IT1257893B - Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana. - Google Patents

Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana.

Info

Publication number
IT1257893B
IT1257893B ITRM920457A ITRM920457A IT1257893B IT 1257893 B IT1257893 B IT 1257893B IT RM920457 A ITRM920457 A IT RM920457A IT RM920457 A ITRM920457 A IT RM920457A IT 1257893 B IT1257893 B IT 1257893B
Authority
IT
Italy
Prior art keywords
glycoprotein
human
epitope
recognize
monoclonal antibodies
Prior art date
Application number
ITRM920457A
Other languages
English (en)
Original Assignee
Ist Superiore Sanita
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ist Superiore Sanita filed Critical Ist Superiore Sanita
Publication of ITRM920457A0 publication Critical patent/ITRM920457A0/it
Priority to ITRM920457A priority Critical patent/IT1257893B/it
Priority to DK93912996T priority patent/DK0648276T3/da
Priority to RU94046414A priority patent/RU2126836C1/ru
Priority to NZ253139A priority patent/NZ253139A/en
Priority to SK1554-94A priority patent/SK280272B6/sk
Priority to JP6501138A priority patent/JPH08501925A/ja
Priority to CZ943181A priority patent/CZ284847B6/cs
Priority to DE69322783T priority patent/DE69322783T2/de
Priority to CA002134752A priority patent/CA2134752A1/en
Priority to HU9403614A priority patent/HU216877B/hu
Priority to KR1019940704598A priority patent/KR100301189B1/ko
Priority to AU43266/93A priority patent/AU672798B2/en
Priority to AT93912996T priority patent/ATE174967T1/de
Priority to US08/356,272 priority patent/US5766946A/en
Priority to PCT/EP1993/001533 priority patent/WO1993025700A1/en
Priority to EP93912996A priority patent/EP0648276B1/en
Priority to ES93912996T priority patent/ES2130271T3/es
Publication of ITRM920457A1 publication Critical patent/ITRM920457A1/it
Priority to FI945865A priority patent/FI945865A/fi
Priority to NO944887A priority patent/NO944887D0/no
Application granted granted Critical
Publication of IT1257893B publication Critical patent/IT1257893B/it
Priority to GR990400860T priority patent/GR3029773T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

E' descritto un anticorpo monoclonale che riconosce specificamente e ad alta affinità un epitopo lineare della quarta ansa extracellulare della P-glicoproteina umana, da utilizzarsi in saggi diagnostici e di riconoscimento di cellule tumorali con un fenotipo resistente a farmaci citotossici (MDR).
ITRM920457A 1992-06-17 1992-06-17 Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana. IT1257893B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
ITRM920457A IT1257893B (it) 1992-06-17 1992-06-17 Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana.
KR1019940704598A KR100301189B1 (ko) 1992-06-17 1993-06-16 당단백질피(p)에대한단일클론항체
AT93912996T ATE174967T1 (de) 1992-06-17 1993-06-16 Monoklonale antikörper gegen glykoprotein p
NZ253139A NZ253139A (en) 1992-06-17 1993-06-16 Monoclonal antibody that recognises human glycoprotein p (pgp), its production and diagnostic kits and compositions containing it
SK1554-94A SK280272B6 (sk) 1992-06-17 1993-06-16 Monoklonálna protilátka, spôsob prípravy monokloná
JP6501138A JPH08501925A (ja) 1992-06-17 1993-06-16 糖蛋白ｐに対するモノクローナル抗体
CZ943181A CZ284847B6 (cs) 1992-06-17 1993-06-16 Monoklonální protilátky proti glykoproteinu P
DE69322783T DE69322783T2 (de) 1992-06-17 1993-06-16 Monoklonale Antikörper gegen Glykoprotein P
CA002134752A CA2134752A1 (en) 1992-06-17 1993-06-16 Monoclonal antibodies to glycoprotein p
HU9403614A HU216877B (hu) 1992-06-17 1993-06-16 Eljárás P-glikoprotein specifikus monoklonális antitestek és ezt termelő sejtvonalak előállítására
DK93912996T DK0648276T3 (da) 1992-06-17 1993-06-16 Monoklone antistoffer mod glycoprotein P
AU43266/93A AU672798B2 (en) 1992-06-17 1993-06-16 Monoclonal antibodies to glycoprotein P
RU94046414A RU2126836C1 (ru) 1992-06-17 1993-06-16 Моноклональное антитело к гликопротеину р человека
US08/356,272 US5766946A (en) 1992-06-17 1993-06-16 Monoclonal antibodies to glycoprotein P
PCT/EP1993/001533 WO1993025700A1 (en) 1992-06-17 1993-06-16 Monoclonal antibodies to glycoprotein p
EP93912996A EP0648276B1 (en) 1992-06-17 1993-06-16 Monoclonal antibodies to glycoprotein p
ES93912996T ES2130271T3 (es) 1992-06-17 1993-06-16 Anticuerpos monoclonales para glicoproteina p.
FI945865A FI945865A (fi) 1992-06-17 1994-12-13 Glykoprofeiini P:lle kohdistettuja monoklonaalisia vasta-aineita
NO944887A NO944887D0 (no) 1992-06-17 1994-12-16 Monoklonale antistoffer mot glykoprotein
GR990400860T GR3029773T3 (en) 1992-06-17 1999-03-23 Monoclonal antibodies to glycoprotein p.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM920457A IT1257893B (it) 1992-06-17 1992-06-17 Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana.

Publications (3)

Publication Number Publication Date
ITRM920457A0 ITRM920457A0 (it) 1992-06-17
ITRM920457A1 ITRM920457A1 (it) 1993-12-17
IT1257893B true IT1257893B (it) 1996-02-16

Family

ID=11401066

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM920457A IT1257893B (it) 1992-06-17 1992-06-17 Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana.

Country Status (20)

Country Link
US (1) US5766946A (it)
EP (1) EP0648276B1 (it)
JP (1) JPH08501925A (it)
KR (1) KR100301189B1 (it)
AT (1) ATE174967T1 (it)
AU (1) AU672798B2 (it)
CA (1) CA2134752A1 (it)
CZ (1) CZ284847B6 (it)
DE (1) DE69322783T2 (it)
DK (1) DK0648276T3 (it)
ES (1) ES2130271T3 (it)
FI (1) FI945865A (it)
GR (1) GR3029773T3 (it)
HU (1) HU216877B (it)
IT (1) IT1257893B (it)
NO (1) NO944887D0 (it)
NZ (1) NZ253139A (it)
RU (1) RU2126836C1 (it)
SK (1) SK280272B6 (it)
WO (1) WO1993025700A1 (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994088A (en) * 1991-03-08 1999-11-30 Board Of Trustees Of The University Of Illinois Methods and reagents for preparing and using immunological agents specific for P-glycoprotein
AU5420494A (en) * 1992-11-02 1994-05-24 Yves Claude Nicolau Method of reducing multidrug resistance in cells and tissues
US5686578A (en) 1994-08-05 1997-11-11 Immunomedics, Inc. Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
WO1997046254A2 (en) * 1996-06-05 1997-12-11 Eugene Mechetner Reagents and methods for inhibiting cytokine release by blood cells
AU5799199A (en) * 1998-09-04 2000-03-27 Immunomedics Inc. Diagnosis of multidrug resistance in cancer and infectious lesions
AU2001236588A1 (en) * 2000-01-31 2001-08-07 The Procter And Gamble Company Antibodies to the staphylococcal multidrug resistance (smr) protein
ES2659877T3 (es) 2000-06-05 2018-03-19 The Brigham And Women's Hospital, Inc. Un gen que codifica un homólogo de glicoproteína p humana multifármaco-resistente en el cromosoma 7p15-21 y usos del mismo
EP1223534A1 (en) * 2001-01-14 2002-07-17 Katz, Emil Peptides representative of polypeptides of interest and antibodies directed thereagainst, and methods, systems and kits for generating and utilizing each
US8663650B2 (en) 2003-02-21 2014-03-04 Ac Immune Sa Methods and compositions comprising supramolecular constructs
US7294701B2 (en) * 2003-04-02 2007-11-13 Technion Research & Development Foundation Ltd. Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same
FR2857875A1 (fr) * 2003-07-25 2005-01-28 Univ Reims Champagne Ardenne Vaccin therapeutique cible contre la p-glycoproteine 170 pour inhiber la resistance multidrogues dans le traitement des cancers
US7807171B2 (en) 2003-07-25 2010-10-05 Ac Immune Sa Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers
US20060068426A1 (en) * 2004-08-20 2006-03-30 Tam James P Cyclic peptides and antibodies thereof
WO2007143139A1 (en) 2006-05-31 2007-12-13 The Brigham And Women's Hospital, Inc. Abcb5 positive mesenchymal stem cells as immunomodulators
FR2906533B1 (fr) 2006-09-28 2013-02-22 Pf Medicament Procede de generation d'anticorps actifs contre un antigene de resistance,anticorps obtenus par ledit procede et leurs utilisations
US7928202B2 (en) 2007-04-12 2011-04-19 The Brigham And Women's Hospital, Inc. Targeting ABCB5 for cancer therapy
WO2012020124A1 (en) 2010-08-12 2012-02-16 Ac Immune S.A. Vaccine engineering
CN103189050B (zh) 2010-10-26 2017-09-29 Ac免疫有限公司 包含通过疏水部分修饰的肽的基于脂质体的构建体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206352A (en) * 1986-03-28 1993-04-27 Board Of Trustees Of The University Of Illinois Compositions for clones containing DNA sequences associated with multidrug resistance in human cells
US5434075A (en) * 1992-03-20 1995-07-18 Board Of Trustees Of The University Of Illinois Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses
US5773280A (en) * 1992-03-20 1998-06-30 The Board Of Trustees Of The University Of Illinois Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses
EP0569141A3 (en) * 1992-04-14 1994-10-26 Hybritech Inc Method for inhibiting the growth of multidrug-resistant tumors by antibodies.
US5369009A (en) * 1992-04-17 1994-11-29 Dana Farber Cancer Institute Antibodies for P-glycoprotein encoded by the mdr1 gene and uses thereof

Also Published As

Publication number Publication date
NO944887L (no) 1994-12-16
EP0648276B1 (en) 1998-12-23
RU2126836C1 (ru) 1999-02-27
GR3029773T3 (en) 1999-06-30
AU672798B2 (en) 1996-10-17
ES2130271T3 (es) 1999-07-01
FI945865A (fi) 1995-02-08
FI945865A0 (fi) 1994-12-13
NO944887D0 (no) 1994-12-16
CZ318194A3 (en) 1995-07-12
DK0648276T3 (da) 1999-08-23
ATE174967T1 (de) 1999-01-15
HUT70469A (en) 1995-10-30
DE69322783D1 (de) 1999-02-04
NZ253139A (en) 1996-09-25
SK280272B6 (sk) 1999-10-08
RU94046414A (ru) 1996-11-10
DE69322783T2 (de) 1999-06-10
JPH08501925A (ja) 1996-03-05
HU9403614D0 (en) 1995-02-28
AU4326693A (en) 1994-01-04
KR100301189B1 (ko) 2001-10-22
EP0648276A1 (en) 1995-04-19
SK155494A3 (en) 1995-07-11
US5766946A (en) 1998-06-16
ITRM920457A0 (it) 1992-06-17
WO1993025700A1 (en) 1993-12-23
ITRM920457A1 (it) 1993-12-17
CZ284847B6 (cs) 1999-03-17
HU216877B (hu) 1999-09-28
CA2134752A1 (en) 1993-12-23

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970627