DK3016665T3 - Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser - Google Patents
Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser Download PDFInfo
- Publication number
- DK3016665T3 DK3016665T3 DK14753019T DK14753019T DK3016665T3 DK 3016665 T3 DK3016665 T3 DK 3016665T3 DK 14753019 T DK14753019 T DK 14753019T DK 14753019 T DK14753019 T DK 14753019T DK 3016665 T3 DK3016665 T3 DK 3016665T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- stem cells
- conditioned medium
- human adult
- adult liver
- Prior art date
Links
- 239000003636 conditioned culture medium Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 210000004185 liver Anatomy 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13175442 | 2013-07-05 | ||
| PCT/EP2014/064437 WO2015001124A1 (en) | 2013-07-05 | 2014-07-07 | Conditioned medium from human adult liver stem cells and its use in the treatment of liver disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3016665T3 true DK3016665T3 (da) | 2019-11-25 |
Family
ID=48792979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14753019T DK3016665T3 (da) | 2013-07-05 | 2014-07-07 | Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20160129047A1 (da) |
| EP (1) | EP3016665B1 (da) |
| JP (1) | JP6474394B2 (da) |
| DK (1) | DK3016665T3 (da) |
| ES (1) | ES2759228T3 (da) |
| WO (1) | WO2015001124A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3016665T3 (da) | 2013-07-05 | 2019-11-25 | Univ Catholique Louvain | Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser |
| EP3140393B1 (en) | 2014-08-28 | 2023-06-14 | Cellaïon SA | Method for producing adult liver progenitor cells |
| CL2015002971A1 (es) * | 2015-10-05 | 2016-06-24 | Univ Del Desarrollo | Composición biofarmacológica que comprende componentes producidos y/o secretados por células troncales mesenquimales (msc), que permite recuperar la capacidad regenerativa tisular, en una situación de esteatosis hepática, o donde la capacidad de regeneración endógena del tejido hepático se encuentra inhibida |
| MA45274A (fr) | 2016-03-02 | 2019-01-09 | Univ Catholique Louvain | Préparations améliorées de cellules progénitrices hépatiques adultes |
| US10716813B2 (en) * | 2016-05-06 | 2020-07-21 | Unicyte Ev Ag | Pharmaceutical carriers containing miRNAs for use in the treatment of fibrotic diseases caused by hyperglycemia |
| WO2020193714A1 (en) | 2019-03-26 | 2020-10-01 | Promethera Biosciences S.A./N.V. | Adult liver progenitor cells for treating acute-on-chronic liver failure |
| TW202128197A (zh) * | 2019-10-09 | 2021-08-01 | 比利時商普羅米修亞生物科技股份有限公司 | 肝前驅或幹細胞、其溶胞產物、及/或條件培養基於血管高通透性表徵之病症的用途 |
| EP3881853A1 (en) * | 2020-03-20 | 2021-09-22 | Promethera Therapeutics Sa | Human allogeneic liver-derived progenitor cells for use in the treatment of inflammatory and infectious lung diseases and systemic inflammation |
| CN113621557A (zh) * | 2021-09-02 | 2021-11-09 | 中国烟草总公司郑州烟草研究院 | 一种人肝微粒体与细胞共培养体系及其构建方法和应用 |
| CN114748505A (zh) * | 2022-01-17 | 2022-07-15 | 桂林医学院 | 骨髓间充质干细胞外泌体的应用 |
| WO2023180122A1 (en) | 2022-03-24 | 2023-09-28 | Université Catholique de Louvain | Use of human allogenic liver-derived progenitor cells for treating and/or preventing cellular senescence |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68927996T2 (de) | 1988-02-05 | 1997-12-04 | Hughes Howard Med Inst | Modifizierte hepatozyten und deren anwendung |
| US6069005A (en) | 1991-08-07 | 2000-05-30 | Albert Einstein College Of Medicine Of Yeshwa University | Hapatoblasts and method of isolating same |
| JP3789930B2 (ja) | 1992-10-09 | 2006-06-28 | アドバンスド ティシュー サイエンシズ，インコーポレーテッド | 肝予備細胞 |
| CA2321664C (en) | 1998-03-03 | 2009-06-02 | Magainin Pharmaceuticals, Inc. | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders |
| US8778899B2 (en) | 1999-06-01 | 2014-07-15 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| US6774120B1 (en) | 1999-06-01 | 2004-08-10 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| AU782683B2 (en) | 2000-01-19 | 2005-08-18 | University Of North Carolina At Chapel Hill, The | Liver tissue source |
| GB0014136D0 (en) | 2000-06-10 | 2000-08-02 | Astrazeneca Ab | Combination therapy |
| ATE371018T1 (de) | 2001-06-22 | 2007-09-15 | Stemcells Inc | Le-zellen (liver engrafting cells), assays und verwendungen davon |
| US20050053588A1 (en) | 2001-10-18 | 2005-03-10 | Li Yin | Conversion of liver stem and progenitor cells to pancreatic functional cells |
| DE10202982A1 (de) | 2002-01-26 | 2003-07-31 | Augustinus Bader | Verfahren und Vorrichtung zum Einbringen von lebenden Zellen in eine biologische Körperflüssigkeit |
| JP2006525994A (ja) | 2003-05-12 | 2006-11-16 | サラ ファーバー， | 非膵島組織における調節された膵ホルモンの産生を誘導する方法 |
| US20050074876A1 (en) | 2003-10-03 | 2005-04-07 | Inserm | Bipotential liver cell lines from wild-type mammalian liver tissue |
| JP4749331B2 (ja) | 2003-10-07 | 2011-08-17 | 株式会社バイオマスター | 脂肪由来前駆細胞の細胞分化 |
| US20060222640A1 (en) | 2005-03-29 | 2006-10-05 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions for treatment of thrombosis |
| CA2608048A1 (en) | 2005-05-10 | 2006-11-16 | United States Of America Department Of Veteran's Affairs | Therapy of kidney diseases and multiorgan failure with mesenchymal stem cells and mesenchymal stem cell conditioned media |
| WO2006126219A1 (en) | 2005-05-26 | 2006-11-30 | Fresenius Medical Care Deutschland G.M.B.H. | Liver progenitor cells |
| KR20080075494A (ko) | 2005-09-21 | 2008-08-18 | 다스크 테크날러지, 엘엘씨 | 장기 및 조직 기능성을 위한 방법 및 조성물 |
| DE602006020071D1 (de) | 2005-12-21 | 2011-03-24 | Univ Catholique Louvain | Isolierte leberstammzellen |
| US8172784B2 (en) | 2006-10-11 | 2012-05-08 | The General Hospital Corporation | Compositions, methods, and devices for treating liver disease |
| WO2008070868A1 (en) | 2006-12-07 | 2008-06-12 | American Symbolic, Llc | Stem cell secretions and related methods |
| ES2423483T3 (es) | 2007-10-29 | 2013-09-20 | Fresenius Medical Care Deutschland Gmbh | Uso de microvesículas (MV) derivadas de células madre para preparar un medicamento para regeneración endotelial/epitelial de tejidos u órganos dañados o lesionados, y métodos relacionados in vitro e in vivo |
| KR101640381B1 (ko) | 2008-02-22 | 2016-07-18 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | 중간엽 줄기세포 입자 |
| US10456425B2 (en) | 2008-06-11 | 2019-10-29 | Fresenius Medical Care Deutschland Gmbh | Conditioned medium of liver progenitor cells |
| FI20095409A0 (fi) | 2009-04-14 | 2009-04-14 | Helsingin Yliopisto | Soluviljelysupplementti |
| SG10201403202XA (en) | 2009-07-23 | 2014-08-28 | Agency Science Tech & Res | Pre-natal mesenchymal stem cells |
| EP2333047A1 (en) | 2009-12-09 | 2011-06-15 | Fresenius Medical Care Deutschland GmbH | Adult stem cell derived conditioned medium and/or adult stem cells for use in the therapeutic treatment of a tumor disease |
| US8415149B2 (en) | 2010-05-06 | 2013-04-09 | Gwo Xi Stem Cell Applied Technology Co., Ltd. | Hepatic progenitor cells and uses thereof |
| PT2667878E (pt) | 2011-01-25 | 2016-06-03 | Univ Catholique Louvain | Composições e métodos para o transplante celular |
| JP6034406B2 (ja) | 2012-01-25 | 2016-11-30 | ユニヴェルシテ カソリック ド ルーヴァンＵｎｉｖｅｒｓｉｔｅ Ｃａｔｈｏｌｉｑｕｅ Ｄｅ Ｌｏｕｖａｉｎ | 細胞移植のための組成物および方法 |
| DK3016665T3 (da) | 2013-07-05 | 2019-11-25 | Univ Catholique Louvain | Konditioneret medium fra humane voksne leverstamceller og dets anvendelse i behandlingen af leverlidelser |
| MA45274A (fr) | 2016-03-02 | 2019-01-09 | Univ Catholique Louvain | Préparations améliorées de cellules progénitrices hépatiques adultes |
-
2014
- 2014-07-07 DK DK14753019T patent/DK3016665T3/da active
- 2014-07-07 WO PCT/EP2014/064437 patent/WO2015001124A1/en active Application Filing
- 2014-07-07 ES ES14753019T patent/ES2759228T3/es active Active
- 2014-07-07 US US14/899,661 patent/US20160129047A1/en not_active Abandoned
- 2014-07-07 JP JP2016522658A patent/JP6474394B2/ja active Active
- 2014-07-07 EP EP14753019.0A patent/EP3016665B1/en active Active
-
2018
- 2018-03-29 US US15/940,897 patent/US10874699B2/en active Active
-
2020
- 2020-11-25 US US17/104,202 patent/US11793837B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015001124A1 (en) | 2015-01-08 |
| US20210077537A1 (en) | 2021-03-18 |
| US11793837B2 (en) | 2023-10-24 |
| US20180289747A1 (en) | 2018-10-11 |
| US20160129047A1 (en) | 2016-05-12 |
| US10874699B2 (en) | 2020-12-29 |
| EP3016665B1 (en) | 2019-09-18 |
| ES2759228T3 (es) | 2020-05-08 |
| EP3016665A1 (en) | 2016-05-11 |
| JP6474394B2 (ja) | 2019-02-27 |
| JP2016523883A (ja) | 2016-08-12 |
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