IT1257893B - Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana. - Google Patents
Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana.Info
- Publication number
- IT1257893B IT1257893B ITRM920457A ITRM920457A IT1257893B IT 1257893 B IT1257893 B IT 1257893B IT RM920457 A ITRM920457 A IT RM920457A IT RM920457 A ITRM920457 A IT RM920457A IT 1257893 B IT1257893 B IT 1257893B
- Authority
- IT
- Italy
- Prior art keywords
- glycoprotein
- human
- epitope
- recognize
- monoclonal antibodies
- Prior art date
Links
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 title abstract 2
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 title abstract 2
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
E' descritto un anticorpo monoclonale che riconosce specificamente e ad alta affinità un epitopo lineare della quarta ansa extracellulare della P-glicoproteina umana, da utilizzarsi in saggi diagnostici e di riconoscimento di cellule tumorali con un fenotipo resistente a farmaci citotossici (MDR).
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM920457A IT1257893B (it) | 1992-06-17 | 1992-06-17 | Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana. |
KR1019940704598A KR100301189B1 (ko) | 1992-06-17 | 1993-06-16 | 당단백질피(p)에대한단일클론항체 |
AT93912996T ATE174967T1 (de) | 1992-06-17 | 1993-06-16 | Monoklonale antikörper gegen glykoprotein p |
NZ253139A NZ253139A (en) | 1992-06-17 | 1993-06-16 | Monoclonal antibody that recognises human glycoprotein p (pgp), its production and diagnostic kits and compositions containing it |
SK1554-94A SK280272B6 (sk) | 1992-06-17 | 1993-06-16 | Monoklonálna protilátka, spôsob prípravy monokloná |
JP6501138A JPH08501925A (ja) | 1992-06-17 | 1993-06-16 | 糖蛋白pに対するモノクローナル抗体 |
CZ943181A CZ284847B6 (cs) | 1992-06-17 | 1993-06-16 | Monoklonální protilátky proti glykoproteinu P |
DE69322783T DE69322783T2 (de) | 1992-06-17 | 1993-06-16 | Monoklonale Antikörper gegen Glykoprotein P |
CA002134752A CA2134752A1 (en) | 1992-06-17 | 1993-06-16 | Monoclonal antibodies to glycoprotein p |
HU9403614A HU216877B (hu) | 1992-06-17 | 1993-06-16 | Eljárás P-glikoprotein specifikus monoklonális antitestek és ezt termelő sejtvonalak előállítására |
DK93912996T DK0648276T3 (da) | 1992-06-17 | 1993-06-16 | Monoklone antistoffer mod glycoprotein P |
AU43266/93A AU672798B2 (en) | 1992-06-17 | 1993-06-16 | Monoclonal antibodies to glycoprotein P |
RU94046414A RU2126836C1 (ru) | 1992-06-17 | 1993-06-16 | Моноклональное антитело к гликопротеину р человека |
US08/356,272 US5766946A (en) | 1992-06-17 | 1993-06-16 | Monoclonal antibodies to glycoprotein P |
PCT/EP1993/001533 WO1993025700A1 (en) | 1992-06-17 | 1993-06-16 | Monoclonal antibodies to glycoprotein p |
EP93912996A EP0648276B1 (en) | 1992-06-17 | 1993-06-16 | Monoclonal antibodies to glycoprotein p |
ES93912996T ES2130271T3 (es) | 1992-06-17 | 1993-06-16 | Anticuerpos monoclonales para glicoproteina p. |
FI945865A FI945865A (fi) | 1992-06-17 | 1994-12-13 | Glykoprofeiini P:lle kohdistettuja monoklonaalisia vasta-aineita |
NO944887A NO944887D0 (no) | 1992-06-17 | 1994-12-16 | Monoklonale antistoffer mot glykoprotein |
GR990400860T GR3029773T3 (en) | 1992-06-17 | 1999-03-23 | Monoclonal antibodies to glycoprotein p. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM920457A IT1257893B (it) | 1992-06-17 | 1992-06-17 | Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM920457A0 ITRM920457A0 (it) | 1992-06-17 |
ITRM920457A1 ITRM920457A1 (it) | 1993-12-17 |
IT1257893B true IT1257893B (it) | 1996-02-16 |
Family
ID=11401066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITRM920457A IT1257893B (it) | 1992-06-17 | 1992-06-17 | Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5766946A (it) |
EP (1) | EP0648276B1 (it) |
JP (1) | JPH08501925A (it) |
KR (1) | KR100301189B1 (it) |
AT (1) | ATE174967T1 (it) |
AU (1) | AU672798B2 (it) |
CA (1) | CA2134752A1 (it) |
CZ (1) | CZ284847B6 (it) |
DE (1) | DE69322783T2 (it) |
DK (1) | DK0648276T3 (it) |
ES (1) | ES2130271T3 (it) |
FI (1) | FI945865A (it) |
GR (1) | GR3029773T3 (it) |
HU (1) | HU216877B (it) |
IT (1) | IT1257893B (it) |
NO (1) | NO944887D0 (it) |
NZ (1) | NZ253139A (it) |
RU (1) | RU2126836C1 (it) |
SK (1) | SK280272B6 (it) |
WO (1) | WO1993025700A1 (it) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5994088A (en) * | 1991-03-08 | 1999-11-30 | Board Of Trustees Of The University Of Illinois | Methods and reagents for preparing and using immunological agents specific for P-glycoprotein |
AU5420494A (en) * | 1992-11-02 | 1994-05-24 | Yves Claude Nicolau | Method of reducing multidrug resistance in cells and tissues |
US5686578A (en) | 1994-08-05 | 1997-11-11 | Immunomedics, Inc. | Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype |
WO1997046254A2 (en) * | 1996-06-05 | 1997-12-11 | Eugene Mechetner | Reagents and methods for inhibiting cytokine release by blood cells |
AU5799199A (en) * | 1998-09-04 | 2000-03-27 | Immunomedics Inc. | Diagnosis of multidrug resistance in cancer and infectious lesions |
AU2001236588A1 (en) * | 2000-01-31 | 2001-08-07 | The Procter And Gamble Company | Antibodies to the staphylococcal multidrug resistance (smr) protein |
ES2659877T3 (es) | 2000-06-05 | 2018-03-19 | The Brigham And Women's Hospital, Inc. | Un gen que codifica un homólogo de glicoproteína p humana multifármaco-resistente en el cromosoma 7p15-21 y usos del mismo |
EP1223534A1 (en) * | 2001-01-14 | 2002-07-17 | Katz, Emil | Peptides representative of polypeptides of interest and antibodies directed thereagainst, and methods, systems and kits for generating and utilizing each |
US8663650B2 (en) | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
US7294701B2 (en) * | 2003-04-02 | 2007-11-13 | Technion Research & Development Foundation Ltd. | Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same |
FR2857875A1 (fr) * | 2003-07-25 | 2005-01-28 | Univ Reims Champagne Ardenne | Vaccin therapeutique cible contre la p-glycoproteine 170 pour inhiber la resistance multidrogues dans le traitement des cancers |
US7807171B2 (en) | 2003-07-25 | 2010-10-05 | Ac Immune Sa | Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers |
US20060068426A1 (en) * | 2004-08-20 | 2006-03-30 | Tam James P | Cyclic peptides and antibodies thereof |
WO2007143139A1 (en) | 2006-05-31 | 2007-12-13 | The Brigham And Women's Hospital, Inc. | Abcb5 positive mesenchymal stem cells as immunomodulators |
FR2906533B1 (fr) | 2006-09-28 | 2013-02-22 | Pf Medicament | Procede de generation d'anticorps actifs contre un antigene de resistance,anticorps obtenus par ledit procede et leurs utilisations |
US7928202B2 (en) | 2007-04-12 | 2011-04-19 | The Brigham And Women's Hospital, Inc. | Targeting ABCB5 for cancer therapy |
WO2012020124A1 (en) | 2010-08-12 | 2012-02-16 | Ac Immune S.A. | Vaccine engineering |
CN103189050B (zh) | 2010-10-26 | 2017-09-29 | Ac免疫有限公司 | 包含通过疏水部分修饰的肽的基于脂质体的构建体 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206352A (en) * | 1986-03-28 | 1993-04-27 | Board Of Trustees Of The University Of Illinois | Compositions for clones containing DNA sequences associated with multidrug resistance in human cells |
US5434075A (en) * | 1992-03-20 | 1995-07-18 | Board Of Trustees Of The University Of Illinois | Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses |
US5773280A (en) * | 1992-03-20 | 1998-06-30 | The Board Of Trustees Of The University Of Illinois | Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses |
EP0569141A3 (en) * | 1992-04-14 | 1994-10-26 | Hybritech Inc | Method for inhibiting the growth of multidrug-resistant tumors by antibodies. |
US5369009A (en) * | 1992-04-17 | 1994-11-29 | Dana Farber Cancer Institute | Antibodies for P-glycoprotein encoded by the mdr1 gene and uses thereof |
-
1992
- 1992-06-17 IT ITRM920457A patent/IT1257893B/it active IP Right Grant
-
1993
- 1993-06-16 WO PCT/EP1993/001533 patent/WO1993025700A1/en active IP Right Grant
- 1993-06-16 SK SK1554-94A patent/SK280272B6/sk unknown
- 1993-06-16 KR KR1019940704598A patent/KR100301189B1/ko not_active IP Right Cessation
- 1993-06-16 JP JP6501138A patent/JPH08501925A/ja active Pending
- 1993-06-16 DE DE69322783T patent/DE69322783T2/de not_active Expired - Fee Related
- 1993-06-16 DK DK93912996T patent/DK0648276T3/da active
- 1993-06-16 US US08/356,272 patent/US5766946A/en not_active Expired - Fee Related
- 1993-06-16 AT AT93912996T patent/ATE174967T1/de not_active IP Right Cessation
- 1993-06-16 RU RU94046414A patent/RU2126836C1/ru not_active IP Right Cessation
- 1993-06-16 CA CA002134752A patent/CA2134752A1/en not_active Abandoned
- 1993-06-16 CZ CZ943181A patent/CZ284847B6/cs not_active IP Right Cessation
- 1993-06-16 HU HU9403614A patent/HU216877B/hu not_active IP Right Cessation
- 1993-06-16 EP EP93912996A patent/EP0648276B1/en not_active Expired - Lifetime
- 1993-06-16 NZ NZ253139A patent/NZ253139A/en unknown
- 1993-06-16 ES ES93912996T patent/ES2130271T3/es not_active Expired - Lifetime
- 1993-06-16 AU AU43266/93A patent/AU672798B2/en not_active Ceased
-
1994
- 1994-12-13 FI FI945865A patent/FI945865A/fi unknown
- 1994-12-16 NO NO944887A patent/NO944887D0/no not_active Application Discontinuation
-
1999
- 1999-03-23 GR GR990400860T patent/GR3029773T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NO944887L (no) | 1994-12-16 |
EP0648276B1 (en) | 1998-12-23 |
RU2126836C1 (ru) | 1999-02-27 |
GR3029773T3 (en) | 1999-06-30 |
AU672798B2 (en) | 1996-10-17 |
ES2130271T3 (es) | 1999-07-01 |
FI945865A (fi) | 1995-02-08 |
FI945865A0 (fi) | 1994-12-13 |
NO944887D0 (no) | 1994-12-16 |
CZ318194A3 (en) | 1995-07-12 |
DK0648276T3 (da) | 1999-08-23 |
ATE174967T1 (de) | 1999-01-15 |
HUT70469A (en) | 1995-10-30 |
DE69322783D1 (de) | 1999-02-04 |
NZ253139A (en) | 1996-09-25 |
SK280272B6 (sk) | 1999-10-08 |
RU94046414A (ru) | 1996-11-10 |
DE69322783T2 (de) | 1999-06-10 |
JPH08501925A (ja) | 1996-03-05 |
HU9403614D0 (en) | 1995-02-28 |
AU4326693A (en) | 1994-01-04 |
KR100301189B1 (ko) | 2001-10-22 |
EP0648276A1 (en) | 1995-04-19 |
SK155494A3 (en) | 1995-07-11 |
US5766946A (en) | 1998-06-16 |
ITRM920457A0 (it) | 1992-06-17 |
WO1993025700A1 (en) | 1993-12-23 |
ITRM920457A1 (it) | 1993-12-17 |
CZ284847B6 (cs) | 1999-03-17 |
HU216877B (hu) | 1999-09-28 |
CA2134752A1 (en) | 1993-12-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970627 |