PT2035549E - Células estaminais mesenquimais abcb5 positivas como imunomoduladores - Google Patents

Células estaminais mesenquimais abcb5 positivas como imunomoduladores Download PDF

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Publication number
PT2035549E
PT2035549E PT77956472T PT07795647T PT2035549E PT 2035549 E PT2035549 E PT 2035549E PT 77956472 T PT77956472 T PT 77956472T PT 07795647 T PT07795647 T PT 07795647T PT 2035549 E PT2035549 E PT 2035549E
Authority
PT
Portugal
Prior art keywords
immunomodulators
stem cells
mesenchymal stem
positive mesenchymal
abcb5 positive
Prior art date
Application number
PT77956472T
Other languages
English (en)
Inventor
Markus H Frank
Original Assignee
Childrens Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center filed Critical Childrens Medical Center
Publication of PT2035549E publication Critical patent/PT2035549E/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT77956472T 2006-05-31 2007-05-31 Células estaminais mesenquimais abcb5 positivas como imunomoduladores PT2035549E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80940706P 2006-05-31 2006-05-31

Publications (1)

Publication Number Publication Date
PT2035549E true PT2035549E (pt) 2014-10-06

Family

ID=38594403

Family Applications (2)

Application Number Title Priority Date Filing Date
PT141681999T PT2772535T (pt) 2006-05-31 2007-05-31 Células estaminais mesenquimais abcb5 positivas como imunomoduladores
PT77956472T PT2035549E (pt) 2006-05-31 2007-05-31 Células estaminais mesenquimais abcb5 positivas como imunomoduladores

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT141681999T PT2772535T (pt) 2006-05-31 2007-05-31 Células estaminais mesenquimais abcb5 positivas como imunomoduladores

Country Status (13)

Country Link
US (4) US8455245B2 (pt)
EP (2) EP2772535B1 (pt)
AU (1) AU2007254894B9 (pt)
CA (1) CA2685492C (pt)
DK (2) DK2772535T3 (pt)
ES (2) ES2511791T3 (pt)
HK (2) HK1129703A1 (pt)
HU (1) HUE059011T2 (pt)
LT (1) LT2772535T (pt)
PL (2) PL2772535T3 (pt)
PT (2) PT2772535T (pt)
SI (2) SI2772535T1 (pt)
WO (1) WO2007143139A1 (pt)

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LT2772535T (lt) 2006-05-31 2022-08-25 Children's Medical Center Corporation Abc5 atžvilgiu teigiamos mezenchiminės kamieninės ląstelės kaip imunomoduliatoriai
ES2687270T3 (es) 2007-04-12 2018-10-24 The Brigham And Women's Hospital, Inc. Fijación como objetivo de ABCB5 para la terapia del cáncer
US11542328B2 (en) 2008-11-14 2023-01-03 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
CA2743464A1 (en) 2008-11-14 2010-05-20 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
EP3865573A1 (en) * 2013-02-19 2021-08-18 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
WO2014182994A1 (en) * 2013-05-10 2014-11-13 Children's Medical Center Corporation Wound healing and tissue engineering
US20150310380A1 (en) * 2014-04-28 2015-10-29 Patent Investment & Licensing Company Dispatch system having control shared with dispatched service providers
KR101723265B1 (ko) * 2013-08-16 2017-04-04 가톨릭대학교 산학협력단 mTOR/STAT3 신호억제제 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물
PT3091991T (pt) * 2013-12-13 2020-02-04 Swedish Stromabio Ab Composições imunomodulatórias
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US9790467B2 (en) * 2015-09-22 2017-10-17 Qt Holdings Corp Methods and compositions for activation or expansion of T lymphocytes
CN113301924A (zh) * 2018-08-18 2021-08-24 哈佛学院校长同事会 原位基因编辑
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WO2020219895A1 (en) * 2019-04-24 2020-10-29 Children's Medical Center Corporation Abcb5+ stem cell therapeutics for liver disease
EP4125960A4 (en) * 2020-03-30 2024-04-03 Children's Medical Center Corporation USE OF STEM CELLS FOR THE TREATMENT OF EXCESSIVE INFLAMMATION
JP2024517954A (ja) * 2021-05-13 2024-04-23 プライムジェン ユーエス インコーポレイテッド 肝疾患を治療するための方法および組成物
US20230256065A1 (en) * 2022-02-16 2023-08-17 Elena RUSYN Autologous stem cell vaccine and methods
CN115260098B (zh) * 2022-06-09 2024-06-04 澳门科技大学 Abcb5抑制剂在制备多耐药性类风湿性关节炎治疗药物中的应用

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EP3865573A1 (en) 2013-02-19 2021-08-18 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
WO2014182994A1 (en) 2013-05-10 2014-11-13 Children's Medical Center Corporation Wound healing and tissue engineering
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CN114245741A (zh) 2019-03-28 2022-03-25 儿童医学中心公司 高功能性的制造的abcb5+间充质干细胞

Also Published As

Publication number Publication date
WO2007143139A1 (en) 2007-12-13
CA2685492A1 (en) 2007-12-13
HK1129703A1 (en) 2009-12-04
HK1201295A1 (en) 2015-08-28
US20080003206A1 (en) 2008-01-03
PL2035549T3 (pl) 2014-12-31
LT2772535T (lt) 2022-08-25
EP2035549B1 (en) 2014-07-09
EP2772535B1 (en) 2022-04-06
CA2685492C (en) 2018-01-16
PT2772535T (pt) 2022-07-04
AU2007254894A1 (en) 2007-12-13
US8455245B2 (en) 2013-06-04
US20230313136A1 (en) 2023-10-05
ES2511791T3 (es) 2014-10-23
PL2772535T3 (pl) 2022-09-05
AU2007254894B2 (en) 2014-10-23
US10017738B2 (en) 2018-07-10
DK2772535T3 (da) 2022-07-04
DK2035549T3 (da) 2014-10-13
AU2007254894B9 (en) 2014-11-13
ES2918323T3 (es) 2022-07-15
HUE059011T2 (hu) 2022-09-28
US11624054B2 (en) 2023-04-11
SI2035549T1 (sl) 2015-03-31
US20130315880A1 (en) 2013-11-28
US20180320131A1 (en) 2018-11-08
EP2035549A1 (en) 2009-03-18
EP2772535A1 (en) 2014-09-03
SI2772535T1 (sl) 2022-08-31

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