DK3508209T3 - Sammensætninger med et svækket newcastle sygdoms-virus og fremgangsmåder til anvendelse til behandling af neoplasi - Google Patents

Sammensætninger med et svækket newcastle sygdoms-virus og fremgangsmåder til anvendelse til behandling af neoplasi Download PDF

Info

Publication number
DK3508209T3
DK3508209T3 DK18188565.8T DK18188565T DK3508209T3 DK 3508209 T3 DK3508209 T3 DK 3508209T3 DK 18188565 T DK18188565 T DK 18188565T DK 3508209 T3 DK3508209 T3 DK 3508209T3
Authority
DK
Denmark
Prior art keywords
neoplasi
animated
compositions
treatment
methods
Prior art date
Application number
DK18188565.8T
Other languages
English (en)
Inventor
Hong Jin
Danielle Carroll
Matthew Mccourt
Xing Cheng
Mark Galinski
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Application granted granted Critical
Publication of DK3508209T3 publication Critical patent/DK3508209T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • A61K35/768Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04Inactivation or attenuation; Producing viral sub-units
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/155Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/17Newcastle disease virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
    • C07K14/535Granulocyte CSF; Granulocyte-macrophage CSF
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16111Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16111Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16141Use of virus, viral particle or viral elements as a vector
    • C12N2710/16143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18111Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18111Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18132Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18111Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18133Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18111Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18141Use of virus, viral particle or viral elements as a vector
    • C12N2760/18143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK18188565.8T 2013-09-03 2014-09-02 Sammensætninger med et svækket newcastle sygdoms-virus og fremgangsmåder til anvendelse til behandling af neoplasi DK3508209T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361873039P 2013-09-03 2013-09-03
EP14761317.8A EP3041490B1 (en) 2013-09-03 2014-09-02 Compositions featuring an attenuated newcastle disease virus and methods of use for treating neoplasia

Publications (1)

Publication Number Publication Date
DK3508209T3 true DK3508209T3 (da) 2022-05-30

Family

ID=51492938

Family Applications (2)

Application Number Title Priority Date Filing Date
DK14761317.8T DK3041490T3 (da) 2013-09-03 2014-09-02 Sammensætninger, som indeholder en svækket newcastle disease-virus, og fremgangsmåder til anvendelse til behandling af neoplasi
DK18188565.8T DK3508209T3 (da) 2013-09-03 2014-09-02 Sammensætninger med et svækket newcastle sygdoms-virus og fremgangsmåder til anvendelse til behandling af neoplasi

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK14761317.8T DK3041490T3 (da) 2013-09-03 2014-09-02 Sammensætninger, som indeholder en svækket newcastle disease-virus, og fremgangsmåder til anvendelse til behandling af neoplasi

Country Status (24)

Country Link
US (2) US10519426B2 (da)
EP (3) EP3508209B1 (da)
JP (2) JP6557234B2 (da)
KR (2) KR102310692B1 (da)
CN (2) CN106163532B (da)
AU (2) AU2014317215C1 (da)
CA (1) CA2922071C (da)
CY (1) CY1121993T1 (da)
DK (2) DK3041490T3 (da)
EA (2) EA039404B1 (da)
ES (2) ES2914577T3 (da)
HK (2) HK1225643B (da)
HR (2) HRP20220653T1 (da)
HU (1) HUE042382T2 (da)
LT (2) LT3508209T (da)
ME (1) ME03345B (da)
MX (2) MX367768B (da)
PL (2) PL3041490T3 (da)
PT (2) PT3041490T (da)
RS (2) RS58332B1 (da)
SI (2) SI3041490T1 (da)
TR (1) TR201902073T4 (da)
TW (1) TWI653334B (da)
WO (1) WO2015032755A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2911A (en) 2005-12-02 2014-05-31 Sinai School Medicine Chimeric Viruses presenting non-native surface proteins and uses thereof
US8591881B2 (en) 2009-02-05 2013-11-26 Mount Sinai School Of Medicine Chimeric Newcastle disease viruses and uses thereof
PE20151921A1 (es) 2013-03-14 2015-12-26 Icahn School Med Mount Sinai Virus de la enfermedad de newcastle y usos de los mismos
EP3508209B1 (en) * 2013-09-03 2022-03-09 MedImmune Limited Compositions featuring an attenuated newcastle disease virus and methods of use for treating neoplasia
CN107073099B (zh) 2014-02-27 2022-09-27 默沙东公司 用于治疗癌症的联合方法
US10563178B2 (en) * 2015-04-28 2020-02-18 University Of Georgia Research Foundation, Inc. PIV5-based amplifying virus-like particles
EP3246410A1 (en) * 2016-05-19 2017-11-22 Klinikum rechts der Isar der Technischen Universität München Vsv/ndv hybrid viruses for oncolytic therapy of cancer
KR101964610B1 (ko) * 2017-03-13 2019-04-03 대한민국 신규한 종양용해성 바이러스 및 이의 용도
JOP20190256A1 (ar) 2017-05-12 2019-10-28 Icahn School Med Mount Sinai فيروسات داء نيوكاسل واستخداماتها
CN107254450A (zh) * 2017-07-20 2017-10-17 扬州大学 克服鸡新城疫母源抗体影响的嵌合新城疫病毒疫苗载体候选株及构建方法
CN108486279A (zh) * 2017-09-21 2018-09-04 山东省农业科学院家禽研究所 一种基于荧光定量pcr技术检测鸽新城疫病毒的方法
EP3552608A1 (en) * 2018-04-09 2019-10-16 Rapo Yerape B.H. Ltd Increased activity of oncoloytic newcastle disease virus
CA3106170A1 (en) * 2018-07-13 2020-01-16 Icahn School Of Medicine At Mount Sinai Apmv and uses thereof for the treatment of cancer
CN110859968A (zh) * 2019-11-21 2020-03-06 四川安可康生物医药有限公司 激活对肿瘤的系统免疫反应的基因生物药物
CN115197949A (zh) * 2021-04-13 2022-10-18 江苏康缘瑞翱生物医药科技有限公司 一种重组新城疫病毒rNDV-OX40L、其基因组、制备方法及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7724558B1 (en) * 1999-03-19 2010-05-25 Nec Corporation Magnetic signal transmission line
AU7607900A (en) * 1999-09-22 2001-04-24 Mayo Foundation For Medical Education And Research Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family
KR100801180B1 (ko) * 2006-09-26 2008-02-05 주식회사 고려비엔피 약독화된 재조합 뉴캐슬병 바이러스 및 이를 함유하는뉴캐슬병 백신
EP2085092A1 (en) * 2008-01-29 2009-08-05 Bayer Schering Pharma Aktiengesellschaft Attenuated oncolytic paramyxoviruses encoding avian cytokines
US20090208495A1 (en) * 2008-02-14 2009-08-20 Bayer Schering Pharma Ag Anti-tumor effective paramyxovirus
US8591881B2 (en) * 2009-02-05 2013-11-26 Mount Sinai School Of Medicine Chimeric Newcastle disease viruses and uses thereof
PE20151921A1 (es) * 2013-03-14 2015-12-26 Icahn School Med Mount Sinai Virus de la enfermedad de newcastle y usos de los mismos
EP3508209B1 (en) * 2013-09-03 2022-03-09 MedImmune Limited Compositions featuring an attenuated newcastle disease virus and methods of use for treating neoplasia
CN109099045A (zh) * 2018-10-30 2018-12-28 浙江斯泰新材料科技股份有限公司 防松锁固型螺钉

Also Published As

Publication number Publication date
JP6557234B2 (ja) 2019-08-07
RS58332B1 (sr) 2019-03-29
PT3508209T (pt) 2022-05-27
US10519426B2 (en) 2019-12-31
JP2019193662A (ja) 2019-11-07
ES2708755T3 (es) 2019-04-11
TR201902073T4 (tr) 2019-03-21
KR102310692B1 (ko) 2021-10-12
AU2014317215A1 (en) 2016-04-14
LT3041490T (lt) 2019-02-25
EA202191926A2 (ru) 2021-10-29
MX2016002771A (es) 2016-09-06
AU2019204419B2 (en) 2021-09-02
PL3041490T3 (pl) 2019-05-31
SI3508209T1 (sl) 2023-01-31
EA202191926A3 (ru) 2022-01-31
CN111944767A (zh) 2020-11-17
JP6862500B2 (ja) 2021-04-21
CN106163532B (zh) 2019-12-31
KR20210048605A (ko) 2021-05-03
LT3508209T (lt) 2022-06-10
AU2014317215C1 (en) 2019-09-12
RS63291B1 (sr) 2022-06-30
HK1225643B (zh) 2017-09-15
MX367768B (es) 2019-09-05
HRP20190250T1 (hr) 2019-05-31
US20160208222A1 (en) 2016-07-21
AU2014317215A8 (en) 2016-04-21
DK3041490T3 (da) 2019-03-04
WO2015032755A1 (en) 2015-03-12
MX2019010364A (es) 2019-10-07
EP3508209A1 (en) 2019-07-10
AU2014317215B2 (en) 2019-03-28
EA201690425A1 (ru) 2016-08-31
EA039404B1 (ru) 2022-01-24
HRP20220653T1 (hr) 2022-06-24
HK1231393A1 (zh) 2017-12-22
CA2922071A1 (en) 2015-03-12
US11471499B2 (en) 2022-10-18
ME03345B (me) 2019-10-20
JP2016533749A (ja) 2016-11-04
CY1121993T1 (el) 2020-10-14
ES2914577T3 (es) 2022-06-14
HUE042382T2 (hu) 2019-06-28
CA2922071C (en) 2022-05-03
AU2019204419A1 (en) 2019-07-11
EP4101457A1 (en) 2022-12-14
EP3508209B1 (en) 2022-03-09
PL3508209T3 (pl) 2022-06-13
KR102285894B1 (ko) 2021-08-04
EP3041490A1 (en) 2016-07-13
CN106163532A (zh) 2016-11-23
TWI653334B (zh) 2019-03-11
EP3041490B1 (en) 2018-11-14
TW201606079A (zh) 2016-02-16
KR20160047570A (ko) 2016-05-02
PT3041490T (pt) 2019-02-06
SI3041490T1 (sl) 2019-03-29
US20200181581A1 (en) 2020-06-11

Similar Documents

Publication Publication Date Title
DK3508209T3 (da) Sammensætninger med et svækket newcastle sygdoms-virus og fremgangsmåder til anvendelse til behandling af neoplasi
DK3035955T3 (da) Sammensætning og vaccine til behandling af lungekræft
DK3142637T3 (da) Keratin treatment formulations and methods
DK3170842T3 (da) Immunologisk effektorcelle af målrettet cld18a2, fremstillingsfremgangsmåde og anvendelse deraf
DK2968208T3 (da) Behandling af kataplexi
DK3121164T3 (da) Sulfamoylpyrrolamidderivater og anvendelse deraf som medikamenter til behandling af hepatitis b
DK3007695T3 (da) Sammensætninger og fremgangsmåder til behandling af anæmi
DK2903967T6 (da) Acylaminopyrimidinderivater til behandling af virusinfektioner og andre sygdomme
DK3089707T3 (da) Vævtransplantater og fremgangsmåder til fremstilling og brug af samme
DK3021838T3 (da) Behandling af fedme
BR112016017742A2 (pt) composição e método auxiliares do sono
DK3626270T3 (da) Behandling af kardiovaskulære sygdomme
DK3238707T3 (da) Sammensætninger og fremgangsmåder til behandling af intestinal hyperpermeabilitet
DK3077467T3 (da) Sikkativsammensætning og anvendelse deraf
DK3050883T3 (da) Fremgangsmåde til fremstilling af diazabicyclooctanderivater og mellemprodukter
DK2961378T3 (da) Fremgangsmåder til behandlingen af mitochondrisk sygdom
DK3068505T3 (da) Spillesystem og -fremgangsmåde
DK2968377T3 (da) Sammensætninger og fremgangsmåder til behandling af en infektionssygdom
DK3083683T3 (da) Sammensætninger og fremgangsmåder til behandling af fedtvævsansamlinger
DK3060908T3 (da) Diagnosticering og behandling af autoimmune sygdomme
DK2976072T3 (da) Epinephrinfinpartikler og fremgangsmåder til anvendelse deraf til behandling af tilstande, der reagerer på epinephrin
DK2892556T3 (da) Sammensætninger og fremgangsmåder til behandling af sygdomme
DK3041831T3 (da) Alfa-te-saltformer: sammensætninger og anvendelser til behandling af sygdom
DK3044229T3 (da) Peptider til anvendelse i behandlingen af oral mucositis
DK3598971T3 (da) Doseringsformer og terapeutiske anvendelser af L-4-chlorkynurenin