MA45274A - Préparations améliorées de cellules progénitrices hépatiques adultes - Google Patents

Préparations améliorées de cellules progénitrices hépatiques adultes

Info

Publication number
MA45274A
MA45274A MA045274A MA45274A MA45274A MA 45274 A MA45274 A MA 45274A MA 045274 A MA045274 A MA 045274A MA 45274 A MA45274 A MA 45274A MA 45274 A MA45274 A MA 45274A
Authority
MA
Morocco
Prior art keywords
progenitor cell
cell preparations
hepatic progenitor
adult hepatic
improved adult
Prior art date
Application number
MA045274A
Other languages
English (en)
Inventor
Pierre-Edouard Dollet
Catherine Lombard
Mustapha Najimi
Etienne Sokal
Original Assignee
Univ Catholique Louvain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication date
Publication of MA45274A publication Critical patent/MA45274A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Nutrition Science (AREA)
MA045274A 2016-03-02 Préparations améliorées de cellules progénitrices hépatiques adultes MA45274A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16158327 2016-03-02

Publications (1)

Publication Number Publication Date
MA45274A true MA45274A (fr) 2019-01-09

Family

ID=55696855

Family Applications (1)

Application Number Title Priority Date Filing Date
MA045274A MA45274A (fr) 2016-03-02 Préparations améliorées de cellules progénitrices hépatiques adultes

Country Status (14)

Country Link
US (1) US20190046584A1 (fr)
EP (1) EP3423566A1 (fr)
JP (1) JP2019506890A (fr)
KR (1) KR20180114073A (fr)
CN (1) CN108779440A (fr)
AU (1) AU2017225825A1 (fr)
BR (1) BR112018067597A8 (fr)
CA (1) CA3013427A1 (fr)
EA (1) EA039743B1 (fr)
IL (1) IL261383A (fr)
MA (1) MA45274A (fr)
MX (1) MX2018010508A (fr)
SG (1) SG11201807041PA (fr)
WO (1) WO2017149059A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2759228T3 (es) 2013-07-05 2020-05-08 Univ Catholique Louvain Medio acondicionado de células madre de hígado de adultos y su uso en el tratamiento de trastornos del hígado
WO2020120666A1 (fr) 2018-12-14 2020-06-18 Promethera Biosciences S.A./N.V. Cellules progénitrices hépatiques exprimant hla-g, et procédé d'obtention de ces compositions de cellules comprenant lesdites cellules et leur utilisation
KR20210116469A (ko) 2018-12-14 2021-09-27 프로메테라 테라푸틱스 에스에이 Hla-e를 발현하는 간 전구 세포를 포함하는 세포 조성물
US20220202874A1 (en) 2019-03-26 2022-06-30 Promethera Therapeutics Sa Adult Liver Progenitor Cells for Treating Non-Alcoholic Fatty Liver Disease
CN113677790B (zh) * 2019-03-26 2024-05-24 普罗米瑟拉疗法公司 用于治疗慢加急性肝衰竭的成体肝祖细胞
CN113939585A (zh) 2019-04-30 2022-01-14 普罗米瑟拉疗法公司 人同种异体肝源性祖细胞的制备
EP3963049A1 (fr) 2019-04-30 2022-03-09 Promethera Therapeutics Sa Préparation de cellules progénitrices allogéniques humaines dérivées du foie
WO2021069553A1 (fr) 2019-10-09 2021-04-15 Promethera Biosciences S.A./N.V. Utilisation de cellules souches ou progénitrices hépatiques, de leurs lysats et/ou de milieu conditionné dans des troubles caractérisés par une hyperperméabilité vasculaire
EP3881853A1 (fr) 2020-03-20 2021-09-22 Promethera Therapeutics Sa Cellules progénitrices allogéniques humaines dérivées du foie à utiliser dans le traitement des maladies pulmonaires inflammatoires et infectieuses et de l'inflammation systémique
CN111778268B (zh) * 2020-06-03 2022-06-21 武汉仝干医疗科技股份有限公司 增强解毒功能基因片段及改造的HepG2细胞
WO2023180122A1 (fr) 2022-03-24 2023-09-28 Université Catholique de Louvain Utilisation de cellules progénitrices allogéniques humaines dérivées du foie pour traiter et/ou prévenir la sénescence cellulaire
WO2024200809A1 (fr) 2023-03-31 2024-10-03 Université Catholique de Louvain Utilisation de cellules progénitrices allogéniques humaines dérivées du foie pour traiter et/ou prévenir le carcinome hépatocellulaire
EP4560009A1 (fr) 2023-11-27 2025-05-28 Cellaïon SA Procédé de préparation de cellules isolées dérivées du foie

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006126219A1 (fr) 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Cellules progeniteurs hepatiques
ES2672205T3 (es) * 2005-12-21 2018-06-13 Université Catholique de Louvain Células madre hepáticas aisladas
CN101356264B (zh) * 2005-12-21 2014-05-14 鲁汶大学 分离的肝脏干细胞
JP5822287B2 (ja) * 2008-05-14 2015-11-24 公立大学法人横浜市立大学 ヒト肝幹細胞、その調製方法、分化誘導方法及び利用方法
US8415149B2 (en) * 2010-05-06 2013-04-09 Gwo Xi Stem Cell Applied Technology Co., Ltd. Hepatic progenitor cells and uses thereof
ES2726802T3 (es) * 2012-01-25 2019-10-09 Univ Catholique Louvain Composiciones y métodos para el trasplante celular
ES2759228T3 (es) * 2013-07-05 2020-05-08 Univ Catholique Louvain Medio acondicionado de células madre de hígado de adultos y su uso en el tratamiento de trastornos del hígado
PT3039123T (pt) * 2013-08-28 2020-01-16 Promethera Biosciences S A / N V Método para produção de células progenitoras de fígado adulto

Also Published As

Publication number Publication date
MX2018010508A (es) 2018-11-09
CA3013427A1 (fr) 2017-09-08
JP2019506890A (ja) 2019-03-14
IL261383A (en) 2018-10-31
EA201891913A1 (ru) 2019-02-28
BR112018067597A2 (pt) 2019-01-08
SG11201807041PA (en) 2018-09-27
EA039743B1 (ru) 2022-03-05
KR20180114073A (ko) 2018-10-17
BR112018067597A8 (pt) 2019-10-15
AU2017225825A1 (en) 2018-08-16
CN108779440A (zh) 2018-11-09
US20190046584A1 (en) 2019-02-14
EP3423566A1 (fr) 2019-01-09
WO2017149059A1 (fr) 2017-09-08

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