DK3016665T3 - Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser - Google Patents
Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser Download PDFInfo
- Publication number
- DK3016665T3 DK3016665T3 DK14753019T DK14753019T DK3016665T3 DK 3016665 T3 DK3016665 T3 DK 3016665T3 DK 14753019 T DK14753019 T DK 14753019T DK 14753019 T DK14753019 T DK 14753019T DK 3016665 T3 DK3016665 T3 DK 3016665T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- stem cells
- conditioned medium
- human adult
- adult liver
- Prior art date
Links
- 239000003636 conditioned culture medium Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 210000004185 liver Anatomy 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13175442 | 2013-07-05 | ||
| PCT/EP2014/064437 WO2015001124A1 (en) | 2013-07-05 | 2014-07-07 | Conditioned medium from human adult liver stem cells and its use in the treatment of liver disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3016665T3 true DK3016665T3 (da) | 2019-11-25 |
Family
ID=48792979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14753019T DK3016665T3 (da) | 2013-07-05 | 2014-07-07 | Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20160129047A1 (da) |
| EP (1) | EP3016665B1 (da) |
| JP (1) | JP6474394B2 (da) |
| DK (1) | DK3016665T3 (da) |
| ES (1) | ES2759228T3 (da) |
| WO (1) | WO2015001124A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3016665T3 (da) | 2013-07-05 | 2019-11-25 | Univ Catholique Louvain | Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser |
| ES2954834T3 (es) | 2014-08-28 | 2023-11-27 | Cellaion Sa | Método para producir células progenitoras del hígado adulto |
| CL2015002971A1 (es) * | 2015-10-05 | 2016-06-24 | Univ Del Desarrollo | Composición biofarmacológica que comprende componentes producidos y/o secretados por células troncales mesenquimales (msc), que permite recuperar la capacidad regenerativa tisular, en una situación de esteatosis hepática, o donde la capacidad de regeneración endógena del tejido hepático se encuentra inhibida |
| MA45274A (fr) * | 2016-03-02 | 2019-01-09 | Univ Catholique Louvain | Préparations améliorées de cellules progénitrices hépatiques adultes |
| JP7011605B2 (ja) * | 2016-05-06 | 2022-01-26 | ユニシテ エーファウ アクチェンゲゼルシャフト | 高血糖症によって引き起こされる線維性疾患の処置における使用のためのｍｉＲＮＡを含有する薬学的担体 |
| KR20220004977A (ko) | 2019-03-26 | 2022-01-12 | 프로메테라 테라푸틱스 에스에이 | 만성 간부전의 급성 악화를 치료하기 위한 성체 간 전구 세포 |
| IL291886A (en) | 2019-10-09 | 2022-06-01 | Cellaion Sa | Use of progenitor cells or liver stem cells, their lysates, and/or conditioned growth medium - in disorders characterized by hyperpermeability of the blood vessels |
| EP3881853A1 (en) * | 2020-03-20 | 2021-09-22 | Promethera Therapeutics Sa | Human allogeneic liver-derived progenitor cells for use in the treatment of inflammatory and infectious lung diseases and systemic inflammation |
| CN113621557A (zh) * | 2021-09-02 | 2021-11-09 | 中国烟草总公司郑州烟草研究院 | 一种人肝微粒体与细胞共培养体系及其构建方法和应用 |
| CN114748505A (zh) * | 2022-01-17 | 2022-07-15 | 桂林医学院 | 骨髓间充质干细胞外泌体的应用 |
| WO2023180122A1 (en) | 2022-03-24 | 2023-09-28 | Université Catholique de Louvain | Use of human allogenic liver-derived progenitor cells for treating and/or preventing cellular senescence |
| WO2024200809A1 (en) | 2023-03-31 | 2024-10-03 | Université Catholique de Louvain | Use of human allogenic liver-derived progenitor cells for treating and/or preventing hepatocellular carcinoma |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68927996T2 (de) | 1988-02-05 | 1997-12-04 | Hughes Howard Med Inst | Modifizierte hepatozyten und deren anwendung |
| US6069005A (en) | 1991-08-07 | 2000-05-30 | Albert Einstein College Of Medicine Of Yeshwa University | Hapatoblasts and method of isolating same |
| DK0671923T3 (da) | 1992-10-09 | 2001-08-13 | Advanced Tissue Sciences Inc | Leverreserveceller |
| EP1067940A4 (en) | 1998-03-03 | 2003-01-02 | Genaera Corp | FACTORS ASSOCIATED WITH ASTHMA AS TARGETS FOR THE TREATMENT OF ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS |
| US6774120B1 (en) | 1999-06-01 | 2004-08-10 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| US8778899B2 (en) | 1999-06-01 | 2014-07-15 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| ES2395821T3 (es) | 2000-01-19 | 2013-02-15 | University Of North Carolina At Chapel Hill | Fuente de tejido de hígado |
| GB0014136D0 (en) | 2000-06-10 | 2000-08-02 | Astrazeneca Ab | Combination therapy |
| DE60221987T2 (de) | 2001-06-22 | 2008-05-15 | Stemcells, Inc., Palo Alto | Le-zellen (liver engrafting cells), assays und verwendungen davon |
| WO2003033697A1 (en) | 2001-10-18 | 2003-04-24 | Ixion Biotechnology, Inc. | Conversion of liver stem and progenitor cells to pancreatic functional cells |
| DE10202982A1 (de) | 2002-01-26 | 2003-07-31 | Augustinus Bader | Verfahren und Vorrichtung zum Einbringen von lebenden Zellen in eine biologische Körperflüssigkeit |
| JP2006525994A (ja) | 2003-05-12 | 2006-11-16 | サラ ファーバー， | 非膵島組織における調節された膵ホルモンの産生を誘導する方法 |
| CA2444292A1 (en) | 2003-10-03 | 2005-04-03 | Inserm | Bipotential liver cell lines from wild-type mammalian liver tissue |
| WO2005035738A1 (en) | 2003-10-07 | 2005-04-21 | Biomaster Inc. | Cell differentiation of adipose-derived precursor cells |
| US20060222640A1 (en) | 2005-03-29 | 2006-10-05 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions for treatment of thrombosis |
| US20080241112A1 (en) | 2005-05-10 | 2008-10-02 | Christof Westenfelder | Therapy of Kidney Diseases and Multiorgan Failure with Mesenchymal Stem Cells and Mesenchymal Stem Cell Conditioned Media |
| WO2006126219A1 (en) | 2005-05-26 | 2006-11-30 | Fresenius Medical Care Deutschland G.M.B.H. | Liver progenitor cells |
| CA2663749A1 (en) | 2005-09-21 | 2007-03-29 | Dask Technologies, Llc | Methods and compositions for organ and tissue functionality |
| DK2281875T3 (da) | 2005-12-21 | 2018-06-06 | Univ Catholique Louvain | Isolerede leverstamceller |
| WO2008060788A2 (en) | 2006-10-11 | 2008-05-22 | The General Hospital Corporation | Compositions, methods, and devices for treating liver disease |
| WO2008070868A1 (en) | 2006-12-07 | 2008-06-12 | American Symbolic, Llc | Stem cell secretions and related methods |
| EP2211875B1 (en) | 2007-10-29 | 2013-05-29 | Fresenius Medical Care Deutschland GmbH | Use of microvesicles (mvs) derived from stem cells for preparing a medicament for endo/epithelial regeneration of damaged or injured tissues or organs, and related in vitro and in vivo methods |
| PT2254586E (pt) | 2008-02-22 | 2015-05-18 | Agency Science Tech & Res | Partículas de células estaminais mesenquimais |
| CN102119031B (zh) | 2008-06-11 | 2014-09-10 | 弗雷森纽斯医疗护理德国有限责任公司 | 肝祖细胞的条件培养基 |
| FI20095409A0 (fi) | 2009-04-14 | 2009-04-14 | Helsingin Yliopisto | Soluviljelysupplementti |
| SG177467A1 (en) | 2009-07-23 | 2012-02-28 | Agency Science Tech & Res | Pre-natal mesenchymal stem cells |
| EP2333047A1 (en) | 2009-12-09 | 2011-06-15 | Fresenius Medical Care Deutschland GmbH | Adult stem cell derived conditioned medium and/or adult stem cells for use in the therapeutic treatment of a tumor disease |
| US8415149B2 (en) | 2010-05-06 | 2013-04-09 | Gwo Xi Stem Cell Applied Technology Co., Ltd. | Hepatic progenitor cells and uses thereof |
| ES2573522T3 (es) | 2011-01-25 | 2016-06-08 | Université Catholique de Louvain | Composiciones y métodos para el trasplante celular |
| US9775890B2 (en) | 2012-01-25 | 2017-10-03 | Université Catholique de Louvain | Factor Xa inhibitor used with liver-derived progenitor cells |
| DK3016665T3 (da) | 2013-07-05 | 2019-11-25 | Univ Catholique Louvain | Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser |
| MA45274A (fr) | 2016-03-02 | 2019-01-09 | Univ Catholique Louvain | Préparations améliorées de cellules progénitrices hépatiques adultes |
-
2014
- 2014-07-07 DK DK14753019T patent/DK3016665T3/da active
- 2014-07-07 US US14/899,661 patent/US20160129047A1/en not_active Abandoned
- 2014-07-07 EP EP14753019.0A patent/EP3016665B1/en active Active
- 2014-07-07 WO PCT/EP2014/064437 patent/WO2015001124A1/en active Application Filing
- 2014-07-07 ES ES14753019T patent/ES2759228T3/es active Active
- 2014-07-07 JP JP2016522658A patent/JP6474394B2/ja active Active
-
2018
- 2018-03-29 US US15/940,897 patent/US10874699B2/en active Active
-
2020
- 2020-11-25 US US17/104,202 patent/US11793837B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2759228T3 (es) | 2020-05-08 |
| EP3016665B1 (en) | 2019-09-18 |
| US20210077537A1 (en) | 2021-03-18 |
| JP2016523883A (ja) | 2016-08-12 |
| EP3016665A1 (en) | 2016-05-11 |
| US10874699B2 (en) | 2020-12-29 |
| US20160129047A1 (en) | 2016-05-12 |
| JP6474394B2 (ja) | 2019-02-27 |
| WO2015001124A1 (en) | 2015-01-08 |
| US20180289747A1 (en) | 2018-10-11 |
| US11793837B2 (en) | 2023-10-24 |
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