Inc. Cholesterol assays for quantifying extracellular vesicles
CN111494417B (zh) * 2020-02-10 2024-04-09 寇晓星 诱导性细胞外囊泡在制备治疗肿瘤药物中的应用
CN113274408A (zh) * 2020-02-19 2021-08-20 中国医学科学院北京协和医院 一种磁性外泌体在制备创面修复或创面愈合产品中的应用
EP3907278A4 (en) 2020-03-13 2022-02-23 Showa Denko Materials Co., Ltd. METHODS FOR PREPARING A CELL SUSPENSION AND METHODS FOR PREPARING AN ADHERENT CELL
CN111500607B (zh) * 2020-03-13 2022-05-03 首都医科大学附属北京口腔医院 种植体周围抗炎用融合基因、外泌体、生物涂料以及制备方法和应用
WO2021205459A1 (en) 2020-04-07 2021-10-14 Ramot At Tel-Aviv University Ltd. Cannabidiol-containing compositions and uses thereof
KR102184428B1 (ko) * 2020-05-25 2020-11-30 주식회사 씨케이엑소젠 중배엽줄기세포 유래의 엑소좀 생산방법 및 이로부터 제조된 배양액
CN111690686B (zh) * 2020-07-19 2021-01-15 广西康久生物科技有限公司 一种miRNA高表达在促进脐带间充质干细胞体外增殖和成骨分化方面的应用
CN111888379A (zh) * 2020-08-17 2020-11-06 济宁医学院附属医院 干细胞来源的微囊泡在制备修复瘢痕的制剂中的应用
WO2022114724A1 (ko) * 2020-11-27 2022-06-02 (주)엑셀세라퓨틱스 고효율 및 고순도 엑소좀 생산용 배지 조성물
WO2022126004A1 (en) * 2020-12-11 2022-06-16 Emory University Hydrogels encapsulating enzymes that dephosphorylate adenosine and uses in medical applications
CN112941026B (zh) * 2021-01-27 2023-03-31 上海交通大学 基于密度梯度离心提取细胞内体的方法
US20220296645A1 (en) * 2021-03-22 2022-09-22 Spiritus Therapeutics, Inc. Diagnostic and therapeutic uses of compositions comprising purified, enriched potent exosomes containing disease-based and therapy based signature cargo
CN113373112B (zh) * 2021-06-30 2022-02-01 中国医学科学院阜外医院 基于通心络预处理的间充质干细胞来源外泌体及其制备方法
CN114010756A (zh) * 2021-10-25 2022-02-08 北京医院 一种卵巢再生贴片及其基于真空装置的制备方法
WO2023123215A1 (zh) * 2021-12-30 2023-07-06 医微细胞生物技术(广州)有限公司 细胞外囊泡的应用
CN114848674A (zh) * 2022-03-25 2022-08-05 四川大学华西医院 一种干细胞微粒在制备治疗帕金森的药物中的应用
CN114703274B (zh) * 2022-04-01 2023-08-15 中国人民解放军总医院 Phpt1在预警和/或治疗高原病中的应用
WO2023223312A1 (en) 2022-05-15 2023-11-23 Nurexone Biologic Ltd. Anti-pten rna interference oligonucleotides and uses thereof
GB202215142D0 (en) * 2022-10-13 2022-11-30 Univ York Novel cell lines and their use in therapy
GB202215141D0 (en) * 2022-10-13 2022-11-30 Univ York Novel cell line and its use in therapy
CN115572709A (zh) * 2022-10-18 2023-01-06 中晶生物技术股份有限公司 三维培养间充质干细胞微球在制备脱发修复与再生药物或制剂中的应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675187A (en) 1983-05-16 1987-06-23 Bristol-Myers Company BBM-1675, a new antibiotic complex
DE4117305C2 (de) 1991-05-27 1994-07-21 Weidmueller Interface Zange zum Ergreifen und/oder Verpressen von Bearbeitungsgegenständen
US5661034A (en) 1991-07-18 1997-08-26 Fuji Yakuhin Kogyo Kabushiki Kaisha Serum-free medium for tissue culture containing tissue inhibitor of metalloproteinases and method for growing cells using the medium
AU5136093A (en) 1992-09-25 1994-04-26 Warner-Lambert Company Peptide antagonists of sh2 binding and therapeutic uses thereof
EP0600832A1 (de) 1992-11-27 1994-06-08 Ciba-Geigy Ag Diaminobenzoe- und Diaminophthalsäurederivate und ihre Verfahren als Proteinkinase-Inhibitoren
EP0600831A1 (de) 1992-11-27 1994-06-08 Ciba-Geigy Ag Phthalazinonderivate
US5387584A (en) 1993-04-07 1995-02-07 Pfizer Inc. Bicyclic ansamycins
US5631159A (en) 1993-09-22 1997-05-20 Creative Biomolecules, Inc. Lipid-modified serum free media
US6139524A (en) 1998-10-16 2000-10-31 Scimed Life Systems, Inc. Stent delivery system with perfusion
US7122019B1 (en) 2000-11-28 2006-10-17 Flowmedica Inc. Intra-aortic renal drug delivery catheter
US7063679B2 (en) 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
AU2005262319A1 (en) * 2004-07-01 2006-01-19 Orthogen Ag Immunosuppressive exosomes
USD544957S1 (en) 2005-03-23 2007-06-19 Rexam Dispensing Systems Nasal spray dispenser
WO2006110582A1 (en) * 2005-04-08 2006-10-19 Xcyte Therapies, Inc. Compositions and methods for the treatment of burns and sepsis
JP2010500047A (ja) * 2006-08-15 2010-01-07 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 間葉系幹細胞馴化培地
US20080256435A1 (en) * 2007-01-26 2008-10-16 Citation Technologies, Inc. Interconnection of Document Preparation, Document Viewing, and Alert Processing in Structured Documents
JP2015529450A (ja) * 2012-07-19 2015-10-08 リニューロン・リミテッドＲｅＮｅｕｒｏｎ Ｌｉｍｉｔｅｄ 幹細胞微粒子

Also Published As

Publication number Publication date
US20150190430A1 (en) 2015-07-09
US20170189449A1 (en) 2017-07-06
US10780128B2 (en) 2020-09-22
CN104127438A (zh) 2014-11-05
JP5718648B2 (ja) 2015-05-13
DK2254586T3 (en) 2015-06-15
CN102014934B (zh) 2014-08-20
US20110003008A1 (en) 2011-01-06
PL2254586T3 (pl) 2015-09-30
HUE026536T2 (en) 2016-06-28
HRP20150510T1 (hr) 2015-06-05
EP2254586A1 (en) 2010-12-01
KR20100122087A (ko) 2010-11-19
KR101640381B1 (ko) 2016-07-18
PT2254586E (pt) 2015-05-18
EP2254586B1 (en) 2015-04-08
ES2537516T3 (es) 2015-06-09
AU2009215934B2 (en) 2013-10-24
WO2009105044A1 (en) 2009-08-27
AU2009215934A1 (en) 2009-08-27
CN104127438B (zh) 2021-01-08
AU2009215934C1 (en) 2014-05-08
JP2011513217A (ja) 2011-04-28
CN102014934A (zh) 2011-04-13

Similar Documents

Publication Publication Date Title
PL2254586T3 (pl) Cząstki mezenchymalnych komórek macierzystych
IL247310B (en) Mesenchymal stem cell differentiation
HK1216883A1 (zh) 幹細胞培養
SG10201403202XA (en) Pre-natal mesenchymal stem cells
EP2315829A4 (en) INDUCED PLURIPOTENT STEM CELLS
ZA201008391B (en) Pluripotent cells
SG10201500674YA (en) Pluripotent stem cells
GB0814249D0 (en) Uses of mesenchymal stem cells
IL212368A0 (en) Compounds that expand hematopoietic stem cells
EP2414510A4 (en) INDUCED PLURIPOTENT STEM CELLS
HK1129703A1 (en) Abcb5 positive mesenchymal stem cells as immunomodulators abcb5
EP2294182A4 (en) CULTS OF MULTIPOTENT STEM CELLS
GB0919773D0 (en) Induced pluripotent stem cell
GB0818256D0 (en) stem cells
GB0724994D0 (en) Mesenchymal stem cell markers
GB0918471D0 (en) Stem cells
GB0812904D0 (en) Porous particles
GB0808778D0 (en) Cell culture technique